Fasting insulin levels independently associated with coronary heart disease in non-diabetic Turkish men and women

International Journal of Cardiology

Volumn 86, Issue 1, 2002, Pages 61-69

  Onat, Altan ^a,e   Ceyhan, Köksal ^c   Sansoy, Vedat ^b   Basar, Ömer ^a   Erer, Burak ^a   Uysal, Ömer ^a   Hergenç, Gülay ^d  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c Siyami Ersek Cardiovascular Surgery Center   (Turkey)

^d YILDIZ TECHNICAL UNIVERSITY   (Turkey)

^e NONE   (Turkey)

Author keywords

Coronary heart disease; Hyperinsulinemia; Inflammation; Risk assessment

Indexed keywords

C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR RISK; CHEMOLUMINESCENCE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DYSLIPIDEMIA; ELECTROCARDIOGRAM; FEMALE; GENDER; GEOMETRY; GLUCOSE INTOLERANCE; HUMAN; HYPERINSULINEMIA; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; PHYSICAL ACTIVITY; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SMOKING; STATISTICAL SIGNIFICANCE; TURKEY (REPUBLIC);

ADULT; BODY MASS INDEX; C-REACTIVE PROTEIN; CORONARY DISEASE; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPERINSULINISM; INSULIN; MALE; MIDDLE AGED; ODDS RATIO; RISK ASSESSMENT; RISK FACTORS; TURKEY;

EID: 0036830575     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5273(02)00190-0     Document Type: Article

References (36)

1. Pyörälä K. Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies. Diabetes Care. 2:1979;131-141.
2. Pyörälä M., Miettinen H., Laakso M., Pyörälä K. Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Circulation. 98:1998;398-404.
3. Fontbonne A., Charles M.A., Thibult N., et al. Hyperinsulinemia as a predictor of coronary heart disease mortality in a healthy population: the Paris Prospective Study, 15-year follow-up. Diabetologia. 34:1991;356-361.
4. Wingard D.L., Ferrara A., Barrett-Connor E. Is insulin really a heart disease risk factor? Diabetes Care. 18:1995;1299-1304.
5. Yarnell J.W.G., Sweetnam P.M., Marks V., Teale J.D., Bolton C.H. Insulin in ischaemic heart disease: are associations explained by triglyceride concentrations? The Caerphilly Prospective Study. Br Heart J. 71:1994;293-296.
6. Ferrara A., Barrett-Connor E.L., Edelstein S.L. Hyperinsulinemia does not increase the risk of fatal cardiovascular disease in elderly men or women without diabetes: the Rancho Bernardo Study, 1984-1991. Am J Epidemiol. 140:1994;857-869.
7. Ruige J.B., Assendelft W.J.J., Dekker J.M., Kostense P.J., Heine R.J., Bouter L.M. Insulin and risk of cardiovascular disease: a meta-analysis. Circulation. 97:1998;996-1001.
8. Després J.-P., Lamarche B., Mauriege P., et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med. 334:1996;952-957.
9. Møller L.F., Jespersen J. Fasting serum insulin levels and coronary heart disease in a Danish cohort: 17-year follow-up. J Cardiovasc Risk. 2:1995;235-240.
10. Perry I.J., Wannamethee S.G., Whincup P.H., Shaper A.G., Walker M.K., Alberti K.G.M.M. Serum insulin and coronary heart disease in middle-aged British men. Am J Epidemiol. 144:1996;224-234.
11. Folsom A.R., Liao F., Szklo M., Smith R., Stevens J., Eckfeldt J.H. A prospective study of coronary heart disease in relation to fasting insulin, glucose and diabetes. The Atherosclerosis Risk in Communities (ARIC) Study. Diabetes Care. 20:1997;935-942.
12. Welin L., Eriksson H., Larsson B., Ohlson L.O., Svardsudd K., Tibblin G. Hyperinsulinemia is not a major risk factor in elderly men: the study of men born in 1912. Diabetologia. 35:1992;766-770.
13. Lempiäinen P., Mykkänen L., Pyörälä K., Laakso M., Kuusisto J. Insulin resistance syndrome predicts coronary heart disease events in elderly non-diabetic men. Circulation. 100:1999;123-128.
14. Howard G., O'Leary D.H., Zaccaro D., et al. Insulin sensitivity and atherosclerosis. Circulation. 93:1996;1809-1817.
15. Onat A., Avcý Gpenocak M., Örnek E., Gözükara Y. Plasma lipids and their interrelation in Turkish adults. J Epidemiol Commun Health. 46:1992;470-476.
16. Onat A. Risk factors and cardiovascular disease in Turkey. Atherosclerosis. 156:2001;1-10.
17. Onat A., Penocak M. Relative risk of factors for coronary heart disease in population with low cholesterol levels. Int J Cardiol. 43:1994;51-60.
18. Rose G., Blackburn H., Gillum R.F., Prineas R.J. Cardiovascular survey methods. 2nd ed. 1982;124-127 Geneva, WHO.
19. WHO Study Group on Prevention of Diabetes Mellitus . Prevention of diabetes mellitus: report of a WHO study group. 1994;17 WHO, Geneva. WHO Technical Report Series No. 844.
20. Rönnemaa T., Pyörälä K., Rönnemaa E.M., Laakso M., Puukka P. Smoking is independently associated with high plasma insulin levels in non-diabetic men. Diabetes Care. 19:1996;1229-1232.
21. Rewers M., Shetterly S.M., Baxter J., Hamman R.F. Insulin and cardiovascular disease in Hispanics and non-Hispanic whites: the San Luis Valley Diabetes Study. Circulation. 85:1992;865. abstract.
22. Haffner S.M., Mykkänen L., Festa A., Burke J.P., Stern M.P. Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state. Circulation. 101:2000;975-980.
23. Hergenç G., Schulte H., Assmann G., von Eckardstein A. Associations of obesity markers, insulin, and sex hormones with HDL-cholesterol levels in Turkish and German individuals. Atherosclerosis. 145:1999;147-156.
24. Zavaroni I., Bonora E., Pagliara M., et al. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med. 320:1989;702-706.
25. Lemieux I., Pascot A., Couillard C., et al. Hypertriglyceridemic waist: a marker of atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation. 102:2000;179-184.
26. Chu N.-F., Spiegelman D., Hotamisligil G., Rifai N., Stampfer M., Rimm E.B. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis. 157:2001;495-503.
27. Onat A., Sansoy V., Yýldýrým B., Kelep; Ý, Uysal Ö, Hergenç G. C-reactive protein and coronary heart disease in Western Turkey. Am J Cardiol. 88:2001;601-607.
28. Festa A., D'Agostino R., Howard G., Mykkänen L., Tracy R.P., Haffner S.M. Chronic subclinical inflammation as part of the insulin resistance syndrome. The Insulin Resistance Atherosclerosis Study (IRAS). Circulation. 102:2000;42-47.
29. Yudkin J.S., Kumari M., Humphries S.E., Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis. 148:2000;209-214.
30. Pyörälä K. Hyperinsulinemia and insulin resistance as predictors of cardiovascular risk. CVD Prevention. 3:2000;28-36.
31. Onat A., Sansoy V. Systolic and diastolic blood pressure related to six other parameters in Turkish adults: strong correlation with relative weight. Int J Cardiol. 63:1998;295-303.
32. Lakka T.A., Lakka H.-M., Salonen J.T. Hyperinsulinemia and the risk of coronary heart disease? N Engl J Med. 335:1996;976-977. letter.
33. Yarnell J.W., Sweetnam P.M., Marks V., Teale J.D., Bolton C.H. Insulin in ischaemic heart disease: are associations explained by triglyceride concentrations? The Caerphilly prospective study. Br Heart J. 71:1994;293-296.
34. Savage P.J., Saad M.F. Insulin and atherosclerosis: villain, accomplice, or innocent bystander? Br Heart J. 69:1993;473-475. editorial.
35. Sniderman A.D., Cianflone K., Arner P., Summers L., Frayn K. The adipocyte, fatty acid trapping, and atherogenesis. Arterioscler Thromb Vasc Biol. 18:1998;147-151.
36. Pan D.A., Lillioja S., Kriketos A.D., et al. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes. 46:1997;983-988.