The labelling of human serum transferrin with 99mtc and a study concerning uptake of the complex by tumour cells

Nuclear Medicine Communications

Volumn 23, Issue 11, 2002, Pages 1085-1090

  Smith, T A D ^a   Walton, P H ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Technetium; Thiourea; Transferrin; Tumour

Indexed keywords

IRON; MERCAPTOETHANOL; TECHNETIUM 99M; THIOUREA; TRANSFERRIN; TRANSFERRIN TC 99M; UNCLASSIFIED DRUG; RADIOPHARMACEUTICAL AGENT; TECHNETIUM;

ARTICLE; BINDING AFFINITY; BINDING SITE; BLADDER CARCINOMA; CELL TRANSPORT; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; DRUG STABILITY; DRUG UPTAKE; ENDOCYTOSIS; HUMAN; HUMAN CELL; INTERNALIZATION; IRON METABOLISM; IRON TRANSPORT; ISOTOPE LABELING; PROTEIN CONTENT; TRANSFERRIN BLOOD LEVEL; TUMOR CELL CULTURE; BLADDER TUMOR; CELL CULTURE; EVALUATION; METABOLISM; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

HUMANS; ISOTOPE LABELING; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TECHNETIUM; TRANSFERRIN; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 0036855409     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/00006231-200211000-00008     Document Type: Article

References (21)

1. Sun H, Li H, Sadler PJ. Transferrin as a metal ion mediator. Chem Rev 1999; 99: 2817-2842.
2. Yeh CJG, Taylor CJ, Faulk WP. Transferrin binding by peripheral blood mononuclear cells in human lymphomas, myelomas and leukemias. Vox Sang 1984; 46: 217.
3. Seymour GJ, Walsh MD, Lavin MF, Strutton G, Gardiner RA. Transferrin receptor expression by human bladder transitional cell carcinomas. Urol Res 1987; 15: 341-344.
4. Whitney JF, Clark JM, Griffin TW, Gautam S, Leslie KO. Transferrin receptor expression in non-small cell lung cancer-histopathologic and clinical correlates. Cancer 1995; 76: 20-25.
5. Goodwin D, Meares C, Diamanti C, et al. Use of specific antibody for rapid clearance of circulating blood background from radiolabeled tumor imaging proteins. Eur J Nucl Med 1984; 9: 209-215.
6. Lang L, Aloj L, Kiesewetter DO, Jagoda E, et al. A review of new oncotropic tracers for PET imaging. Nucl Med Biol 1996; 23: 669-672.
7. Aloj L, Lang L, Jagoda E, Neumann RD, Eckelman WC. Evaluation of human transferrin radiolabeled with N-succinimidyl-4-[fluorine-18](fluoromethyl)benzoate. J Nucl Med 1996; 37: 1408-1412.
8. McArdle HJ, Douglas AJ, Morgan EH. Uptake of transferrin and iron by cultured rat placental cells. J Cell Physiol 1985: 122: 405-409.
9. Harris WR, Sheldon J. Equilibrium constants for the binding of aluminium to human serum transferrin. Inorg Chem 1990; 29: 119-124.
10. Harris WR, Chen Y, Wein K. Equilibrium constants for the binding of indium(III) to human serum transferrin. Inorg Chem 1994; 33: 4991-4998.
11. 3+) to human serum transferrin. J Biol Chem 1996; 271: 9483.
12. Harris WR, Pecorraro VL. Thermodynamic binding constants for gallium transferrin. Biochemistry 1983; 22: 292-299.
13. Hoffer P. Gallium: mechanisms. J Nucl Med 1990; 21: 282-285.
14. Kiratli PO, Canpinar H, Ruacan S, Kansu E. Correlation of flow cytometric parameters and transferrin receptors with gallium-67 scintigraphic images in lymphoma patients. Nucl Med Commun 2000; 21: 925-931.
15. Dilworth JR, Parrott SJ. The biomedical chemistry of technetium and rhenium. Chem Soc Rev 1998; 27: 43-55.
16. Paik CH, Vierasv F, Eckelman WC, et al. Exchange labeling of proteins-Tc-99m labeled transferrin. J Radioanal Chem 1980; 60: 281-289.
17. McArdle HJ, Douglas AJ, Bowen BJ, Morgan EH. The mechanism of iron uptake by the rat placenta. J Cell Phsyiol 1985; 124: 446-450.
18. Hashimoto M, Wada H, Omori T, Yoshihara K. Formation of Tc(III)-EDTA complex. J Radioanalyt Nucl Chem Lett 1991; 153: 283-291.
19. Thakur ML, DeFulvio J, Richard MD, Park CH. Technetium-99m labeled monoclonal antibodies: Evaluation of reducing agents. Nucl Med Biol 1991; 18: 227-233.
20. Welling MM, Paulusma-Annema A, Henia SB, Pauwels EKJ, Nibbering PH. Antimicrobial peptides discriminate between bacterial infections and sterile inflammations. Eur J Nucl Med 2000; 27: 292-301.
21. 99mTc. Nucl Med Biol 1991; 18: 667-676.