Effects of low-dose dopexamine on splanchnic oxygenation during major abdominal surgery

Critical Care Medicine

Volumn 27, Issue 11, 1999, Pages 2389-2393

  Müller, Matthias ^a   Boldt, Joachim ^b   Schindler, Ehrenfried ^a   Sticher, Jochen ^a   Kelm, Christoph ^a   Roth, Sabine ^a   Hempelmann, Gunter ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b Justus Liebig University Giessen ^*

Author keywords

Catecholamines; Dopexamine; Gastric intramucosal PCO2; Gastric tonometry; Gastrointestinal blood flow; Hemodynamics; Major abdominal surgery; Monitoring; Splanchnic oxygenation; Tissue PO2

Indexed keywords

CARBON DIOXIDE; DOPEXAMINE; OXYGEN;

ABDOMINAL SURGERY; ADULT; AGED; ARTICLE; CARBON DIOXIDE TENSION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; GASTRECTOMY; HEMICOLECTOMY; HUMAN; INTESTINE; MAJOR SURGERY; OXYGEN TISSUE LEVEL; OXYGEN TRANSPORT; OXYGENATION; PANCREATICODUODENECTOMY; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPLANCHNIC BLOOD FLOW; STOMACH;

EID: 0032760208     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199911000-00011     Document Type: Article

References (35)

1. 1. Price HL, Deutsch S, Marshall BE, et al: Hemodynamic and metabolic effects of hemorrhage in man with particular reference to the splanchnic circulation. Circ Res 1966; 18:469-474.
2. 2. Brinkmann A, Wolf C-F, Kneitinger E, et al: Impact on oxygen transport due to prostacyclin release during major abdominal surgery. Intensive Care Med 1994; 20 (Suppl 1):S44.
3. 3. Papa M, Halperin Z, Rubinstein E, et al: The effect of ischemia of the dog's colon transmural migration of bacteria and endotoxin. J Surg Res 1983; 35:264-269.
4. 4. Landow L, Andersen LW: Splanchnic ischaemia and its role in multiple organ failure. Acta Anaesthesiol Scand 1994; 38:626-639.
5. 5. Roumen RMH, van der Vliet JA, Wevers RA, et al: Intestinal permeability is increased after major vascular surgery. J Vasc Surg 1993; 17:734-737.
6. 6. Smith GW, O'Connor SE: An introduction to the pharmacologic properties of Dopacard (dopexamine hydrochloride). Am J Cardiol 1988; 62:9C-17C.
7. 7. Leier CV: Regional blood flow responses to vasodilators and inotropes in congestive heart failure. Am J Cardiol 1988; 62: 86E-93E.
8. 8. Leier CV, Binkley P, Carpenter J, et al: Cardiovascular pharmacology of dopexamine in low output congestive heart failure. Am J Cardiol 1988; 62:94-99.
9. 9. Schmidt H, Secchi A, Wellmann R, et al: Dopexamine maintains intestinal villus blood flow during endotoxemia in rats. Crit Care Med 1996; 24:1233-1237.
10. 10. Maynard ND, Bihari DJ, Dalton RN, et al: Increasing splanchnic blood flow in the critically ill. Chest 1995; 108:1648-1654.
11. 11. Trinder TJ, Lavery GG, Fee JP, et al: Correction of splanchnic oxygen deficit in the intensive care unit: dopexamine and colloid versus placebo. Anaesth Intensive Care 1995; 23:178-182.
12. 12. Gardebäck M, Settergren G: Dopexamine and dopamine in the prevention of low gastric mucosal pH following cardiopulmonary bypass. Acta Anaesthesiol Scand 1995; 39: 1066-1070.
13. 13. Evans TW: Gut permeability following cardiac surgery. Clin Intensive Care 1995; 6:35-36.
14. 14. Barneschi MG, Rossi R, Pieraccioli E, et al: Effect of dopexamine in splanchnic perfusion during surgery of the abdominal aorta. Minerva Anestesiol 1996; 60:245-252.
15. 15. Hamilton-Davies C, Mythen MG, Jacobsen J, et al: Comparison of commonly used clinical indicators of hypovolaemia with tonometry. Crit Care Med 1995; 23:A86
16. 16. Kessler M, Lübbers DM: Aufbau und Anwendungsmöglichkeiten verschiedener PO2-Elektroden. Pflügers Arch Ges Physiol 1966; 291/3:82.
17. 17. Kessler M, Lubbers DW, Krumme BA, et al: Oxygen tension in different tissues. Bibl Anat 1977; 16:146-149.
18. 2 of the large intestine in man. Anasthesio Intensivmed Notfallmed Schmerzther 1995; 30:108-110
19. 19. Fiddian-Green RG: Assessment of the adequacy of mucosal oxygenation in patients with intraluminally located silicone tonometers. In: Microcirculation in Circulatory Disorders. Manabe H, Zweifach BW, Messmer K (Eds). Berlin, Springer-Verlag, 1988, pp 481-487
20. 20. Fiddian-Green RG: Gastric intramucosal pH, tissue oxygenation and acid-base balance. Br J Anaesth 1995; 74:591-606
21. 21. Montgomery A, Almqvist P, Arvidsson D, et al: Early detection of gastrointestinal mucosal ischemia in porcine E. coli sepsis. Acta Chir Scand 1990; 156:613-620
22. 22. Landow L, Phillips DA, Heard SO, et al: Gastric tonometry and venous oximetry in cardiac surgery patients. Crit Care Med 1991; 19:1226-1233
23. 23. Knichwitz G, Kuhmann M, Brodner G, et al: Gastric tonometry: Precision and reliability are improved by a phosphate buffered solution. Crit Care Med 1996; 24:512-516
24. 2 is an important source of error in the assessment of gastric intramucosal pH. Crit Care Med 1994; 22:1877-1879
25. 2-measurement of six standard blood gas analysers with a phosphate-buffered solution for gastric tonometry. Anaesthesia 1995; 50:532-534
26. 26. Fiddian-Green RG, Baker S: Predictive value of the stomach wall pH for complications after cardiac operations: Comparison with other monitoring. Crit Care Med 1987; 15: 153-156
27. 27. Berendes E, Lippert G, Loick HM, et al: Effects of enflurane and isoflurane on splanchnic oxygenation in humans. J Clin Anesth 1996; 8:456-468
28. 28. Boyd O, Grounds RM, Bennett ED: A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA 1993; 270:2699-2707
29. 29. Ruttimann Y, Schutz Y, Jequier E, et al: Thermogenic and metabolic effects of dopamine in healthy men. Crit Care Med 1991; 19:1030-1036
30. 30. Green CJ, Frazer RS, Underhill S, et al: Metabolic effects of dobutamine in normal man. Clin Sci 1992; 82:77-83
31. 31. Napoleone P, Ricci A, Amenta F: Dopexamine hydrochloride in the human splanchnic vasculature: A biochemical, radiologand binding and autoradiographic study. Clin Intensive Care 1993; 4:56-61
32. 32. Lund N, de Asla RJ, Cladis F, et al: Dopexamine hydrochloride in septic shock: Effects on oxygen delivery and oxygenation of gut, liver, and muscle. J Trauma 1995; 38: 767-775
33. 33. Uusaro A, Ruokonen E, Takala J: Gastric mucosal pH does not reflect changes in splanchnic blood flow after cardiac surgery. Br J Anaesth 1995; 74:149-154
34. 34. VanderMeer J, Wang H, Fink MP: Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 1995; 23:1217-1226
35. 35. Giraud GD, MacCannell KL: Decreased nutrient blood flow during dopamine-and epinephrine-induced intestinal vasodilation. J Pharmacol Exp Ther 1984; 230:214-220