Transcription through intergenic chromosomal memory elements of the Drosophila bithorax complex correlates with an epigenetic switch

Molecular and Cellular Biology

Volumn 22, Issue 22, 2002, Pages 8026-8034

  Rank, Gerhard ^a   Prestel, Matthias ^a   Paro, Renato ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN BXD; PROTEIN MCP; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN STRUCTURE; CHROMOSOMAL MEMORY ELEMENT; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA RESPONSIVE ELEMENT; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE SWITCHING; HOMEOBOX; INHERITANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; REPORTER GENE; TRANSCRIPTION REGULATION; TRANSGENE;

DROSOPHILA; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0036841029     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.22.8026-8034.2002     Document Type: Article

References (42)

1. Akam, M., and A. Martinez-Arias. 1985. The distribution of Ultrabithorax transcripts in Drosophila embryos. EMBO J. 4:1689-1700.
2. Ashe, H. L., J. Monks, M. Wijgerde, P. Fraser, and N. J. Proudfoot. 1997. Intergenic transcription and transinduction of the human beta-globin locus. Genes Dev. 11:2494-2509.
3. Bender, W., and D. P. Fitzgerald. Transcription activates repressed domains in the Drosophila bithorax complex. Development, in press.
4. Brand, A. H., A. S. Manoukian, and N. Perrimon. 1994. Ectopic expression in Drosophila. Methods Cell Biol. 44:635-654.
5. Busturia, A., and M. Bienz. 1993. Silencers in Abdominal-B, a homeotic Drosophila gene. EMBO J. 12:1415-1425.
6. Busturia, A., A. Lloyd, F. Bejarano, M. Zavortink, H. Xin, and S. Sakonju. 2001. The MCP silencer of the Drosophila Abd-B gene requires both Pleiohomeotic and GAGA factor for the maintenance of repression. Development 128:2163-2173.
7. Cavalli, G., and R. Paro. 1998. Chromo domain proteins: Linking chromatin structure to epigenetic regulation. Curr. Opin. Cell Biol. 10:354-360.
8. Cavalli, G., and R. Paro. 1998. The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis. Cell 93:505-518.
9. Cavalli, G., and R. Paro. 1999. Epigenetic inheritance of active chromatin after removal of the main transactivator. Science 286:955-958.
10. Celniker, S. E., S. Sharma, D. J. Keelan, and E. B. Lewis. 1990. The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain. EMBO J. 9:4277-4286.
11. Chan, C. S., L. Rastelli, and V. Pirrotta. 1994. A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression. EMBO J. 13:2553-2564.
12. Cumberledge, S., A. Zaratzian, and S. Sakonju. 1990. Characterization of two RNAs transcribed from the cis-regulatory region of the abd - A domain within the Drosophila bithorax complex. Proc. Natl. Acad. Sci. USA 87:3259-3263.
13. Francis, N. J., and R. E. Kingston. 2001. Mechanisms of transcriptional memory. Nat. Rev. Mol. Cell. Biol. 2:409-421.
14. Gyurkovics, H., J. Gausz, J. Kummer, and F. Karch. 1990. A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation. EMBO J. 9:2579-2585.
15. Hagstrom, K., M. Müller, and P. Schedl. 1996. Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex. Genes Dev. 10:3202-3215.
16. Hogga, I., and F. Karch. Transcription through the iab-7 cis-regulatory domain of the bithorax complex interferes with Polycomb mediated silencing. Development, in press.
17. Hogness, D. S., H. D. Lipshitz, P. A. Beachy, D. A. Peattie, R. B. Saint, M. Goldschmidt-Clermont, P. J. Harte, E. R. Gavis, and S. L. Helfand. 1985. Regulation and products of the Ultrabithorax domain of the bithorax complex. Cold Spring Harbor Symp. Quant. Biol. 50:181-195.
18. Karch, F., M. Galloni, L. Sipos, J. Gausz, H. Gyurkovics, and P. Schedl. 1994. Mcp and Fab-7: Molecular analysis of putative boundaries of cisregulatory domains in the bithorax complex of Drosophila melanogaster. Nucleic Acids Res. 22:3138-3146.
19. Karch, F., B. Weiffenbach, M. Peifer, W. Bender, I. Duncan, S. Celniker, M. Crosbi, and E. B. Lewis. 1985. The abdominal region of the bithorax complex. Cell 43:81-96.
20. Kong, S., D. Bohl, C. Li, and D. Tuan. 1997. Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene. Mol. Cell. Biol. 17:3955-3965.
21. Lewis, E. B. 1978. A gene complex controlling segmentation in Drosophila. Nature 276:565-570.
22. Lipshitz, H. D., D. A. Peattie, and H. S. Hogness. 1987. Novel transcripts from the Ultrabithorax domain of the bithorax complex. Genes Dev. 1:307-322.
23. Lyko, F., J. D. Brenton, M. A. Surani, and R. Paro. 1997. An imprinting element from the mouse H19 locus functions as a silencer in Drosophila. Nat. Genet. 16:171-173.
24. Martin, C. H., C. A. Mayeda, C. A. Davis, C. L. Ericsson, J. D. Knafels, D. R. Mathog, S. E. Celniker, E. B. Lewis, and M. J. Palazzolo. 1995. Complete sequence of the bithorax complex of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 92:8398-8402.
25. Maurange, C., and R. Paro. A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development. Genes Dev., in press.
26. McGinnis, W., and R. Krumlauf. 1992. Homeobox genes and axial patterning. Cell 68:283-302.
27. Mihaly, J., I. Hogga, J. Gausz, H. Gyurkovics, and F. Karch. 1997. In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element. Development 124:1809-1820.
28. Muller, J. 1995. Transcriptional silencing by the Polycomb protein in Drosophila embryos. EMBO J. 14:1209-1220.
29. Muller, J., and M. Bienz. 1991. Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo. EMBO J. 10: 3147-3155.
30. Muller, M., K. Hagstrom, H. Gyurkovics, V. Pirrotta, and P. Schedl. 1999. The mcp element from the Drosophila melanogaster bithorax complex mediates long-distance regulatory interactions. Genetics 153:1333-1356.
31. Orlando, V., E. Jane, P. V. Chinwalla, P. Harte, and R. Paro. 1998. Binding of trithorax and Polycomb proteins to the bithorax complex: Dynamic changes during early Drosophila embryogenesis. EMBO J. 17:5141-5150.
32. Poux, S., R. Melfi, and V. Pirrotta. 2001. Establishment of Polycomb silencing requires a transient interaction between Polycomb and ESC. Genes Dev. 15:2509-2514.
33. Ristaldi, M. S., D. Drabek, J. Gribnau, D. Poddie, N. Yannoutsous, A. Cao, F. Grosveld, and A. M. Imam. 2001. The role of the -50 region of the human gamma-globin gene in switching. EMBO J. 20:5242-5249.
34. Rozovskaia, T., S. Tillib, S. Smith, Y. Sedkov, O. Rozenblatt-Rosen, S. Petruk, T. Yano, T. Nakamura, L. Ben-Simchon, J. Gildea, C. M. Croce, A. Shearn, E. Canaani, and A. Mazo. 1999. Trithorax and ASH1 interact directly and associate with the trithorax group-responsive bxd region of the Ultrabithorax promoter. Mol. Cell. Biol. 19:6441-6447.
35. Sanchez-Herrero, E., and M. Akam. 1989. Spatially ordered transcription of regulatory DNA in the bithorax complex of Drosophila. Development 107: 321-329.
36. Sanchez-Herrero, E., I. Vernós, R. Marco, and G. Morata. 1985. Genetic organisation of Drosophila bithorax complex. Nature 313:108-113.
37. Strutt, H., G. Cavalli, and R. Paro. 1997. Colocalization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression. EMBO J. 16:3621-3632.
38. Tautz, D., and C. Pfeifle. 1989. A non-radioactive method for the localisation of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98:81-85.
39. Wittschieben, B. O., G. Otero, T. de Bizemont, J. Fellows, H. Erdjument-Bromage, R. Ohba, Y. Li, C. D. Allis, P. Tempst, and J. Q. Svejstrup. 1999. A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol. Cell 4:123-128.
40. Zhou, J., H. Ashe, C. Burks, and M. Levine. 1999. Characterization of the transvection mediating region of the abdominal-B locus in Drosophila. Development 126:3057-3065.
41. Zink, B., Y. Engström, W. J. Gehring, and R. Paro. 1991. Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster. EMBO J. 10:153-162.
42. Zink, D., and R. Paro. 1995. Drosophila Polycomb-group regulated chromatin inhibits the accessibility of a trans-activator to its target DNA. EMBO J. 14:5660-5671.