Polymorphisms of ethanol-oxidizing enzymes in alcoholics with inactive ALDH2

Human Genetics

Volumn 97, Issue 4, 1996, Pages 431-434

  Higuchi, Susumu ^a   Muramatsu, Taro ^a   Matsushita, Sachio ^a   Murayama, Masanobu ^b   Hayashida, Motoi ^a  

^a KURIHAMA NATIONAL HOSPITAL   (Japan)

^b Akagi Kougen Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; CYTOCHROME P450;

ADULT; ALCOHOL OXIDATION; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0029927517     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02267061     Document Type: Article

References (23)

1. American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders, 3rd edn revised. American Psychiatric Association, Washington, DC
2. Badger TM, Huang J, Ronis M, Lumpkin CK (1993) Induction of cytochrome P450 2E1 during chronic ethanol exposure occurs via transcription of the CYP 2E1 gene when blood alcohol concentrations are high. Biochem Biophys Res Commun 190:780-785
3. Bosron WF, Li T-K (1986) Genetic polymorphism of human liver alcohol and aldehyde dehydrogenase, and their relationship to alcohol metabolism and alcoholism. Hepatology 6:502-510
4. Bosron WF, Li T-K (1988) Catalytic and structural properties of the human liver ββ alcohol dehydrogenase isoenzymes. In: Kuriyama K, Takada A, Ishii H (eds) Biomedical and social aspects of alcohol and alcoholism. Elsevier, Amsterdam, pp 31-34
5. Bosron WF, Magnes LJ, Li T-K (1983) Kinetic and electrophoretic properties of native and recombined isoenzymes of human liver alcohol dehydrogenase. Biochemistry 22:1852-1857
6. Carr LG, Hartleroad JY, Liang Y, Mendenhall C, Moritz T, Thomasson H (1995) Polymorphism at the P450IIE1 locus is not associated with alcoholic liver disease in Caucasian men. Alcoholism 19:182-184
7. 2 allele is dominant. J Clin Invest 83:314-316
8. Gonzalez FJ, Ueno T, Umeno M, Song BJ, Veech RL, Gelboin HV (1991) Microsomal ethanol oxidizing system: transcriptional and posttranscriptional regulation of cytochrome P450. CYP2E1. Alcohol Alcohol 26 (Suppl 1) : 97-101
9. Harada S, Agarwal DP, Goedde HW (1982) Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet II:827
10. Harada S, Zhang S (1993) New strategy for detection of ALDH2 mutant Alcohol Alcohol 28:11-13
11. Hayashi S, Watanabe J. Kawajiri K (1991) Genetic polymorphisms in the 5′-flanking region change transcnptional regulation of the human cytochrome P450 IIE1 gene. J Biochem (Tokyo) 110:559-565
12. Higuchi S (1996) Polymorphisms of ethanol metabolizing enzyme genes and alcoholism. Alcohol Alcohol (in press)
13. Higuchi S, Muramatsu T, Shigemori K, Saito M. Kono H, Dufour MC, Harford TC (1992) The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese. J Stud Alcohol 53:170-175
14. Higuchi S, Matsushita S, Imazeki H, Kinoshita T, Takagi S, Kono H (1994) Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet 343:741-742
15. Mizoi Y, Tatsuno Y, Adachi J, Kogame M, Fukunaga T, Fujiwara S, Hishida S. Ijiri I (1983) Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese. Pharmacol Biochem Behav 18 (Suppl 1):127-133
16. Muramatsu T, Wang Z-C, Fang Y-R, Hu K-B, Heqin Y, Yamada K. Higuchi S, Harada S, Kono H (1995) Alcohol and aldehyde dehydrogenase genotyping and drinking behavior of Chinese living in Shanghai. Hum Genet 96 : 151-154
17. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
18. SAS Institute (1985) SAS user's guide: basic, version 5. SAS Institute, Cary, NC
19. Takeshita T, Morimoto K, Mao XQ, Hashimoto T, Furuyama J (1994) Characterization of the three genotypes of low Km aldehyde dehydrosenase in a Japanese population. Hum Genet 94:217-223
20. Thomasson HR, Edenberg HJ, Crabb DW, Mai X-L, Jerome RE, Li T-K, Wang S-P, Lin Y-T, Lu R-B, Yin S-J (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48:677-681
21. Thomasson HR, Crabb DW, Edenberg HJ, Li T-K (1993) Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. Behav Genet 23:131-136
22. Thomasson HR, Crabb DW, Edenberg HJ, Li T-K, Hwu H-G, Chen C-C, Yeh E-K, Yin S-J (1994) Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. Alcoholism 18:640-643
23. Xu Y, Carr LG, Bosron WF, Li T-K, Edenberg HJ (1988) Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 2:209-214