A review of new oncotropic tracers for PET imaging

Nuclear Medicine and Biology

Volumn 23, Issue 6, 1996, Pages 669-672

  Lang, L ^a   Aloj, L ^a   Kiesewetter, D O ^a   Jagoda, E ^a   Lee, J T ^a   Paik, C H ^a   Carrasquillo, J A ^a   Eckelman, W C ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

antibody fragments; F 18 radiolabeling; muscarinics; transferrin

Indexed keywords

3 [3 (FLUOROPROPYLTHIO) 1,2,5 THIADIAZOL 4 YL] 1,2,5,6 TETRAHYDRO 1 METHYLPYRIDINE; FLUORINE 18; QUINUCLIDINYL BENZILATE; RADIOPHARMACEUTICAL AGENT; TRANSFERRIN; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CONTROLLED STUDY; DRUG SYNTHESIS; ISOTOPE LABELING; ONCOLOGY; POSITRON EMISSION TOMOGRAPHY;

EID: 0030221011     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/0969-8051(96)00064-9     Document Type: Conference Paper

References (34)

1. 1. Ackerman M. S., Roeske W. R., Heck R. J. and Kore M. (1989) Identification and characterization of muscarinic receptors in cultured human pancreatic carcinoma cells. Pancreas 4, 363-370.
2. 18F](fluoromethyl)benzoate. J. Nucl. Med. (in press).
3. 3. Aloj L., Lang L. and Eckelman W. C. (1995) Fluorine-18 labeled transferrin for measuring tumor metabolism. J. Nucl. Med. 36, 38P.
4. 4. Carrasquillo J. A. (1989) Radioimmunoscintigraphy with polyclonal or monoclonal antibodies. In: Antibodies in Radiodiagnosis and Therapy (Edited by Zalutsky M. R.), pp. 169-198. CRC Press Inc., Boca Raton.
5. 5. Choi C. W., Lang L., Lee J. T., Webber K. O., Yoo T. M., Chang H. K., Le N., Jagoda E., Paik C. H., Pastan I., Eckelman W. C. and Carrasquillo J. A. (1995) Cancer Res. 55, 5323-5329.
6. 6. Divgi C. R., Welt S., Kris M., Real F. X., Yeh S. D., Gralla R., Merchant B., Schweighart S., Unger M., Larson S. M., et al. (1991) Phase I and imaging trial of indium 111-labeled anti-epidermal growth factor receptor monoclonal antibody 225 in patients with squamous cell lung carcinoma. J. Natl. Cancer Inst. 16, 97-104.
7. 7. Dehdashti F., McGuire A. H., VanBrocklin H. F., Siegel B. A., Andriole D. P., Griffeth L. K., Pomper M. G., Katzenellenbogen J. A. and Welch M. J. (1991) J. Nucl. Med. 32, 1346-1347.
8. 8. Di Chiro G. (1991) Which PET radiopharmaceutical for brain tumors? J. Nucl. Med. 32, 1346-1347.
9. 9. Eckelman W. C. (1995) Radiolabeling with technetium-99m to study high-capacity and low-capacity biochemical systems. Eur. J. Nucl. Med. 22, 249-263.
10. 10. Eckelman W. C. and Richards P. (1970) Instant 99m-Tc-DTPA. J. Nucl. Med. 11, 761.
11. 11. Eckelman W. C. (1994) The application of receptor theory to receptor-binding and enzyme-binding oncologic radiopharmaceuticals. Nucl. Med. Biol. 21, 759-769.
12. 12. Eckelman W. C. and Gibson R. E. (1995) The path from in vitro autoradiography to ex vivo autoradiography to in vivo autoradiography by external imaging. In: In Vitro/In Vivo Autoradiography and Correlative Imaging (Edited by Stumpf W. and Soloman H., pp, 529-559. Academic Press, New York.
13. 13. Faulk W. P., Hsi B. L. and Stevens P. J. (1980) Transferrin and transferrin receptors in carcinoma of the breast. Lancet ii, 390-392.
14. 14. Gurwitz D., Razon N., Sokolovsky M. and Soreq H. (1984) Expression of muscarinic binding sites in primary human brain tumors. Brain Res. 316, 61-70.
15. 15. Inoue T, Cavanaugh P. G., Steck P. A., Brunner N. and Nicolson G. L. (1993) Differences in transferrin response and numbers of transferrin receptors in rat and human mammary carcinoma lines of different metastatic potentials. J. Cell. Physiol. 156, 212-217.
16. 16. Kiesewetter D. O. (1993) Asymmetric synthesis of benzilic acid analogs using 8-phenylmenthol as a chiral auxiliary. Tetrahed. Asym. 4, 2183-2198.
17. 17. Kiesewetter D. O., Silverton J. V. and Eckelman W. C. (1995a). Synthesis and biological properties of chiral fluoroalkyl quinuclidinyl benzilates. J. Med. Chem. 38, 1720-1735.
18. 18F labeled muscarinic agonist with M2 selectivity. J. Med. Chem. 38, 5-8.
19. 18F]N-succinimidyl 4-(fluoromethyl)benzoate for protein labeling. Appl. Radiat. Isot. 12, 1155-1163.
20. 18F](fluoromethyl)benzoate for protein labeling. J. Label Compel Radiopharm. 37, 551-553.
21. 21. Larson S. M. (1978) Mechanism of localization of gallium-67 in tumors. Semin. Nucl. Med. 8, 193-198.
22. 22. Lazarus A. H. and Baines M. G. (1985) A rapid and efficient microtechnique for the analysis of functional transferrin receptors on tumor cells. J. Immunol. Meth. 79, 213-221.
23. 23. Mintun M. A., Welch M. J., Siegel B. A., Mathias C. J., Brodack J. W., McGuire A. H. and Katzenellenhogen J. A. (1988) Breast cancer: PET imaging of estrogen receptors. Radiology 169(1), 45-48.
24. 24. Morin D., Zini R., Lange F., Lange J. and Tillement J. P. (1987). Alterations of beta-adrenergic, muscarinic cholinergic receptors and imipramine binding sites in human lung tumors. Int. J. Clin. Pharmacol. Ther. Toxicol. 25, 605-608.
25. 25. Niitsu Y, Kohgo Y, Nishisato T., Kondo H., Kato J, Urushizaki Y. and Urushizaki I. (1987) Transferrin receptors in human cancerous tissues. Tohoku J. Exp. Med. 153, 239-243.
26. 26. Pressman D. and Korngold L. (1953) The in vivo localization of anti-Wagner osteogenic sarcoma antibodies. Cancer 6, 619-623.
27. 27. Pressman D. (1957) Radiolabeled antibodies. Proc. Natl. Acad. Sci. NY 69, 644-650.
28. 28. Richards P., Tucker W. D. and Srivastava S. C. (1982) Introduction: Technetium-99m: An historical perspective. Int. J. Appl. Rad. Isot. 33(10), 793-799.
29. 29. Sauerberg P., Olesen P. H. and Nielsen S. (1992) Novel functional M1 selective muscarinic agonists: Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines. J. Med. Chem. 35, 2274-2283.
30. 30. Shindelman J. E., Ortmeyer A. E. and Sussman H. H. (1981) Demonstration of the transferrin receptor in human breast cancer tissue: Potential marker for identifying dividing cells. Int. J. Cancer 27, 329-334.
31. 31. Waldmann T. A. (1993) The IL-2/IL-2 receptor system: A target for rational immune intervention. Trends Pharmacol. Sci. 14, 159-164.
32. 32. Warner F. W., Demanuelle M., Stjernholm R., Cohn I. and Baddley W. H. (1977) Response to transferrin bound iron to treatment of rat lymphosarcoma with cis-dichlorodiammine-platinum (II). J. Clin. Hematol. Oncol. 7, 180-189.
33. 33. Webber K. O., Reiter Y., Brinkman U., Kreitman R. and Pastan I. (1995). Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: Comparison with its single-chain analog. Mol. Immunol. 32, 249-258.
34. 67Ga localization in malignant disease. Nucl. Med. Biol. (in press).