Differential effects of direct and indirect dopamine agonists on prepulse inhibition: A study in D1 and D2 receptor knock-out mice

Journal of Neuroscience

Volumn 22, Issue 21, 2002, Pages 9604-9611

  Ralph Williams, Rebecca J ^a   Lehmann Masten, Virginia ^b   Otero Corchon, Veronica ^c   Low, Malcolm J ^d   Geyer, Mark A ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Amphetamine; Apomorphine; D1 receptor; D2 receptor; Dizocilpine; Dopamine; Knock out; Mice; Prepulse inhibition; SKF82958; Startle response

Indexed keywords

3 ALLYL 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; AMPHETAMINE; APOMORPHINE; DIZOCILPINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG EFFECT; GENE MUTATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREPULSE INHIBITION; PRIORITY JOURNAL; STARTLE REFLEX;

EID: 0036848588     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-21-09604.2002     Document Type: Article

References (32)

1. Bakshi VP, Swerdlow NR, Geyer MA (1994) Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. J Pharmacol Exp Ther 271:787-794.
2. Braff DL, Geyer MA (1990) Sensorimotor gating and schizophrenia: Human and animal model studies. Arch Gen Psychiatry 47:181-188.
3. Braff DL, Grillon C, Geyer MA (1992) Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 49:206-215.
4. Bullock AE, Slobe BS, Vazquez V, Collins AC (1997) Inbred mouse strains differ in the regulation of startle and prepulse inhibition of the startle response. Behav Neurosci 111:1353-1360.
5. Curzon P, Decker MW (1998) Effects of phencyclidine (PCP) and (+)MK-801 on sensorimotor gating in CD-1 mice. Prog Neuropsychopharmacol Biol Psychiatry 22:129-146.
6. Diaz-Torga G, Feierstein C, Libertun C, Gelman D, Kelly MA, Low MJ, Rubinstein M, Becu-Villalobos D (2002) Disruption of the D2 dopamine receptor alters GH and IGF-I secretion and causes dwarfism in male mice. Endocrinology 143:1270-1279.
7. Drago J, Gerfen CR, Lachowicz JE, Steiner H, Hollon TR, Love PE, Ooi GT, Grinberg A, Lee EJ, Huang SP, Bartlett PF, Jose PA, Sibley DR, Westphal H (1994) Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci USA 91:12564-12568.
8. Dulawa SC, Geyer MA (1996) Psychopharmacology of prepulse inhibition in mice. Chin J Physiol 39:139-146.
9. Dulawa SC, Hen R, Scearce-Levie K, Geyer MA (1997) Serotonin1B receptor modulation of startle reactivity, habituation, and prepulse inhibition in wild-type and serotonin1B knock-out mice. Psychopharmacology (Berl) 132:125-134.
10. Elmer GI, Pieper JO, Rubinstein M, Low MJ, Grandy DK, Wise RA (2002) Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice. J Neurosci 22:RC224(1-6).
11. Furuya Y, Kagaya T, Ogura H, Nishizawa Y (1999) Competitive NMDA receptor antagonists disrupt prepulse inhibition without reduction of startle amplitude in a dopamine receptor-independent manner in mice. Eur J Pharmacol 364:133-140.
12. Geyer MA, Swerdlow NR (1998) Measurement of the startle response and its use in preclinical measures of prepulse inhibition and habituation. In: Current Protocols in Neuroscience (Crawley JN, Skolnick P, eds), pp 8.7.1-8.7.15. New York: Wiley.
13. Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR (2001) Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: A decade in review. Psychopharmacology (Berl) 156:117-154.
14. Geyer MA, McIlwain KL, Paylor R (2002) Mouse genetic models for prepulse inhibition: An early review. Mol Psychiatry, in press.
15. Hoffman HS, Ison JR (1980) Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system processes sensory input. Psychol Rev 87:175-189.
16. Holmes A, Hollon TR, Gleason TC, Liu Z, Dreiling J, Sibley DR, Crawley JN (2001) Behavioral characterization of dopamine D5 receptor null mutant mice. Behav Neurosci 115:1129-1144.
17. Keith VA, Mansbach RS, Geyer MA (1991) Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle. Biol Psychiatry 30:557-566.
18. Kelly MA, Rubinstein M, Asa SL, Zhang G, Saez C, Bunzow JR, Allen RG, Hnasko R, Ben-Jonathan N, Grandy DK, Low MJ (1997) Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron 19:103-113.
19. Kelly MA, Rubinstein M, Phillips TJ, Lessov CN, Burkhart-Kasch S, Zhang G, Bunzow JR, Fang Y, Gerhardt GA, Grandy DK, Low MJ (1998) Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. J Neurosci 18:3470-3479.
20. LaHoste GJ, Henry BL, Marshall JF (2000) Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials. J Neurosci 20:6666-6671.
21. Logue SF, Owen EH, Rasmussen DL, Wehner JM (1997) Assessment of locomotor activity, acoustic and tactile startle, and prepulse inhibition of startle in inbred mouse strains and F1 hybrids: Implications of genetic background for single gene and quantitative trait loci analyses. Neuroscience 80:1075-1086.
22. McGhie A, Chapman J (1961) Disorders of attention and perception in early schizophrenia. Br J Med Psychol 34:103-116.
23. Paylor R, Crawley JN (1997) Inbred strain differences in prepulse inhibition of the mouse startle response. Psychopharmacology (Berl) 132:169-180.
24. Peng RY, Mansbach RS, Braff DL, Geyer MA (1990) A D2 dopamine receptor agonist disrupts sensorimotor gating in rats: Implications for dopaminergic abnormalities in schizophrenia. Neuropsychopharmacology 3:211-218.
25. Ralph RJ, Varty GB, Kelly MA, Wang YM, Caron MG, Rubinstein M, Grandy DK, Low MJ, Geyer MA (1999) The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice. J Neurosci 19:4627-4633.
26. Ralph RJ, Paulus MP, Fumagalli F, Caron MG, Geyer MA (2001a) Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: Differential effects of D1 and D2 receptor antagonists. J Neurosci 21:305-313.
27. Ralph RJ, Paulus MP, Geyer MA (2001b) Strain-specific effects of amphetamine on prepulse inhibition and patterns of locomotor behavior in mice. J Pharmacol Exp Ther 298:148-155.
28. Ralph-Williams RJ, Lehmann-Masten V, Geyer MA (2002) Dopamine D1 rather than D2 receptor agonists disrupt prepulse inhibition of startle in mice. Neuropsychopharmacology:http://www.acnp.org/citations/Npp062002331, in press.
29. Schwarzkopf SB, Bruno JP, Mitra T (1993) Effects of haloperidol and SCH 23390 on acoustic startle and prepulse inhibition under basal and stimulated conditions. Prog Neuropsychopharmacol Biol Psychiatry 17:1023-1036.
30. Smith DR, Striplin CD, Geller AM, Mailman RB, Drago J, Lawler CP, Gallagher M (1998) Behavioural assessment of mice lacking D1A dopamine receptors. Neuroscience 86:135-146.
31. Swerdlow NR, Braff DL, Taaid N, Geyer MA (1994) Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry 51:139-154.
32. Wan FJ, Taaid N, Swerdlow NR (1996) Do D1/D2 interactions regulate prepulse inhibition in rats? Neuropsychopharmacology 14:265-274.