No association between lck gene polymorphisms and protein level in type 1 diabetes

Diabetes

Volumn 51, Issue 11, 2002, Pages 3326-3330

  Nervi, Solange ^a   Nicodeme, Sandra ^b   Gartioux, Corinne ^b   Atlan, Catherine ^a   Lathrop, Marc ^b   Reviron, Denis ^c   Naquet, Philippe ^d   Matsuda, Fumihiko ^b   Imbert, Jean ^e   Vialettes, Bernard ^a,f  

^a AIX MARSEILLE UNIVERSITY   (France)

^b CENTRE NATIONAL DE GÉNOTYPAGE   (France)

^c ETABLISSEMENT FRANÇAIS DU SANG   (France)

^d CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^e INSERM   (France)

^f Hôpital SainteMarguerite   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN TYROSINE KINASE;

ADULT; ARTICLE; CHROMOSOME 1P; CONTROLLED STUDY; FEMALE; GENE DELETION; GENETIC ORGANIZATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; INTRON; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0036830618     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.11.3326     Document Type: Article

References (25)

1. Todd JA: From genome to aetiology in a multifactorial disease, type 1 diabetes (Review Article). Bioessays 21:164-174, 1999
2. Delovitch TL, Singh B: The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD. Immunity 7:727-738, 1997
3. De Maria R, Todaro M, Stassi G, Di Blasi F, Giordano M, Galluzzo A, Giordano C: Defective T cell receptor/CD3 complex signaling in human type 1 diabetes. Eur J Immunol 24:999-1002, 1994
4. Nervi S, Atlan-Gepner C, Fossat C, Vialettes B: Constitutive impaired TCR/CD3-mediated activation of T cells in IDDM patients co-exist with normal co-stimulation pathways. J Autoimmun 13:247-255, 1999
5. Kukreja A, Cost G, Marker J, Zhang C, Sun Z, Lin-Su K, Ten S, Sanz M, Exley M, Wilson B, Porcelli S, Maclaren N: Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest 109:131-140, 2002
6. Halminen M, Simell O, Knip M, Ilonen J: Cytokine expression in unstimulated PBMC of children with type 1 diabetes and subjects positive for diabetes-associated antibodies. Scand J Immunol 53:510-513, 2001
7. Nervi S, Atlan-Gepner C, Kahn-Perles B, Lecine P, Vialettes B, Imbert J, Naquet P: Specific deficiency of p561ck expression in T lymphocytes from type 1 diabetic patients. J Immunol 165:5874-5883, 2000
8. Zhang J, Salojin K, Delovitch TL: Sequestration of CD4-associated Lck from the TCR complex may elicit T cell hyporesponsiveness in nonobese diabetic mice. J Immunol 160:1148-1157, 1998
9. Lyons PA, Hancock WW, Denny P, Lord CJ, Hill NJ, Armitage N, Siegmund T, Todd JA, Phillips MS, Hess JF, Chen SL, Fischer PA, Peterson LB, Wicker LS: The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137, Immunity 13:107-115, 2000
10. Hermiston ML, Xu Z, Majeti R, Weiss A: Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. J Clin Invest 109:9-14, 2002
11. lck. Nature 357:161-164, 1992
12. Yamashita M, Hashimoto K, Kimura M, Kubo M, Tada T, Nakayama T: Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation. Int Immunol 10:577-591, 1998
13. Gonzalez-Garcia A, Borlado L, Leonardo E, Merida I, Martinez AC, Carrera AC: Lck is necessary and sufficient for Fas-ligand expression and apoptotic cell death in mature cycling T cells. J Immunol 158:4104-4112, 1997
14. Seddon B, Legname G, Tomlinson P, Zamoyska R: Long-term survival but impaired homeostatic proliferation of naive T cells in the absence of p56Lck. Science 290:127-131, 2000
15. Voronova AF, Adler HT, Sefton BM: Two lck transcripts containing different 5′ untranslated regions are present in T cells. Mol Cell Biol 7:4407-4413, 1987
16. Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Diabet Med 15:539-547, 1998
17. Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES: Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet 22:231-238, 1999
18. Collins FS, Guyer MS, Chakravarti A: Variations on a theme: Cataloging human DNA sequence variation. Science 278:1580-1581, 1997
19. Cannavo G, Paiardini M, Galati D, Cervasi B, Montroni M, De Vico G, Guetard D, Bocchino ML, Picerno I, Magnani M, Silvestri G, Piedimonte G: Abnormal intracellular kinetics of cell-cycle-dependent proteins in lymphocytes from patients infected with human immunodeficiency virus: A novel biologic link between immune activation, accelerated T-cell turnover, and high levels of apoptosis. Blood 97:1756-1764, 2001
20. Isomaki P, Panesar M, Annenkov A, Clark JM, Foxwell BM, Chernajovsky Y, Cope AP: Prolonged exposure of T cells to TNF down-regulates TCR zeta and expression of the TCR/CD3 complex at the cell surface. J Immunol 166:5495-5507, 2001
21. Gringhuis SI, Leow A, Papendrecht-Van Der Voort EA, Remans PH, Breedveld FC, Verweij CL: Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synoxdal fluid T lymphocytes in rheumatoid arthritis. J Immunol 164:2170-2179, 2000
22. Romagnoli P, Strahan D, Cantagrel A, van Meerwijk JP: A potential role for protein tyrosine kinase p56(lck) in rheumatoid arthritis synovial fluid T lymphocyte hyporesponsiveness. Int Immunol 13:305-312, 2001
23. Matache C, Onu A, Stefanescu M, Tanaseanu S, Dragomir C, Dolganiuc A, Szegli G: Dysregulation of p56lck kinase in patients with systemic lupus erythematosus. Autoimmunity 34:27-38, 2001
24. Ramanathan M, Weinstock-Guttman B, Nguyen LT, Badgett D, Miller C, Patrick K, Brownscheidle C, Jacobs L: In vivo gene expression revealed by cDNA arrays: The pattern in relapsing-remmitting multiple sclerosis patients compared with normal subjects. J Neuroimmunol 116:213-219, 2001
25. Singh RAK, Zang YCQ, Shrivastava A, Hong J, Wang GT, Li S, Tejada-Simon MV, Kozovska M, Rivera VM, Zhang JZ: Th1 and Th2 deviation of myelin-autorective T cells by altered peptide ligands is associated with reciprocal regulation of lck, fyn, and ZAP-70. J Immunol 163:6393-6402, 1999