IgG1 subclass dominates autoimmune response to tyrosine phosphatase-like molecule IA-2 in Chinese type 1 diabetes patients

Hormone and Metabolic Research

Volumn 34, Issue 10, 2002, Pages 596-600

  Ng, W Y ^a   Lui, K F ^a   Cheah, J S ^a   Thai, A C ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

IA 2 Antibodies; Immune Mediated Diabetes; Isotypes

Indexed keywords

AUTOANTIBODY; C PEPTIDE; GLUTAMATE DECARBOXYLASE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN SUBCLASS; INSULIN; ORAL ANTIDIABETIC AGENT; PROTEIN TYROSINE PHOSPHATASE; SULFUR 35; ICA512 AUTOANTIBODY; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNE DISEASE; CHILD; CHINESE; CLINICAL ARTICLE; CLONAL VARIATION; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; TH1 CELL; AGE; ASIAN; BLOOD; IMMUNOLOGY; MIDDLE AGED; ONSET AGE; PRESCHOOL CHILD;

ADOLESCENT; ADULT; AGE FACTORS; AGE OF ONSET; ASIAN CONTINENTAL ANCESTRY GROUP; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; MALE; MIDDLE AGED;

EID: 0036810886     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-35422     Document Type: Article

References (23)

1. Liblau RS, Singer SM, McDevitt HO. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 1995; 16: 34-38
2. Rabinovitch A. Immunoregulatory and cytokine imbalance in the pathogeneisis of IDDM. Therapeutic intervention by immunostimulation? Diabetes 1994; 43: 613-621
3. De Carli M, D'Elios MM, Zancuoghi G, Romagnani S, Del Prete G. Human Th1 and Th2 cells: Functional properties, regulation of development and role in autoimmunity. Autoimmunity 1994; 18: 301-308
4. Widhe M, Ekerfelt C, Forsberg P, Bergstrom S, Ernerudh J. IgG subclasses in Lyme borreliosis: A study of specific IgG subclass distribution in an interferon-gamma-predominated disease. Scand J Immunol 1998; 47: 575-581
5. Sousa AO, Henry S, Maroja FM, Lee FK, Brum L, Singh M, Lagrange PH, Aucouturier P. IgG subclass distribution of antibody response to protein and polysaccharide mycobacterial antigens in leprosy and tuberculosis patients. Clin Exp Immunol 1998; 111: 48-55
6. Bonifacio E, Scirpoli M, Kredel K, Fuchtenbusch M, Ziegler A-G. Early autoantibody responses in prediabetes are IgG1 dominated and suggest antigen-specific regulation. J Immunol 1999; 163: 525-532
7. Pozzilli P, Di Mario U. Autoimmune diabetes not requiring insulin at diagnosis (latent autoimmune diabetes of the adult). Diabetes Care 2001; 24: 1460-1467
8. Tuomi T, Carlsson A, Li H, Isomaa A, Miettinen A, Nissen M, Ehrnstrom B-J, Forsen B, Snickars B, Lahti K, Forsblom C, Saloranta C, Taskinen M-R, Groop LC. Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies. Diabetes 1999; 48: 150-157
9. Ng WY, Thai AC, Lui KF, Yeo PPB, Cheah JS. Systemic levels of cytokines and GAD-specific autoantibodies isotypes in Chinese IDDM patients. Diabetes Res Clin Pract 1999; 43: 127-135
10. Ng WY, Thai AC, Lui KF, Yeo PPB, Cheah JS. Non-restricted immunoglobulin-G subclass islet cell antibodies in Chinese. Autoimmunity 1993; 15:305-309
11. Lan MS, Lu J, Goto Y, Notkins AL. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2 from human insulinoma. DNA Cell Biol 1994; 13: 505-514
12. Lan MS, Wasserfall NK, Maclaren NH, Notkins AL. IA-2, a transmembranous protein of the protein tyrosine phosphatases family, is a major autoantigen in insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 1996; 93: 63-67
13. Zhang B, Lan M, Notkins A. Autoantibodies to IA-2 in IDDM: Location of major antigenic determinants. Diabetes 1997; 46: 40-43
14. Dozio N, Belloni C, Girardi AM, Genovese S, Sodoyez JC, Bottazzo GF, Pozza G, Bosi E. Heterogenous IgG subclass distribution of islet cell antibodies. J Autoimmun 1994; 7: 45-53
15. Millward A, Hussain MJ, Peakman M, Pyke DA, Leslie RD, Vergani D. Characterization of islet cell antibody in insulin dependent diabetes: Evidence for IgG1 subclass restriction and polyclonality. Clin Exp Immunol 1988; 71: 353-356
16. Schatz DA, Barrett DJ, Maclaren NK, Riley WJ. Polyclonal nature of islet cell antibodies in insulin-dependent diabetes. Autoimmunity 1988; 1: 45-50
17. Omar MA, Srikanta S, Eisenbarth GS. Human islet cell antibodies: Immunoglobulin class and subclass distribution defined by monoclonal antibodies. Diabetes Res 1987; 4: 155-157
18. Kasuga A, Shimada A, Ozawa Y, Maruyama T, Oya K, Satura T. IgG1 is the dominant subclass of antibody against glutamic acid decarboxylase among type 1 diabetes in Japanese. Endocr J 2000; 47: 57-62
19. Petersen JS, Kulmala P, Clausen JT, Knip M, Dyrberg T, and the Childhood Diabetes in Finland Study Group. Progression to type 1 diabetes is associated with a change in the immunoglobulin isotype profile of autoantibodies to glutamic acid decarboxylase (GAD65). Clin Immunol Immunopathol 1999; 90: 276-281
20. Couper JJ, Harrison LC, Aldis JJE, Colman PG, Honeyman MC, Ferrante A. IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetes. Hum Immunol 1998; 59: 493-499
21. Hawa M, Fava D, Medici F, Deng Y-J, Notkins AL, De Mattia G, Leslie RDG. Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes. Diabetes Care 2000; 23: 228-233
22. Seissler J, Elkamp K, Schott M, Scherbaum WA, DENIS Study Group. IA-2 autoantibodies restricted to the IgG4 subclass are associated with protection from type 1 diabetes. Horm Metab Res 2002; 34: 186-191
23. Lohmann T, Kellner K, Verlohren H-J, Krug J, Steindorf J, Scherbaum WA, Seissler J. Titre and combination of ICA and autoantibodies to glutamic acid decarboxylase discriminate two clinically distinct types of latent autoimmune diabetes in adults (LADA). Diabetologia 2001; 44: 1005-1010