Determination of local tissue concentrations of bupivacaine released from biodegradable microspheres and the effect of vasoactive compounds on bupivacaine tissue clearance studied by microdialysis sampling

Pharmaceutical Research

Volumn 19, Issue 11, 2002, Pages 1745-1752

  McDonald, S ^a   Faibushevich, A A ^a   Garnick, S ^b   Mclaughlin, K ^c   Lunte, C ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b BIOANALYTICAL SYSTEMS INC   (United States)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Bupivacaine; Controlled release; Microdialysis sampling; Microspheres; Vasoactive compounds

Indexed keywords

BUPIVACAINE; DEXAMETHASONE; MICROSPHERE; VASOACTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADATION; CALIBRATION; CHROMATOGRAPHY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG FORMULATION; DRUG TISSUE LEVEL; FEMALE; GRANULOMATOUS INFLAMMATION; MICRODIALYSIS; MUSCLE BIOPSY; NONHUMAN; PRIORITY JOURNAL; RAT; SUSTAINED RELEASE PREPARATION; TISSUE REACTION;

ANIMALS; BUPIVACAINE; DRUG DELIVERY SYSTEMS; FEMALE; METABOLIC CLEARANCE RATE; MICRODIALYSIS; MICROSPHERES; MUSCLE, SKELETAL; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; VASOCONSTRICTOR AGENTS;

EID: 0036844754     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020725917197     Document Type: Article

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