Different toxicological profile of two COMT inhibitors in vivo: The role of uncoupling effects

Journal of Neural Transmission

Volumn 109, Issue 11, 2002, Pages 1391-1401

  Haasio, K ^a   Nissinen, E ^a   Sopanen, L ^a   Heinonen, E H ^a  

^a ORION CORPORATION   (Finland)

Author keywords

COMT inhibitor; Entacapone; Hepatotoxicity; Levodopa; Parkinson's disease; Tolcapone; Uncoupling

Indexed keywords

ENTACAPONE; TOLCAPONE; BENZOPHENONE DERIVATIVE; CATECHOL DERIVATIVE; CATECHOL METHYLTRANSFERASE; ENZYME INHIBITOR; NITROPHENOL; UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREATHING; CONTROLLED STUDY; DROWSINESS; IN VIVO STUDY; LIVER CELL DAMAGE; LIVER TOXICITY; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RAT; RECTUM TEMPERATURE; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; LIVER; LIVER MITOCHONDRION; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; BENZOPHENONES; CATECHOL O-METHYLTRANSFERASE; CATECHOLS; ENZYME INHIBITORS; LIVER; MALE; MITOCHONDRIA, LIVER; NITROPHENOLS; OXIDATIVE PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; UNCOUPLING AGENTS;

EID: 0036831588     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-002-0748-x     Document Type: Article

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