Fast regulation of cytochrome P450 activities by phosphorylation and consequences for drug metabolism and toxicity

Biological Chemistry

Volumn 383, Issue 10, 2002, Pages 1587-1592

  Oesch Bartlomowicz, Barbara ^a   Oesch, Franz ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

cAMP; Drug metabolism; P450; Phosphorylation; Regulation

Indexed keywords

2 AMINOANTHRACENE; 2 FLUORENYLAMINE; ADENOSINE TRIPHOSPHATE; AROMATIC AMIDE; AROMATIC AMINE; CARCINOGEN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOPHOSPHAMIDE; CYTOCHROME P450; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2E1; FLUORENYLACETOHYDROXAMIC ACID; GLUCAGON; HORMONE; IFOSFAMIDE; ISOENZYME; N (2 FLUORENYL)ACETAMIDE; OKADAIC ACID; OXAZAPHOSPHORINE DERIVATIVE; PHENOBARBITAL; PHOSPHODIESTERASE INHIBITOR; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROMUTAGEN; PROTEIN KINASE INHIBITOR; THEOPHYLLINE; UNINDEXED DRUG; UNSPECIFIC MONOOXYGENASE; VANADIC ACID; DRUG;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; DRUG INTERACTION; HUMAN; METABOLISM; PHOSPHORYLATION; REVIEW;

ANIMALS; CARCINOGENS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; HORMONES; HUMANS; ISOENZYMES; PHARMACEUTICAL PREPARATIONS; PHOSPHORYLATION;

EID: 0036805785     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.179     Document Type: Article

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