Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolat reductase

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 17, Issue 5, 2002, Pages 293-302

  Chowdhury, Shafinaz F ^a   Guerrero, Ramon Hurtado ^b   Brun, Reto ^c   Ruiz Perez, Luis M ^b   Gonzalez Pacanowska, Dolores ^b   Gilbert, Ian H ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CSIC   (Spain)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Dihydrofolate reductase; Leishmania; Trypanoma brucei; Trypanosoma cruzi

Indexed keywords

2,4 DIAMINO 5 BENZYLPYRIMIDINE DERIVATIVE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; RECOMBINANT ENZYME; ANTITRYPANOSOMAL AGENT; FOLIC ACID ANTAGONIST; PYRIMIDINE DERIVATIVE;

ALKYLATION; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; LEISHMANIA; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; HUMAN; IN VITRO STUDY; LEISHMANIA DONOVANI; PARASITOLOGY; PERITONEUM MACROPHAGE; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANIMALS; DRUG DESIGN; FOLIC ACID ANTAGONISTS; HUMANS; LEISHMANIA DONOVANI; MACROPHAGES, PERITONEAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 0036818117     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636021000059083     Document Type: Article

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