Scale-up of polymerization processes

Current Opinion in Drug Discovery and Development

Volumn 5, Issue 6, 2002, Pages 960-965

  Meyer, Thierry ^a  

^a EPFL   (Switzerland)

Author keywords

Optimization; Polymerization; Process control; Process development; Reactors; Scale up

Indexed keywords

ENVIRONMENTAL PROTECTION; INDUSTRIAL PRODUCTION; MATHEMATICAL MODEL; POLYMERIZATION; PROCESS CONTROL; PROCESS DESIGN; PROCESS DEVELOPMENT; REACTOR; REVIEW; SCALE UP;

ANIMALS; HUMANS; POLYMERS; TECHNOLOGY, PHARMACEUTICAL;

EID: 0036869697     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (45)

1. Mak CP, Muhle H, Achini R: Integrated solutions to environmental protection in process R&D. Chimia (1997) 51:184-188.
2. Stoessel F: Safety issues in scale-up of chemical processes. Curr Opin Drug Discovery Dev (2001) 4:834-839. An analysis focusing on safety issues related to the scale-up process is presented. The most important aspects are emphasized and discussed.
3. Euzen J-P, Trambouze P, Wauquier J-P: Scale-up Methodology for Chemical Processes. Editions Technip, Paris, France (1993).
4. Samant KD, Ng KM: Development of liquid-phase agitated reactors: Synthesis, simulation, and scaleup. AlChe J (1999) 45:2371-2391.
5. Meyer T: Scale-up of polymerization process: A practical example. 5th International Conference on the Scale-up of Chemical Processes, Jersey, UK (2002).
6. Mukesh D: Troublefree reaction scaleup. Chem Eng (2002) 109:46-53. The considerations reported in this paper, as well as the practical data presented, adequately describe the problems related to scale-up process. A general overview of the crucial aspects of scale-up is also presented.
7. Tatterson G: From discovery to production. Chem Process (1999) 62:45-49.
8. Bedle RW, Huhn GF, Jensen JH, Xing YD: Reaction kinetics of a condensation polymer between 1,10-dibromodecane and hexamethylenediamine: Scale-up considerations. Org Process Res Dev (1998) 2:105-110.
9. De Labouret A, Thioune O, Fessi H, Devissaguet JP, Puisieux F: Application of an original process for obtaining colloidal dispersions of some coating polymers: Preparation, characterization, industrial scale-up. Drug Dev Ind Pharm (1995) 21:229-241.
10. Ratnagiri R, Scott CE, Shih CK: The effect of scaleup on the processing behavior of a blend exhibiting phase inversion during compounding. Polymer Eng Sci (2001) 41:1019-1037.
11. Beers KJ, Ray WH: A linkage moment approach to modeling condensation polymerization with multiple monomers. I. Linear polymers. J Appl Polym Sci (2001) 79:246-265.
12. O'Shaughnessy B, Yu J: Non-steady state free radical polymerization kinetics at high conversions: Entangled regimes. Macromolecules (1998) 31:5240-5254.
13. Jiang Y, McAuley KB, Hsu CC: Effects of operating conditions on heat removal from polyethylene reactors. AlChe J (1997) 43:2073-2082.
14. Agrawal AK, Devika K, Manabe T: Simulation of hydrolytic polymerization of nylon-6 in industrial reactors: Part I. Mono-acid-stabilized systems in VK tube reactors. Ind Eng Chem Res (2001) 40:2563-2572.
15. Giudici R, Nascimento CAO, Tresmondi A, Domingues A, Pellicciotta R: Mathematical modeling of an industrial process of nylon-6,6 polymerization in a two-phase flow tubular reactor. Chem Eng Sci (1999) 54:3243-3249.
16. Nascimento CAO, Giudici R, Scherbakoff N: Modeling of industrial nylon-6,6 polymeration process in a twin-screw extruder reactor. II. Neural networks and hybrid models. J Appl Polym Sci (1999) 72:905-912.
17. Villa CM, Van Horn BL, Ray WH: Dynamics of polymerization reactors vath evaporative cooling and wall heat transfer. Polym React Eng (1999) 7:151-194.
18. Fontes CHO, Embirugu M: Multivariable correlation analysis and its application to an industrial polymerization reactor. Comput Chem Eng (2001) 25:191-201.
19. Ghasem NM: Chaotic behavior of industrial fluidized-bed reactors for polyethylene production. Chem Eng Technol (2001) 24:297-303.
20. Ghasem NM: Effect of polymer growth rate and diffusion resistance on the behavior of industrial polyethylene fluidized bed reactor. Chem Eng Technol (2001) 24:1049-1057.
21. Abel O, Heibig A, Marquardt Vi, Zwick H, Daszkowski T: Productivity optimization of an industrial semi-batch polymerization reactor under safety constraints. J Process Contr (2000) 10:351-362.
22. Ubrich O, Srinivasan B, Lerena F, Bonvin D, Stoessel F: The use of calorimetry for on-line optimisation of isothermal semi-batch reactors. Chem Eng Sci (2001) 56:5147-5156.
23. Pinto JM, R Giudici: Optimization of a cocktail of initiators for suspension polymerization of vinyl chloride in batch reactors. Chem Eng Sci (2001) 56:1021-1028.
24. Neogi D, CE Schiags: Multivariate statistical analysis of an emulsion batch process. Ind Eng Chem Res (1998) 37:3971-3979.
25. Raether B, Nuyken O, Wieland P, Bremser W: Free-radical synthesis of block copolymers on an industrial scale. Macromol Symp (2002) 177:25-42.
26. Jacobsen S, Fritz HG, Degée P, Dubois P, Jerôme R: Continuous reactive extrusion polymerisation of L-lactide - An engineering view. Macromol Symp (2000) 153:261-273.
27. Murthy AKS: Design and scaleup of slurry-hydrogenation systems: Heat removal, mass transfer and kinetics are key for this multiphase catalytic reaction. Chem Eng (1999) 106:94-98.
28. Galli P: 40 Years of industrial dfvelopments in the field of isotactic polyolefins. Macromol Symp (1995) 89:13-26.
29. Ohshima M, Tanigaki M: Quality control of polymer production processes. J Proces Contr (2000) 10:135-148.
30. Cervantes AM, Tonelli S, Brandolin A, Bandoni JA, Biegier LT: Large-scale dynamic optimization for grade transitions in a low density polyethylene plant. Comput Chem Eng (2002) 26:227-237.
31. Seki H, Ogawa M, Ooyama S, Akamatsu K, Ohshima M, Yang W: Industrial application of a nonlinear model predictive control to polymerization reactors. Control Eng Pract (2001) 9:819-828.
32. Capilia C, Ferrer A, Romero R, Huaida A: Integration of statistical and engineering process control in a continuous polymerization process. Technometrics (1999) 41:14-28.
33. Padilla S, Alvarez J: Control of continuous copolymeruation reactors. AlChe J (1997) 43:448-463.
34. Grassi B, Reed WF: Online polymerization monitoring in a continuous reactor. Macromol Chem Physic (2002) 203:586-597.
35. Florenzano FH, Strelitzki R, Reed WF: Absolute, on-line monitoring of molar mass during polymerization reactions. Macromolecules (1998) 31:7226-7238.
36. Zeilmann T, Cavin L, Meyer T: Inline conversion monitoring in PMMA polymerization. 14th International Congress of Chemical and Process Engineering CHISA 2000, Prague, Czech Republic (2000).
37. Zeilmann T, Lavanchy F, Meyer T: Inline conversion monitoring in MMA high solid content polymerization process. Chimia (2001) 55:249-250.
38. Guinot P, Othman N, Févotte G, McKenna TF: On-line monitoring of emulsion copolymerisations using hardware sensors and calorimetry. Polym React Eng (2000) 8:115-134.
39. Jaeckle CM, MacGregor JF: Industrial applications of product design through the inversion of latent variable models. Chemometr Intell Lab (2000) 50:199-210.
40. am Ende DJ, Clifford PJ, Northrup DL: The role of reaction calorimetry in the development and scale-up of aromatic nitrations. Thermochimi Acta (1996) 289:143-154.
41. Singh J: Safe scaleup of exothermic reactions. Chem Eng (1997) 104:92-95.
42. Špatenka P, Endres HJ, Krumeich J, Cook RW: Process control of plasma polymerization in a large industrial reactor. Surf Coat Tech (1999) 119:1228-1232.
43. Congalidis JP, Richards JR: Process control of polymerization reactors: An industrial perspective. Polym React Eng (1998) 6:71-111. An excellent review on emulsion polymerization process control, giving an industrial perspective on the subject.
44. Tirrell M: Chemical engineering of polymers: Production of flexible, functional materials. Chem Eng Sci (1995) 50:4123-4141.
45. Sakai T: Polymer processing technology in the 21st Century from the viewpoint of the Japanese plastics industry - Global trends and initiatives. Int Polym Proc (2001) 16:3-13.