메뉴 건너뛰기




Volumn 30, Issue 11, 2002, Pages 2509-2514

Endotoxin-induced hyperlactatemia results from decreased lactate clearance in hemodynamically stable rats

Author keywords

Acidosis; Anaerobic metabolism; Lactate; Lipopolysaccharide; Liver; Rat; Sepsis; Splanchnic; Tracer methods

Indexed keywords

CARBON 14; ENDOTOXIN; LACTIC ACID; LIPOPOLYSACCHARIDE;

EID: 0036852909     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200211000-00017     Document Type: Article
Times cited : (20)

References (33)
  • 1
    • 0023815459 scopus 로고
    • Early impairment of oxidative metabolism and energy production in severe sepsis
    • Astiz M, Rackow EC, Weil MH, et al: Early impairment of oxidative metabolism and energy production in severe sepsis. Circ Shock 1988; 26:311-320
    • (1988) Circ Shock , vol.26 , pp. 311-320
    • Astiz, M.1    Rackow, E.C.2    Weil, M.H.3
  • 2
    • 0026527574 scopus 로고
    • Lactic acidosis in critical illness
    • Mizock BA, Falk JL: Lactic acidosis in critical illness. Crit Care Med 1992; 20:80-93
    • (1992) Crit Care Med , vol.20 , pp. 80-93
    • Mizock, B.A.1    Falk, J.L.2
  • 3
    • 0026602489 scopus 로고
    • Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis
    • Hotchkiss RS, Karl IE: Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA 1992; 267:1503-1510
    • (1992) JAMA , vol.267 , pp. 1503-1510
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 4
    • 0031968240 scopus 로고    scopus 로고
    • Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction
    • Levraut J, Ciebiera JP, Chave S, et al: Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med 1998; 157:1021-1026
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 1021-1026
    • Levraut, J.1    Ciebiera, J.P.2    Chave, S.3
  • 6
    • 17544394686 scopus 로고    scopus 로고
    • Impaired hepatic extraction and increased splanchnic production contribute to lactic acidosis in canine sepsis
    • Chrusch C, Bands C, Bose D, et al: Impaired hepatic extraction and increased splanchnic production contribute to lactic acidosis in canine sepsis. Am J Respir Crit Care Med 2000; 161:517-526
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 517-526
    • Chrusch, C.1    Bands, C.2    Bose, D.3
  • 7
    • 0030894938 scopus 로고    scopus 로고
    • Splanchnic buffering of metabolic acid during early endotoxemia
    • Kellum JA, Bellomo R, Kramer DJ, et al: Splanchnic buffering of metabolic acid during early endotoxemia. J Crit Care 1997; 12:7-12
    • (1997) J Crit Care , vol.12 , pp. 7-12
    • Kellum, J.A.1    Bellomo, R.2    Kramer, D.J.3
  • 8
    • 0029941084 scopus 로고    scopus 로고
    • Transvisceral lactate fluxes during early endotoxemia
    • Bellomo R, Kellum JA, Pinsky MR: Transvisceral lactate fluxes during early endotoxemia. Chest 1996; 110:198-204
    • (1996) Chest , vol.110 , pp. 198-204
    • Bellomo, R.1    Kellum, J.A.2    Pinsky, M.R.3
  • 9
    • 0031697571 scopus 로고    scopus 로고
    • Liver as a focus of impaired oxygenation and cytokine production in a porcine model of endotoxicosis
    • Bathe OF, Rudston-Brown B, Chow AW, et al: Liver as a focus of impaired oxygenation and cytokine production in a porcine model of endotoxicosis. Crit Care Med 1998; 26:1698-1706
    • (1998) Crit Care Med , vol.26 , pp. 1698-1706
    • Bathe, O.F.1    Rudston-Brown, B.2    Chow, A.W.3
  • 10
    • 0031847810 scopus 로고    scopus 로고
    • Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic rate during long-term endotoxin-induced shock in pigs
    • Santak B, Radermacher P, Adler J, et al: Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic rate during long-term endotoxin-induced shock in pigs. Br J Pharmacol 1998; 124:1689-1697
    • (1998) Br J Pharmacol , vol.124 , pp. 1689-1697
    • Santak, B.1    Radermacher, P.2    Adler, J.3
  • 11
    • 0031028314 scopus 로고    scopus 로고
    • The regional production of cytokines and lactate in sepsis-related multiple organ failure
    • Douzinas EE, Tsidemiadou PD, Pitaridis MT, et al: The regional production of cytokines and lactate in sepsis-related multiple organ failure. Am J Respir Crit Care Med 1997; 155:53-59
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 53-59
    • Douzinas, E.E.1    Tsidemiadou, P.D.2    Pitaridis, M.T.3
  • 12
    • 0035119011 scopus 로고    scopus 로고
    • The hepatosplanchnic area is not a common source of lactate in patients with severe sepsis
    • De Backer D, Creteur J, Silva E, et al: The hepatosplanchnic area is not a common source of lactate in patients with severe sepsis. Crit Care Med 2001; 29:256-261
    • (2001) Crit Care Med , vol.29 , pp. 256-261
    • De Backer, D.1    Creteur, J.2    Silva, E.3
  • 13
    • 0019182292 scopus 로고
    • Effect of injury and infection on visceral metabolism and circulation
    • Wilmore DW, Goodwin CW, Aulick LH, et al: Effect of injury and infection on visceral metabolism and circulation. Ann Surg 1980; 192:491-504
    • (1980) Ann Surg , vol.192 , pp. 491-504
    • Wilmore, D.W.1    Goodwin, C.W.2    Aulick, L.H.3
  • 14
    • 0033060998 scopus 로고    scopus 로고
    • Nonstressed rat model of acute endotoxemia that unmasks the endotoxin- induced TNF-alpha response
    • Beno DW, Kimura RE: Nonstressed rat model of acute endotoxemia that unmasks the endotoxin- induced TNF-alpha response. Am J Physiol 1999; 276:H671-H678
    • (1999) Am J Physiol , vol.276
    • Beno, D.W.1    Kimura, R.E.2
  • 15
    • 0032939063 scopus 로고    scopus 로고
    • Abdominal surgery reduces the ability of rat spleen cells to synthesize and secrete active tumour necrosis factor-alpha (TNF-alpha) by a multilevel regulation
    • Lahat N, Rahat MA, Brod V, et al: Abdominal surgery reduces the ability of rat spleen cells to synthesize and secrete active tumour necrosis factor-alpha (TNF-alpha) by a multilevel regulation. Clin Exp Immunol 1999; 115:19-25
    • (1999) Clin Exp Immunol , vol.115 , pp. 19-25
    • Lahat, N.1    Rahat, M.A.2    Brod, V.3
  • 16
    • 0025966706 scopus 로고
    • Influence of anesthesia, postanesthetic state, and restraint on superior mesenteric arterial flow in normal rats
    • Colombato LA, Sabba C, Polio J, et al: Influence of anesthesia, postanesthetic state, and restraint on superior mesenteric arterial flow in normal rats. Am J Physiol 1991; 260:G1-G6
    • (1991) Am J Physiol , vol.260
    • Colombato, L.A.1    Sabba, C.2    Polio, J.3
  • 17
    • 0029078054 scopus 로고
    • The effect of surgical bowel manipulation and anesthesia on intestinal glucose absorption in rats
    • Uhing MR, Kimura RE: The effect of surgical bowel manipulation and anesthesia on intestinal glucose absorption in rats. J Clin Invest 1995; 95:2790-2798
    • (1995) J Clin Invest , vol.95 , pp. 2790-2798
    • Uhing, M.R.1    Kimura, R.E.2
  • 18
    • 0023926694 scopus 로고
    • Portal venous and aortic glucose and lactate changes in a chronically catheterized rat
    • Kimura RE, LaPine TR, Gooch III WM: Portal venous and aortic glucose and lactate changes in a chronically catheterized rat. Pediatr Res 1988; 23:235-240
    • (1988) Pediatr Res , vol.23 , pp. 235-240
    • Kimura, R.E.1    LaPine, T.R.2    Gooch W.M. III3
  • 19
    • 0029047852 scopus 로고
    • Active transport of 3-O-methyl-glucose by the small intestine in chronically catheterized rats
    • Uhing MR, Kimura RE: Active transport of 3-O-methyl-glucose by the small intestine in chronically catheterized rats. J Clin Invest 1995; 95:2799-2805
    • (1995) J Clin Invest , vol.95 , pp. 2799-2805
    • Uhing, M.R.1    Kimura, R.E.2
  • 20
    • 0017352154 scopus 로고
    • Glucose and lactate kinetics after endotoxin administration in dogs
    • Wolfe RR, Elahi D, Spitzer JJ: Glucose and lactate kinetics after endotoxin administration in dogs. Am J Physiol 1977; 232:E180-E185
    • (1977) Am J Physiol , vol.232
    • Wolfe, R.R.1    Elahi, D.2    Spitzer, J.J.3
  • 21
    • 0023923954 scopus 로고
    • Evaluation of the isotopic equilibration between lactate and pyruvate
    • Wolfe RR, Jahoor F, Miyoshi H: Evaluation of the isotopic equilibration between lactate and pyruvate. Am J Physiol 1988; 254:E532-E535
    • (1988) Am J Physiol , vol.254
    • Wolfe, R.R.1    Jahoor, F.2    Miyoshi, H.3
  • 22
    • 0025292764 scopus 로고
    • Isotopic measurement of glucose and lactate kinetics
    • Wolfe RR: Isotopic measurement of glucose and lactate kinetics. Ann Med 1990; 22:163-170
    • (1990) Ann Med , vol.22 , pp. 163-170
    • Wolfe, R.R.1
  • 23
    • 0024267801 scopus 로고
    • A model for measurement of lactate disappearance with isotopic tracers in the steady state
    • Stanley WC, Lehman SL: A model for measurement of lactate disappearance with isotopic tracers in the steady state. Biochem J 1988; 256:1035-1038
    • (1988) Biochem J , vol.256 , pp. 1035-1038
    • Stanley, W.C.1    Lehman, S.L.2
  • 24
    • 0025197263 scopus 로고
    • Obtaining a representative blood sample in lactate tracer studies
    • Lehman SL, Brooks GA: Obtaining a representative blood sample in lactate tracer studies. Horm Metab Res 1990; 22:470-477
    • (1990) Horm Metab Res , vol.22 , pp. 470-477
    • Lehman, S.L.1    Brooks, G.A.2
  • 25
    • 0023749042 scopus 로고
    • Measuring tracee turnover from tracer specific activity in the steady state
    • Lehman SL, Stanley WC: Measuring tracee turnover from tracer specific activity in the steady state. Am J Physiol 1988; 255:E94-E98
    • (1988) Am J Physiol , vol.255
    • Lehman, S.L.1    Stanley, W.C.2
  • 26
    • 0025833840 scopus 로고
    • Measurement of lactate production by tracer techniques
    • Lehman SL: Measurement of lactate production by tracer techniques. Med Sci Sports Exerc 1991; 23:935-938
    • (1991) Med Sci Sports Exerc , vol.23 , pp. 935-938
    • Lehman, S.L.1
  • 27
    • 0023759450 scopus 로고
    • In vivo evidence that most of the intraluminally absorbed glucose is absorbed intact into the portal vein and not metabolized to lactate
    • Rich-Denson C, Kimura RE: In vivo evidence that most of the intraluminally absorbed glucose is absorbed intact into the portal vein and not metabolized to lactate. Biochem J 1988; 254:931-934
    • (1988) Biochem J , vol.254 , pp. 931-934
    • Rich-Denson, C.1    Kimura, R.E.2
  • 28
    • 0029947642 scopus 로고    scopus 로고
    • Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability
    • Gore DC, Jahoor F, Hibbert JM, et al: Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability. Ann Surg 1996; 224:97-102
    • (1996) Ann Surg , vol.224 , pp. 97-102
    • Gore, D.C.1    Jahoor, F.2    Hibbert, J.M.3
  • 29
    • 0026531497 scopus 로고
    • Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic, endotoxin-treated dogs
    • Curtis SE, Cain SM: Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic, endotoxin-treated dogs. Am Rev Respir Dis 1992; 145:348-354
    • (1992) Am Rev Respir Dis , vol.145 , pp. 348-354
    • Curtis, S.E.1    Cain, S.M.2
  • 30
    • 0027008668 scopus 로고
    • Whole body and regional 02 uptake/delivery and lactate flux in endotoxic dogs
    • Cain SM, Curtis SE: Whole body and regional 02 uptake/delivery and lactate flux in endotoxic dogs. Adv Exp Med Biol 1992; 316:401-408
    • (1992) Adv Exp Med Biol , vol.316 , pp. 401-408
    • Cain, S.M.1    Curtis, S.E.2
  • 31
    • 0026643956 scopus 로고
    • Influence of omega-3 fatty acids on splanchnic blood flow and lactate metabolism in an endotoxemic rat model
    • Pscheidl EM, Wan JM, Blackburn GL, et al: Influence of omega-3 fatty acids on splanchnic blood flow and lactate metabolism in an endotoxemic rat model. Metabolism 1992; 41:698-705
    • (1992) Metabolism , vol.41 , pp. 698-705
    • Pscheidl, E.M.1    Wan, J.M.2    Blackburn, G.L.3
  • 33
    • 0029180674 scopus 로고
    • Hepatocellular dysfunction occurs earlier than the onset of hyperdynamic circulation during sepsis
    • Wang P, Ba ZF, Chaudry IH: Hepatocellular dysfunction occurs earlier than the onset of hyperdynamic circulation during sepsis. Shock 1995; 3:21-26
    • (1995) Shock , vol.3 , pp. 21-26
    • Wang, P.1    Ba, Z.F.2    Chaudry, I.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.