메뉴 건너뛰기




Volumn 40, Issue 4, 1999, Pages 232-241

Serenoa repens (Permixon®): A 5α-reductase types I and II inhibitor - New evidence in a coculture model of BPH

Author keywords

5 reductase type I; 5 reductase type II; BPH; Coculture; Permixon ; PSA

Indexed keywords

PROSTATE SPECIFIC ANTIGEN; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR; TESTOSTERONE;

EID: 0032811371     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0045(19990901)40:4<232::AID-PROS4>3.0.CO;2-0     Document Type: Article
Times cited : (102)

References (44)
  • 1
    • 0016828393 scopus 로고
    • The treatment of benign prostatic hypertrophy with flutamide (SCH 13521): A placebo controlled study
    • Caine M, Perlberg S, Gordon R. The treatment of benign prostatic hypertrophy with flutamide (SCH 13521): a placebo controlled study. J Urol 1975;114:564-568.
    • (1975) J Urol , vol.114 , pp. 564-568
    • Caine, M.1    Perlberg, S.2    Gordon, R.3
  • 2
    • 0345334279 scopus 로고
    • A double-blind radiological controlled study of the effect of flutamide on benign hypertrophy - Clinical efficacy
    • Stone N, Ray PS, Smith JA. A double-blind radiological controlled study of the effect of flutamide on benign hypertrophy - clinical efficacy. J Urol 1989;141:240.
    • (1989) J Urol , vol.141 , pp. 240
    • Stone, N.1    Ray, P.S.2    Smith, J.A.3
  • 3
    • 0024557877 scopus 로고
    • Treatment of benign prostatic hyperplasia by androgen deprivation: Effects on prostate size and urodynamic parameters
    • Bosch RJ, Griffiths DJ, Blom J, Schroeder FH. Treatment of benign prostatic hyperplasia by androgen deprivation: effects on prostate size and urodynamic parameters. J Urol 1989;141:68-72.
    • (1989) J Urol , vol.141 , pp. 68-72
    • Bosch, R.J.1    Griffiths, D.J.2    Blom, J.3    Schroeder, F.H.4
  • 4
    • 0029072228 scopus 로고
    • Induction of benign prostatic hyperplasia in intact dogs by near physiological levels of 5 alpha-dihydrotestosterone and 17 beta-estradiol
    • Winter ML, Bosland MC, Wade DR, Falvo RE, Nagamani M, Liehr JGP. Induction of benign prostatic hyperplasia in intact dogs by near physiological levels of 5 alpha-dihydrotestosterone and 17 beta-estradiol. Prostate 1995;26:325-333.
    • (1995) Prostate , vol.26 , pp. 325-333
    • Winter, M.L.1    Bosland, M.C.2    Wade, D.R.3    Falvo, R.E.4    Nagamani, M.5    Liehr, J.G.P.6
  • 5
    • 0026089071 scopus 로고
    • Influence of age and endocrine factors on the volume of benign prostatic hyperplasia
    • Partin AW, Oesterling JE, Epstein JI, Horton R, Walsh PC. Influence of age and endocrine factors on the volume of benign prostatic hyperplasia. J Urol 1991;145:405-409.
    • (1991) J Urol , vol.145 , pp. 405-409
    • Partin, A.W.1    Oesterling, J.E.2    Epstein, J.I.3    Horton, R.4    Walsh, P.C.5
  • 6
    • 0016359646 scopus 로고
    • Steroid 5-alpha-reductase deficiency in a man: An inherited form of pseudohermaphroditism
    • Imperato-McGinley J, Guevro L, Gauteri T, Petersen RE. Steroid 5-alpha-reductase deficiency in a man: an inherited form of pseudohermaphroditism. Science 1974;186:1213-1215.
    • (1974) Science , vol.186 , pp. 1213-1215
    • Imperato-McGinley, J.1    Guevro, L.2    Gauteri, T.3    Petersen, R.E.4
  • 8
    • 0031938574 scopus 로고    scopus 로고
    • The localization and expression of 5α-reductase type I and type II mRNA in human hyperplastic prostate and in primary cultures
    • Habib FK, Ross M, Bayne CW, Grigor K, Buck AC, Chapman K. The localization and expression of 5α-reductase type I and type II mRNA in human hyperplastic prostate and in primary cultures. J Endocrinol 1998;156:509-517.
    • (1998) J Endocrinol , vol.156 , pp. 509-517
    • Habib, F.K.1    Ross, M.2    Bayne, C.W.3    Grigor, K.4    Buck, A.C.5    Chapman, K.6
  • 9
    • 0025689849 scopus 로고
    • The clinical development of 5α-reductase inhibitor, finasteride
    • Stoner E. The clinical development of 5α-reductase inhibitor, finasteride. J Steroid Biochem Mol Biol 1990;37:375-378.
    • (1990) J Steroid Biochem Mol Biol , vol.37 , pp. 375-378
    • Stoner, E.1
  • 10
    • 0028301655 scopus 로고
    • Inhibition of the activity of "basic" α-reductase (type I) detected in DU145 cells and expressed in insect cells
    • Delos S, Iehlé C, Martin PM, Raynaud JP. Inhibition of the activity of "basic" α-reductase (type I) detected in DU145 cells and expressed in insect cells. J Steroid Biochem Mol Biol 1994;48: 347-352.
    • (1994) J Steroid Biochem Mol Biol , vol.48 , pp. 347-352
    • Delos, S.1    Iehlé, C.2    Martin, P.M.3    Raynaud, J.P.4
  • 11
    • 0030430231 scopus 로고    scopus 로고
    • Phytotherapy for the prostate
    • Buck AC. Phytotherapy for the prostate. Br J Urol 1996;78:325-336.
    • (1996) Br J Urol , vol.78 , pp. 325-336
    • Buck, A.C.1
  • 15
    • 0031706319 scopus 로고    scopus 로고
    • Effects of long-term treatment with Serenoa repens (Permixon®) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia
    • Di Silverio F, Monti S, Sciarra A, Varasano PA, Martini C, Lanzara S, D'Eramo G, Di Nicola S, Toscano V. Effects of long-term treatment with Serenoa repens (Permixon®) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia. Prostate 1998;37:77-83.
    • (1998) Prostate , vol.37 , pp. 77-83
    • Di Silverio, F.1    Monti, S.2    Sciarra, A.3    Varasano, P.A.4    Martini, C.5    Lanzara, S.6    D'Eramo, G.7    Di Nicola, S.8    Toscano, V.9
  • 17
    • 0031937447 scopus 로고    scopus 로고
    • Effect of the lipidosterolic extract of Serenoa repens (Permixon®) and its major components on basic fibroblast growth factor-induced proliferation of cultures of human prostate biopsies
    • Paubert-Braquet M, Cousse H, Raynaud JP, Mencia-Huerta J-M, Braquet P. Effect of the lipidosterolic extract of Serenoa repens (Permixon®) and its major components on basic fibroblast growth factor-induced proliferation of cultures of human prostate biopsies. Eur Urol 1998;33:340-345.
    • (1998) Eur Urol , vol.33 , pp. 340-345
    • Paubert-Braquet, M.1    Cousse, H.2    Raynaud, J.P.3    Mencia-Huerta, J.-M.4    Braquet, P.5
  • 19
  • 20
    • 0021282157 scopus 로고
    • Inhibition of androgen metabolism and binding by a liposterolic extract of "Serenoa repens B" in human foreskin fibroblasts
    • Sultan C, Terraza A, Devillier C, Carilla E, Briley M, Loire C, Descomps B. Inhibition of androgen metabolism and binding by a liposterolic extract of "Serenoa repens B" in human foreskin fibroblasts. J Steroid Biochem 1984;20:515-519.
    • (1984) J Steroid Biochem , vol.20 , pp. 515-519
    • Sultan, C.1    Terraza, A.2    Devillier, C.3    Carilla, E.4    Briley, M.5    Loire, C.6    Descomps, B.7
  • 21
    • 0027476325 scopus 로고
    • Comparison of finasteride (Proscar®), a 5α-reductase inhibitor, and various commercial plant extracts in in vitro and in vivo 5α-reductase inhibition
    • Rhodes L, Primka RL, Berman C, Vergult G, Gabriel M, Pierre-Malice M, Gibelin B. Comparison of finasteride (Proscar®), a 5α-reductase inhibitor, and various commercial plant extracts in in vitro and in vivo 5α-reductase inhibition. Prostate 1993;22: 43-51.
    • (1993) Prostate , vol.22 , pp. 43-51
    • Rhodes, L.1    Primka, R.L.2    Berman, C.3    Vergult, G.4    Gabriel, M.5    Pierre-Malice, M.6    Gibelin, B.7
  • 23
    • 0029807732 scopus 로고    scopus 로고
    • Testosterone metabolism in primary cultures of epithelial cells and stroma from benign prostatic hyperplasia
    • Tsugaya M, Habib FK, Chisholm GD, Ross M, Tozawa K, Hayashi Y, Kohri K, Tanaka S. Testosterone metabolism in primary cultures of epithelial cells and stroma from benign prostatic hyperplasia. Urol Res 1996;24:265-271.
    • (1996) Urol Res , vol.24 , pp. 265-271
    • Tsugaya, M.1    Habib, F.K.2    Chisholm, G.D.3    Ross, M.4    Tozawa, K.5    Hayashi, Y.6    Kohri, K.7    Tanaka, S.8
  • 24
    • 0345334267 scopus 로고
    • Regulation of prostate growth in culture with the pollen extract, cernitin T-60 and the impact of the drug on the EGF tissue profiles
    • Vahlensick W, Rutishuaser G, editors. Stuttgart and New York: Thieme Verlag
    • Habib FK. Regulation of prostate growth in culture with the pollen extract, cernitin T-60 and the impact of the drug on the EGF tissue profiles. In: Vahlensick W, Rutishuaser G, editors. Benign prostate diseases. Stuttgart and New York: Thieme Verlag; 1992. p 120-128.
    • (1992) Benign Prostate Diseases , pp. 120-128
    • Habib, F.K.1
  • 25
    • 0023158779 scopus 로고
    • Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of radiosensitivity
    • Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity. Cancer Res 1987;47:943-946.
    • (1987) Cancer Res , vol.47 , pp. 943-946
    • Carmichael, J.1    DeGraff, W.G.2    Gazdar, A.F.3    Minna, J.D.4    Mitchell, J.B.5
  • 26
    • 0029926673 scopus 로고    scopus 로고
    • 5α-reductase expression by prostate cancer cell lines and benign prostatic hyperplasia in vitro
    • Smith CM, Ballard SA, Worman N, Buettner R, Master J. 5α-reductase expression by prostate cancer cell lines and benign prostatic hyperplasia in vitro. J Clin Endocrinol Metab 1996;81: 1361-1366.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1361-1366
    • Smith, C.M.1    Ballard, S.A.2    Worman, N.3    Buettner, R.4    Master, J.5
  • 28
    • 0029621142 scopus 로고
    • Improved procedures for electron microscopic visualisation of the cytoskeleton of cultured cells
    • Svitkina TM, Veskhorsky AB, Bonisy GG. Improved procedures for electron microscopic visualisation of the cytoskeleton of cultured cells. J Struct Biol 1995;115:290-303.
    • (1995) J Struct Biol , vol.115 , pp. 290-303
    • Svitkina, T.M.1    Veskhorsky, A.B.2    Bonisy, G.G.3
  • 30
    • 0344040436 scopus 로고
    • National experience on therapeutic use of Serenoa repens
    • Pisani E. National experience on therapeutic use of Serenoa repens. New Trends Androl Sci 1985;1:110-112.
    • (1985) New Trends Androl Sci , vol.1 , pp. 110-112
    • Pisani, E.1
  • 31
    • 0022621170 scopus 로고
    • The value of Permixon® in benign prostatic hypertrophy
    • Reece-Smith H, Memon A, Smart CJ, Dewbury K. The value of Permixon® in benign prostatic hypertrophy. Br J Urol 1986;58: 36-40.
    • (1986) Br J Urol , vol.58 , pp. 36-40
    • Reece-Smith, H.1    Memon, A.2    Smart, C.J.3    Dewbury, K.4
  • 32
    • 0029066391 scopus 로고
    • Placebo controlled evaluation of the efficacy and tolerability of Permixon® in benign prostatic hyperplasia after exclusion of placebo responders
    • Descotes JL, Rambeaud JJ, Deschaseaux P, Faure G. Placebo controlled evaluation of the efficacy and tolerability of Permixon® in benign prostatic hyperplasia after exclusion of placebo responders. Clin Drug Invest 1995;5:291-297.
    • (1995) Clin Drug Invest , vol.5 , pp. 291-297
    • Descotes, J.L.1    Rambeaud, J.J.2    Deschaseaux, P.3    Faure, G.4
  • 33
    • 0029007017 scopus 로고
    • Phytotherapeutic agents in the management of symptomatic benign prostatic hyperplasia
    • Fitzpatrick JM, Lynch TH. Phytotherapeutic agents in the management of symptomatic benign prostatic hyperplasia. Urol Clin North Am 1995;22:407-412.
    • (1995) Urol Clin North Am , vol.22 , pp. 407-412
    • Fitzpatrick, J.M.1    Lynch, T.H.2
  • 34
    • 0344903117 scopus 로고    scopus 로고
    • Comparative inhibition of type 1 and type 2 5 alpha-reductase activity by the N-hexane lipid/sterol extract of Serenoa Repens (Permixon®) and by finasteride
    • Dimopoulos CA, Di Silverio F, editors
    • Iehlé C, Délos S, Martin P-M, Raynaud J-P. Comparative inhibition of type 1 and type 2 5 alpha-reductase activity by the n-hexane lipid/sterol extract of Serenoa repens (Permixon®) and by finasteride. In: Dimopoulos CA, Di Silverio F, editors. Bologna: Monduzzi Editore; 1996. p 22-33.
    • (1996) Bologna: Monduzzi Editore , pp. 22-33
    • Iehlé, C.1    Délos, S.2    Martin, P.-M.3    Raynaud, J.-P.4
  • 35
    • 0000617112 scopus 로고
    • Permixon®, a new treatment for benign prostatic hyperplasia, acts directly at the cytosolic androgen receptor in rat prostate
    • Briley M, Carilla E, Fauran F. Permixon®, a new treatment for benign prostatic hyperplasia, acts directly at the cytosolic androgen receptor in rat prostate. Br J Pharmacol 1983;79:327-336.
    • (1983) Br J Pharmacol , vol.79 , pp. 327-336
    • Briley, M.1    Carilla, E.2    Fauran, F.3
  • 36
    • 0025045495 scopus 로고
    • Androgen receptor gene expression in human prostate carcinoma cell lines
    • Tilley WD, Wilson CM, Marcelli M, McPhaul MJ. Androgen receptor gene expression in human prostate carcinoma cell lines. Cancer Res 1990;50:5382-5386.
    • (1990) Cancer Res , vol.50 , pp. 5382-5386
    • Tilley, W.D.1    Wilson, C.M.2    Marcelli, M.3    McPhaul, M.J.4
  • 37
    • 0030474629 scopus 로고    scopus 로고
    • Androgen independence of primary epithelial cultures of the prostate is associated with a down-regulation of androgen receptor gene expression
    • Grant ES, Batchelor KW, Habib FK. Androgen independence of primary epithelial cultures of the prostate is associated with a down-regulation of androgen receptor gene expression. Prostate 1996;29:339-349.
    • (1996) Prostate , vol.29 , pp. 339-349
    • Grant, E.S.1    Batchelor, K.W.2    Habib, F.K.3
  • 38
    • 0018815211 scopus 로고
    • Characterisation of a human prostate adenocarcinoma cell line (DU145) as a monolayer culture and as a solid tumour in athymic mice
    • Mickey DD, Stone KR, Wunderli H, Mickey GH, Paulson DF. Characterisation of a human prostate adenocarcinoma cell line (DU145) as a monolayer culture and as a solid tumour in athymic mice. Prog Clin Biol Res 1980;37:67-84.
    • (1980) Prog Clin Biol Res , vol.37 , pp. 67-84
    • Mickey, D.D.1    Stone, K.R.2    Wunderli, H.3    Mickey, G.H.4    Paulson, D.F.5
  • 39
    • 0018779369 scopus 로고
    • Establishment and characterisation of a human prostate carcinoma cell line (PC-3)
    • Kaighn ME, Narayan KS, Ohnuki Y, Lechner JF, Jones LW. Establishment and characterisation of a human prostate carcinoma cell line (PC-3). Invest Urol 1979;17:16-23.
    • (1979) Invest Urol , vol.17 , pp. 16-23
    • Kaighn, M.E.1    Narayan, K.S.2    Ohnuki, Y.3    Lechner, J.F.4    Jones, L.W.5
  • 41
    • 0009413722 scopus 로고    scopus 로고
    • Down-regulation of prostate-specific antigen expression by finasteride through inhibition of complex formation between androgen receptor and steroid receptor-binding consensus in the promoter of the PSA gene in LNCaP cells
    • Wang LG, Liu XM, Kreis W, Budman DR. Down-regulation of prostate-specific antigen expression by finasteride through inhibition of complex formation between androgen receptor and steroid receptor-binding consensus in the promoter of the PSA gene in LNCaP cells. Cancer Res 1997;57:714-719.
    • (1997) Cancer Res , vol.57 , pp. 714-719
    • Wang, L.G.1    Liu, X.M.2    Kreis, W.3    Budman, D.R.4
  • 42
    • 0026082779 scopus 로고
    • + 4-ene-oxide-reductase; EC1.3.1.22) in a stable and active form
    • + 4-ene-oxide-reductase; EC1.3.1.22) in a stable and active form. J Steroid Biochem Mol Biol 1991;38:73-77.
    • (1991) J Steroid Biochem Mol Biol , vol.38 , pp. 73-77
    • Sargent, N.S.E.1    Habib, F.K.2
  • 44
    • 0026469615 scopus 로고
    • Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign hypertrophy patient
    • Di Silverio F, D'Eramo G, Lubrako C, Flummia GP, Sciarra A, Palma E, Caponero M, Sciarra F. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign hypertrophy patient. Eur Urol 1992;21:309-314.
    • (1992) Eur Urol , vol.21 , pp. 309-314
    • Di Silverio, F.1    D'Eramo, G.2    Lubrako, C.3    Flummia, G.P.4    Sciarra, A.5    Palma, E.6    Caponero, M.7    Sciarra, F.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.