Higher order chromatin degradation: Implications for neurodegeneration

Neurochemical Research

Volumn 27, Issue 11, 2002, Pages 1447-1451

  Konat, Gregory W ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endonuclease; Hydrogen peroxide; Oxidative stress; Programmed cell death; Somatic mutations

Indexed keywords

ENDONUCLEASE; HYDROGEN PEROXIDE; OLIGOMER;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHROMATIN; CHROMOSOME; DEGRADATION; ENZYME DEGRADATION; GENOME; HIGHER ORDER CHROMATIN DEGRADATION; KINETICS; NERVE CELL; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SOMATIC MUTATION;

ANIMALS; APOPTOSIS; CHROMATIN; HUMANS; HYDROLYSIS; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS;

ANIMALIA;

EID: 0036866581     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021688119574     Document Type: Article

References (50)

1. Okada, T. A. and Comings, D. E. 1979. Higher order structure of chromosomes. Chromosoma 72:1-14.
2. Filipski, J., Leblanc, J., Youdale, T., Sikorska, M., and Walker, P. R. 1990. Periodicity of DNA folding in higher order chromatin structures. EMBO J. 9:1319-1327.
3. Münkel, C., Eils, R., Dietzel, S., Zink, D., Mehring, C., Wedemann, G., Cremer, T., and Langowski, J. 1999. Compartmentalization of interphase chromosomes observed in simulation and experiment. J. Mol. Biol. 285:1053-1065.
4. Stein, E. S. and Berezney, R. 1999. 25 Years of contribution to characterizing gene expression and replication with three-dimensional context of nuclear architecture. Crit. Rev. Eukaryot. Gene Exp. 9:v-vi.
5. Wolffe, A. P. and Guschin, D. 2000. Chromatin structural features and targets that regulate transcription. J. Struct. Biol. 129:102-122.
6. Brown, D. G., Sun, X. M., and Cohen, G. M. 1993. Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation. J. Biol. Chem. 268:3037-3039.
7. Sun, X. M., Snowden, R. T., Dinsdale, D., Ormerod, M. G., and Cohen, G. M. 1993. Changes in nuclear chromatin precede internucleosomal DNA cleavage in the induction of apoptosis by etoposide. Biochem. Pharmacol. 2:187-195.
8. Oberhammer, F., Wilson, J. W., Dive, C., Morris, I. D., Hickman, J. A., Wakeling, A. E., Walker, P. R., and Sikorska, M. 1993. Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J. 12:3679-3684.
9. Cohen, G. M., Sun, X. M., Fearnhea, H., MacFarlane, M., Brown, D. G., Snowden, R. T., and Dinsdale, D. 1994. Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. J. Immunol. 153:507-516.
10. 2+ in the formation of high molecular weight DNA fragments in thymocyte apoptosis. Biophys. Biochem. Res. Commun. 202:120-127.
11. Beere, H. M., Chresta, C. M., Alejo-Herberg, A., Skladanowski, A., Dive, C., Larsen, A. K., and Hickman, J. A. 1995. Investigation of the mechanism of higher order chromatin fragmentation observed in drug-induced apoptosis. Mol. Pharmacol. 47:986-996.
12. Lagarkova, M. A., Iarovaia, O. V., and Razin, S. V. 1995. Large scale fragmentation of mammalian DNA in the course of apoptosis procedes via excision of chromosomal DNA loops and their oligomers. J. Biol. Chem. 270:20239-20245.
13. Bode, J., Kohwi, Y., Dickinson, L., Joh, T., Klehr, D., Mielke, C., and Kohwi-Shigematsu, T. 1992. Biological significance of unwinding capability of nuclear matrix-associated DNAs. Science 255:195-197.
14. Dickinson, L. A., Joh, T., Kohwi, Y., and Kohwi-Shigematsu, T. 1992. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. Cell 70:631-645.
15. Oberhammer, F., Fritsch, G., Schmeid, M., Pavelka, M., Printz, D., Purchio, T., Lassmann, H., Schulte-Hermann, R. 1993. Condensation of the chromatin at the membrane of an apoptotic nucleus is not associated with activation of an endonuclease. J. Cell Sci. 104:317-326.
16. Hendzel, M. J., Nishioka, K., Raymond, Y., Allis, C. D., Bazett-Jones, D. P., and Th'ng, P. H. 1998. Chromatin condensation is not associated with apoptosis. J. Biol. Chem. 273:24470-24478.
17. Pandey, S., Walker, P. R., and Sikorska, M. 1994. Separate pools of endonuclease activity are responsible for internucleosomal and high molecular mass DNA fragmentation during apoptosis. Biochem. Cell Biol. 72:625-629.
18. Walker, P. R., Weaver, V. M., Lach, B., LeBlanc, J., and Sikorska, M. 1994. Endonuclease activities associated with high molecular weight and internucleosomal DNA fragmentation in apoptosis. Exp. Cell Res. 213:100-106.
19. Weaver, V. M., Carson, C. E., Walker, P. R., Chaly, N., Lach, B., Raymond, Y., and Sikorska, M. 1996. Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes. J. Cell Sci. 109:45-56.
20. Sikorska, M. and Walker, P. R. 1998. Endonuclease activities and apoptosis. Pages 211-242. In: When Cells Die. A Comprehensive Evaluation of Apoptosis and Programmed Cell Death. Lockshin, R. A., Zakeri, Z., and Tilly, J. L. (Eds), Wiley-Liss, New York, Chichester, Weinheim, Brisbane, Singapore, Toronto.
21. Khodarev, N. N., Sokolova, I. A., and Vaughan, A. T. M. 1998. Mechanisms of induction of apoptotic DNA fragmentation. Int. J. Radiat. Biol. 73:455-467.
22. Liu, Q. Y., Padney, S., Singh, R. K., Lin, W., Ribecco, M., Borowy-Borowski, H., Smith, B., LeBlanc, J., Walker, P. R., and Sikorska, M. 1998. DNaseY: A rat DNase-like gene coding for a constitutively expressed chromatin-bound endonuclease. Biochemistry 37:10134-10143.
23. Shiokawa, D. and Tanuma, S. 1998. Molecular cloning and expression of a cDNA encoding an apoptotic endonuclease DNase γ. Biochem. J. 332:713-720.
24. Walker, P. R., LeBlanc, J., and Sikorska, M. 1997. Evidence that DNA fragmentation in apoptosis is initiated and propagated by single-strand breaks. Cell Death Differ. 4:506-515.
25. Mouzannar, R., Miric, S. J., Wiggins, R. C., and Konat, G. W. 2001. Hydrogen peroxide induces rapid digestion of oligodendrocyte chromatin into high molecular weight fragments. Neurochem. Int. 38:9-15.
26. Bai, H. and Konat, G. W. 2002. Hydrogen peroxide mediates higher order chromatin digestion. Neurochem. Int. (in press).
27. Konat, G. W., Mouzannar, R., and Bai, H. 2001. Higher order chromatin degradation in glial cells: The role of calcium. Neurochem. Int. 39:179-186.
28. Quillet-Mary, A., Jaffrezou, J.-P., Mansat, V., Brodier, C., Naval, J., and Laurent, G. 1995. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J. Biol. Chem. 272:21388-21395.
29. Bredesen, D. E. 1995. Neural apoptosis. Ann. Neurol. 38:839-851.
30. Um, H. D., Orenstein, J. M., and Wahl, S. M. 1996. Fas mediates apotosis in human monocytes by a reactive oxygen intermediate dependent pathway. J. Immunol. 156:3469-3477.
31. Kroemer, G., Zamzami, N., and Susin, S. A. 1997. Mitochondrial control of apoptosis. Immunol. Today 18:43-51.
32. Rhee, S. G. 1999. Redox signaling: Hydrogen peroxide as intracellular messenger. Exp. Mol. Med. 31:53-59.
33. Josephson, R. A., Silverman, H. S., Lakatta, E. G., Stern, M. D., and Zweier, J. L. 1991. Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes. J. Biol. Chem. 266:2354-2361.
34. Ueda, N. and Shah, S. V. 1992. Role of intracellular calcium in hydrogen peroxide induced renal tubular cell injury. Am. J. Physiol. 263:F214-F221.
35. 1 cells. J. Cell Physiol. 129:356-366.
36. 2+-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis. J. Biol. Chem. 269:14857-14860.
37. 2+ alone. FEBS Lett. 349:385-391.
38. Ucker, D. S., Obermiller, P. S., Eckhart, W., Apgar, J. R., Berger, N. A., and Meyers, J. 1992. Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes. Mol. Cell Biol. 12:3060-3069.
39. Oberhammer, F. A., Hochegger, K., Froschl, G., Tiefenbacher, R., and Pavelka, M. 1994. Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J. Cell Biol. 126:827-837.
40. Neamati, N., Fernandez, A., Wright, S., Kiefer, J., and McConkey, D. J. 1995. Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei. J. Immunol. 154:3788-3795.
41. 2 in vitro. Brain Res. 671:181-186.
42. Rathmell, W. K. and Chu, G. 1998. Mechanisms for DNA double-strand break repair in eukaryotes. Pages 299-316. In: DNA Damage and Repair, Vol. 2: DNA Repair in Higher Eukaryotes. Nickoloff, J. A. and Hoekstra, M. F., Humana Press, Totowa, NJ.
43. Speit, G., Hochsattel, R., and Vogel, W. 1984. The contribution of DNA single-strand breaks to the formation of chromosome aberrations and SCEs. Basic Life Sci. 29 Pt A:229-244.
44. Nickol, J. M. and Felsenfeld, G. 1983. DNA conformation at the 5′ end of the chicken adult beta-globin gene. Cell 35:467-477.
45. Boles, T. C. and Hogan, M. E. 1987. DNA structure equilibria in the human c-myc gene. Biochemistry 26:367-376.
46. Reynolds, W. F. and Gottesfeld, J. M. 1985. Torsional stress induces an S1 nuclease-hypersensitive site within the promoter of the Xenopus laevis oocyte-type 5S RNA gene. Proc. Natl. Acad. Sci. U.S.A 82:4018-4022.
47. Ruiz-Carrillo, A. 1984. The histone H5 gene is flanked by S1 hypersensitive structures. Nucleic Acid Res. 12:6473-6492.
48. Wang, J. N. C. and Hogan, M. 1985. An equilibrium between distorted and undistorted DNA in the adult chicken beta A-globin gene. J. Biol. Chem. 260:8194-8202.
49. Turker, M. S., Gage, B. M., Rose, J. A., Elroy, D., Ponomareva, O. N., Stambrook, P. J., and Tischfield, J. A. 1999. A novel signature mutation for oxidative damage resembles a mutational pattern found commonly innhuman cancers. Cancer Res. 59:1837-1839.
50. Stohs, S. J. 1995. The role of free radicals in toxicity and disease. J. Basic Clin. Physiol. Pharmacol. 6:205-228.