메뉴 건너뛰기




Volumn 54, Issue 11, 2002, Pages 1545-1552

Inhibition and possible induction of rat CYP2D after short- and long-term treatment with antidepressants

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; APOPROTEIN; CLOMIPRAMINE; CYTOCHROME P450 2D; DESIPRAMINE; ETHYLMORPHINE; FLUOXETINE; IMIPRAMINE; MIRTAZAPINE; NEFAZODONE; REACTIVE OXYGEN METABOLITE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRICYCLIC ANTIDEPRESSANT AGENT; CYTOCHROME P450; ETHYLMORPHINE DEETHYLASE; ETHYLMORPHINE O-DEETHYLASE; ISOENZYME;

EID: 0036847924     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/002235702162     Document Type: Article
Times cited : (31)

References (45)
  • 1
    • 0029808757 scopus 로고    scopus 로고
    • Single and multiple dose pharmacokinetics of nefazodone in subjects classified as extensive and poor metabolizers of dextromethorphan
    • Barbhaiya, R. H., Buch, A. B., Greene, D. S. (1996). Single and multiple dose pharmacokinetics of nefazodone in subjects classified as extensive and poor metabolizers of dextromethorphan. Br. J. Pharmacol. 42: 573-581
    • (1996) Br. J. Pharmacol. , vol.42 , pp. 573-581
    • Barbhaiya, R.H.1    Buch, A.B.2    Greene, D.S.3
  • 2
    • 0030858099 scopus 로고    scopus 로고
    • Regulation of expression of cytochrome P-450 2D mRNA in rat brain with steroid hormones
    • Baum, L. O., Strobel, H. W. (1997) Regulation of expression of cytochrome P-450 2D mRNA in rat brain with steroid hormones. Brain Res. 765: 67-73
    • (1997) Brain Res. , vol.765 , pp. 67-73
    • Baum, L.O.1    Strobel, H.W.2
  • 3
    • 0028916159 scopus 로고
    • Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs
    • Bensoussan, C., Delaforge, M., Mansuy, D. (1995) Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs. Biochem. Pharmacol. 49: 591-602
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 591-602
    • Bensoussan, C.1    Delaforge, M.2    Mansuy, D.3
  • 4
    • 0029812219 scopus 로고    scopus 로고
    • Anatomical distribution of NADPH-cytochrome P450 reductase and cytochrome P4502D forms in rat brain: Effects of xenobiotics and sex steroids
    • Bergh, A. F., Strobel, H. W. (1996) Anatomical distribution of NADPH-cytochrome P450 reductase and cytochrome P4502D forms in rat brain: effects of xenobiotics and sex steroids. Mol. Cell. Biochem. 162: 31-41
    • (1996) Mol. Cell. Biochem. , vol.162 , pp. 31-41
    • Bergh, A.F.1    Strobel, H.W.2
  • 5
    • 0022481857 scopus 로고
    • Bufuralol 1′-hydroxylase activity of the rat
    • Boobis, A. R., Seddon, C. E., Davies, D. S. (1986) Bufuralol 1′-hydroxylase activity of the rat. Biochem. Pharmacol. 35: 2961-2965
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 2961-2965
    • Boobis, A.R.1    Seddon, C.E.2    Davies, D.S.3
  • 7
    • 0025733250 scopus 로고
    • Role of P4502D6, the target of the sparteine-debrisoquine oxidation polymorphism, in the metabolism of imipramine
    • Brøsen, K., Zeugin, T., Meyer, U. A. (1991) Role of P4502D6, the target of the sparteine-debrisoquine oxidation polymorphism, in the metabolism of imipramine. Clin. Pharmacol. Ther. 49: 609-617
    • (1991) Clin. Pharmacol. Ther. , vol.49 , pp. 609-617
    • Brøsen, K.1    Zeugin, T.2    Meyer, U.A.3
  • 8
    • 0032853328 scopus 로고    scopus 로고
    • Isoform-selective metabolism of mianserin by cytochrome P-450 2D
    • Chow, T., Hiroi, T., Imaoka, S., Chiba, K., Funae, Y. (1999a) Isoform-selective metabolism of mianserin by cytochrome P-450 2D. Drug Metab. Dispos. 27: 1200-1204
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 1200-1204
    • Chow, T.1    Hiroi, T.2    Imaoka, S.3    Chiba, K.4    Funae, Y.5
  • 9
    • 0032911164 scopus 로고    scopus 로고
    • Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver
    • Chow, T., Imaoka, S., Hiroi, T., Funae, Y. (1996b) Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver. Drug Metab. Dispos. 27: 188-192
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 188-192
    • Chow, T.1    Imaoka, S.2    Hiroi, T.3    Funae, Y.4
  • 10
    • 0028059720 scopus 로고
    • Involvement of CYP2D6, CYP3A4, and other cytochromes P450 isoenzymes in N-dealkylation reactions
    • Coutts, R. T., Su, P., Baker, G. B. (1994) Involvement of CYP2D6, CYP3A4, and other cytochromes P450 isoenzymes in N-dealkylation reactions. J. Pharmacol. Toxicol. Methods 31: 177-186
    • (1994) J. Pharmacol. Toxicol. Methods , vol.31 , pp. 177-186
    • Coutts, R.T.1    Su, P.2    Baker, G.B.3
  • 11
    • 0026787192 scopus 로고
    • The effect of selective re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes
    • Crewee, H. K., Lennard, M. S., Tucker, G. T., Woods, F. R., Haddock, R. E. (1992) The effect of selective re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. Br. J. Clin. Pharmacol. 34: 262-265
    • (1992) Br. J. Clin. Pharmacol. , vol.34 , pp. 262-265
    • Crewee, H.K.1    Lennard, M.S.2    Tucker, G.T.3    Woods, F.R.4    Haddock, R.E.5
  • 12
    • 0025080528 scopus 로고
    • Alteration of cytochrome P-450 by prolonged administration of imipramine and/or lithium to rats
    • Daniel, W., Netter, K. J. (1992) Alteration of cytochrome P-450 by prolonged administration of imipramine and/or lithium to rats. Naunyn Schmiedebergs Arch. Pharmacol. 342: 234-240
    • (1992) Naunyn Schmiedebergs Arch. Pharmacol. , vol.342 , pp. 234-240
    • Daniel, W.1    Netter, K.J.2
  • 13
    • 0032788774 scopus 로고    scopus 로고
    • The influence of selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics of thioridazine and its metabolites: In vivo and in vitro studies
    • Daniel, W.A., Syrek, M., Haduch, A., Wójcikowski, J. (1999) The influence of selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics of thioridazine and its metabolites: in vivo and in vitro studies. Exp. Toxicol. Pathol. 51: 309-314
    • (1999) Exp. Toxicol. Pathol. , vol.51 , pp. 309-314
    • Daniel, W.A.1    Syrek, M.2    Haduch, A.3    Wójcikowski, J.4
  • 14
    • 0023568113 scopus 로고
    • MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isoenzymes (P450buf1, P450db1) catalyzing debrisoquine 4-hydroxylation
    • Fonne-Pfister, R., Bargetzi, M. J., Meyer, U. A. (1987) MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isoenzymes (P450buf1, P450db1) catalyzing debrisoquine 4-hydroxylation. Biochem. Biophys. Res. Commun. 148: 1144-1150
    • (1987) Biochem. Biophys. Res. Commun. , vol.148 , pp. 1144-1150
    • Fonne-Pfister, R.1    Bargetzi, M.J.2    Meyer, U.A.3
  • 15
    • 0026006832 scopus 로고
    • A simple, rapid method for the simultaneous determination of morphine and its principal metabolites in plasma using high-performance liquid chromatography and fluorometric detection
    • Glare, P. A., Walsh, T. D., Pippenger, C. E. (1991) A simple, rapid method for the simultaneous determination of morphine and its principal metabolites in plasma using high-performance liquid chromatography and fluorometric detection. Ther. Drug Monit. 13: 226-232
    • (1991) Ther. Drug Monit. , vol.13 , pp. 226-232
    • Glare, P.A.1    Walsh, T.D.2    Pippenger, C.E.3
  • 18
    • 0032917167 scopus 로고    scopus 로고
    • Mirtazapine. A review of its use in major depression
    • Holm, K. J., Markham, A. (1999) Mirtazapine. A review of its use in major depression. Drugs 57: 607-631
    • (1999) Drugs , vol.57 , pp. 607-631
    • Holm, K.J.1    Markham, A.2
  • 19
    • 0034655747 scopus 로고    scopus 로고
    • Regulation of cytochrome P450 (CYP) genes by nuclear receptors
    • Honkakoski, P., Negishi, M. (2000) Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem. J. 347: 321-337
    • (2000) Biochem. J. , vol.347 , pp. 321-337
    • Honkakoski, P.1    Negishi, M.2
  • 20
    • 0029738965 scopus 로고    scopus 로고
    • Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine
    • Jeppesen, U., Gram, L. F., Vistisen, K., Loft, S., Poulsen, H. E., Brøsen, K. (1996) Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. Eur. J. Clin. Pharmacol. 51: 73-78
    • (1996) Eur. J. Clin. Pharmacol. , vol.51 , pp. 73-78
    • Jeppesen, U.1    Gram, L.F.2    Vistisen, K.3    Loft, S.4    Poulsen, H.E.5    Brøsen, K.6
  • 21
    • 0016840091 scopus 로고
    • Irreversible protein binding of [14C]imipramine with rat and human liver microsomes
    • Kappus, H., Remmer, H. (1975) Irreversible protein binding of [14C]imipramine with rat and human liver microsomes. Biochem. Pharmacol. 24: 1079-1084
    • (1975) Biochem. Pharmacol. , vol.24 , pp. 1079-1084
    • Kappus, H.1    Remmer, H.2
  • 22
    • 0024796958 scopus 로고
    • The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
    • Kimura, S., Umeno, M., Skoda, R. C., Meyer, U. A., Gonzalez, F. J. (1989) The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am. J. Hum. Genet. 45: 889-904
    • (1989) Am. J. Hum. Genet. , vol.45 , pp. 889-904
    • Kimura, S.1    Umeno, M.2    Skoda, R.C.3    Meyer, U.A.4    Gonzalez, F.J.5
  • 23
    • 0024418697 scopus 로고
    • The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man
    • Kobayashi, S., Murray, S., Watson, D., Sesardic, D., Davies, D. S., Boobis, A. R. (1989) The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man. Biochem. Pharmacol. 38: 2795-2799
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 2795-2799
    • Kobayashi, S.1    Murray, S.2    Watson, D.3    Sesardic, D.4    Davies, D.S.5    Boobis, A.R.6
  • 24
    • 0344517077 scopus 로고    scopus 로고
    • Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro
    • Kobayashi, K., Ishizuka, T., Shimada, N., Yoshimura, Y., Kamijma, K., Chiba, K. (1999) Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro. Drug Metab. Dispos. 27: 763-766
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 763-766
    • Kobayashi, K.1    Ishizuka, T.2    Shimada, N.3    Yoshimura, Y.4    Kamijma, K.5    Chiba, K.6
  • 25
    • 0001292697 scopus 로고
    • A sensitive fluorometric assay for morphine in plasma and brain
    • Kupfenberg, H., Burkhalter, A., Way, E. L. (1964) A sensitive fluorometric assay for morphine in plasma and brain. J. Pharmacol. Exp. Ther. 145: 247-251
    • (1964) J. Pharmacol. Exp. Ther. , vol.145 , pp. 247-251
    • Kupfenberg, H.1    Burkhalter, A.2    Way, E.L.3
  • 26
    • 0033815944 scopus 로고    scopus 로고
    • (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes
    • Margolis, J. M., O'Donnell, J. P., Mankowski, D. C., Ekins, S., Obach, R. S. (2000) (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab. Dispos. 28: 1187-1191
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 1187-1191
    • Margolis, J.M.1    O'Donnell, J.P.2    Mankowski, D.C.3    Ekins, S.4    Obach, R.S.5
  • 29
    • 0030434804 scopus 로고    scopus 로고
    • Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: In relation to covalent binding of its reactive intermediate
    • Masubuchi, Y., Igarashi, S., Suzuki, T., Horiee, T., Narimatsu, S. (1996) Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: in relation to covalent binding of its reactive intermediate. J. Pharmacol. Exp. Ther. 279: 724-731
    • (1996) J. Pharmacol. Exp. Ther. , vol.279 , pp. 724-731
    • Masubuchi, Y.1    Igarashi, S.2    Suzuki, T.3    Horiee, T.4    Narimatsu, S.5
  • 30
    • 0024416946 scopus 로고
    • The CYP2D gene subfamily: Analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats
    • Matsunaga, E., Zanger, U. M., Hardwick, J. P., Gelboin, H. V., Meyer, U. A., Gonzales, F. J. (1989) The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats. Biochemistry 28: 7349-7355
    • (1989) Biochemistry , vol.28 , pp. 7349-7355
    • Matsunaga, E.1    Zanger, U.M.2    Hardwick, J.P.3    Gelboin, H.V.4    Meyer, U.A.5    Gonzales, F.J.6
  • 31
    • 0025164996 scopus 로고
    • The rat debrisoquine 4-hydroxylase CYP2D gene subfamily: Complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme binding region of the cytochrome P450 active site
    • Matsunaga, E., Umeno, M., Gonzalez, F. J. (1990) The rat debrisoquine 4-hydroxylase CYP2D gene subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme binding region of the cytochrome P450 active site. J. Mol. Evol. 30: 155-169
    • (1990) J. Mol. Evol. , vol.30 , pp. 155-169
    • Matsunaga, E.1    Umeno, M.2    Gonzalez, F.J.3
  • 32
    • 0030053749 scopus 로고    scopus 로고
    • Inhibition of microsomal cytochromes P450 in rat liver by the tricycle antidepressant drug desipramine and its primary oxidized metabolites
    • McNeil, C. M., Murray, M. (1996) Inhibition of microsomal cytochromes P450 in rat liver by the tricycle antidepressant drug desipramine and its primary oxidized metabolites. Biochem. Pharmacol. 51; 15-20
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 15-20
    • McNeil, C.M.1    Murray, M.2
  • 33
    • 0033947897 scopus 로고    scopus 로고
    • Regional and cellular distribution of CYP2D subfamily members in rat brain
    • Miksys, S., Rao, Y., Sellers, E. M., Kwan, M., Mendis, D., Tyndale, R. F. (2000) Regional and cellular distribution of CYP2D subfamily members in rat brain. Xenobiotica 30: 547-564
    • (2000) Xenobiotica , vol.30 , pp. 547-564
    • Miksys, S.1    Rao, Y.2    Sellers, E.M.3    Kwan, M.4    Mendis, D.5    Tyndale, R.F.6
  • 34
    • 0026623034 scopus 로고
    • Inhibition and metabolite complexation of rat hepatic microsomal cytochrome P450 by tricyclic antidepressants
    • Murray, M., Field, S. L. (1992) Inhibition and metabolite complexation of rat hepatic microsomal cytochrome P450 by tricyclic antidepressants. Biochem. Pharmacol. 43: 2065-2071
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 2065-2071
    • Murray, M.1    Field, S.L.2
  • 35
    • 0025136874 scopus 로고
    • Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ), a possible parkinsonian inducing substance, in an animal model of a poor debrisoquine metabolizer
    • Ohta, S., Tachikava, Y., Makino, Y., Tasaki, Y., Hirobe M. (1990) Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ), a possible parkinsonian inducing substance, in an animal model of a poor debrisoquine metabolizer. Life Sci. 46: 599-605
    • (1990) Life Sci. , vol.46 , pp. 599-605
    • Ohta, S.1    Tachikava, Y.2    Makino, Y.3    Tasaki, Y.4    Hirobe, M.5
  • 37
    • 0029979348 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 by nefazodone in vitro: Studies of dextromethorphan O- and N-demethylation
    • Schmider, J., Greenblatt, D. J., von Moltke, L. L., Harmatz, J. S., Shader, R. I. (1996) Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation. Br. J. Clin. Pharmacol. 41: 339-343
    • (1996) Br. J. Clin. Pharmacol. , vol.41 , pp. 339-343
    • Schmider, J.1    Greenblatt, D.J.2    Von Moltke, L.L.3    Harmatz, J.S.4    Shader, R.I.5
  • 39
    • 0035049437 scopus 로고    scopus 로고
    • Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain
    • Siegle, I., Fritz, R., Eckhardt, K., Zanger, U. M., Eichelbaum, M. (2001) Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain. Pharmacogenetics 11: 237-245
    • (2001) Pharmacogenetics , vol.11 , pp. 237-245
    • Siegle, I.1    Fritz, R.2    Eckhardt, K.3    Zanger, U.M.4    Eichelbaum, M.5
  • 40
    • 0023950223 scopus 로고
    • Inhibition of desipramine 2-hydroxylation by quinidine and quinine
    • Steiner, E., Dumond E., Spina, E., Dahlqvist, R. (1988) Inhibition of desipramine 2-hydroxylation by quinidine and quinine. Clin. Pharmacol. Ther. 43: 577-581
    • (1988) Clin. Pharmacol. Ther. , vol.43 , pp. 577-581
    • Steiner, E.1    Dumond, E.2    Spina, E.3    Dahlqvist, R.4
  • 41
    • 0033810675 scopus 로고    scopus 로고
    • Metabolism of the antidepressant mirtazapine in vitro: Contribution of cytochromes P-450 1A2, 2D6, and 3A4
    • Störmer, E., von Moltke, L. L., Schader, R. I., Greenblatt, D. J. (2000) Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4. Drug Metab. Dispos. 28: 1168-1175
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 1168-1175
    • Störmer, E.1    Von Moltke, L.L.2    Schader, R.I.3    Greenblatt, D.J.4
  • 42
    • 2642709237 scopus 로고    scopus 로고
    • Promazine pharmacokinetics during concurrent treatment with tricyclic antidepressants
    • Syrek, M., Wójcikowski, J., Daniel, W. A. (1997) Promazine pharmacokinetics during concurrent treatment with tricyclic antidepressants. Pol. J. Pharmacol. 51: 453-462
    • (1997) Pol. J. Pharmacol. , vol.51 , pp. 453-462
    • Syrek, M.1    Wójcikowski, J.2    Daniel, W.A.3
  • 43
    • 0032809128 scopus 로고    scopus 로고
    • Characterization of cytochrome P-450 2D1 activity in rat brain: High-affinity kinetics for dextromethorphan
    • Tyndale, R. F., Li, Y., Li, N.-Y., Messina, E., Miksys, S., Sellers, E. M. (1999) Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan. Drug Metab. Dispos. 27: 924-930
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 924-930
    • Tyndale, R.F.1    Li, Y.2    Li, N.-Y.3    Messina, E.4    Miksys, S.5    Sellers, E.M.6
  • 44
    • 0031574143 scopus 로고    scopus 로고
    • Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity
    • Wan J., Imaoka, S., Chow, T., Hiroi, T., Yabusaki, Y., Funae, Y. (1998) Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity. Arch. Biochem. Biophys. 348: 383-390
    • (1997) Arch. Biochem. Biophys. , vol.348 , pp. 383-390
    • Wan, J.1    Imaoka, S.2    Chow, T.3    Hiroi, T.4    Yabusaki, Y.5    Funae, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.