Toxigenic Helicobacter pylori induces changes in the gastric mucosal microcirculation in rats

Gut

Volumn 51, Issue 5, 2002, Pages 641-647

  Kalia, N ^a   Bardhan, K D ^b   Atherton, J C ^c   Brown, N J ^a  

^a ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^b ROTHERHAM GENERAL HOSPITAL   (United Kingdom)

^c QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE ORANGE; BACTERIAL TOXIN; BOVINE SERUM ALBUMIN; FLUORESCEIN ISOTHIOCYANATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAGA GENE; CAPILLARY FLOW; CONJUGATION; CONTROLLED STUDY; DUODENUM ULCER; FLUORESCENCE MICROSCOPY; GASTRITIS; GENE ISOLATION; GENOTYPE; HELICOBACTER PYLORI; INFLAMMATION; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; MALE; MICROCIRCULATION; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; STATISTICAL SIGNIFICANCE; STOMACH MUCOSA; STRAIN IDENTIFICATION; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION; ULCER; VACA GENE; VASOCONSTRICTION; VEIN DIAMETER;

ANIMALS; CAPILLARIES; CAPILLARY LEAK SYNDROME; GASTRIC MUCOSA; HELICOBACTER PYLORI; IMAGE PROCESSING, COMPUTER-ASSISTED; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTE ACTIVATION; MALE; PLATELET ACTIVATION; RATS; RATS, WISTAR; STATISTICS, NONPARAMETRIC; VENULES;

EID: 0036838429     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.51.5.641     Document Type: Article

References (42)

1. Wyatt JI. Histopathology of gastroduodenal inflammation: The impact of Helicobacter pylori. Histopathology 1995;26:1-15.
2. Granger DN, Grisham MB, Kvietys PR. Mechanisms of microvascular injury. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract. 3rd edn. New York: Raven Press, 1994:1693-722.
3. Neilson H, Anderson LP. Chemotactic activity of Helicobacter pylori sonicate for human polymorphonuclear leukocytes and monocytes. Gut 1992;33:738-42.
4. Craig PM, Territo MC, Karnes WE, et al. Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils. Gut 1992;33:1020-3.
5. Mai UE, Perez-Perez GI, Wahl LM, et al. Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism. J Clin Invest 1991;87:894-900.
6. Reymunde A, Deren J, Nachamkin I, et al. Production of chemoattractant by Helicobacter pylori. Dig Dis Sci 1993;38:1697-701.
7. Yoshida N, Granger DN, Evans DJ, et al. Mechanisms involved in Helicobacter pylori-induced inflammation. Gastroenterology 1993;105:1431-40.
8. Kurose I, Granger DN, Evans DJ, et al. Helicobacter pylori-induced microvascular protein leakage in rats: Role of neutrophils, mast cells and platelets. Gastroenterology 1994;107:70-9.
9. Mai UE, Perez-Perez GI, Allen JB, et al. Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present within the gastric mucosa. J Exp Med 1992;175:517-25.
10. Kalia N, Brown NJ, Jacob S, et al. Studies on the gastric mucosal microcirculation. 2. Platelet aggregation induced by Helicobacter pylori water soluble extracts in vivo. Gut 1997;41:748-52.
11. Kalia N, Bardhan KD, Reed MWR, et al. Mechanisms of Helicobacter pylori-induced rat gastric mucosal microcirculation in vivo. Dig Dis Sci 2000;45:763-72
12. Atherton JC, Peek RM, Tham KT, et al. Clinical and pathological importance of heterogeneity in vac A, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 1997;112:92-9.
13. Atherton JC. The clinical relevance of strain types in Helicobacter pylori. Gut 1997;40:710-13.
14. Cover TL. The vacuolating cytotoxin of Helicobacter pylori. Mol Microbiol 1996;20:241-6.
15. Atherton JC, Cao P, Peek RM Jr, et al. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 1995;270:17771-7
16. Letley DP, Atherton JC. Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity. J Bacteriol 2000;182:3278-80.
17. Pagliaccia C, de Bernard M, Lupetti, P, et al. The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity. Proc Natl Acad Sci USA 1998;95:10212-17.
18. Censini S, Lange C, Xiang Z, et al. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 1996;93:14648-53.
19. Leunk RD, Johnson PT, David BC, et al. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J Med Microbiol 1988;26:93-9.
20. Cover TL, Tummuru MK, Cao P, et al. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem 1994;269:10566-73.
21. Tangelder GJ, Slaaf DW, Reneman RS. Fluorescent labeling of blood platelets in vivo. Thromb Res 1982;28:803-20.
22. Miller FN, Joshua IG, Anderson GL. Quantitation of vasodilator induced macromolecular leakage by in vivo fluorescent microscopy. Microvasc Res 1982;24:56-67.
23. Peek RM, Miller GG, Tham KT, et al. Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains. Lab Invest 1995;73:760-70.
24. Shimada T, Terano A. Chemokine expression in Helicobacter pylori-infected gastric mucosa. J Gastroenterology 1998;33:613-17.
25. Li SD, Kersulyte D, Lindley U, et al. Multiple genes in the left half of the cag pathogenicity island of Helicobacter pylori are required for tyrosine kinase-dependent transcription of interleukin-8 in gastric epithelial cells. Infect Immun 1999;67:3893-9.
26. Ando T, Kusugami K, Ohsugo M. Interleukin-8 activity correlates with histological severity in Helicobacter pylori-associated antral gastritis. Am J Gastroenterol 1996;91:1150-6.
27. Ding SZ, Cho CH, Lam SK. Helicobacter pylori induces interleukin-8 expression in endothelial cells and the signal pathway is protein tyrosine kinase dependent. Biochem Biophys Res Commun 1997;240:561-5.
28. Yamaoka Y, Kodama T, Kita M, et al. Relationship of vacA genotypes of Helicobacter pylori to cagA status, cytotoxin production, and clinical outcome. Helicobacter 1998;3:241-53.
29. Ghiara P, Marchetti M, Blaser MJ, et al. Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease. Infect Immun 1995;63:4154-60.
30. Atuma C, Engstrand L, Holm L. Extracts of Helicobacter pylori reduce gastric mucosal blood flow through a Vac A- and Cag A - Independent pathway in rats. Scand J Gastroenterol 1998;33:1256-61.
31. Atuma C, Engstrand L, Holm L. Helicobacter pylori extracts reduce gastric mucosal blood flow by a nitric oxide-independent but mast cell and platelet activating factor receptor-dependent pathway in rats. Scand J Gastroenterol 1999;34:1183-9.
32. Brzozowski T, Konturek PC, Konturek SJ, et al. Water extracts of Helicobacter pylori delay healing of chronic gastric ulcers in rats: Role of cytokines and gastrin-somatostatin link. Digestion 1999;60:22-33.
33. Brzozowski T, Konturek PC, Konturek SJ, et al. Gastric secretion and ulcer healing in mouse stomach infected with cytotoxin expressing strain of Helicobacter pylori. J Physiol Pharmacol 1998;49:387-403.
34. Konturek PC, Brzozowski T, Konturek SJ, et al. Mouse model of Helicobacter pylori infection: Studies of gastric function and ulcer healing. Aliment Pharmacol Ther 1999;13:333-46.
35. Wu DC, Wang WM, Lu CYL, et al. The hemodynamic changes of gastroduodenal regional blood flow after Helicobacter pylori eradication in patients with duodenal ulcer scar. Kaohsiung J Med Sci 1999;15:19-25.
36. Page CP. Platelets as inflammatory cells. Immunopharmacology 1989;17:51-9.
37. Caccese D, Pratico D, Ghiselli A, et al. Superoxide anion and hydroxyl radical release by collagen-induced platelet aggregation-role of arachidonic acid metabolism. Thromb Haemost 2000;83:485-90.
38. Mannaioni PF, Di Bello MG, Masini E. Review. Platelets and inflammation: Role of platelet derived growth factor, adhesion molecules and histamine. Inflamm Res 1997;46:4-18.
39. Collins CE, Rampton DS. Platelet dysfunction: A new dimension in inflammatory bowel disease. Gut 1995;36:5-8.
40. Collins CE, Cahill MR, Newland AC, et al. Platelets circulate in an activated state in Inflammatory Bowel Disease. Gastroenterology 1994;106:840-5.
41. Elizalde JI, Gomez J, Lozano M, et al. Platelet activation in mice and human Helicobacter pylori infection. J Clin Invest 1997;100:996-1005.
42. Satin B, Del Giudice G, Della Bianca V, et al. The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor. J Exp Med 2000;191:1467-76.