Reciprocity of hypoglycaemia and exercise in blunting respective counterregulatory responses: Possible role of cortisol as a mediator

Diabetes, Nutrition and Metabolism - Clinical and Experimental

Volumn 15, Issue 5, 2002, Pages 341-348

  Galassetti, P ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autonomic nervous system; Glucagon; Glucocorticoids

Indexed keywords

ADRENALIN; CORTICOSTEROID; GLUCAGON; GLUCOCORTICOID RECEPTOR; GLUCOSE; HYDROCORTISONE; INSULIN; KETONE BODY; LACTIC ACID; MINERALOCORTICOID RECEPTOR;

ARTICLE; AUTONOMIC DYSFUNCTION; AUTONOMIC NERVOUS SYSTEM; BODY WEIGHT; BRAIN METABOLISM; CARDIOVASCULAR RISK; EXERCISE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPOGLYCEMIA; HYPOTHESIS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SENSITIVITY; MEDIATOR; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STRESS;

AUTONOMIC NERVOUS SYSTEM; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; EXERCISE; HUMANS; HYDROCORTISONE; HYPOGLYCEMIA;

EID: 0036826471     PISSN: 03943402     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (70)

1. Gerich J.E., Langlois M., Noacco C., Karam J., Forsham P.H.: Lack of a glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha-cell defect. Science 182: 171-173, 1973.
2. Amiel S.A., Sherwin R.S., Simonson D., Tamborlane V.: Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 37: 901-907, 1988.
3. Simonson D.C., Tamborlane W.V., DeFronzo R.A., Sherwin R.S.: Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with Type I diabetes. Ann. Intern. Med. 103: 184-190, 1985.
4. Heller S.R., Cryer P.E.: Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after one episode of hypoglycemia in nondiabetic humans. Diabetes 40: 223-226, 1991.
5. Friedmann B., Kindermann W.: Energy metabolism and regulatory hormones in women and men during exercise. Eur. J. Appl. Physiol. 59: 1-9, 1989.
6. Davis M.R., Mellman M.J., Shamoon H.: Physiologic hyperinsulinemia enhances counterregulatory hormone responses to hypoglycemia in IDDM. J. Clin. Endocrinol. Metab. 76: 1383-1385, 1992.
7. Davis M.R., Mellman M.J., Shamoon H.: Further defects in counterregulatory responses induced by recurrent hypoglycemia in IDDM. Diabetes 41: 1335-1340, 1992.
8. Widom B., Simonson D.: Intermittent hypoglycemia impairs glucose counterregulation. Diabetes 41: 1597-1602, 1992.
9. Davis M.R, Shamoon H.: Counterregulatory adaptation to recurrent hypoglycemia in normal humans. J. Clin. Endocrinol. Metab. 73: 995-1001, 1991.
10. Dagogo-Jack S., Craft S., Cryer P.E.: Hypoglycemia-associated autonomic failure in insulin dependent diabetes mellitus. J. Clin. Invest. 91: 819-828, 1993.
11. Davis S.N., Shavers C., Mosqueda-Garcia R., Costa F.: Effects of differing antecedent hypoglycemia on subsequent counterregulation in normal humans. Diabetes 46: 1328-1335, 1997.
12. Veneman T., Mitrakou A., Mokan M., Cryer P., Gerich J.: Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetes 42: 1233-1237, 1993.
13. Powell A., Sherwin R.S., Shulman G.I.: Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats. J. Clin. Invest. 92: 2667-2674, 1993.
14. Mitrakou A., Fanelli C., Veneman T., Perriello G., Calderone S., Platanisiotis D., Rambotti A., Raptis S., Brunetti P., Cryer P.: Reversibility of unawareness of hypoglycemia in patients with insulinomas. N. Engl. J. Med. 329: 834-839, 1993.
15. Davis M., Shamoon R.H.: Deficient counterregulatory hormone responses during hypoglycemia in a patient with insulinoma. J. Clin. Endocrinol. Metab. 72: 788-792, 1991.
16. Maran A., Taylor J., Macdonald I. A., Amiel S.A.: Evidence for reversibility of defective counterregulation in a patient with insulinoma. Diabet. Med. 9: 765-768, 1992.
17. Cryer P.E.: Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM. Diabetes 41: 255-260, 1992.
18. Boyle P.J., Nagy R.J., O'Connor A.M., Kempers S.F., Yeo R.A., Qualls C.: Adaptation in brain glucose uptake following recurrent hypoglycemia. Proc. Natl. Acad. Sci. U.S.A. 91: 9352-9356, 1994.
19. Boyle P.S., Kempers S., O'Connor A., Nagy R.: Brain glucose uptake and unawareness of hypoglycemia in patients with insulin-dependent diabetes mellitus. N. Engl. J. Med. 333: 1720-1731, 1995.
20. Segel S.A., Fanelli C.G., Dence C. S., Markham J., Videen T.O., Paramore D.S., Powers W.J., Cryer P.E.: Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia. Diabetes 50: 1911-1917, 2001.
21. Veneman T., Mitrakou A., Mokan M., Cryer P. E., Gerich J.E.: Effects of hyperketonemia or hyperlacticacidemia on symptoms, cognitive dysfunction, and counterregulatory hormone responses during hypoglycemia in normal humans. Diabetes 43: 1311-1317, 1994.
22. Maran A., Cranston I., Lomas J., Macdonald I., Amiel S.A.: Protection by lactate of cerebral function during hypoglycaemia. Lancet 343: 16-20, 1994.
23. Shum K., Inouye K., Chan O., Mathoo J., Bilinski D., Matthews S.G., Vranic M.: Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation. Am. J. Physiol. 281: E455-E465, 2001.
24. Anderson E., Hoffman P., Balon T., Senkey C., Mark A.: Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J. Clin. Invest. 87: 2246-2252, 1991.
25. Berne C., Fagius J., Pollare T., Hjemdahl P.: The sympathetic response to euglycemic hyperinsulinemia. Evidence from microelectrode nerve recordings in healthy subjects. Diabetologia 35: 873-879, 1992.
26. Davis S.N., Dobbins R., Colburn C., Tarumi C., Jacobs J., Neal D., Cherrington A.D.: Effects of hyperinsulinemia on the subsequent hormonal response to hypoglycemia in conscious dogs. Am. J. Physiol. 264: E748-E755, 1993.
27. Davis S.N., Goldstein R.E., Jacobs J., Price Wolfe L.R., Cherrington A.D.: The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans. Diabetes 42: 263-272, 1993.
28. Davis S.N., Colburn C., Dobbins R., Nadeau S., Neal D., Williams P., Cherrington A.D.: Evidence that the brain of the conscious dog is insulin sensitive. J. Clin. Invest. 95: 593-602, 1995.
29. Fruehwald-Shultes B., Kerner W., Deininger E., Wellhoener P., Born J., Fehm H.L., Peters A.: Protective effect of insulin against hypoglycemia-associated counterregulatory failure. J. Clin. Endocrinol. Metab. 84: 1551-1557, 1999.
30. Rowe J., Young J., Minaker K.: Effect of insulin and glucose infusions on sympathetic nervous activity in normal man. Diabetes 30: 219-225, 1981.
31. Liang C.-S., Doherty J., Faillace R.: Insulin infusion in conscious dogs: effect on systemic and coronary hemodynamics, regional blood flows, and catecholamines. J. Clin. Invest. 69: 1321-1336, 1982.
32. Heller S.R., Cryer P.E: Hypoinsulinemia is not critical to glucose recovery from hypoglycemia in humans. Am. J. Physiol. 261, E41-E48, 1991.
33. de Kloet E.R., Wallach G., McEwen B.S.: Differences in corticosterone and dexamethasone binding to rat brain and pituitary. Endocrinology 96, 598-609, 1975.
34. de Kloetand E.R., McEwen B.S.: Differences between cytosol receptor complexes with corticosterone and dexamethasone in hippocampal tissue from rat brain. Biochim. Biophys. Acta 421: 124-132, 1976.
35. de Kloet E.R., Reul J.M.: Feedback action and tonic influence of corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems. Psychoneuroendocrinology 12: 83-105, 1987.
36. de Kloet E.R., Ratka A., Reul J.M., Sutanto W., Van Eekelen J.A.: Corticosteroid receptor types in brain: regulation and putative function. Ann. N.Y. Acad. Sci. 512: 351-361, 1987.
37. Bradbury M.J., Akana S.F., Cascio C.S., Levin N., Jacobson L., Dallman M.F.: Regulation of basal ACTH secretion by corticosterone is mediated by both type I (MR) and type II (GR) receptors in rat brain. J. Steroid Biochem. Mol. Biol. 40: 133-142, 1991.
38. Lamberts S.W., de Quijada M., Visser T.J.: Regulation of prolactin secretion in patients with Cushing's disease. A comparative study on the effects of dexamethasone, lysine vasopressin and ACTH on prolactin secretion by the rat pituitary gland in vitro. Neuroendocrinology 32: 150-154, 1981.
39. Dodt C., Keyser B., Molle M., Fehm H.L., Elam M.: Acute suppression of muscle sympathetic nerve activity by hydrocortisone in humans. Hypertension 35: 758-763, 2000.
40. Schnall A.M., Brodkey J.S., Kaufman B., Pearson O.H.: Pituitary function after removal of pituitary microadenomas in Cushing's disease. J. Clin. Endocrinol. Metab. 47: 410-417, 1978.
41. Szemeredi K., Bagdy G., Stull R., Calogero A.E., Kopin I.J., Goldstein D.S.: Sympathoadrenomedullary inhibition by chronic glucocorticoid treatment in conscious rats. Endocrinology 123: 2585-2590, 1988.
42. Golczynska A.J., Lenders W., Goldstein D.S.: Glucocorticoid-induced sympathoinhibition in humans. Clin. Pharmacol. Ther. 58: 90-98, 1995.
43. Macefield V.G., Williamson P.M., Wilson L.R., Kelly J.J., Gandevia S.C., Whitworth J.A.: Muscle sympathetic vasoconstrictor activity in hydrocortisone-induced hypertension in humans. Blood Press 7: 215-222, 1998.
44. Scheuer D.A., Mifflin S.W.: Glucocorticoids modulate baroreflex control of renal sympathetic nerve activity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280: R1440-R1449, 2001.
45. Flugge G.: Effects of cortisol on brain alpha2-adrenoceptors: potential role in stress: Neurosci. Biobehav. Rev. 23: 949-956, 1999.
46. Davis S.N., Shavers C., Allen E., Mosqueda-Garcia R.: Antecedent hypoglycemia causes deficient subsequent counterregulation via increases in cortisol levels. J. Clin. Invest. 98, 680-691, 1996.
47. Davis S.N., Shavers C., Costa F.: Prevention of an increase in plasma cortisol during hypoglycemia preserves subsequent counterregulatory responses. J. Clin. Invest. 100: 429-438, 1997.
48. Baulieu E.E., Robel P.: Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc. Natl. Acad. Sci U.S.A. 95: 4089-4091, 1998.
49. Carette P., Poulain B.: Excitatory effect of dehydroepiandrosterone, its sulphate ester and pregnenolone sulphate, applied by iontophoresis and pressure, on single neurones in the septo-preoptic area of the guinea pig. Neurosci. Lett. 45: 205-210, 1984.
50. Majewska M.D., Demirgoren S., Spivak C.E., London E.D.: The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor. Brain Res. 526: 143-146, 1990.
51. Flynn M.A., Weaver-Osterholtz D., Sharpe-Timms K.L., Allen S., Krause G.: Dehydroepiandrosterone replacement in aging humans. J. Clin. Endocrinol. Metab. 84: 1527-1533, 1999.
52. Wright B.E., Porter J.R., Browne E.S., Svec F.: Antiglucocorticoid action of dehydroepiandrosterone in young obese Zucker rats. Int. J. Obes. Relat. Metab. Disord. 16: 579-583, 1992.
53. Shepherd A., Cleary M.P.: Metabolic alterations after dehydroepiandrosterone treatment in Zucker rats. Am. J. Physiol. 246: E123-E128, 1984.
54. Diamond L., Cusan J.L., Gomez A., Belanger F., Labrie F.: Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women. J. Endocrinol. 150 Suppl: S43-S50, 1996.
55. Kaminska M., Harris J., Gijsbers K., Dubrovsky B.: Dehydroepiandrosterone sulfate (DHEAS) counteracts decremental effects of corticosterone on dentate gyrus LTP. Implications for depression. Brain Res. Bull. 52: 229-234, 2000.
56. Reddy D.S., Kaur G., Kulkarni S.K.: Sigma (sigma1) receptor mediated anti-depressant-like effects of neurosteroids in the Porsolt forced swim test. Neuroreport 9: 3069-3073, 1998.
57. Mion D. Jr., Rea R.F., Anderson E.A., Kahn D., Sinkey C.A., Mark A.L.: Effects of fludrocortisone on sympathetic nerve activity in humans. Hypertension 23: 123-130, 1994.
58. Izzo J.L. Jr., Horwitz D., Lawton W.J., Keiser H.R.: Fludrocortisone suppression of sympathetic nervous activity. Clin. Pharmacol. Ther. 33: 102-106, 1983.
59. Miyajima E., Tochikubo O., Yamada Y., Ishii M: Muscle sympathetic nerve activity in mineralcorticoid hypertension. Hypertension 18, 387-388, 1991.
60. Davis S.N., Neill A.R., Ping L.: Activation of brain Type II corticosteroid receptor is not responsible for blunting of autonomic nervous system responses to subsequent hypoglycemia. Diabetes 50: A53, 2001.
61. Sanders N.M., Ritter S.: Hindbrain glucoreceptive sites exhibit impaired responsiveness to gluocoprivation following systemic 2-deoxy-D-glucose (2DG)-induced glucoprivation or dexamethasone (DEX). Diabetes 50 (S2), A53. 2001.
62. Sonnenberg G. E., Kemmer F.W., Berger M.: Exercise in type I (insulin-dependent) diabetic patients treated with continuous subcutaneous insulin infusion: prevention of exercise-induced hypoglycaemia. Diabetologia 33: 696-703, 1990.
63. Sotsky M. J., Shilo S., Shamoon H.: Regulation of counterregulatory hormone secretion in man during exercise and hypoglycemia. J. Clin. Endocrinol. Metab. 68: 9-16, 1989.
64. Schneider S., Vitug A., Ananthakrishnan R., Khachadurian A.: Impaired adrenergic response to prolonged exercise in Type I diabetes. Metabolism 40: 1219-1225, 1991.
65. Bottini P., Boschetti E., Pampanelli S., Ciofetta M., Del Sindaco P., Scionti L., Brunetti P., Bolli G.B.: Contribution of autonomic neuropathy to reduce plasma adrenaline responses to hypoglycemia in IDDM. Diabetes 46: 814-823, 1997.
66. Galassetti P., Mann S., Tate D., Neill R.A., Costa F., Wasserman D.H., Davis S.N.: Effects of antecedent prolonged exercise on subsequent counterregulatory responses to hypoglycemia. Am. J. Physiol. Endocrinol. Metab. 280: E908-E917, 2001.
67. Davis S.N., Galassetti P., Wasserman D.H., Tate D.: Effects of antecedent hypoglycemia on subsequent counterregulatory responses to exercise. Diabetes 49: 73-81, 2000.
68. Galassetti P., Tate D., Neill R.A., Morris P.G., Davis S.N: Effect of antecedent hypoglycemia on neuroendocrine responses to subsequent exercise in Type 1 Diabetes. Diabetes 50 (Suppl. 2), A54. 2001.
69. Rattarasarn C., Dagogo-Jack S., Zachwieja J., Cryer P.E.: Hypoglycemia-induced autonomic failure in IDDM is specific for stimulus of hypoglycemia and is not attributable to prior autonomic activation. Diabetes 43: 809-818, 1994.
70. McGregor V.P., Greiwe J.S., Banarer S., Cryer P.: Limited impact of vigorous exercise on defenses against hypoglycemia: relavence to hypoglycemia-associated autonomic failure. Diabetes 40: A138, 2001.