Does dopexamine influence regional vascular tone and oxygenation during intestinal hypotension?

Acta Anaesthesiologica Scandinavica

Volumn 46, Issue 10, 2002, Pages 1217-1226

  Lehtipalo, S ^a   Biber, B ^a   Frojse R ^b   Arnerlov C ^b   Johansson, G ^a   Winso O ^a  

^a Anesthesiology and Intensive Care ^*  (Sweden)

^b UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Autoregulation; Dopexamine; Intestinal hypotension; Intestinal vascular resistance; Intestinal vasodilation; Mucosal blood flow; Tissue oxygen tension

Indexed keywords

DOPEXAMINE;

ANALYSIS OF VARIANCE; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; AUTOREGULATION; BLOOD VESSEL TONE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HEMODYNAMIC MONITORING; HYPOTENSION; INTESTINAL HYPOTENSION; INTESTINE BLOOD FLOW; INTESTINE PERFUSION; MESENTERY BLOOD FLOW; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; TISSUE OXYGENATION; VASCULAR RESISTANCE;

ANIMALS; DOPAMINE; FEMALE; HEMODYNAMIC PROCESSES; HYPOTENSION; INTESTINAL MUCOSA; INTESTINES; JEJUNUM; LACTIC ACID; MESENTERIC ARTERY, SUPERIOR; OXYGEN; REGIONAL BLOOD FLOW; SWINE; VASCULAR RESISTANCE; VASODILATOR AGENTS;

EID: 0036846451     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.2002.461009.x     Document Type: Article

References (39)

1. Lundgren O, Svanvik J. Mucosal hemodynamics in the small intestine of the cat during reduced perfusion pressure. Acta Physiol Scand 1973: 88: 551-563.
2. Papa M, Halperin Z, Rubinstein E, Orenstein A, Gafin S, Adar R. The effect of ischemia of the dog's colon on transmural migration of bacteria and endotoxin. J Surg Res 1983: 35: 264-269.
3. Landow L, Andersen LW. Splanchnic ischaemia and its role in multiple organ failure. Acta Anaesthesiol Scand 1994: 38: 626-639.
4. Nieuwenhuijzen GA, Goris RJ. The gut: The 'motor' of multiple organ dysfunction syndrome? Curr Opin Clin Nutr Metab Care 1999: 2: 399-404.
5. Boldt J, Papsdorf M, Piper S, Padberg W, Hempelmann G. Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery. Acta Anaesthesiol Scand 1998: 42: 941-947.
6. Brown RA, Dixon J, Farmer JB et al. Dopexamine: A novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors. Br J Pharmacol 1985: 85: 599-608.
7. Fitton A, Benfield P. Dopexamine hydrochloride. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in acute cardiac insufficiency. Drugs 1990: 39: 308-330.
8. Maynard ND, Bihari DJ, Dalton RN, Smithies MN, Mason RC. Increasing splanchnic blood flow in the critically III. Chest 1995: 108: 1648-1654.
9. Tighe D, Moss R, Haywood G et al. Dopexamine hydrochloride maintains portal blood flow and attenuates hepatic ultrastructural changes in a porcine peritonitis model of multiple system organ failure. Circ Shock 1993: 39: 199-206.
10. Schmidt H, Secchi A, Wellmann R, Bach A, Bhrer H, Martin E. Dopexamine maintains intestinal villus blood flow during endotoxemia in rats. Crit Care Med 1996: 24: 1233-1237.
11. Uusaro A, Ruokonen E, Takala J. Gastric mucosal pH does not reflect changes in splanchnic blood flow after cardiac surgery. Br J Anaesth 1995: 74: 149-154.
12. Gardeback M, Settergren G. Dopexamine and dopamine in the prevention of low gastric mucosal pH following cardiopulmonary by-pass. Acta Anaesthesiol Scand 1995: 39: 1066-1070.
13. Kiefer P, Tugtekin I, Wiedeck H et al. Effect of a dopexamine-induced increase in cardiac index on splanchnic hemodynamics in septic shock. Am J Respir Crit Care Med 2000: 161: 775-779.
14. Meier-Hellmann A, Bredle DL, Specht M, Hannemann L, Reinhart K. Dopexamine increases splanchnic blood flow but decreases gastric mucosal pH in severe septic patients treated with dobutamine. Crit Care Med 1999: 27: 2166-2171.
15. Muller M, Boldt J, Schindler E et al. Effects of low-dose dopexamine on splanchnic oxygenation during major abdominal surgery. Crit Care Med 1999: 27: 2389-2393.
16. Cain SM, Curtis SE. Systemic and regional oxygen uptake and delivery and lactate flux in endotoxic dogs infused with dopexamine. Crit Care Med 1991: 19: 1552-1560.
17. Bastien O, Piriou V, Aouifi A, Evans R, Lehot JJ. Effects of dopexamine on blood flow in multiple splanchnic sites measured by laser Doppler velocimetry in rabbits undergoing cardiopulmonary bypass. Br J Anaesth 1999: 82: 104-109.
18. Nordin A, Makisalo H, Mildh L, Hockerstedt K. Dopexamine improves liver oxygenation during crystalloid resuscitation from experimental hemorrhagic shock. Crit Care Med 1997: 25: 663-668.
19. Studer W, Wu X. Supraceliac aortic cross-clamping and declamping. Effects of dopexamine and dopamine on systemic and mesenteric hemodynamics, metabolism and intestinal tonometry in a rat model. Acta Anaesthesiol Scand 2000: 44: 241-248.
20. Raner C, Biber B, Henriksson B-Å, Martner J, Winsö O. Effects of isoflurane on feline intestinal blood flow during hemorrhage-induced hypovolemia. Acta Anaesthesiol Scand 1986: 33: 463-468.
21. Sundeman H, Biber B, Raner C, Winsö O. Autoregulation and vasodilator responses by isoflurane and desflurane in the feline renal vascular bed. Acta Anaesthesiol Scand 1997: 41: 1180-1186.
22. Lundgren O, Svanvik J. Mucosal hemodynamics in the small intestine of the cat during vasoconstrictor-induced hypertension. Am J Physiol 1988: 254: H709-H718.
23. Meininger GA, Trzeciakowski JP. Vasoconstriction is amplified by autoregulation during reduced perfusion pressure. Acta Physiol Scand 1973: 88: 551-563.
24. Wheaton LG, Saar MG, Schlossberg L, Bulkley GB. Gross anatomy of the splanchnic vasculature. In: Granger DN, Bulkley GB, eds. Measurement of Blood Flow: Applications to the Splanchnic Circulation. Baltimore/London: Williams & Wilkins, 1981: 43-45.
25. Shepherd AP, Riedel GL. Effect of pulsatile pressure and metabolic rate on intestinal autoregulation. Am J Physiol 1982: 242: H769-H775.
26. Shimokawa A, Kunitake T, Takasaki M, Kannan H. Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumented rats. J Auton Nerv Syst 1998: 72: 46-54.
27. Gaskell WH. On the changes of blood stream in muscle through stimulation of their nerves. J Anat 1877: 11: 11-12.
28. Folkow B. Intravascular pressure as a factor regulating the tone of small vessels. Acta Physiol Scand 1949: 17: 289-316.
29. Folkow B. Description of the myogenic hypothesis. Circ Res 1964: 14: 279-285.
30. Johnson PC. Review of previous studies and current theories of autoregulation. Circ Res Suppl 1964: 15: 2-9.
31. Texter C, Merrill S, Schwartz M, Van Derstappen G, Haddy FJ. Relationship of blood flow to pressure in the intestinal vascular bed of the dog. Am J Physiol 1962: 202: 253-256.
32. Lundgren O. Microcirculation of the gastrointestinal tract and pancreas. The cardiovascular system IV. In: Renkin EM, Michel CC, eds. Handbook of Physiology. Bethesda Maryland: Am. Physiol. Soc, 1984: 829-832.
33. Johnson PC. Myogenic nature of increase in intestinal vascular resistance with venous pressure elevation. Circ Res 1959: 6: 992-999.
34. Granger DN, Richardson PD, Kvietys PR, Mortillaro NA. Intestinal blood flow. Gastroenterology 1980: 78: 837-863.
35. Granger DN, Granger HJ. Systems analysis of intestinal hemodynamics and oxygenation. Am J Physiol 1983: 245: G786-G796.
36. Germann R, Haisjackl M, Hasiberder W et al. Dopamine and mucosal oxygenation in the porcine jejunum. J Appl Physiol 1994: 77 (6): 2845-2852.
37. Thoren A, Elam M, Ricksten S-E. Differential effects of dopamine, dopexamine and dobutamine on jejunal mucosal perfusion early after cardiac surgery. Crit Care Med 1999: 65 (6): 548-553.
38. Carlet J. From mega to more reasonable doses of corticosteroids: A decade to recreate hope. Crit Care Med 1999: 27 (4): 672-674.
39. Korstanje C, Mathy MJ, van Charldorp K, de Jonge A, van Zwieten PA. Influence of respiratory acidosis or alkalosis on pressor responses mediated by alpha 1- and alpha 2- adrenoceptors in pithed normotensive rats. Naunyn Schmiedebergs Arch Pharmacol 1985: 330 (3): 187-192.