메뉴 건너뛰기




Volumn 45, Issue 3, 2002, Pages 213-224

Emerging medical therapies for pulmonary arterial hypertension

Author keywords

[No Author keywords available]

Indexed keywords

AMBISENTAN; AMBRISENTAN; ANTICOAGULANT AGENT; ARGININE; BERAPROST; BOSENTAN; CALCIUM CHANNEL BLOCKING AGENT; DIGOXIN; DIURETIC AGENT; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; ILOPROST; OXYGEN; PROSTACYCLIN; PROSTACYCLIN DERIVATIVE; SILDENAFIL; SITAXSENTAN; TERBOGREL; THROMBOXANE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; UNIPROST;

EID: 0036875131     PISSN: 00330620     EISSN: None     Source Type: Journal    
DOI: 10.1053/pcad.2002.130160     Document Type: Article
Times cited : (41)

References (70)
  • 2
    • 0024449294 scopus 로고
    • Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry
    • Pietra GG, Edwards WD, Kay JM, et al: Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry [see comments]. Circulation 80:1198-1206, 1989
    • (1989) Circulation , vol.80 , pp. 1198-1206
    • Pietra, G.G.1    Edwards, W.D.2    Kay, J.M.3
  • 3
    • 0034804704 scopus 로고    scopus 로고
    • Medical therapy of pulmonary hypertension. The prostacyclins
    • Galie N, Manes A, Branzi A: Medical therapy of pulmonary hypertension. The prostacyclins. Clin Chest Med 22:529-537, 2001
    • (2001) Clin Chest Med , vol.22 , pp. 529-537
    • Galie, N.1    Manes, A.2    Branzi, A.3
  • 4
    • 0024422399 scopus 로고
    • Primary pulmonary hypertension. Vascular structure; morphometry, and responsiveness to vasodilator agents
    • Palevsky HI, Schloo BL, Pietra GG, et al: Primary pulmonary hypertension. Vascular structure; morphometry, and responsiveness to vasodilator agents [see comments]. Circulation 80:1207-1221, 1989
    • (1989) Circulation , vol.80 , pp. 1207-1221
    • Palevsky, H.I.1    Schloo, B.L.2    Pietra, G.G.3
  • 5
    • 0031031440 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • Rubin LJ: Primary pulmonary hypertension. N Engl J Med 336:111-117, 1997
    • (1997) N Engl J Med , vol.336 , pp. 111-117
    • Rubin, L.J.1
  • 6
    • 0035038492 scopus 로고    scopus 로고
    • Pulmonary hypertension in systemic sclerosis: Risk factors for progression and consequences for survival
    • MacGregor AJ, Canavan R, Knight C, et al: Pulmonary hypertension in systemic sclerosis: Risk factors for progression and consequences for survival. Rheumatology (Oxford); 40:453-459, 2001
    • (2001) Rheumatology (Oxford) , vol.40 , pp. 453-459
    • MacGregor, A.J.1    Canavan, R.2    Knight, C.3
  • 7
    • 0034719427 scopus 로고    scopus 로고
    • Congenital heart disease in adults. Second of two parts
    • published erratum appears in N Engl J Med 342:988, 2000
    • Brickner ME, Hillis LD, Lange RA: Congenital heart disease in adults. Second of two parts [published erratum appears in N Engl J Med 342:988, 2000]. N Engl J Med 342:334-342, 2000
    • (2000) N Engl J Med , vol.342 , pp. 334-342
    • Brickner, M.E.1    Hillis, L.D.2    Lange, R.A.3
  • 8
    • 0031844681 scopus 로고    scopus 로고
    • Pulmonary vascular disorders in portal hypertension
    • Herve P, Lebrec D, Brenot F, et al: Pulmonary vascular disorders in portal hypertension. Eur Respir J 11:1153-1166, 1998
    • (1998) Eur Respir J , vol.11 , pp. 1153-1166
    • Herve, P.1    Lebrec, D.2    Brenot, F.3
  • 9
    • 0028298825 scopus 로고
    • Pulmonary hypertension in patients with human immunodeficiency virus infection. Comparison with primary pulmonary hypertension
    • Petitpretz P, Brenot F, Azarian R, et al: Pulmonary hypertension in patients with human immunodeficiency virus infection. Comparison with primary pulmonary hypertension. Circulation 89:2722-2727, 1994
    • (1994) Circulation , vol.89 , pp. 2722-2727
    • Petitpretz, P.1    Brenot, F.2    Azarian, R.3
  • 10
    • 0031690520 scopus 로고    scopus 로고
    • Primary pulmonary hypertension: Insights into pathogenesis from epidemiology
    • Galie N, Manes A, Uguccioni L, et al: Primary pulmonary hypertension: insights into pathogenesis from epidemiology. Chest 114(3 suppl):184S-194S, 1998
    • (1998) Chest , vol.114 , Issue.3 SUPPL.
    • Galie, N.1    Manes, A.2    Uguccioni, L.3
  • 11
    • 0034960745 scopus 로고    scopus 로고
    • Do we need controlled clinical trials in pulmonary arterial hypertension?
    • Galie N: Do we need controlled clinical trials in pulmonary arterial hypertension? Eur Respir J 17:1-3, 2001
    • (2001) Eur Respir J , vol.17 , pp. 1-3
    • Galie, N.1
  • 12
    • 0025356811 scopus 로고
    • Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Results of a randomized trial
    • Rubin LJ, Mendoza J, Hood M, et al: Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Results of a randomized trial. Ann Intern Med 112:485-491, 1990
    • (1990) Ann Intern Med , vol.112 , pp. 485-491
    • Rubin, L.J.1    Mendoza, J.2    Hood, M.3
  • 13
    • 0030031888 scopus 로고    scopus 로고
    • A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension
    • The Primary Pulmonary Hypertension Study Group
    • Barst RJ, Rubin LJ, Long WA, et al: A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group [see comments]. N Engl J Med 334:296-302, 1996
    • (1996) N Engl J Med , vol.334 , pp. 296-302
    • Barst, R.J.1    Rubin, L.J.2    Long, W.A.3
  • 14
    • 17144452827 scopus 로고    scopus 로고
    • Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial
    • Badesch DB, Tapson VF, McGoon MD, et al: Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial [see comments]. Ann Intern Med 132:425-434, 2000
    • (2000) Ann Intern Med , vol.132 , pp. 425-434
    • Badesch, D.B.1    Tapson, V.F.2    McGoon, M.D.3
  • 15
    • 0037126044 scopus 로고    scopus 로고
    • Survival in primary pulmonary hypertension. The impact of epoprostenol therapy
    • McLaughlin VV, Shillington A, Rich S: Survival in primary pulmonary hypertension. The impact of epoprostenol therapy. Circulation 106:1477-1482, 2002
    • (2002) Circulation , vol.106 , pp. 1477-1482
    • McLaughlin, V.V.1    Shillington, A.2    Rich, S.3
  • 16
    • 0037151645 scopus 로고    scopus 로고
    • Long-term intravenous epoprostenol infusion in primary pulmonary hypertension prognostic factors and survival
    • Sitbon O, Humbert M, Nunes H, et al: Long-term intravenous epoprostenol infusion in primary pulmonary hypertension Prognostic factors and survival. J Am Coll Cardiol 40:780, 2002
    • (2002) J Am Coll Cardiol , vol.40 , pp. 780
    • Sitbon, O.1    Humbert, M.2    Nunes, H.3
  • 17
    • 20244386797 scopus 로고    scopus 로고
    • Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension
    • Langleben D, Christman BW, Barst RJ, et al: Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension. Am Heart J 143:E4, 2002
    • (2002) Am Heart J , vol.143
    • Langleben, D.1    Christman, B.W.2    Barst, R.J.3
  • 18
    • 0037086133 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension. A double-blind, randomized, placebo-controlled trial
    • Simonneau G, Barst RJ, Galie N, et al: Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension. A double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med 165:800-804, 2002
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 800-804
    • Simonneau, G.1    Barst, R.J.2    Galie, N.3
  • 19
    • 0036569119 scopus 로고    scopus 로고
    • Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension. A randomised double-blind placebo-controlled trial
    • Galie N, Humbert M, Vachiery JL, et al: Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension. A randomised double-blind placebo-controlled trial. J Am Coll Cardiol 39:1496-1502, 2002
    • (2002) J Am Coll Cardiol , vol.39 , pp. 1496-1502
    • Galie, N.1    Humbert, M.2    Vachiery, J.L.3
  • 20
    • 0036682273 scopus 로고    scopus 로고
    • Inhaled Iloprost in severe pulmonary hypertension
    • Olschewski H, Simonneau G, Galie N, et al: Inhaled Iloprost in severe pulmonary hypertension. N Engl J Med 347:322-329, 2002
    • (2002) N Engl J Med , vol.347 , pp. 322-329
    • Olschewski, H.1    Simonneau, G.2    Galie, N.3
  • 21
    • 0035818316 scopus 로고    scopus 로고
    • Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: A randomised placebo-controlled study
    • Channick RN, Simonneau G, Sitbon O, et al: Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: A randomised placebo-controlled study. Lancet 358:1119-1123, 2001
    • (2001) Lancet , vol.358 , pp. 1119-1123
    • Channick, R.N.1    Simonneau, G.2    Sitbon, O.3
  • 22
    • 0037149718 scopus 로고    scopus 로고
    • Bosentan therapy for pulmonary arterial hypertension
    • Rubin LJ, Badesch DB, Barst RJ, et al: Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 346:896-903, 2002
    • (2002) N Engl J Med , vol.346 , pp. 896-903
    • Rubin, L.J.1    Badesch, D.B.2    Barst, R.J.3
  • 23
    • 0026628265 scopus 로고
    • An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
    • Christman BW, McPherson CD, Newman JH, et al: An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension [see comments]. N Engl J Med 327:70-75, 1992
    • (1992) N Engl J Med , vol.327 , pp. 70-75
    • Christman, B.W.1    McPherson, C.D.2    Newman, J.H.3
  • 24
    • 0017094798 scopus 로고
    • An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
    • Moncada S, Gryglewski R, Bunting S, et al: An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263:663-665, 1976
    • (1976) Nature , vol.263 , pp. 663-665
    • Moncada, S.1    Gryglewski, R.2    Bunting, S.3
  • 25
    • 0024794487 scopus 로고
    • Decreased arterial wall prostaglandin production in neonatal calves with severe chronic pulmonary hypertension
    • Badesch DB, Orton EC, Zapp LM, et al: Decreased arterial wall prostaglandin production in neonatal calves with severe chronic pulmonary hypertension. Am J Respir Cell Mol Biol 1:489-498, 1989
    • (1989) Am J Respir Cell Mol Biol , vol.1 , pp. 489-498
    • Badesch, D.B.1    Orton, E.C.2    Zapp, L.M.3
  • 26
    • 0033032949 scopus 로고    scopus 로고
    • Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
    • Tuder RM, Cool CD, Geraci MW, et al: Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 159:1925-1932, 1999
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1925-1932
    • Tuder, R.M.1    Cool, C.D.2    Geraci, M.W.3
  • 27
    • 0025356811 scopus 로고
    • Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Results of a randomized trial
    • Rubin LJ, Mendoza J, Hood M, et al: Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Results of a randomized trial. Ann Intern Med 112:485-491, 1990
    • (1990) Ann Intern Med , vol.112 , pp. 485-491
    • Rubin, L.J.1    Mendoza, J.2    Hood, M.3
  • 28
    • 0030031888 scopus 로고    scopus 로고
    • A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension
    • The Primary Pulmonary Hypertension Study Group
    • Barst RJ, Rubin LJ, Long WA, et al: A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group [see comments]. N Engl J Med 334:296-302, 1996
    • (1996) N Engl J Med , vol.334 , pp. 296-302
    • Barst, R.J.1    Rubin, L.J.2    Long, W.A.3
  • 29
    • 17144452827 scopus 로고    scopus 로고
    • Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial
    • Badesch DB, Tapson VF, McGoon MD, et al: Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial [see comments]. Ann Intern Med 132:425-434, 2000
    • (2000) Ann Intern Med , vol.132 , pp. 425-434
    • Badesch, D.B.1    Tapson, V.F.2    McGoon, M.D.3
  • 30
    • 0033551155 scopus 로고    scopus 로고
    • Long-term prostacyclin for pulmonary hypertension with associated congenital heart defects
    • Rosenzweig EB, Kerstein D, Barst RJ: Long-term prostacyclin for pulmonary hypertension with associated congenital heart defects. Circulation 99:1858-1865, 1999
    • (1999) Circulation , vol.99 , pp. 1858-1865
    • Rosenzweig, E.B.1    Kerstein, D.2    Barst, R.J.3
  • 31
    • 0033522395 scopus 로고    scopus 로고
    • Compassionate use of continuous prostacyclin in the management of secondary pulmonary hypertension: A case series
    • McLaughlin VV, Genthner DE, Panella MM, et al: Compassionate use of continuous prostacyclin in the management of secondary pulmonary hypertension: A case series [see comments]. Ann Intern Med 130:740-743, 1999
    • (1999) Ann Intern Med , vol.130 , pp. 740-743
    • McLaughlin, V.V.1    Genthner, D.E.2    Panella, M.M.3
  • 32
    • 0033679134 scopus 로고    scopus 로고
    • Epoprostenol (prostacyclin) therapy in HIV-associated pulmonary hypertension
    • Aguilar RV, Farber HW: Epoprostenol (prostacyclin) therapy in HIV-associated pulmonary hypertension. Am J Respir Crit Care Med 162:1846-1850, 2000
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 1846-1850
    • Aguilar, R.V.1    Farber, H.W.2
  • 33
    • 0029055964 scopus 로고
    • Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
    • Giaid A, Saleh D: Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 333:214-221, 1995
    • (1995) N Engl J Med , vol.333 , pp. 214-221
    • Giaid, A.1    Saleh, D.2
  • 34
    • 0031770719 scopus 로고    scopus 로고
    • Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension
    • Archer S, Djaballah K, Humbert Marc, et al: Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension. Am J Respir Crit Care Med 158:1061-1067, 1998
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 1061-1067
    • Archer, S.1    Djaballah, K.2    Humbert, M.3
  • 35
    • 0032855452 scopus 로고    scopus 로고
    • Effect of nebulized epoprostenol (prostacyclin) on exhaled nitric oxide in patients with pulmonary hypertension due to congenital heart disease and in normal controls
    • Forrest IA, Small T, Corris PA: Effect of nebulized epoprostenol (prostacyclin) on exhaled nitric oxide in patients with pulmonary hypertension due to congenital heart disease and in normal controls. Clin Sci (Lond) 97:99-102, 1999
    • (1999) Clin Sci (Lond) , vol.97 , pp. 99-102
    • Forrest, I.A.1    Small, T.2    Corris, P.A.3
  • 36
    • 0031674060 scopus 로고    scopus 로고
    • Urinary cGMP concentrations in severe primary pulmonary hypertension
    • Bogdan M, Humbert M, Francoual J, et al: Urinary cGMP concentrations in severe primary pulmonary hypertension. Thorax 53:1059-1062, 1998
    • (1998) Thorax , vol.53 , pp. 1059-1062
    • Bogdan, M.1    Humbert, M.2    Francoual, J.3
  • 37
    • 0033977505 scopus 로고    scopus 로고
    • A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension
    • German PPH study group
    • Hoeper MM, Olschewski H, Ghofrani HA, et al: A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. German PPH study group. J Am Coll Cardiol 35:176-182, 2000
    • (2000) J Am Coll Cardiol , vol.35 , pp. 176-182
    • Hoeper, M.M.1    Olschewski, H.2    Ghofrani, H.A.3
  • 38
    • 0029896789 scopus 로고    scopus 로고
    • Pulsed delivery of inhaled nitric oxide to patients with primary pulmonary hypertension: An ambulatory delivery system and initial clinical tests
    • Channick RN, Newhart JW, Johnson FW, et al: Pulsed delivery of inhaled nitric oxide to patients with primary pulmonary hypertension: An ambulatory delivery system and initial clinical tests. Chest 109:1545-1549, 1996
    • (1996) Chest , vol.109 , pp. 1545-1549
    • Channick, R.N.1    Newhart, J.W.2    Johnson, F.W.3
  • 39
    • 0027752805 scopus 로고
    • The L-arginine-nitric oxide pathway
    • Moncada S, Higgs A: The L-arginine-nitric oxide pathway. N Engl J Med 329:2002-2012, 1993
    • (1993) N Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 40
    • 0026034713 scopus 로고
    • Increased plasma endothelin-1 in pulmonary hypertension: Marker or mediator of disease?
    • Stewart DJ, Levy RD, Cernacek P, et al: Increased plasma endothelin-1 in pulmonary hypertension: Marker or mediator of disease? Ann Intern Med 114:464-469, 1991
    • (1991) Ann Intern Med , vol.114 , pp. 464-469
    • Stewart, D.J.1    Levy, R.D.2    Cernacek, P.3
  • 41
    • 0001892899 scopus 로고
    • Comparative relation of neurohormonal activation to hemodynamics in primary or precapillary secondary pulmonary hypertension
    • abstr
    • Galiè N, Borgatti ML, Ussia GP, et al: Comparative relation of neurohormonal activation to hemodynamics in primary or precapillary secondary pulmonary hypertension. J Am Coll Cardiol 25:40A, 1995 (abstr)
    • (1995) J Am Coll Cardiol , vol.25
    • Galiè, N.1    Borgatti, M.L.2    Ussia, G.P.3
  • 42
    • 0001295078 scopus 로고    scopus 로고
    • Relation of endothelin-1 to survival in patients with primary pulmonary hypertension
    • abstr
    • Galiè N, Grigoni F, Bacchi-Reggiani L, et al: Relation of endothelin-1 to survival in patients with primary pulmonary hypertension. Eur J Clin Invest 26(supp 1):273, 1996 (abstr)
    • (1996) Eur J Clin Invest , vol.26 , Issue.SUPPL. 1 , pp. 273
    • Galiè, N.1    Grigoni, F.2    Bacchi-Reggiani, L.3
  • 43
    • 0027324745 scopus 로고
    • Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
    • Giaid A, Yanagisawa M, Langleben D, et al: Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 328:1732-1739, 1993
    • (1993) N Engl J Med , vol.328 , pp. 1732-1739
    • Giaid, A.1    Yanagisawa, M.2    Langleben, D.3
  • 44
    • 0034619523 scopus 로고    scopus 로고
    • Endothelins and endothelin receptor antagonists: Therapeutic considerations for a novel class of cardiovascular drugs
    • Luscher TF, Barton M: Endothelins and endothelin receptor antagonists: Therapeutic considerations for a novel class of cardiovascular drugs. Circulation 102:2434-2440, 2000
    • (2000) Circulation , vol.102 , pp. 2434-2440
    • Luscher, T.F.1    Barton, M.2
  • 45
    • 0030862759 scopus 로고    scopus 로고
    • Nonspecific endothelin-receptor antagonist blunts monocretaline-induced pulmonary hypertension in rats
    • Hill NS, Warburton RR, Pietras L, et al: Nonspecific endothelin-receptor antagonist blunts monocretaline-induced pulmonary hypertension in rats. J Appl Physiol 83:1209-1215, 1997
    • (1997) J Appl Physiol , vol.83 , pp. 1209-1215
    • Hill, N.S.1    Warburton, R.R.2    Pietras, L.3
  • 46
    • 0028952366 scopus 로고
    • Acute hemodynamic effects of the prostacyclin analog 15AU81 in severe congestive heart failure
    • Patterson JH, Adams KF, Jr., Gheorghiade M, et al: Acute hemodynamic effects of the prostacyclin analog 15AU81 in severe congestive heart failure. Am J Cardiol 75:26A-33A, 1995
    • (1995) Am J Cardiol , vol.75
    • Patterson, J.H.1    Adams K.F., Jr.2    Gheorghiade, M.3
  • 47
    • 0001035221 scopus 로고    scopus 로고
    • Acute hemodynamic effects of subcutaneous UT 15 in primary pulmonary hypertension
    • abstr
    • Gaine SP, Barst RJ, Rich S, et al: Acute hemodynamic effects of subcutaneous UT 15 in primary pulmonary hypertension. Am J Crit Care Med 159:A161, 1999 (abstr)
    • (1999) Am J Crit Care Med , vol.159
    • Gaine, S.P.1    Barst, R.J.2    Rich, S.3
  • 48
    • 0000040340 scopus 로고    scopus 로고
    • Efficacy and safety of UT-15, a prostacyclin analogue for primary pulmonary hypertension
    • abstr
    • McLaughlin V, Barst R, Rich S, et al: Efficacy and safety of UT-15, a prostacyclin analogue for primary pulmonary hypertension. Eur Heart J 20:486, 1999 (abstr)
    • (1999) Eur Heart J , vol.20 , pp. 486
    • McLaughlin, V.1    Barst, R.2    Rich, S.3
  • 49
    • 0035128302 scopus 로고    scopus 로고
    • Pharmacological and clinical properties of beraprost sodium, orally active prostacyclin analogue
    • Nishio S, Kurumatani H: [Pharmacological and clinical properties of beraprost sodium, orally active prostacyclin analogue]. Nippon Yakurigaku Zasshi 117:123-130, 2001
    • (2001) Nippon Yakurigaku Zasshi , vol.117 , pp. 123-130
    • Nishio, S.1    Kurumatani, H.2
  • 50
    • 0030070515 scopus 로고    scopus 로고
    • Protective effect of beraprost sodium, a stable prostacyclin analogue, in development of monocrotaline-induced pulmonary hypertension
    • Miyata M, Ueno Y, Sekine H, et al: Protective effect of beraprost sodium, a stable prostacyclin analogue, in development of monocrotaline-induced pulmonary hypertension. J Cardiovasc Pharmacol 27:20-26, 1996
    • (1996) J Cardiovasc Pharmacol , vol.27 , pp. 20-26
    • Miyata, M.1    Ueno, Y.2    Sekine, H.3
  • 51
    • 0343488567 scopus 로고    scopus 로고
    • Orally active prostacyclin analogue in primary pulmonary hypertension
    • Okano Y, Yoshioka T, Shimouchi A, et al: Orally active prostacyclin analogue in primary pulmonary hypertension. Lancet 349:1365, 1997
    • (1997) Lancet , vol.349 , pp. 1365
    • Okano, Y.1    Yoshioka, T.2    Shimouchi, A.3
  • 52
    • 3042686863 scopus 로고    scopus 로고
    • Effect of orally active prostacyclin analogue on survival of outpatients with primary pulmonary hypertension
    • Nagaya N, Uematsu M, Okano Y, et al: Effect of orally active prostacyclin analogue on survival of outpatients with primary pulmonary hypertension. J Am Coll Cardiol 34:1188-1192, 1999
    • (1999) J Am Coll Cardiol , vol.34 , pp. 1188-1192
    • Nagaya, N.1    Uematsu, M.2    Okano, Y.3
  • 53
    • 0031842301 scopus 로고    scopus 로고
    • Long-term intravenous prostaglandin (epoprostenol or iloprost) for treatment of severe pulmonary hypertension
    • Higenbottam T, Butt AY, McMahon A, et al: Long-term intravenous prostaglandin (epoprostenol or iloprost) for treatment of severe pulmonary hypertension. Heart 80:151-155, 1998
    • (1998) Heart , vol.80 , pp. 151-155
    • Higenbottam, T.1    Butt, A.Y.2    McMahon, A.3
  • 54
    • 0031920988 scopus 로고    scopus 로고
    • Treatment of pulmonary hypertension with the continuous infusion of a prostacyclin analogue, iloprost
    • Higenbottam TW, Butt AY, Dinh-Xaun AT, et al: Treatment of pulmonary hypertension with the continuous infusion of a prostacyclin analogue, iloprost. Heart 79:175-179, 1998
    • (1998) Heart , vol.79 , pp. 175-179
    • Higenbottam, T.W.1    Butt, A.Y.2    Dinh-Xaun, A.T.3
  • 55
    • 0032969960 scopus 로고    scopus 로고
    • Pulmonary hypertension secondary to systemic lupus erythematosus: Prolonged survival following treatment with intermittent low dose iloprost
    • Mok MY, Tse HF, Lau CS: Pulmonary hypertension secondary to systemic lupus erythematosus: Prolonged survival following treatment with intermittent low dose iloprost. Lupus 8:328-331, 1999
    • (1999) Lupus , vol.8 , pp. 328-331
    • Mok, M.Y.1    Tse, H.F.2    Lau, C.S.3
  • 56
    • 0029993602 scopus 로고    scopus 로고
    • Aerosolized prostacyclin and iloprost in severe pulmonary hypertension
    • Olschewski H, Walmrath D, Schermuly R, et al: Aerosolized prostacyclin and iloprost in severe pulmonary hypertension. Ann Intern Med 124:820-824, 1996
    • (1996) Ann Intern Med , vol.124 , pp. 820-824
    • Olschewski, H.1    Walmrath, D.2    Schermuly, R.3
  • 57
    • 0034696634 scopus 로고    scopus 로고
    • Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial
    • German PPH Study Group
    • Olschewski H, Ghofrani HA, Schmehl T, et al: Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group [see comments]. Ann Intern Med 132:435-443, 2000
    • (2000) Ann Intern Med , vol.132 , pp. 435-443
    • Olschewski, H.1    Ghofrani, H.A.2    Schmehl, T.3
  • 58
    • 0034702248 scopus 로고    scopus 로고
    • Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue
    • Hoeper MM, Schwarze M, Ehlerding S, et al: Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N Engl J Med 342:1866-1870, 2000
    • (2000) N Engl J Med , vol.342 , pp. 1866-1870
    • Hoeper, M.M.1    Schwarze, M.2    Ehlerding, S.3
  • 59
    • 0032810972 scopus 로고    scopus 로고
    • Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis
    • Olschewski H, Ghofrani HA, Walmrath D, et al: Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis. Am J Respir Crit Care Med 160:600-607, 1999
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 600-607
    • Olschewski, H.1    Ghofrani, H.A.2    Walmrath, D.3
  • 60
    • 0000768665 scopus 로고    scopus 로고
    • Effect of the oral endothelin receptor antagonist bosentan on echocardiographic and Doppler measures in patients with pulmonary arterial hypertension
    • Galie N, Hinderliter AL, Torbicki A, et al: Effect of the oral endothelin receptor antagonist bosentan on echocardiographic and Doppler measures in patients with pulmonary arterial hypertension. J Am Coll Cardiol 39:224A, 2002
    • (2002) J Am Coll Cardiol , vol.39
    • Galie, N.1    Hinderliter, A.L.2    Torbicki, A.3
  • 61
    • 0012782672 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of bosentan, an oral dual endothelin receptor antagonist in children with pulmonary arterial hypertension: BREATHE-3
    • Abstr Suppl
    • Barst R, Ivy D, Widlitz AC, et al: Pharmacokinetics and safety of bosentan, an oral dual endothelin receptor antagonist in children with pulmonary arterial hypertension: BREATHE-3. Eur Heart J 23(Abstr suppl):489, 2002
    • (2002) Eur Heart J , vol.23 , pp. 489
    • Barst, R.1    Ivy, D.2    Widlitz, A.C.3
  • 62
    • 0035043336 scopus 로고    scopus 로고
    • Sitaxsentan (ICOS-Texas Biotechnology)
    • Wu-Wong JR: Sitaxsentan (ICOS-Texas Biotechnology). Curr Opin Investig Drugs 2:531-536, 2001
    • (2001) Curr Opin Investig Drugs , vol.2 , pp. 531-536
    • Wu-Wong, J.R.1
  • 63
    • 0036135708 scopus 로고    scopus 로고
    • Endothelin receptor blockade and in-stent restenosis
    • Kirchengast M: Endothelin receptor blockade and in-stent restenosis. J Cardiovasc Pharmacol 38(suppl 2):S31-S34, 2001
    • (2001) J Cardiovasc Pharmacol , vol.38 , Issue.SUPPL. 2
    • Kirchengast, M.1
  • 64
    • 0029083303 scopus 로고
    • Short-term pulmonary vasodilation with L-arginine in pulmonary hypertension
    • Mehta S, Stewart DJ, Langleben D, et al: Short-term pulmonary vasodilation with L-arginine in pulmonary hypertension. Circulation 92:1539-1545, 1995
    • (1995) Circulation , vol.92 , pp. 1539-1545
    • Mehta, S.1    Stewart, D.J.2    Langleben, D.3
  • 65
    • 0035060156 scopus 로고    scopus 로고
    • Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension
    • Nagaya N, Uematsu M, Oya H, et al: Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir Crit Care Med 163:887-891, 2001
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 887-891
    • Nagaya, N.1    Uematsu, M.2    Oya, H.3
  • 66
    • 0034047308 scopus 로고    scopus 로고
    • Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension
    • Weimann J, Ullrich R, Hromi J, et al: Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension. Anesthesiology 92:1702-1712, 2000
    • (2000) Anesthesiology , vol.92 , pp. 1702-1712
    • Weimann, J.1    Ullrich, R.2    Hromi, J.3
  • 68
    • 0034241419 scopus 로고    scopus 로고
    • Sildenafil as a selective pulmonary vasodilator in childhood primary pulmonary hypertension
    • Abrams D, Schulze-Nelck I, Magee AG: Sildenafil as a selective pulmonary vasodilator in childhood primary pulmonary hypertension. Heart 84:E4, 2000
    • (2000) Heart , vol.84
    • Abrams, D.1    Schulze-Nelck, I.2    Magee, A.G.3
  • 69
    • 0036013752 scopus 로고    scopus 로고
    • Transitioning from IV epoprostenol to subcutaneous treprostinil in pulmonary arterial hypertension(*)
    • Vachiery JL, Hill N, Zwicke D, et al: Transitioning from IV epoprostenol to subcutaneous treprostinil in pulmonary arterial hypertension(*). Chest 121:1561-1565, 2002
    • (2002) Chest , vol.121 , pp. 1561-1565
    • Vachiery, J.L.1    Hill, N.2    Zwicke, D.3
  • 70
    • 0001140172 scopus 로고    scopus 로고
    • Long-term effectiveness of additional oral sildenafil for improvement of patients with severe pulmonary arterial hypertension treated with inalative iloprost therapy
    • Ghofrani A, Wiedermann R, Schermuly R, et al: Long-term effectiveness of additional oral sildenafil for improvement of patients with severe pulmonary arterial hypertension treated with inalative iloprost therapy. Am J Respir Crit Care Med 165:A411, 2002
    • (2002) Am J Respir Crit Care Med , vol.165
    • Ghofrani, A.1    Wiedermann, R.2    Schermuly, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.