Examination of single and multiple mutations involved in resistance to quinolones in Staphylococcus aureus by a combination of PCR and denaturing high-performance liquid chromatography (DHPLC)

Journal of Antimicrobial Chemotherapy

Volumn 50, Issue 5, 2002, Pages 649-655

  Hannachi M'Zali, Fatima ^a   Ambler, Jane E ^d   Taylor, Claire F ^b   Hawkey, Peter M ^c  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d BAYER AG   (Germany)

Author keywords

Denaturing high performance liquid chromatography; DHPLC; DNA; Fluoroquinolones; Mutation detection; Topoisomerases

Indexed keywords

ASPARTIC ACID; CIPROFLOXACIN; GENOMIC DNA; GLUTAMINE; LEUCINE; LEVOFLOXACIN; LYSINE; METICILLIN; MOXIFLOXACIN; PHENYLALANINE; PROLINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SERINE; SPARFLOXACIN; TROVAFLOXACIN; VALINE; 4 QUINOLONE DERIVATIVE; ANTIINFECTIVE AGENT; BACTERIAL DNA;

AMINO ACID SUBSTITUTION; AMPLICON; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; BASE PAIRING; CHROMATOGRAPHY; CONTROLLED STUDY; DNA SEQUENCE; GENE AMPLIFICATION; GENETIC CODE; GENETIC IDENTIFICATION; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE PHENOTYPE CORRELATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MUTATIONAL ANALYSIS; NONHUMAN; POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS AUREUS; STRAIN DIFFERENCE; DRUG EFFECT; GENETICS; HUMAN; METHODOLOGY; MUTATION;

STAPHYLOCOCCUS AUREUS;

4-QUINOLONES; AMINO ACID SUBSTITUTION; ANTI-INFECTIVE AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; HUMANS; MUTATION; POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS AUREUS;

EID: 0036850388     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkf243     Document Type: Article

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