Herbs commonly used by women: An evidence-based review

Disease-a-Month

Volumn 48, Issue 10, 2002, Pages 671-696

  Tesch, Bonnie J ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Alternative medicine; Herbal medicine; Herbs; Phytomedicine

Indexed keywords

ECHINACEA EXTRACT; GARLIC EXTRACT; GINKGO BILOBA EXTRACT; GINSENG EXTRACT; HERBACEOUS AGENT; HYPERICUM PERFORATUM EXTRACT; ORAL CONTRACEPTIVE AGENT; VALERIAN; VITEX AGNUS CASTUS EXTRACT;

ACNE; AGITATION; BLEEDING; BLOOD PRESSURE REGULATION; CIMICIFUGA RACEMOSA; CLIMACTERIUM; CLINICAL TRIAL; CONFUSION; CONSTIPATION; DEMENTIA; DEPRESSION; DIARRHEA; DIET SUPPLEMENTATION; DRUG EFFICACY; DRUG FORMULATION; DRUG IMPURITY; DRUG MANUFACTURE; DRUG SAFETY; EUPHORIA; FEMALE; FOOD AND DRUG ADMINISTRATION; GASTROINTESTINAL DISEASE; HALLUCINATION; HEADACHE; HERBAL MEDICINE; HUMAN; HYPERTENSION; HYPOMANIA; INFORMATION PROCESSING; INSOMNIA; MANIA; MASTALGIA; MENOPAUSAL SYNDROME; MENORRHAGIA; MENSTRUATION DISORDER; META ANALYSIS; MUSCLE RELAXATION; NERVOUSNESS; PREMENSTRUAL SYNDROME; RASH; RESPIRATORY TRACT INFECTION; RESTLESSNESS; REVIEW; SEDATION; SEROTONIN SYNDROME; SIDE EFFECT; SWEATING; UNITED STATES; VAGINA BLEEDING; VERTIGO; VOMITING; WELLBEING; XEROSTOMIA;

EID: 0036814034     PISSN: 00115029     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-5029(02)90011-8     Document Type: Review

References (184)

1. Eisenberg DM, David RB, Ettner SL, et al. Trends in alternative medicine use in the United States, 1990-1997. JAMA 1998;280:1569-75.
2. Druss BG, Rosenheck RA. Association between use of unconventional therapies and conventional medical services. JAMA 1999;285:651-6.
3. Astin JA. Why patients use alternative medicine: Results of a national study. JAMA 1988;279:1548-53.
4. Brody JE. Americans gamble on herbs as medicine. New York Times February 9:2, 1999.
5. Soller RW. Regulation in the herb market: The myth of the "unregulated industry." HerbalGram 2000;49:64-7.
6. Siegel R. Kola, ginseng, and mislabeled herbs. JAMA 1978;237:24.
7. DuPont R, Bogema S. Benzodiazapines in a health-catalog product. JAMA 1990;264:959.
8. Capobianco DJ, Brizis PW, Fox TP. Proximal muscle weakness induced by herbs. N Engl J Med 1993;329:1430.
9. Winslow LC, Kroll DJ. Herbs as medicines. Arch Intern Med 1998;158:2192-9.
10. D'Arcy PF. Adverse reactions and interactions with herbal medicines, I: Adverse reactions. Adverse Drug React Toxicol Rev 1991;10:189-208.
11. Miller LG. Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med 1998;158:2200-11.
12. Ernst E. Harmless herbs? A review of the recent literature. Am J Med 1998;104:170-8.
13. Chase M. Health journal. Wall Street Journal. November 16:B1, 1998.
14. Blumenthal M, Gruenwald J, Hall T, et al, editors. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications; 1998.
15. Chung KF, McCusker M, Page CP, et al. Effect of ginkgolide mixture in antagonizing skin and platelet responses to platelet activating factor in man. Lancet 1987;1:248-51.
16. Schulz V, Hänsel R, Tyler VE. Rational phytotherapy: A physicians' guide to herbal medicine. New York, NY, Springer-Verlag.
17. Blumenthal M. Herb sales down 3% in mass market retail stores sales in natural food stores still growing, but at lower rate. HerbalGram 2000;49:68.
18. Kleinjen J, Knipschild P. Ginkgo biloba. Lancet 1992;340:1136-9.
19. Kleinjen K, Knipschild P. Ginkgo biloba for cerebral insufficiency. Br J Clin Pharmacol 1992;34:352-8.
20. Rigney U, Kimber S, Hindmarch I. The effects of acute doses of standardized ginkgo biloba extract on memory and psychomotor performance in volunteers. Phytother Res 1999;13:408-15.
21. LeBars PL, Katz MM, Berman N, et al. A placebo-controlled, double-blind, randomized trial of an extract of ginkgo biloba for dementia. JAMA 1997;278:1327-32.
22. Oken BS, Storzbach DM, Kaye JA. The efficacy of ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol 1998;55:1409-15.
23. Ernst E, Pittler MH. Ginkgo biloba for dementia: A systematic review of double blind, placebo-controlled trials. Clinical Drug Investigation 1999;17:301-8.
24. Pittler MH, Ernst E. Ginkgo biloba extract for the treatment of intermittent claudication: A meta-analysis of randomized trials. Am J Med 2000;108:276-81.
25. Roncin JP, Schwartz F, D'Arbigny P. EGb 761 in control of acute mountain sickness and vascular reactivity to cold exposure. Aviat Space Environ Med 1996;67:445-52.
26. Cohen AJ, Bartilik BD. Gingko biloba for drug-induced sexual dysfunction. Presented at the American Psychiatric Association Annual Meeting, San Diego, CA, May 1997.
27. Arenz A, Klein M, Fiehe K, et al. Occurrence of neurotoxic 4′-o-methylpyridoxine in ginkgo biloba leaves. Ginkgo medications and Japanese ginkgo food. Planta Med 1996;62:548-51.
28. Vale S. Subarachnonid hemorrhage associated with ginkgo biloba. Lancet 1998; 352:36.
29. Rosenblatt M, Mindel J. Spontaneous hyphema associated with ingestion of ginkgo biloba extract [letter]. N Engl J Med 1997;336:1108.
30. Rowin J, Lewis SL. Spontaneous bilateral subdural hematomas associated with chronic ginkgo biloba ingestion have also occurred. Neurology 1996:1775-6.
31. Matthews MK. Associate of ginkgo biloba with intracerebral hemorrhage. Neurology 1998;50:1933-4.
32. Gilbert GJ. Ginkgo biloba (letter). Neurology 1997;48:1137.
33. Jenike MA, editor. Hypericum: A novel antidepressant. J Geriatr Psychiatry Neurol 1994;7(suppl 1):1-68.
34. Laakmann G, Schule C, Baghai T, et al. St. John's Wort in mild to moderate depression: The relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry 1998;31:54-9.
35. Lenoir S, Degenring FH, Saller R. A double-blind randomised trial to investigate three different concentrations of a standardised fresh plant extract obtained from the shoots tips of Hypericum perforatum L. Phytomedicine 1999;6:141-6.
36. Müller WE, Singer A, Wonnemann M, et al. Hyperforin represents the neurotransmitter uptake inhibiting constituent of hypericum extract. Pharmacopsychiatry 1998;31:16-21 suppl.
37. Linde K, Gilbert R, Mulrow C, et al. St. John's Wort for depression: An overview and meta analysis of randomized clinical trials. BMJ 1996;313:253-8.
38. Linde K, Mulrow CD. Review: St. John's Wort for depression. The Cochrane Database of Systematic Reviews 1999;2:1-38.
39. Gaster B, Holroyd J. St. John's Wort for depression: A systematic review. Arch Intern Med 2000;160:152-6.
40. Ernst E. Herbal medicines: Where is the evidence? Growing evidence of effectiveness is counterbalanced by inadequate regulation. BMJ 2000;321:395-6.
41. Woelk H. Remotiv/Imipramine Study Group. Comparison of St. John's Wort and imipramine for treating depression: Randomised controlled trial. BMJ 2000;321:536-9.
42. Harrer G, Schmidt U, Kuhn U, et al. Comparison of equivalence between the St. John's Wort extract LoHyp-57 and fluoxetine. Arzneimittelforschung 1999;49:289-6.
43. Schrader E. Equivalence of a St. John's wort extract (Ze 117) and fluoxetine: A randomized, controlled study in mild-moderate depression. Int Clin Psychopharmacol 2000;15:61-8.
44. Stevinson C, Dixon M, Ernst E. Hypericum for fatigue - A pilot study. Phytomedicine 1998;5:443-7.
45. Hübner WP, Lande S, Poduweit H, et al. Hypericum treatment of mild depression with somatic symptoms. J Geriatr Psychiatry Neurol 1994;7(suppl 1):12-4.
46. Martinez B, Kasper S, Ruhrmann S, et al. Hypericum in the treatment of seasonal affective disorders. J Geriatr Psychiatry Neurol 1994;7(suppl 1):29-33.
47. Ernst E, Rand JI, Barnes J, et al. Adverse effects profile of the herbal antidepressant St John's wort (Hypericum perforatum L). Eur J Clin Pharmacol 1998;54:589-94.
48. Bove GM. Acute neuropathy after exposure to sun in a patient treated with St. John's Worst [letter]. Lancet 1998;352:1121-2.
49. Moses EL, Mallinger AG. St. John's Wort: Three cases of possible mania induction. J Clin Psychopharmacol 2000;20:115-7.
50. O'Breasail AM, Argouarch S. Hypomania and St. John's Wort. Can J Psychiatry 1998;43:746-7.
51. Schneck C. St. John's Wort and hypomania (letter). J Clin Psych 1998;59:689.
52. Lantz MS, Buchalter E, Giambanco V. St. John's Wort and antidepressant drug interactions in the elderly. J Geriatr Psychiatry Neurol 1999;12:7-10.
53. Gordon JB. SSRIs and St. John's Wort: Possible toxicity [letter]? Am Fam Physician 1998;7:950-3.
54. Demott K. St John's wort tied to serotonin syndrome. Clinical Psychiatry News 1998;26:28.
55. Ernst E. Second thoughts about safety of St. John's Wort. Lancet 1999;354:2014-6.
56. Johne A, Brockmöller J, Bauer S, et al. Pharmacokinetics and drug disposition: Pharmacokinetic interaction of digoxin with an herbal extract from St. John's Wort (hypericum perforatum). Clin Pharmacol Ther 1999;66:338-45.
57. Ruschitzka F, Meier PJ, Turina M, et al. Acute heart transplant rejection due to St. John's Wort. Lancet 2000;355:548-9.
58. Piscitelli SC, Burstein AH, Chaitt D, et al. Indinavar concentrations and St. John's Wort. Lancet 2000;355:547-8.
59. Yue QY, Bergquist C, Gerden B. Safety of St. John's wort. Lancet 2000;355:576-7.
60. Nebel A, Schneider BJ, Baker RA, et al. Potential metabolic interaction between St. John's wort and theophylline. Ann Pharmacother 1999;33:502.
61. Gregory PJ. Drug interactions with St. John's Wort. Pharmacist's Letter/Prescriber's Letter. Stockton, CA, Therapeutic Research Center, 2000.
62. Abramowicz M, editor. Drug interactions with St. John's Wort. The Medical Letter 2000;42:56.
63. Muscat, M. St. John's Wort paces new wave of regulations. Altern Ther Health Med 2000;6:27.
64. National Institutes of Health. NIH Office of Dietary Supplements Announces Funding of Dietary Supplements Research Centers. NIH News Release, October 6, 1999. National Institutes of Health. Bethesda, MD. Available at: www.nccaminfo\@nccam.nih.gov.
65. Binaway C. NIH Hypericum Trial Seeking Participants. Duke Clinical Research Institute (letter to the editor). The Integrative Medicine Consult. Feb. 16, 2000.
66. Hornig M. Hypericum (St. John's Wort) for treatment of depression. Alternative Medicine Alert 1998;1:4-7.
67. Mar C, Bent S. An evidence-based review of the 10 most commonly used herbs. WMJ 1999;171:168-71.
68. Li TSC, Harries D. Medicinal values of ginseng. The Herb, Spice, and Medicinal Plant Digest 1996;14:1-5.
69. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: Multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685-93.
70. Lui J, Staba EJ. The ginsenosides of various ginseng plants and selected products. J Nat Prod 1989;43:34-6.
71. Vogler BK, Pittler MH, Ernst E. The efficacy of ginseng. A systematic review of randomised clinical trials. Eur J Clin Pharmacol 1999;55:567-75.
72. Bahrke MS, Morgan WR. Evaluation of the ergogenic properties of ginseng: An update. Sports Med 2000;29:113-33.
73. Bucci LR. Selected herbals and human exercise performance. Am J Clin Nutr 2000;72(suppl 2):624S-36S.
74. Sotaniemi EA, Haapakkoski E, Rautio A. Ginseng therapy in non-insulin-independent diabetic patients. Diabetes Care 1995;18:1373-75.
75. Vuksan V, Sievenpiper JL, Koo VY, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000;160:1009-13.
76. Onomura M, Tsukada H, Fukuda K, et al. Effects of ginseng radix on sugar absorption in the small intestine. Am J Chin Med 1999;27:347-54.
77. Yun TK, Choi SY. Non-organ specific cancer prevention of ginseng: A prospective study in Korea. Int J Epidemiol 1998;27:359-64.
78. Wiklund IK, Mattsson LA, Lindgren R, et al. Swedish Alternative Medicine Group. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. IInt J Clin Pharmacol Res 1999;19:89-99.
79. Tode T, Kikuchi Y, Hirata J, et al. Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int J Gynaecol Obstet 1999;67:169-74.
80. Shin HR, Kim JY, Yun TK, et al. The cancer-preventive potential of Panax ginseng: A review of human and experimental evidence. Cancer Causes Control 2000;11:565-76.
81. Yun TK. Update from Asia. Asian studies on cancer chemoprevention (review). Ann NY Acad Sci 1992;889:157-2.
82. Liu CX, Liu CX, Xiao PG, et al. Recent advances on ginseng research in China. J Ethnopharmacol 1992;36:27-38.
83. Punnonen R, Lukola A. Oestrogen-like effect of ginseng. BMJ 1978;281:1110.
84. Greenspan EM. Ginseng and vaginal bleeding. JAMA 1983;249:2018.
85. Hopkins MP, Androff L, Benninghoff AS. Ginseng face cream and unexplained vaginal bleeding. Am J Obstet Gynecol 1988;159:1121-2.
86. Palmer BV, Montgomery ACV, Monteiro JCMP. Ginseng and mastalgia. BMJ 1978;1:1284.
87. Koriech OM. Ginseng and mastalgia. BMJ 1978;10:1556.
88. Wilkie A, Cordess C. Ginseng - Root just like a carrot? J R Soc Med 1994;87:594-5.
89. Gonzales-Seijo JC, Ramos YM, Lastra I. Manic episode and ginseng: Report of a possible case. J Clin Psychopharmacol 1995;15:447-8.
90. Siegel RK. Problems with the panacea. JAMA 1979;241:1614-5.
91. McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. CMAJ 1996;155:293-5.
92. Janetzky K, Morreale AP. Probable interactions between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-3.
93. Jones BP, Runikis AM. Interaction of ginseng with phenelzine. J Clin Psychopharmacol 1987;7:201-2.
94. Schiedermayer D. Gingeng for the improvement of constitutional symptoms. Alternative Medicine Alert 1998;1:37-41.
95. Castleman M. Ginseng. Herb Quarterly 1990;48:17-24.
96. Koch HP. Garlic. in Lawson LD, editor. The Science and Therapeutic Application of Allium Sativum L and Related Species. 2. Baltimore, MD: Williams & Wilkins; 1996.
97. Gebhardt R. Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes. Lipids 1993;28:613-9.
98. Reuter MD. Allium sativum an allium ursinum, Part 2. Pharmacology and medicinal application. Phytomedicine 1995;2:73-91.
99. Bordia A. Effect of garlic on human platelet aggregation in vitro. Atherosclerosis 1978;30:355-60.
100. Koscielny J, Klübendorf D, Latza R, et al. The antiatherosclerotic effect of allium sativum. Atherosclerosis 1999;144:237-49.
101. Warshafsky S, Kamer RS, Sivak L. Effect of garlic on total serum cholesterol. Ann Intern Med 1994;119:599-605.
102. Silagy C, Neil A. Garlic as a lipid-lowering agent - A meta-analysis. J R Coll Physicians Lond 1994;28:2-8.
103. Jain AK, Vargas R, Gotzkowsky S, et al. Can garlic reduce levels of serum lipids? A controlled clinical study. Am J Med 1993;94:632-5.
104. Adler AJ, Holub BJ. Effect of garlic and fish oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. Am J Clin Nutr 1997;65:445-50.
105. Steiner M, Khan AH, Holbert D, et al. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr 1996;64:866-70.
106. Simons LA, Balasubramanian S, von Konigsmark M, et al. On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolemia. Atherosclerosis 1995;113:219-25.
107. Neil HA, Silagy CA, Lancaster T, et al. Garlic powder in the treatment of moderate hyperlipidemia: A controlled trial and meta-analysis. J R Coll Physicians London 1996;30:329-34.
108. Isaacsohn JL, Moser M, Stein EA, et al. Garlic powder and plasma lipids and lipoproteins: A multicenter, randomized, placebo-controlled trial. Arch Intern Med 1998;158:1189-94.
109. Berthold HK, Sudhop K, vonBergmann K. Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism: a randomized controlled trial. JAMA 1998;279:1900-2.
110. Superko HR, Krauss RM. Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein(a). J Am Coll Card 2000;35:321-6.
111. Lawson LD. Effect of garlic on serum lipids (letter). JAMA 1998;290:1568.
112. Stevinson C, Pittler MH, Ernst E. Garlic for treating hypercholesterolemia: A meta-analysis of randomized clinical trials. Ann Intern Med 2000;133:420-9.
113. Silagy C, Neil A. A meta-analysis of the effect of garlic on blood pressure. J Hypertens 1994;12:463-8.
114. Kleijnen J, Knipschild P, TerRiet G. Garlic, onions, and cardiovascular risk factors: A review of the evidence from human experiments with emphasis on commercially available preparations. Br J Clin Pharm 1989;28:535-44.
115. Jappe U, Bonnekoh B, Hausen BM, et al. Garlic-related dermatoses: Case report and review of the literature. Am J Contact Dermat 1999;10:37-9.
116. Perez-Pimiento AJ, Moneo I, Santaolalla M, et al. Anaphylactic reaction to young garlic. Allergy 1999;54:626-9.
117. Sunter WH. Warfarin and garlic (letter). Pharmaceutical Journal 1999;246:722.
118. Burnham BE. Garlic as a possible risk for postoperative bleeding. Plast Reconstr Surg 1995;95:213.
119. German K, Kuma U, Blackford HN. Garlic and the risk of TURP bleeding. Br J Urol 1995;76:518.
120. Rose KD, Croissant PD, Parliament CF, et al. Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion: A case report. Neurosurgery 1990;26:880-2.
121. Foster S. Echinacea: Nature's Immune Enhancer. Rochester, VT: Health Arts Press; 1991.
122. Braunig B. Echinacea purpurea radix for strengthening the immune response in flu-like infections. Zeitschrft fur Phytotherapie 1992;13:7-13.
123. Schoneberger D. The influence of the immunestimulating effects of pressed juices from echinacea purpurea on the course and intensity of the common cold: Results of a double-blind-clinical trial. Forum Immunologie 1992;2:18-22.
124. Kattapong JV. Echinacea for colds. Alternative Medicine Alert 2000;3:128-30.
125. Wacker A. Virus inhibition by echinea purpura. Planta Med 1978;33:89-102.
126. Melchart D, Linde K, Worku F, et al. Immunomodulation with echinacea - A systematic review of controlled clinical trials. Phytomedicine 1994;1:245-5.
127. Melchart D, Walther E, Linde K, et al. Echinacea root extracts for the prevention of upper respiratory tract infections. A double-blind, placebo-controlled randomized trial. Arch Fam Med 1998;7:541-5.
128. Hoheisel O, Sandberg M, Bertram S, et al. Echinacea treatment shortens the course of the common cold: A double-blind, placebo-controlled clinical trial. European Journal of Clinical Research 1997;9:261-9.
129. Turner RB, Risker RK, Gangemi JD, et al. Ineffectiveness of echinacea for prevention of experimental rhinovirus colds. Antimicrob Agents Chemother 2000;44:1708-9.
130. Grimm W, Müller HH. A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections. Am J Med 1999;106:138-43.
131. Brinkeborn RM, Shah DV, Dengenring FH. Echinaforce® and other echinacea fresh plant preparations in the treatment of the common cold: A randomized, placebo controlled, double-blind clinical trial. Phytomedicine 1999;6:1-5.
132. Barrett B, Vohmann M, Calabrese C, et al. Echinacea for upper respiratory infection (Review of 9 treatment and 4 prevention trials). Fam Pract 1999;48:628-35.
133. Percival SS. Use of echinacea in medicine. Biochem Pharmacol 2000;60:155-8.
134. Muscat M. Botanical Products Development: SBBR and STTR. NCCAM Report. Altern Ther Health Med. 6 2000.
135. Myers SP, Wohlmuth H. Echinacea associated anaphylaxis. Med J Aust 1998;168: 583-4.
136. Mullins RJ. Echinacea-associated anaphylaxis. Med J Aust 1998;168:170-1.
137. AAAAI: Today's Findings from the AAAAI Annual Meeting Unveil New Research on Alternative Therapies and Food Allergy: Echinaecea can Cause Allergic Reactions [Press Release]. Milwaukee, WI, American Academy of Allergy, Asthma and Immunology, March 7, 2000.
138. Houghton PJ. The biologic activity of valerian and related plants. J Ethnopharmacol 1988;22:121-42.
139. Santos MS, Ferreira F, Cunha AP, et al. An aqueous extract of valerian influences the transport of GABA in synaptosomes. Planta Med 1994;60:278-9.
140. Mennini T, Bernasconi P, Bomdardelli E, et al. In vitro study of interaction of extracts and pure compounds from valerian, a officinalis root with GABA, benzodiazepine and barbituate receptors in rat brain. Fitoterpia 1993;54:291-300.
141. Leathwood PD, Chauffard F, Heck E, et al. Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacol Biochem Behav 1982;17:65-71.
142. Leathwood PD, Chauffard F. Aqueous extract of valerian reduces sleep latency to fall asleep in man. Planta Med 1984;50:144-8.
143. Vorbach EU, Görtelmeyer R, Brünig J. Therapie von insomnien: Wirksamkeit und verträglichkeit eines baldrianpräparats. Psychopharmakotherapie 1996;13:109-15.
144. Hobbs C. Valerian: A literature review. HerbalGram 1989;21:19-34.
145. Hiller KO, Ketler G. Neuropharmacological studies on ethanol extracts of Valeriana officinalis L: Behavioural and anticonvulsant activities. Physiother Res Int 1996;10:145-51.
146. Capasso A, Defeo V, DeSimon F, et al. Pharmacological effects of aqueous extracts from Valeriana ascendens. Physiother Res Int 1996;10:309-12.
147. Felter H, Lloyd J. King's American Dispensatory. 1898. Sandy, OR: Eclectic Medical Publishing; 1992.
148. Herrick JW. Iroquois Medical Botany. Syracuse, NY: Syracuse University Press; 1995 pp. 119.
149. Tyler V. Was Lydia E. Pinkham's vegetable compound an effective remedy? Pharmacy in History 1998;37:24-8.
150. Anonymous. Harvard Women's Health Watch. 7:6, 2000.
151. Wade C, Kronenberg F, Kelly A, et al. Hormone-modulating herbs: Implications for women's health. JAMA 1999;54:181-3.
152. Jarry H, Harnischfeger G, Duker EM. The endocrine effects of constituents of cimicifuga racemosa: In vitro binding of constituents to estrogen receptors. Planta Med 1985;4:316-9.
153. Lehmann-Willenbrock E, Riedel H. Clinical and endocrinological examinations concerning therapy of climacteric symptoms following hysterectomy with remaining ovaries. Zentralbl Gynakol 1988;110:611-8.
154. Duker EM, Kopanski L, Jarry H, et al. Effects of extracts from cimicifuga racemosa on gonadotropin release in menopausal women and ovariectomized rats. Planta Med 1991;57:420-4.
155. Harnischfeger G, Cillien N. Influence of cimicifuga racemosa extract fractions on the proliferation of human carcinoma cells in vitro with regard to their estrogen receptor sensitivity. Paper presented at the 44th Annual Congress of Georg August Universitat, Gottingen, Germany, 1996.
156. Nesselhut T, Schellhase T, Dietrich C, et al. Studies on mamma carcinoma cells regarding the proliferative potential of herbal medications with estrogen-like effects. Arch Gynecol Obstet 1993;254:817-8.
157. Schaper and Brummer: Scientific Brochure of Remifemin (English Translation). Salzgitter, Germany, Schaper & Brummer, 1997.
158. Dixon-Shanies D, Shaikh N. Growth inhibition of human breast cancer cells by herbs and phytoestrogens. Oncol Rep 1999;6:1383-7.
159. Freudenstein J, Bodinet C. Influence of an isopropanolic aqueous extract of Cimicifuga racemosae rhizoma on the proliferation of MCF-7 cells. 23rd International LOF-Symposium on Phytoestrogens. University of Ghent, Belgium, 1999.
160. Tillem J. Black cohosh for the treatment of perimenopausal and menopausal symptoms. Alternative Medicine Alert 2000;3:17-9.
161. Daiber W. Climacteric complaints: Success without using hormones! Arztliche Praxis 1983;35:1946-7.
162. Petho A. Klimakterische beschwerden. Is change-over of a hormone treatment to an herbal gynecological remedy practicable? Arztliche Praxis 1987;38:1551-3.
163. Stolze H. An alternative to treat menopausal complaints. Gynecology 1982;3:14-6.
164. Vorberg G. Successful hormone-free therapy with Remifemin. Zietschrift fuer Allgemeinmedizin 1984;60:626-9.
165. Warnecke G. Influence of phytotherapy on menopausal syndrome: Successful treatments with monoextract of cimicifuga. Medizinische Welt 1985;36:871-4.
166. Liske E. Therapeutic efficacy and safety of cimicifuga racemosa for gynecologic disorders. Advances in Natural Therapy 1998;15:45-53.
167. Stoll W. Phytopharmacon influences atrophic vaginal epithelium: Double-blind study - Cimicifuga vs estrogenic substances. Therapeuticum 1987;1:23-31.
168. Pepping J. Black cohosh: Cimicifuga racemosa. Am J Health Syst Pharm 1999;56:1400-2.
169. McFarlin BL, Gibson MH, O'Rear J, et al. A national survey of herbal preparation use by nurse-midwives for labor stimulation. Review of the literature and recommendations for practice. Journal of Nurse-Midwifery 1999;44:205-16.
170. Brown DJ. Herbal research review: Vitex agnus castus clinical monograph. Quarterly Review of Natural Medicine Summer 1994:111-21.
171. Snow JM. Vitex agnus-castus L (Verbenaceae). Protocol Journal of Botanical Medicine 1996;1:20-3.
172. Gomaa CS, El-Moghazy MA, Halim FA, et al. Flavonoids and iridoids from Vitex agnus-castus. Planta Med 1978;33:277.
173. Chaste tree (monograph). The Review of Natural Products. St. Louis, MO, Facts & Comparisons, 1998.
174. Jarry H, Leonhardt S, Gorkow C, et al. In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus: Direct evidence for dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol Diabetes 1994;102:448-54.
175. Sliutz G, Speiser P, Schultz AM, et al. Agnus castus extracts inhibit prolactin secretion of rat pituitary cells. Horm Metab Res 1993;25:253-5.
176. Halbreich U. Serum prolactin in women with pre-menstrual syndrome. Lancet 1976;2:654-6.
177. Mayo J. Premenstrual syndrome: A natural approach to management. Clin Nutr Insights 1997;5:1-8.
178. Bohnert KJ. The use of Vitex agnus castus for hyperprolactinemia. Quarterly Review of Natural Medicine 1997;19:21.
179. Loch E, Bohnert KJ, Peeters M, et al. The treatment of menstrual disorders with Vitex agnus-castus tincture. Der Frauenarzt 1991;32:867-70.
180. Dittmar F, Bohnert KJ, Peeters M, et al. Premenstrual syndrome: Treatment with a phytopharmaceutical. Therapiewoche Gynakol 1992;5:60-8.
181. Peteres-Welter C, Albrecht M. Menstrual abnormalities and PMS. Vitex agnus castus in a study of application. Therapiewoche Gynakol 1994;7:49-52.
182. Feldmann HU, Albrecht M, Lamertz M, et al. The treatment of corpus luteum insufficiency and premenstrual syndrome. Experience in a multi-center study under clinical practice conditions (in German). Gynecologie 1990;12:422-5.
183. Laurtzen C, Reuter HD, Repges R, et al. Treatment of premenstrual tension syndrome with Vitex agnus castus. A controlled, double-blind study versus pyridoxine. Phytomedicine 1997;4:183-9.
184. Hardy ML. Herbs of special interest to women. J Am Pharm Assoc 2000;40:234-42.