Acute xenograft rejection, late xenograft rejection and long term survival xenografts in the hamster-to-rat heart transplantation model: Histological characterisation under low-dose of FK506

APMIS

Volumn 110, Issue 10, 2002, Pages 737-745

  Ginestà, Mireia Morell ^a   Ribas, Yolanda ^a   Mollevi, David G ^a   Vidal, August ^b   Mañez, Rafael ^c   Figueras, Joan ^a   Jaurrieta, Eduardo ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^c HOSPITAL JUAN CANALEJO   (Spain)

Author keywords

Hamster to rat; Heart; Histopathology; Immunosuppression; Rejection; Xenograft

Indexed keywords

COMPLEMENT COMPONENT C3; CYCLOPHOSPHAMIDE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL INJURY; CONTROLLED STUDY; DOSE RESPONSE; GRAFT SURVIVAL; HAMSTER; HEART MUSCLE FIBROSIS; HEART TRANSPLANTATION; HISTOPATHOLOGY; HUMORAL IMMUNITY; IMMUNITY; IMMUNOFLUORESCENCE; IMMUNOGLOBULIN DEPOSITION; IMMUNOSUPPRESSIVE TREATMENT; MALE; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL TIME; VASCULAR ENDOTHELIUM; XENOGRAFT;

ACUTE DISEASE; ANIMALS; CRICETINAE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE AGENTS; MALE; MESOCRICETUS; MODELS, IMMUNOLOGICAL; RATS; RATS, INBRED LEW; TACROLIMUS; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0036818261     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0463.2002.1101008.x     Document Type: Article

References (20)

1. Hasan R, Van der Bogaerde JB, Wallwork J, White DJG. Evidence that long-term survival of concordant xenografts is achieved by inhibition of antispecies antibody production. Transplantation 1992;54:408-13.
2. Murase N, Starzl TE, Demetris AJ, Valdivia L, Tanabe M, Cramer D, et al. Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs. Transplantation 1993;55:701-8.
3. Chong ASF, Ma LL, Yin D, Blinder L, Shen J, Williams JW. Tolerance of T-independent xenoantibody responses in the hamster-to-rat xenotransplantation model is species-restricted but not tissue-specific. Xenotransplantation 2000;7:48-57.
4. Nielsen B, Steinbrüchel DA, Laenkholm AV, Kemp E. The histology at various stages of acute rejection in concordant xenogeneic heart transplantation. APMIS 1992;100:249-55.
5. Langer A, Valdivia LA, Murase N, Woo J, Celli S, Fung JJ, et al. Humoral and cellular immunopathology of hepatic and cardiac hamster-intorat xenograft rejection. Am J Pathol 1993;143:85-98.
6. Ono K, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969;57:225-9.
7. Xiao F, Chong AS, Foster P, Sankary H, McChesney L, Koukoulis G, et al. Leflunomide controls rejection in hamster to rat cardiac xenografts. Transplantation 1994;58:828-34.
8. Wang J, Xu R, Jin R, Chen Z, Fidler JM. Immunosuppressive activity of the Chinese medical plant Triperygium wildfordii. Transplantation 2000;70:456-64.
9. Sankary HN, Yin DP, Chong ASF, Ma LL, Blinder L, Shen JK, et al. FK506 treatment in combination with leflunomide in hamster-to-rat heart and liver xenograft transplantation. Transplantation 1998;66:832-7.
10. Chong ASF, Shen J, Xiao F, Blinder L, Wei L, Sankary H, et al. Delayed xenograft rejection in the concordant hamster heart into Lewis rat model. Transplantation 1996;62:90-6.
11. Shen J, Short J, Blinder L, Karademir S, Foster P, Sankary H, et al. Quantification of the changes in splenic architecture during the rejection of cardiac allografts or xenografts. Transplantation 1997;64:448-53.
12. Lin Y, Vandeputte M, Waer M. Accommodation and T-independt B cell tolerance in rats with long term surviving hamster heart xenografts. J Immunol 1998;160:369-75.
13. Lin Y, Gobels J, Xia G, Ji P, Vandeputte M, Waer M. Induction of specific transplantation tolerance across xenogeneic barriers in the T-independent immune compartment. Nat Med 1998:4:173-80.
14. Mollevi DG, Ribas Y, Ginesta MM, Serrano T, Mestre M, Vidal A, et al. Heart and liver transplantation under low-dose tacrolimus: Graft survival after withdrawal of immunosuppression. Transplantation 2001;71:217-23.
15. Chong ASF, Ma LL, Shen J, Blinder L, Yin DP, Williams JW. Modification of humoral responses by the combinations of leflunomide and cyclosporine in Lewis rats transplanted with hamster hearts. Transplantation 1997;64:1650-7.
16. Lin Y, Vandeputte M, Waer M. Suppression of T-independent IgM xenoantibody formation by leflunomide during xenografting of hamster hearts in rats. Transplantation 1998;65:332-9.
17. Bach FH, Ferran C, Hechenleitner P, Mark W, Koyamada N, Miyatake T, et al. Accommodation of vascularized xenografts: Expression of protective genes by donor endothelial cells in a host Th2 cytokine environment. Nat Med 1997;3:196-204.
18. Shen J, Chong ASF, Xiao F, Liu W, Huang W, Blinder L, et al. Histological characterization and pharmacological control of chronic rejection in xenogeneic and allogeneic heart transplantation. Transplantation 1998;66:692-8.
19. Nielsen B, Steinbrüchel, Kemp E. An ultrastructural analysis of concordant and discordant cardiac xenografts in unmodified recipients. APMIS 1994;102:197-207.
20. Brouard S, Blancho G, Moreau A, Heslan JM, Cuturi MC, Soulillou JP. Long-term survival of hamster-to-rat cardiac xenografts in the absence of a Th2 shift. Transplantation 1998;65:1555-63.