Phemphigoid gestationis with predominant involvement of oral mucous membranes and IgA autoantibodies targeting the C-terminus of BP180

Journal of the American Academy of Dermatology

Volumn 47, Issue 5, 2002, Pages 780-784

  Shimanovich, Iakov ^a   Skrobek, Christian ^a   Rose, Christian ^a   Nie, Zhuxiang ^b   Hashimoto, Takashi ^b   Bröcker, Eva Bettina ^a   Zillikens, Detlef ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; BETAMETHASONE; BULLOUS PEMPHIGOID ANTIGEN 180; CORTICOSTEROID; HYBRID PROTEIN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G3; MEMBRANE PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ANTIIDIOTYPIC ANTIBODY; BP180 AUTOANTIGEN; IMMUNOGLOBULIN A;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; BULLOUS SKIN DISEASE; CASE REPORT; CESAREAN SECTION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MOUTH MUCOSA; PEMPHIGOID; PEMPHIGOID GESTATIONIS; PREGNANCY; PRIORITY JOURNAL; SKIN BIOPSY; VAGINA BLEEDING; BULLOUS PEMPHIGOID; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY;

ADULT; ANTIBODIES, ANTI-IDIOTYPIC; AUTOANTIGENS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN A; IMMUNOSORBENT TECHNIQUES; MOUTH MUCOSA; PEMPHIGOID GESTATIONIS; PEMPHIGOID, BULLOUS; PREGNANCY;

EID: 0036826859     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1067/mjd.2002.113677     Document Type: Article

References (22)

1. Shornick JK, Bangert JL, Freeman RG, Gilliam JN. Herpes gestationis: Clinical and histological features of twenty-eight cases. J Am Acad Dermatol 1983;8:214-24.
2. Shornick JK. Herpes gestationis. J Am Acad Dermatol 1987;17:539-56.
3. Katz SI. Herpes gestationis (pemphigoid gestationis). In: Freedberg IM, et al, editors. Dermatology in General Medicine. New York: McGraw-Hill; 1999. p. 686-9.
4. Morrison LH, Labib RS, Zone JJ, Anhalt GJ. Herpes gestationis antibodies recognize a 180-kD human epidermal antigen. J Clin Invest 1988;81:2023-6.
5. Zillikens D. Acquired skin disease of hemidesmosomes. J Dermatol Sci 1999;20:134-54.
6. Giudice GJ, Emery DE, Zelickson BD, Anhalt GJ, Liu Z, Diaz LA. Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain. J Immunol 1993;151:5742-50.
7. Matsumura K, Amagai M, Nishikawa T, Hashimoto T. The majority of bullous pemphigoid and herpes gestationis serum samples react with the NC16a domain of the 180-kDa bullous pemphigoid antigen. Arch Dermatol Res 1996;288:507-9.
8. Zillikens D, Rose PA, Balding SD, Liu Z, Olague-Marchan M, Diaz LA, et al. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies. J Invest Dermatol 1997;109:573-9.
9. Chimanovitch I, Schmidt E, Messer G, Döpp R, Partscht K, Bröcker EB, et al. IgG1 and IgG3 are the major immunoglobulin sub-classes targeting epitopes within BP180 NC16A in pemphigoid gestationis. J Invest Dermatol 1999;113:140-2.
10. Lin MS, Gharia MA, Fu CL, Olague-Marchan M, Hacker M, Harman KE, et al. Molecular mapping of the major epitopes recognized by herpes gestationis autoantibodies. Clin Immunol 1999;92:285-92.
11. Balding SD, Prost C, Diaz LA, Bernard P, Bedane C, Aberdam D, et al. Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain. J Invest Dermatol 1996;106:141-6.
12. Bedane C, McMillan JR, Balding SD, Bernard P, Prost C, Bonnetblanc JM, et al. Bullous pemphigoid and cicatricial pemphigoid autoantibodies react with ultrastructurally separable epitopes on the BP180 ectodomain: Evidence that BP180 spans the lamina lucida. J Invest Dermatol 1997;108:901-7.
13. Murakami H, Hashimoto T, Bhogal BS, Black MM, Zillikens D, Yancey KB, et al. Analysis of cicatricial pemphigoid antigens. J Dermatol Sci 1998;17:39-44.
14. Egan CA, Taylor TB, Meyer LJ, Petersen MJ, Zone JJ. Bullous pemphigoid sera that contain antibodies to LABD97 that recognize epitopes distal to the NC16A domain. J Invest Dermatol 1999;112:148-52.
15. Nie Z, Hashimoto T. IgA antibodies of cicatricial pemphigoid sera specifically react with C-terminus of BP180. J Invest Dermatol 1999;112:254-5.
16. Perriard J, Janin F, Favre B, Büdinger L, Hertl M, Saurat JH, et al. IgG autoantibodies from bullous pemphigoid (BP) patients bind antigenic sites on both the extracellular and the intracellular domains of the BP antigen 180. J Invest Dermatol 1999;112:141-7.
17. Zillikens D, Kawahara Y, Ishiko A, Shimizu H, Mayer J, Rank CV, et al. A novel subepidermal blistering disease with autoantibodies to a 200-kDa antigen of the basemnet membrane zone. J Invest Dermatol 1996;106:1333-8.
18. Hodge L, Black MM, Ramnarin N, Bhogal BS. Indirect complement immunofluorescence in the assessment of bullous pemphigoid, cicatricial pemphigoid, and herpes gestationis. Clin Exp Dermatol 1978;3:61-7.
19. Zillikens D, Herzele K, Georgi M, Schmidt E, Chimanovitch I, Schumann H, et al. Autoantibodies in a subgroup of patients with linear IgA disease react with the NC16A domain of BP180. J Invest Dermatol 1999;113:497-503.
20. Marinkovich MP, Taylor TB, Keene DR, Burgeson RE, Zone JJ. LAD-1, the linear IgA dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells. J Invest Dermatol 1996;106:734-8.
21. Ahmed AR, Kurgis BS, Rogers RS. Cicatricial pemphigoid. J Am Acad Dermatol 1991;24:987-1001.
22. Yancey KB. Cicatricial pemphigoid. In: Freedberg IM, et al, editors. Dermatology in General Medicine. New York: McGraw-Hill; 1999. p. 674-9.