Inhibition by nitric oxide-releasing compounds of prostacyclin production in human endothelial cells

British Journal of Pharmacology

Volumn 125, Issue 2, 1998, Pages 247-254

  Kosonen, Outi ^a,c   Kankaanranta, Hannu ^a,d   Malo Ranta, Ulla ^a   Ristimäki, Ari ^b   Moilanen, Eeva ^a,c  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d Department of Respiratory Medicine ^*  (Finland)

Author keywords

Cyclooxygenase (COX); Endothelial cells; Nitric oxide (NO); Nitric oxide releasing compounds; Prostacyclin

Indexed keywords

3 (3 CHLORO 2 METHYLPHENYL) 5 (4 METHYLBENZENESULFONYLIMINO) 1,2,3,4 OXATRIAZOLE; ARACHIDONIC ACID; LIPOPOLYSACCHARIDE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; PHOSPHOLIPASE; PROSTACYCLIN; PROSTAGLANDIN SYNTHASE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INFLAMMATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

CELLS, CULTURED; CYCLOOXYGENASE 2; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; EPOPROSTENOL; HUMANS; ISOENZYMES; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PENICILLAMINE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; TRIAZOLES;

EID: 0031666382     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702042     Document Type: Article

References (45)

1. AMIN, A.R., ATTUR, M., PATEL, R.N., THAKKER, G.D., MARSHALL, P.J., REDISKE, J., STUCHIN, S.A., PATEL, I.R. & ABRAMSON, S.B. (1997). Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. J. Clin. Invest., 99, 1231-1237.
2. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
3. CORELL, T., PEDERSEN, S.B., LISSAU, B., MOILANEN, E., METSÄ-KETELÄ, T., KANKAANRANTA, H., VUORINEN, P., VAPAATALO, H., RYDELL, E., ANDERSSON, R., MARCINKIEWICZ, E., KORBUT, R. & GRYGLEWSKI, R.J. (1994). Pharmacology of mesoionic oxatriazole derivatives in blood, cardiovascular and respiratory systems. Pol. J. Pharmacol., 46, 553-566.
4. CURTIS, J.F., REDDY, N.G., MASON, R.P., KALYANARAMAN, B. & ELING, T.E. (1996). Nitric oxide: a prostaglandin H synthase 1 and 2 reducing cosubstrate that does not stimulate cyclooxygenase activity or prostaglandin H synthase expression in murine macrophages. Arch. Biochem. Biophys., 335, 369-376.
5. DAVIDGE, S.T., BAKER, P.N., MCLAUGHLIN, M.K. & ROBERTS, J.M. (1995). Nitric oxide produced by endothelial cells increases production of eicosanoids through activation of prostaglandin H synthase. Circ. Res., 77, 274-283.
6. DEWITT, D.L. (1991). Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim. Biophys. Acta., 1083, 121-134.
7. FEELISCH, M. (1993). Biotransformation to nitric oxide of organic nitrates in comparison to other nitrovasodilators. Eur. Heart. J., 14 (suppl. I), 123-132.
8. FRANCHI, A.M., CHAUD, M., RETTORI, V., SUBURO, A., MCCANN, S.M. & GIMENO, M. (1994). Role of nitric oxide in eicosanoid synthesis and uterine motility in estrogen-treated rat uteri. Proc. Natl. Acad. Sci. U.S.A., 91, 539-543.
9. FUTAKI, N., TAKAHASHI, S., YOKOYAMA, M., ARAI, I., HIGUCHI, S. & OTOMO, S. (1994). NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins, 47, 55-59.
10. GREEN, L.C., WAGNER, D.A., GLOWGOWSKI, J., SKEEPER, P.L., WISHNOK, J.S. & TANNENBAUM, S.R. (1982). Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Anal. Biochem., 124, 131-138.
11. HAJJAR, D.P., LANDER, H.M., PEARCE, S.F.A., UPMACIS, R.K. & POMERANTZ, K.B. (1995). Nitric oxide enhances prostaglandin-H synthase-1 activity by a heme-independent mechanism: evidence implicating nitrosothiols. J. Am. Chem. Soc., 117, 3340-3346.
12. HENRY, Y., LEPOIVRE, M., DRAPIER, J.-C., DUCROCQ, C., BOUCHER, J.-L. & GUISSANI, A. (1993). EPR characterization of molecular targets for NO in mammalian cells and organelles. FASEB J., 7, 1124-1134.
13. HLA, T., RISTIMÄKI, A., APPLEBY, S. & BARRIOCANAL, J.G. (1993). Cyclooxygenase gene expression in inflammation and angiogenesis. Ann. N.Y. Acad. Sci., 696, 197-204.
14. IGNARRO, L.J. (1991). Signal transduction mechanisms involving nitric oxide. Biochem. Pharmacol., 41, 485-490.
15. JÄRVINEN, T.A.H., MOILANEN, T., JÄRVINEN, T.L.N. & MOILANEN, E. (1995). Nitric oxide mediates interleukin-1-induced inhibition of glycosaminoglycan synthesis in rat articular cartilage. Med. Inflammation, 4, 107-111.
16. JÄRVINEN, T.A.H., MOILANEN, T., JÄRVINEN, T.L.N. & MOILANEN, E. (1996). Endogenous nitric oxide and prostaglandin E2 do not regulate the synthesis of each other in interleukin-1β-stimulated rat articular cartilage. Inflammation, 20, 683-692.
17. KANKAANRANTA, H., RYDELL, E., PETERSSON, A.S., HOLM, P., MOILANEN, E., CORELL, T., KARUP, G., VUORINEN, P., PEDERSEN, S.B., WENNMALM Å & METSÄ-KETELÄ, T. (1996). Nitric oxide-donating properties of mesoionic 3-aryl substituted oxatriazole-5-imine derivatives. Br. J. Pharmacol., 117, 401-406.
18. KARUP, G., PREIKSCHAT, H., WILHELMSEN, E.S., PEDERSEN, S.B., MARCINKIEWICZ, E., CIESLIK, K. & GRYGLEWSKI, R.J. (1994). Mesoionic oxatriazole derivatives - a new group of NO-donors. Pol. J. Pharmacol., 46, 541-552.
19. KARTHEIN, R., NASTAINCZYK, W. & RUF, H.H. (1987). EPR Study of ferric native prostaglandin H synthase and its ferrous NO derivative. Eur. J. Biochem., 166, 173-180.
20. KNOWLES, R.G. & MONCADA, S. (1994). Nitric oxide synthases in mammals. Biochem. J., 298, 249-258.
21. KOSONEN, O., KANKAANRANTA, H., VUORINEN, P. & MOILANEN, E. (1997). Inhibition of human lymphocyte proliferation by nitric oxide-releasing oxatriazole derivatives. Eur. J. Pharmacol., 337, 55-61.
22. MALO-RANTA, U., YLÄ-HERTTUALA, S., METSÄ-KETELÄ, T., JAAKKOLA, O., MOILANEN, E., VUORINEN, P. & NIKKARI, T. (1994). Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein. FEBS Lett., 337, 179-183.
23. MINGHETTI, L., POLAZZI, E., NICOLINI, A., CREMINON, C. & LEVI, G. (1996). Interferon-γ and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression. J. Neurochem., 66, 1963-1970.
24. MOILANEN, E., AROLA, O., MALO-RANTA, U., YLÄ-HERTTUALA, S., VUORINEN, P., METSÄ-KETELÄ, T. & VAPAATALO, H. (1994). Nitric oxide donors inhibit neutrophil adhesion to endothelial cells. In The Biology of Nitric Oxide. ed. Moncada, S., Feelisch, M., Busse, R. & Higgs, E.A. Vol. 4, pp. 271-275. London: Portland Press.
25. MOILANEN, E., MOILANEN, T., KNOWLES, R., CHARLES, I., KADOYA, Y., AL-SAFFAR, N., REVELL, P.A. & MONCADA, S. (1997). Nitric oxide synthase is expressed in human macrophages during foreign body inflammation. Am. J. Pathol., 150, 881-887.
26. MOILANEN, E., VUORINEN, P., KANKAANRANTA, H., METSÄ-KETELÄ, T. & VAPAATALO, H. (1993). Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions. Br. J. Pharmacol., 109, 852-858.
27. MONCADA, S. & HIGGS, E.A. (1995). Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J., 9, 1319-1330.
28. MOSSALAYI, M.D., PAUL-EUGENE, N., OUAAZ, F., AROCK, M., KOLB, J.P., KILCHHERR, E., DEBRE, P. & DUGAS, B. (1994). Involvement of FcεRII/CD23 and L-arginine-dependent pathway in IgE-mediated stimulation of human monocyte functions. Int Immunol., 6, 931-934.
29. MURPHY, M.E. & NOACK, E. (1994). Nitric oxide assay using hemoglobin method. Methods Enzymol., 233, 240-250.
30. NATHAN, C. (1992). Nitric oxide as a secretory product of mammalian cells. FASEB. J., 6, 3051-3064.
31. O'BANION, M.K., WINN, V.D. & YOUNG, D.A. (1992). cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc. Natl. Acad. Sci. U.S.A., 89, 4888-4892.
32. ROSENKRANZ-WEISS, P., SESSA, W.C., MILSTIEN, S., KAUFMAN, S., WATSON, C.A. & POBER, J.S. (1994). Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. J. Clin. Invest., 93, 2236-2243.
33. SAKURAI, H., KOHSAKA, H., LIU, M.K., HIGASHIYAMA, H., HIRATA, Y., KANNO, K., SAITO, I. & MIYASAKA, N. (1995). Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. J. Clin. Invest., 96, 2357-2363.
34. SALVEMINI, D., CURRIE, M.G. & MOLLACE, V. (1996). Nitric oxide-mediated cyclooxygenase activation. J. Clin. Invest., 97, 2562-2568.
35. STADLER, J., HARBRECHT, B.G., DI SILVIO, M., CURRAN, R.D., JORDAN, M.L., SIMMONS, R.L. & BILLIAR T.R. (1993). Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells. J. Leukoc. Biol., 53, 165-172.
36. SWIERKOSZ, T.A., MITCHELL, J.A., WARNER, T.D., BOTTING, R.M. & VANE, J.R. (1995). Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids. Br. J. Pharmacol., 114, 1335-1342.
37. TETSUKA, T., DAPHNA-IKEN, D., MILLER, B.W., GUAN, Z., BAIER, L.D. & MORRISON, A.R. (1996). Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells. J. Clin. Invest., 97, 2051-2056.
38. 2 negatively modulates induction of nitric oxide synthase by interleukin-1. Proc. Natl. Acad. Sci. U.S.A., 91, 12168-12172.
39. THOMSEN, L.L., MILES, D.W., HAPPERFIELD, L., BOBROW, L.G., KNOWLES, R.G. & MONCADA, S. (1995). Nitric oxide synthase activity in human breast cancer. Br. J. Cancer, 72, 41-44.
40. TSAI, A.L., WEI, C. & KULMACZ, R.J. (1994). Interaction between nitric oxide and prostaglandin H synthase. Arch. Biochem. Biophys., 313, 367-372.
41. VANE, J.R., ÄNGGÅRD, E.E. & BOTTING, R.M. (1990). Regulatory functions of the vascular endothelium. N. Engl. J. Med., 323, 27-36.
42. VILPO, J.A., VILPO, L.M., VUORINEN, P., MOILANEN, E. & METSÄ-KETELÄ, T. (1994). Cytotoxicity of mesoionic oxatriazoles: a novel series of nitric oxide donors. In The Biology of Nitric Oxide. ed. Moncada, S., Feelisch, M., Busse, R. & Higgs, E.A. Vol. 4, pp. 286-291. London: Portland Press.
43. VIRTA, M., KARP, M. & VUORINEN, P. (1994). Nitric oxide donor-mediated killing of bioluminescent Escherichia coli. Antimicrob. Agents Chemother., 38, 2775-2779.
44. VOULDOUKIS, I., RIVEROS-MORENO, V., DUGAS, B., OUAAZ, F., BECHEREL, P., DEBRE, P., MONCADA, S. & MOSSALAYI, M.D. (1995). The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fcε/CD23 surface antigen. Proc. Natl. Acad. Sci. U.S.A., 92, 7804-7808.
45. ZIMMERMAN, G.A., WHATLEY, R.E., MCINTYRE, T.M., BENSON, D.M. & PRESCOTT, S.M. (1990). Endothelial cells for studies of platelet-activating factor and arachidonate metabolites. Methods Enzymol., 187, 520-527.