Magnetic Resonance Imaging (MRI) as a method to investigate movement of water during the extrusion of pastes

Pharmaceutical Research

Volumn 16, Issue 5, 1999, Pages 666-671

  Tomer, Gil ^a   Newton, John Michael ^a   Kinchesh, Paul ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Extrusion; Magnetic resonance imaging (MRI); Spheronization; Water mapping; Water movement

Indexed keywords

ANALYTIC METHOD; ARTICLE; CRYSTALLIZATION; IMAGE PROCESSING; NUCLEAR MAGNETIC RESONANCE IMAGING; PASTE; PRIORITY JOURNAL; RELAXATION TIME; SAMPLING; SPHERONIZATION; TABLET MANUFACTURE; WATER CONTENT; WATER FLOW;

CELLULOSE; MAGNETIC RESONANCE SPECTROSCOPY; MICROSPHERES; OINTMENTS; PARABENS; SIGNAL PROCESSING, COMPUTER-ASSISTED; WATER;

EID: 0032912109     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018864322400     Document Type: Article

References (18)

1. 1 P. J. Harrison, J.M. Newton, and R.C. Rowe. The characterization of wet powder masses suitable for extrusion/spheronization. J. Pharm. Pharmacol. 37:686-691 (1985).
2. 2 K. E. Fielden, J. M. Newton, and R. C. Rowe. The effect of lactose particle size on the extrusion properties of microcrystalline cellulose-lactose mixtures. J. Pharm. Pharmacol. 41:217-221 (1989).
3. 3 L. Baert, J. P. Remon, P. Knight, and J. M. Newton. A comparison between the extrusion forces and spheres quality of a gravity feed extruder and a ram extruder. Int J. Pharm. 86:187-192 (1992).
4. 4 P. J. Harrison. Extrusion of wet powder masses. PhD Thesis, University of London. (1982)
5. 5 P. J. Harrison, J. M. Newton, and R. C. Rowe. Convergent flow analysis in the extrusion of wet powder masses. J. Pharm. Pharmacol. 36:796-798 (1984).
6. 6 P. T. Callaghan. Principles of nuclear magnetic resonance microscopy. Clarendon Press, Oxford, 1993: p. 79.
7. 7 G. C. Borgia, A. Brancolini, A. Camanzi, and G. Maddinelli. Capillary water determination in core plugs: a combined study based on imaging techniques and relaxation analysis. Magn. Res. Imag. 12:221-224 (1994).
8. 8 A. R. Rajabi-Sibboomi, R. W. Bowtell, A. Henderson, M. C. Davies, and C. D. Melia. Structure and behaviour in hydrophilic matrix systained release dosage forms: 2. NMR-imaging studies of dimensional changes in the gel layer and core of HPMC tablets undergoing hydration. J. Cont. Rel. 31:121-128 (1994).
9. 9 M. Kojima, S. Ando, K. Kataoka, T. Hirota, K. Aoyagi, and H. Nakagami. Magnetic resonance imaging (MRI) study of swelling and water mobility in micronized low-substituted hydroxypropylcellulose matrix tablets. Chem. Pharm. Bull. 46:324-328 (1998).
10. 10 T. M. Hyde, L. F. Gladden, and R. Payne. A nuclear magnetic resonance imaging study of the effect of incorporating a macromolecular drug in poly(glycolic acid-DL-lactic acid). J. Contr. Rel. 36:261-275 (1995).
11. 11 J. Gotz and H. Buggisch. NMR imaging of pastes in a ram extruder. J. Non-Newtonian Fluid Mech. 49:251-275 (1993).
12. 12 S. W. Sinton and A. W. Chow. NMR imaging for studies of suspension rheology. Paper presented at Society of Rheology, Sante Fe, NM. 21-25 October (1990).
13. 13 G. T. Gullberg, M. A. Simons, F. W. Wehrli, and D. N. G. Row. Time-of-flight NMR imaging of plug and laminar flow. SPIE physics and engineering of computerized multidimensional imaging and processing 671:314-319 (1990).
14. 14 C. K. Agemura, R. J. Kautenand, and K. L. McCarthy. Flow fields in straight and tapered screw extruders using magnetic resonance imaging. J. Food Eng. 25:55-72 (1995).
15. 15 L. F. Gladden. Nuclear magnetic resonance in chemical engineering: principles and applications. Chem. Eng. Sci. 49:3339-3408 (1994).
16. 16 A. Ovensten, J. J. Benbow. Effects of die geometry on extrusion. Trans. Br. Cer. Soc. 67:543-567 (1968).
17. 14N in solution. J. Magn. Reson. 97:208-212 (1992).
18. 18 J. P. Tordella. Unstable flow of molten polymers. In R. E. Frederick (ed.), RHEOLOGY: Theory and Application, Academic press: New-York and London, 1969, pp. 57-92.