Ethylnitrosourea-induced apoptosis in primordial germ cells of the rat fetus

Experimental and Toxicologic Pathology

Volumn 54, Issue 3, 2002, Pages 193-196

  Katayama, Kei ichi ^a   Ueno, Masaki ^a   Yamauchi, Hirofumi ^a   Nakayama, Hiroyuki ^a   Doi, Kunio ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Apoptosis; p53; Primordial germ cell

Indexed keywords

ETHYLNITROSOUREA; PROTEIN P53; ALKYLATING AGENT; DNA FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CONGENITAL MALFORMATION; CONTROLLED STUDY; DNA DAMAGE; FERTILITY; FETUS; GENE MUTATION; GONAD; NONHUMAN; OVARY; PRIMORDIAL GERM CELL; PROGENY; PROTEIN EXPRESSION; RAT; TESTIS WEIGHT; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; FEMALE; FISCHER 344 RAT; GERM CELL; MALE; METABOLISM; PATHOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; ULTRASTRUCTURE;

ANIMALIA;

ALKYLATING AGENTS; ANIMALS; APOPTOSIS; DNA FRAGMENTATION; ETHYLNITROSOUREA; FEMALE; FETUS; GERM CELLS; GONADS; MALE; PREGNANCY; RATS; RATS, INBRED F344; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036855211     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1078/0940-2993-00254     Document Type: Article

References (18)

1. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
2. Hallas BH, Das GD: N-ethyl-N-nitrosourea-induced teratogenesis of brain in the rat. A cellular and cytoarchitectural analysis of the neocortex. J Neurol Sci 1978; 39: 111-122.
3. Katayama K, Ishigami N, Suzuki M, et al.: Teratologic studies on rat perinates and offsprings from dams administered with ethylnitrosourea (ENU). Exp Anim 2000a; 49: 181-187.
4. Katayama K, Ishigami N, Uetsuka K, et al.: Ethylnitrosourea (ENU)-induced apoptosis in the rat fetal tissues. Histol Histopathol 2000b; 15: 707-711.
5. Katayama K, Uetsuka K, Ishigami N, et al.: Apoptotic cell death and cell proliferative activity in the rat fetal central nervous system from dams administered with ethylnitrosourea (ENU). Histol Histopathol 2001; 16: 79-85.
6. Katayama K, Ohtsuka R, Takai H, et al.: Expression of p53 and its transcriptional target genes mRNAs in the ethylnitrosourea-induced apoptosis and cell cycle arrest in the fetal central nervous system. Histol Histopathol 2002a; 17: 715-720.
7. Katayama K, Ueno M, Takai H, et al.: Ethylnitrosourea induces apoptosis and growth arrest in the trophoblastic cells of rat placenta. Biol Reprod 2002b; 67: 431-435.
8. Kemper CH, Peters PW: Migration and proliferation of primordial germ cells in the rat. Teratology 1987; 36: 117-124.
9. Ko LJ, Prives C: p53: Puzzle and paradigm. Genes Dev 1996; 10: 1054-1072.
10. Koestner A: Characterization of N-nitrosourea-induced tumors of the nervous system; their prospective value for studies of neurocarcinogenesis and brain tumor therapy. Toxicol Pathol 1990; 18: 186-192.
11. Leonard JR, D'Sa-Eipper C, Klocke BJ, et al.: Neural precursor cell apoptosis and glial tumorigenesis following transplacental ethyl-nitrosourea exposure. Oncogene 2001; 20: 8281-8286.
12. Matsui Y, Nagano R, Obinata M: Apoptosis of fetal testicular cells is regulated by both p53-dependent and independent mechanisms. Mol Reprod Dev 2000; 55: 399-405.
13. Nagao T: Congenital defects in the offspring of male mice treated with ethylnitrosourea. Mutat Res 1988; 202: 25-33.
14. Nagao T, Sato M, Marumo H, et al.: Testicular development and fertility of mice treated prenatally with N-nitroso-N-ethylurea at various gestational stages. Teratog Carcinog Mutagen 1996; 16: 183-198.
15. Pfaffenroth MJ, Das GD, McAllister JP: Teratologic effects of ethylnitrosourea on brain development in rats. Teratology 1974; 9: 305-315.
16. Russell WL, Hunsicker PR, Raymer GD, et al.: Dose-response curve for ethylnitrosourea-indused specific-locus mutations in mouse spermatogonia. Proc Natl Acad Sci USA 1982; 79: 3589-3591.
17. Shibuya T, Murota T, Horiya N, et al.: The induction of recessive mutations in mouse primordial germ cells with N-ethyl-N-nitrosourea. Mutat Res 1993; 290: 273-280.
18. Wada A, Sato M, Takashima H, et al.: Congenital malformations in the offspring of male mice treated with ethylnitrosourea at the embryonic stage. Teratog Carcinog Mutagen 1994; 14: 271-279.