Antiphospholipid antibodies and down syndrome: A case series

Journal of Pediatric Hematology/Oncology

Volumn 24, Issue 7, 2002, Pages 575-578

  Requena Silla, Yolanda ^a   Rosenfield, Cathy G ^b   Miller, Laurie C ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

Anticardiolipin antibodies; Antiphospholipid antibodies; Down syndrome; Pediatrics; Trisomy 21

Indexed keywords

CARDIOLIPIN ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; PHOSPHOLIPID ANTIBODY;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE HEPATITIS; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; DISEASE ASSOCIATION; DOWN SYNDROME; FEMALE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MALE; MEDICAL RECORD; PRIORITY JOURNAL; SCREENING TEST; SPONTANEOUS ABORTION; THROMBOCYTOPENIA;

ADOLESCENT; ADULT; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; CHILD; DOWN SYNDROME; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE;

EID: 0036817235     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043426-200210000-00018     Document Type: Article

References (17)

1. Ming JE, Stiehm ER. Syndromic immunodeficiencies with humoral defects. Immunol Allergy Clin North Am 2001;21:91-111.
2. Cuadrado E, Barrena MJ. Immune dysfunction in Down's syndrome: Primary immune deficiency or early senescence of the immune system? Clin Immunol Immunopathol 1996;78:209-14.
3. Guariso G, Ruffatti A, Casonato A, et al. Antiphospholipid syndrome in a child with trisomy 21: The relationship between anticardiolipin G antibodies and the von Willebrand factor. Clin Exp Rheumatol 1992;10:613-6.
4. Vaarala O, Palusuo T, Kleemola M, et al. Anticardiolipin response in acute infections. Clin Immunol Immunopathol 1986;41:8-15.
5. Asherson RA. Antiphospholipid antibodies, malignancies and paraproteinemias. J Autoimmun 2000;15:117-22.
6. Bick RL, Baker WF. Antiphospholipid syndrome and thrombosis. Semin Thromb Hemost 1999;25:333-50.
7. Marino B. Congenital heart disease in patients with Down's syndrome: Anatomic and genetic aspects. Biomed Pharmacother 1993;47:197-200.
8. Taub JW. Relationship of chromosome 21 and acute leukemia in children with Down syndrome. J Pediatr Hematol Oncol 2001;23:175-8.
9. Murphy M, Insoft RM, Pike-Nobile L, et al. Overexpression of LFA-1 and ICAM-1 in Down syndrome thymus. Implications for abnormal thymocyte maturation. J Immunol 1993;150:5696-703.
10. Gattorno M, Buoncompagni A, Molinari AC, et al. Antiphospholipid antibodies in pediatric systemic lupus erythematosus, juvenile chronic arthritis and overlap syndromes: SLE patients with both lupus anticoagulant and high-titre anticardiolipin antibodies are at risk for clinical manifestations related to the antiphospholipid syndrome. Br J Rheumatol 1995;34::873-81.
11. Fong KY, Loizou S, Boey ML, et al. Anticardiolipin antibodies, haemolytic anaemia and thrombocytopenia in systemic lupus erythematosus. Br J Rheumatol 1992;31:453-5.
12. Silvestrini M, Cupini LM, Matteis M, et al. Migraine in patients with stroke and antiphospholipid antibodies. Headache 1993;33:421-6.
13. Greaves M, Cohen H, MacHin SJ, et al. Guidelines on the investigation and management of the antiphospholipid syndrome. Br J Haematol 2000;109: 704-15.
14. Bick RL. Recurrent miscarriage syndrome and infertility caused by blood coagulation protein or platelet defects. Hematol Oncol Clin North Am 2000;14: 1117-31.
15. Molta C, Meyer O, Dosquet C, et al. Childhood-onset systemic lupus erythematosus: Antiphospholipid antibodies in 37 patients and their first-degree relatives. Pediatrics 1993;92:849-53.
16. Goldberg N, Conti-Kelly AM, Greco T. A family study of anticardiolipin antibodies and associated clinical conditions. Am J Med 1995;98:473-9.
17. Baker W, Bick RL. Treatment of hereditary and acquired thrombophilic disorders. Semin Thromb Hemost 1999;25:387-406.