Androgen receptor gene CAG repeat length varies in a race-specific fashion in men without prostate cancer

Urology

Volumn 53, Issue 2, 1999, Pages 378-380

  Sartor, Oliver ^a   Zheng, Qiang ^a   Eastham, James A ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; PROSTATE SPECIFIC ANTIGEN;

ADULT; ARTICLE; CANCER RISK; CAUCASIAN; FINGER; HUMAN; MAJOR CLINICAL STUDY; MALE; NEGRO; PHYSICAL EXAMINATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTATE CANCER; RACE DIFFERENCE; RECEPTOR GENE; RECTUM; TRINUCLEOTIDE REPEAT;

AFRICAN CONTINENTAL ANCESTRY GROUP; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; MALE; MIDDLE AGED; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 0032918844     PISSN: 00904295     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-4295(98)00481-6     Document Type: Article

References (18)

1. Chang C., Kokontis J., Liao S. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science. 240:1988;324-326.
2. Roche P.J., Hoare S.A., Parker M.G. A consensus DNA binding site for the androgen receptor. Mol Endocrinol. 6:1992;2229-2235.
3. Edwards A., Hammond H.A., Jin L., et al. Genetic variation at five trimeric and tetrameric tandem repeat loci in four human populations. Genomics. 12:1992;241-253.
4. La Spada A.R., Wilson E.M., Lubahn D.B., et al. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature. 352:1991;77-79.
5. Amato A.A., Prior T.W., Barohn R.J., et al. Kennedy's disease a clinicopathologic correlation with mutations in the androgen receptor gene . Neurology. 43:1993;791-794.
6. Nagashima T., Seko K., Hirose K., et al. Familial bulbospinal muscular atrophy associated with testicular atrophy and sensory neuropathy autopsy case report of two brothers . J Neurol Sci. 87:1988;141-152.
7. Choong C.S., Kemppainen J.A., Zhou Z.X., et al. Reduced androgen receptor gene expression with first exon CAG repeat expansion. Mol Endocrinol. 10:1996;1527-1535.
8. Mhatre A.N., Trifiro M.A., Kaufman M., et al. Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy. Nature Genet. 5:1993;184-187.
9. Chamberlain N.L., Driver E.D., Miesfeld R.L. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res. 22:1994;3181-3186.
10. Ingles S.A., Ross R.K., Yu M.C., et al. Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. J Natl Cancer Inst. 89:1997;166-170.
11. Giovannucci E., Stampfer M.J., Krithivas K., et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci. 94:1997;3320-3323.
12. Hardy D.O., Scher H.I., Bogenreider T., et al. Androgen receptor CAG repeat lengths in prostate cancer correlation with age of onset . J Endocrinol Metab. 81:1996;4400-4405.
13. Stanford J.L., Just J.J., Gibbs M., et al. Polymorphic repeats in the androgen receptor gene molecular markers of prostate cancer risk . Cancer Res. 57:1997;1194-1198.
14. Irvine R.A., Yu M.C., Ross R.K., et al. The CAG and GGC microsatellites of the androgen receptor are in linkage disequilibrium in men with prostate cancer. Cancer Res. 55:1995;1937-1940.
15. Sartor O., Zheng Q. Determination of CAG repeat length in the androgen-receptor gene using frozen serum. Urology. 49:1997;301-304.
16. Mebane C., Gibbs T., Horn J. Current status of prostate cancer in North American black males. J Natl Med Assoc. 82:1990;782-783.
17. Boring C.C., Squires T.S., Health C.W. Cancer statistics for African Americans 1992 . CA Cancer J Clin. 42:1992;7-17.
18. Morton R.A. Jr. Racial differences in adenocarcinoma of the prostate in North American men. Urology. 44:1994;637-645.