A single 8,5′-cyclo-2′-deoxyadenosine lesion in a TATA box prevents binding of the TATA binding protein and strongly reduces transcription in vivo

DNA Repair

Volumn 1, Issue 11, 2002, Pages 967-975

  Marietta, Cheryl ^a   Gulam, Huzaefah ^a   Brooks, P J ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Aging; DNA repair; Neurodegeneration; Oxidative stress; Xeroderma pigmentosum

Indexed keywords

8,5' CYCLO 2' DEOXYADENOSINE; ADENOSINE DERIVATIVE; PROTEIN; PURINE DERIVATIVE; TATA BINDING PROTEIN; UNCLASSIFIED DRUG; 8,5'-CYCLO-2'-DEOXYADENOSINE; DEOXYADENOSINE DERIVATIVE; LUCIFERASE; PRIMER DNA;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION; GENE FUNCTION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; ISOMER; MAMMAL CELL; MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; RECOGNITION; TATA BOX; CELL CULTURE; COMPARATIVE STUDY; CYTOMEGALOVIRUS; DNA REPAIR; DRUG EFFECT; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OXIDATIVE STRESS; PLASMID; SITE DIRECTED MUTAGENESIS; XERODERMA PIGMENTOSUM;

CUCUMBER MOSAIC VIRUS; MAMMALIA; ZIZIPHUS MAURITIANA;

CELLS, CULTURED; CYTOMEGALOVIRUS; DEOXYADENOSINES; DNA DAMAGE; DNA PRIMERS; DNA REPAIR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HUMANS; LUCIFERASES; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDATIVE STRESS; PLASMIDS; PROMOTER REGIONS (GENETICS); TATA BOX; TATA-BOX BINDING PROTEIN; TRANSCRIPTION, GENETIC; TRANSFECTION; XERODERMA PIGMENTOSUM;

EID: 0036837134     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-7864(02)00148-9     Document Type: Article

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