Dopexamine maintains intestinal villus blood flow during endotoxemia in rats

Critical Care Medicine

Volumn 24, Issue 7, 1996, Pages 1233-1237

  Schmidt, Heinfried ^a   Secchi, Andreas ^a   Wellmann, Ruth ^a   Bach, Alfons ^a   Böhrer, Hubert ^a   Martin, Eike ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

blood flow; dopexamine; endotoxemia; gut; microcirculation; multiple organ failure; perfusion; video microscopy; villus

Indexed keywords

DOPEXAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY PERFUSION; ARTICLE; CONTROLLED STUDY; CRITICAL ILLNESS; DRUG EFFECT; ENDOTOXEMIA; HYPOXEMIA; INTESTINE BLOOD FLOW; INTESTINE VILLUS; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY VASCULAR RESISTANCE; MICROCIRCULATION; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENERGIC BETA-AGONISTS; ANIMALS; ARTERIOLES; DOPAMINE; DOPAMINE AGONISTS; ENDOTOXINS; INTESTINAL MUCOSA; MALE; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 0030007746     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199607000-00028     Document Type: Article

References (42)

1. Knaus WA, Wagner DP: Multiple systems organ failure: Epidemiology and prognosis. Crit Care Clin 1989; 5: 221-232
2. Deitch EA: Multiple organ failure: Pathophysiology and potential future therapy. Ann Surg 1992; 216:117-134
3. Knaus WA, Draper EA, Wagner DP, et al: Prognosis in acute organ system failure. Ann Surg 1985; 202:685-693
4. Baron P, Traber LD, Traber DL, et al: Gut failure and translocation following burn and sepsis. J Surg Res 1994; 57: 197-204
5. Deitch EA: The role of intestial barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Arch Surg 1990; 125:403-404
6. Berg RD: Translocation of indigenous bacteria from the intestinal tract. In: Human Intestinal Microflora in Health and Disease. Vol 15. Hentges DJ (Ed). Orlando, Academic Press, 1983, pp 333-352
7. O'Dwyer ST, Mitchie HR, Ziegler TR, et al: A single dose of endotoxin increases intestinal permeability in healthy humans. Arch Surg 1988; 123:1459-1464
8. Deitch EA, Specian RD, Berg RD: Endotoxin-induced bacterial translocation and mucosal permeability: Role of xanthine oxidase, complement activation and macrophage products. Crit Care Med 1991; 19:785-791
9. Jennings G, Lunn PG, Elia M: The effect of endotoxin on gastrointestinal transit time and intestinal permeability. Clin Nutr 1995; 14:35-41
10. Fink MP, Antonsson JB, Wang H, et al: Increased intestinal permeability in endotoxic pigs. Mesenteric hypoperfusion as an etiologic factor. Arch Surg 1991; 126:211-218
11. Haglund U: Systemic mediators released from the gut in critical illness. Crit Care Med 1993; 21:15-18
12. Fink MP, Kaups KL, Wang H, et al: Maintenance of superior mesenteric arterial perfusion prevents increased intestinal mucosal permeability in endotoxic pigs. Surgery 1991; 110:154-161
13. Leier CV: Regional blood flow responses to vasodilators and inotropes in congestive heart failure. Am J Cardiol 1988; 62:86E-93E
14. Smithies M, Yee TH, Jackson L, et al: Protecting the gut and the liver in the critically ill: Effects of dopexamine. Crit Care Med 1994; 22:789-795
15. Lund N, Asla RJ, Papadakos PJ, et al: Dopexamine hyrochloride in septicemia: Effects on gut, liver and muscle oxygenation. Crit Care Med 1992; 20(Suppl4): 46
16. Trinder TJ, Lavery GG, Fee JPH, et al: Correction of splanchnic oxgen deficit in the intensive care unit: Dopexamine and colloid versus placebo. Anaesth Intensive Care 1995; 23:178-182
17. Kuhly P, Oschmann G, Specht M, et al: Dopexamine hydrochloride does not improve gastric and sigmoid mucosal acidosis in patients with sepsis. Br J Anesth 1995; 74(Suppl 1):121
18. Lundgren O, Svanvik J: Mucosal hemodynamics in the small intestine of the cat during reduced perfusion pressure. Acta Physiol Scand 1973; 88:551-563
19. Shepherd AP, Kiel JW: A model of countercurrent shunting of oxygen in the intestinal villus. Am J Physiol 1992; 262:H1136-1142
20. Bohlen HG, Gore RW: Preparation of rat intestinal muscle and mucosa for quantitative microcirculatory studies. Microvasc Res 1976; 11:103-110
21. Gore RW, Bohlen HG: Microvascular pressures in rat intestinal muscle and mucosal villi. Am J Physiol 1977; 233: H685-H693
22. Butcher EC, Weissmann IL: Direct fluorescent labelling of cells with fluorescein or rhodamin isocyanate. I. Technical aspects. J Immunol Meth 1980; 37:97-108
23. Sarelius IH, Duling BR: Direct measurement of microvessel hematocrit, red cell flux, velocity and transit time. Am J Physiol 1982; 243:H1018-1026
24. Chun K, Drugas D, Biewer J, et al: Intestinal villus microcirculatory response to hemorrhage in adult and immature rats. J Pediatr Surg 1992; 27:322-328
25. Barbee JH, Cokelet GR: The Fahraeus effect. Microvasc Res 1971; 3:6-16
26. Albrecht KH, Gaehtgens P, Pries A, et al: The Fahraeus effect in narrow capillaries (i.d. 3.3 to 11.0 μm). Microvasc Res 1979; 18:33-47
27. Marshall JC, Christou NV, Meakins JL: The gastrointestinal tract. The "undrained abscess" of multiple organ failure. Ann Surg 1993; 218:111-119
28. Deitch EA: Bacterial translocation of the gut flora. J Trauma 1990; 30 (Suppl): 184-189
29. Deitch EA, Ma WJ, Ma L, et al: Endotoxin-induced bacterial translocation: A study of mechanisms. Surgery 1990; 106:292-300
30. Landow L, Andersen LW: Splanchnic ischemia and its role in multiple organ failure. Acta Anaesthesiol Scand 1994; 38:626-639
31. Haglund U: Gut ischemia. Gut 1994; 35 (Suppl 1):S73-S76
32. Chiu CJ, Mc Ardle AH, Brown R, et al: Intestinal mucosal lesion in low-flow states. Arch Surg 1970; 101:478-483
33. Reilly PM, Bulkley GB: Vasoactive mediators and splanchnic perfusion. Crit Care Med 1993; 21:55-68
34. Gianotti L, Alexander JW, Fukushima R, et al: Translocation of Candida albicans is related to the blood flow of individual intestinal villi. Circ Shock 1993; 40:250-257
35. Bone RC: Gram-negative sepsis. Background, clinical features, and intervention. Chest 1991; 100:802-808
36. American College of Chest Physicians/ Society of Critical Care Medicine Consensus Conference Committee: American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
37. Fink MP, Heard SO: Laboratory models of sepsis and septic shock. J Surg Res 1990; 49:186-196
38. Whitworth PW, Cryer HM, Garrison RN, et al: Hypoperfusion of the intestinal microcirculation without decreased cardiac output during live Escherichia coli sepsis in rats. Circ Shock 1989; 27:111-122
39. Theuer CJ, Wilson MA, Steeb GD, et al: Microvascular vasoconstriction and mucosal hypoperfusion of the rat small intestine during bacteremia. Circ Shock 1993; 40:61-68
40. Smith GW, O'Connor SE: An introduction to the pharmacologic properties of Dopacard (dopexamine hydrochloride). Am J Cardiol 1988; 62:9C-17C
41. Napoleone P, Ricci A, Amenta F: Dopexamine hydrochloride in the human splanchnic vasculature: A biochemical, radioligand binding and autoradiographic study. Clin Intensive Care 1993; 4:56-61
42. Amenta F, Ricci A, Napoleone P, et al: Anatomical localisation of the binding and functional characterisation of responses to dopexamine hydrochloride in the rat mesenteric vasculature. Pharmacology 1991; 42:211-222