Bullous pemphigoid sera that contain antibodies to BPAg2 also contain antibodies to LABD97 that recognize epitopes distal to the NC16A domain

Journal of Investigative Dermatology

Volumn 112, Issue 2, 1999, Pages 148-152

  Egan, Conleth A ^a   Taylor, Ted B ^a   Meyer, Laurence J ^c   Petersen, Marta J ^a   Zone, John J ^b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b Salt Lake City Veterans Aff Med C   (United States)

^c NONE

Author keywords

Basement membrane; Blisters; Skin

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; PEMPHIGUS ANTIBODY;

AMINO ACID SEQUENCE; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ANTIGEN DETECTION; ANTIGEN RECOGNITION; ARTICLE; BASEMENT MEMBRANE; BLISTER; CLINICAL ARTICLE; HUMAN; IMMUNOGLOBULIN DEPOSITION; PEMPHIGOID; PRIORITY JOURNAL; PROTEIN DETERMINATION;

EID: 0032944415     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1999.00490.x     Document Type: Article

References (24)

1. Bhogal B, Wojnarowska F, Marsden RA, Das A, Black MM, McKee PH: Linear IgA bullous dermatosis of adults and children: an immunoelectron microscopic study. Br J Dermatol 117:289-296, 1987
2. Chan LS, Vanderlugt CJ, Hashimoto T, et al: Epitope spreading: lessons from autoimmune skin diseases. J Invest Dermatol 110:103-109, 1998
3. Diaz LA, Ratrie H, Saunders WS, Futamura S, Squiquera HL, Anhalt GJ, Giudice GJ: Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. J Clin Invest 86:1088-1094, 1990
4. Dmochowski M, Hashimoto T, Bhogal BS, Black MM, Zone JJ, Nishikawa T: Immunoblotting studies of linear IgA disease. J Dermatol Sci 6:194-200, 1993
5. Giudice GJ, Emery DJ, Diaz LA: Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180. J Invest Dermatol 99:243-250, 1992
6. Giudice GJ, Emery DJ, Zelickson BD, Anhalt GJ, Liu Z, Diaz LA: Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non- collagenous site on the BP180 ectodomain. J Immunol 151:5742-5750, 1993
7. Gordon T, Topfer F, Keech C, Reynolds P, Chen W, Rischmueller M, McCluskey J: How does autoimmunity to La and Ro initiate and spread? Autoimmunity 18:87-92, 1994
8. Hirako Y, Usukura J, Uematsu J, Hashimoto T, Kitajima Y, Owaribe K: Cleavage of BP180a 180- kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide. J Biol Chem 273:9711-9717, 1998
9. Labib RS, Anhalt GJ, Patel HP, Mutasim DF, Diaz LA: Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J Immunol 136:1231-1235, 1986
10. Laemmli UK: Cleavage of structural proteins during the assembly of the head bacteriophage T4. Nature 227:680-685, 1970
11. Marinkovich MP, Tran HH, Rao SK, et al: LAD-1 is absent in a subset of junctional epidermolysis bullosa patients. J Invest Dermatol 109:356-359, 1997
12. Meyer LJ, Taylor TB, Kadunce DP, Thuong-Nguyen V, Zone JJ: Bullous pemphigoid antigens: extraction and degradation of antigens during preparation. J Invest Dermatol 96:991-993, 1991
13. Olmsted JB: Affinity purification of antibodies from diazontized paper blots of heterogenous protein samples. J Biol Chem 256:11955-11957, 1981
14. Pas HH, Kloosterhuis GJ, Heeres K, van der Meer JB, Jonkman MF: Bullous pemphigoid and linear IgA dermatosis sera recognize a similar 120-kDa keratinocyte collagenous glycoprotein with antigenic cross-reactivity to BP180. J Invest Dermatol 108:423-429, 1997
15. Prost C, De Leca AC, Combemale P, et al: Diagnosis of adult linear IgA dermatosis by immunoelectronmicroscopy in 16 patients with linear IgA deposits. J Invest Dermatol 92:39-45, 1989
16. Smith DE, Fisher PA: Identification, developmental regulation, and response to heat shock of two antigenically related forms of a major nuclear envelope protein in Drosopholia embryos: application of an improved method for affinity purification of antibodies using polypeptides immobilized on nitrocellulose blots. J Cell Biol 99:20-28, 1984
17. Stanley JR, Tanaka T, Mueller S, Klaus-Kovtun V, Roop D: Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies. J Clin Invest 82:1864-1870, 1988
18. Stingl G, Honigsmann H, Holubar K, Wolff K: Ultrastructural localization of immunoglobulins in skin of patients with dermatitis herpetiformis. J Invest Dermatol 67:507-512, 1976
19. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354, 1979
20. Yaoita H, Katz SI: Circulating IgA anti-basement membrane zone antibodies in dermatitis herpetiformis. J Invest Dermatol 69:558-560, 1977
21. Zillikens D, Giudice GJ, Diaz LA: Bullous pemphigoid. An autoimmune blistering disease of the elderly. J Geriatr Dermatol 4:35-41, 1996
22. Zillikens D, Rose PA, Balding SD, Liu Z, Olague-Marchan M, Diaz LA, Giudice GJ: Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies. J Invest Dermatol 109:573-579, 1997
23. Zone JJ, Taylor TB, Kadunce DP, Meyer LJ: Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis. J Clin Invest 85:812-820, 1990
24. Zone JJ, Taylor TB, Meyer LJ, Petersen MJ: The 97 kDa linear IgA bullous disease antigen is identical to a portion of the extracellular domain of the 180 kDa bullous pemphigoid antigen BPAg2. J Invest Dermatol 110:207-210, 1998