The interface between depression and cerebrovascular disease - Some hope but no hype

Clinical and Experimental Hypertension

Volumn 24, Issue 7-8, 2002, Pages 639-646

  Perez, Jorge ^a   Tardito, Daniela ^b  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Antidepressants; CAMP signaling; Depression; Platelets; Stroke

Indexed keywords

CEREBROVASCULAR DISEASE; CLINICAL RESEARCH; COMORBIDITY; CONFERENCE PAPER; DEPRESSION; DISEASE ASSOCIATION; HUMAN; PATHOPHYSIOLOGY; PROGNOSIS; STROKE;

CEREBROVASCULAR DISORDERS; DEPRESSION; HUMANS; PREVALENCE; RISK FACTORS;

EID: 0036814680     PISSN: 10641963     EISSN: None     Source Type: Journal    
DOI: 10.1081/CEH-120015340     Document Type: Conference Paper

References (24)

1. Langhorne, P.; Stott, D.J.; Robertson, L.; MacDonald, J.; Jones, L.; McAlpine, C.; Dick, F.; Taylor, G.S.; Murray, G. Medical complication after stroke. A multicenter study. Stroke 2000, 31, 1223-1229.
2. van de Weg, F.B.; Kulk, D.J.; Lankhorst, G.J. Post-stroke depression and functional outcome, a cohort study investigating the influence of depression on functional recovery from stroke. Clin. Rehabil. 1999, 13, 268-272.
3. Rao, R. Cerebrovascular disease and late life depression, an age old association revisited. Int. J. Geriat. Psychiatry 2000, 15, 419-433.
4. Ramasubbu, R. Relationship between depression and cerebrovascular disease, conceptual issue. J. Affect. Disor. 1998, 57, 1-11.
5. Lebowitz, D.; Pearson, J.L.; Schneider, L.S.; Reynolds, C.F.; Alexopoulos, G.S.; Livingston Bruce, M.; Conwell, Y.; Katz, I.R.; Meyers, B.S.; Morrison, M.F.; Mossey, J.; Niederehe, G.; Parmelee, P. Diagnosis and treatment of depression in late life. JAMA 1997, 278, 1186-1190.
6. Casey, D. Depression in the elderly. South Med. J. 1994, 87, 559-563.
7. Alexopoulos, G.S.; Meyers, B.S.; Young, R.C.; Campbell, S.; Silbersweig, D.; Charlson, M. "Vascular depression" hypothesis. Arch. Gen. Psychiatry 1997, 54, 915-922.
8. Krishnam, R.R. Depression as a contributing factor in cerebrovascular disease. Am. Hearth. J. 2000, 140, S70-S76.
9. Musselman, D.L.; Evans, D.L.; Nemeroff, C.B. The relationship of depression to cardiovascular disease. Arch. Gen. Psychiatry 1998, 55, 580-592.
10. Ford, D.E.; Mead, L.A.; Chang, P.P.; Copper-Patrick, L.; Wang, N.Y.; Klag, M.J. Depression is a risk factor for coronary artery disease in men. Arch. Intern. Med. 1998, 158, 1422-1426.
11. Nemeroff, C.B.; Musselman, D.L. Are platelets a link between depression and ischemic hearth disease? Am. Hearth. J. 2001, 140, S57-S62.
12. Nesse, R.M. Is Depression an adaptation? Arch. Gen. Psychiatry 2000, 57, 14-20.
13. Carson, A.J.; MacHale, S.; Allen, K.; Lawrie, S.M.; Dennis, M.; House, A.; Sharpe, M. Depression after stroke and lesion location, a systematic review. Lancet 2000, 356, 122-126.
14. Pineyro, G.; Blier, P. Autoregulation of serotonin neurons, role in antidepressant drug action. Pharmacol. Rev. 1999, 51, 533-591.
15. Suhara, T.; Sudo, Y.; Yoshida, K.; Okubo, Y.; Fukuda, H.; Obata, T.; Yoshikawa, K.; Suzuki, K.; Sasaki, Y. Lung as reservoir for antidepressants in pharmacokinetic drug interactions. Lancet 1998, 351, 332-335.
16. Perez, J.; Tardito, D.; Mori, S.; Racagni, G.; Smeraldi, E.; Zanardi, R. Abnormalities of cAMP signaling in affective disorders, implications for pathophysiology and treatment. Bipolar Disord. 2000, 2, 27-36.
17. Popoli, M.; Brunello, N.; Perez, J.; Racagni, G. Second messenger-regulated protein kinases in the brain, their functional role and the action of antidepressant drugs. J. Neurochem. 2000, 74, 21-33.
18. Griffin, L.D.; Mellon, S.H. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. PNAS 1999, 96, 13512-13517.
19. Goodnick, P.J.; Goldstein, B.J. Selective serotonin reuptake inhibitors in affective disorders - I. Basic pharmacology. J. Psychopharmacol. 1998, 12 (B), S5-S20.
20. Manji, H.K.; Lenox, R.H. Signaling, cellular insights into the pathophysiology of bipolar disorder. Biol. Psychiatry 2000, 48, 518-530.
21. Perez, J.; Tardito, D. Implications of the cAMP signaling pathway in psychiatric disorders, a systematic review of the evidence. CNS Spectrum. 2001, 4, 294-305.
22. Perez, J.; Tardito, D.; Mori, S.; Racagni, G.; Smeraldi, E.; Zanardi, R. Abnormalities of cyclic adenosine monophosphate signaling in platelets from untreated patients with bipolar disorder. Arch. Gen. Psychiatry 1999, 56, 248-253.
23. Perez, J.; Tardito, D.; Mori, S.; Racagni, G.; Smeraldi, E.; Zanardi, R. Altered Rapl1 endogenous phosphorylation and levels in platelets from patients with bipolar disorder. J. Psychiatry Res. 2000, 34, 99-104.
24. Perez, J.; Tardito, D.; Racagni, G.; Smeraldi, E.; Zanardi, R. Protein kinase A and Rap1 levels in platelets of untreated patients with major depression. Mol. Psychiatry 2001, 6, 44-49.