Teratologic studies on rat perinates and offspring from dams treated with ethylnitrosourea (ENU)

Experimental Animals

Volumn 49, Issue 3, 2000, Pages 181-187

  Katayama, Kei Ichi ^a   Ishigami, Noriaki ^a   Suzuki, Michio ^a   Ohtsuka, Ryoichi ^a   Kiatipattanasakul, Wijit ^a   Nakayama, Hiroyuki ^a   Doi, Kunio ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Ectrodactyly; Ethylnitrosourea; Microencephaly; Rat

Indexed keywords

ETHYLNITROSOUREA; TERATOGENIC AGENT;

ANIMAL; APOPTOSIS; ARTICLE; BODY WEIGHT; BRAIN CORTEX; CHEMICALLY INDUCED DISORDER; CONGENITAL MALFORMATION; DRUG EFFECT; FEMALE; FETUS WEIGHT; FISCHER 344 RAT; FORELIMB; INTRAUTERINE GROWTH RETARDATION; NEWBORN; ORGAN SIZE; PATHOLOGY; PHYSIOLOGY; PREGNANCY; RAT; TAIL; TOXICITY TESTING;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BODY WEIGHT; CEREBRAL CORTEX; ETHYLNITROSOUREA; FEMALE; FETAL GROWTH RETARDATION; FETAL WEIGHT; FORELIMB; ORGAN SIZE; PREGNANCY; RATS; RATS, INBRED F344; TAIL; TERATOGENS; TOXICITY TESTS;

EID: 0034220310     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.49.181     Document Type: Article

References (15)

1. Barrow, M.V. and Taylor, W. J. 1969. A rapid method for detecting malformations in rat fetuses. J. Morphol. 127: 291-306.
2. Bosch, D.A. 1977. Short and long term effects of methyl-and ethylnitrosourea (MNU & ENU) on the developing nervous system of the rat. I. Long term effects: The induction of (multiple) gliomas. Acta Neurol. Scand. 55: 85-105.
3. Bosch, D.A. 1977. Short and long term effects of methyl-and ethylnitrosourea (MNU & ENU) on the developing nervous system of the rat. II. Short term effects: Concluding remarks on chemical neuro-oncogenesis. Acta Neurol. Scand. 55: 106-122.
4. Druckrey, H., Ivankovic, S., and Preussmann, R. 1967. Teratologic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant rats. Nature 210: 1378-1379.
5. Faustman, E.M., Kirby, Z., Gage, D., and Varnum, M. 1989. In vitro developmental toxicity of five direct-acting alkylating agents in rodent embryos: Structure-activity patterns. Teratology 40: 199-210.
6. Fujiwara, H. 1980. Cytotoxic effects of ethylnitrosourea on central nervous system of rat embryos. Special references to carcinogenesis and teratogenesis. Acta Pathol. Jpn. 30: 375-387.
7. Hallas, B.H. and Das, G.D. 1978. N-ethyl-N-nitrosourea-induced teratogenesis of brain in the rat. A cellular and cytoarchitectural analysis of the neocortex. J. Neurol. Sci. 39: 111-122.
8. Hallas, B.H. and Das, G.D. 1979. An aberrant nucleus in the telencephalon following administration of ENU during neuroembryogenesis. Teratology 19: 159-164.
9. Inouye, M. 1976. Differential staining of cartilage and bone in fetal mouse skeleton by alcian blue and alizarin red S. Cong. Anom. 16: 171-173.
10. Katayama, K., Ishigami, N., Uetsuka, K., Nakayama, H., and Doi, K. 2000. Ethylnitrosourea(ENU)-induced apoptosis in the rat fetal tissues. Histol. Histopathol. (in press).
11. Nagao, T., Sato. M., Marumo, H., Shibuya, T., and Imai, K. 1996. Testicular development and fertility of mice treated prenatally with N-nitroso-N-ethylurea at various gestational stages Teratog. Carcinog. Mutagen. 16: 183-198.
12. Ohnishi, M. 1989. Craniofacial malformations induced by N-ethyl-N-nitrosourea in rat embryos in vivo and in vitro. Kobe J. Med. Sci. 35: 47-63.
13. Oyanagi, K., Yoshida, Y., and Ikuta, F. 1988. Cytoarchitectonic investigation of the rat spinal cord following ethylnitrosourea administration at different developmental stages. Virchows Arch. Pathol. Anat. Histopathol. 412: 215-224.
14. Oyanagi, K., Kakita, A., Yamada, M., Kawasaki, K., Hayashi, S., and Ikuta, F. 1998. Process of repair in the neuroepithelium of developing rat brain during neurogenesis: Chronological and quantitative observation of DNA-replicating cells. Brain Res. Dev. Brain Res. 108: 229-238.
15. Pfaffenroth, M.J., Das, G.D., and McAllister, J. P. 1974. Teratologic effects of ethylnitrosourea on brain development in rats. Teratology 9: 305-315.