High resolution mapping of quantitative trait loci by linkage disequilibrium analysis

European Journal of Human Genetics

Volumn 10, Issue 10, 2002, Pages 607-615

  Fan, Ruzong ^a,b   Xiong, Momiao ^c  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

High resolution mapping; Linkage disequilibrium mapping; Linkage mapping; QTL

Indexed keywords

ARTICLE; CHROMOSOMAL LOCALIZATION; CONSTANTS AND COEFFICIENTS; CONTROLLED STUDY; DNA FLANKING REGION; FAMILY STUDY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; HERITABILITY; HUMAN; INTERMETHOD COMPARISON; LINEAR REGRESSION ANALYSIS; LINKAGE ANALYSIS; MARKER GENE; POPULATION RESEARCH; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; QUANTITATIVE TRAIT LOCUS MAPPING; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL;

CHROMOSOME MAPPING; COMPUTATIONAL BIOLOGY; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; QUANTITATIVE TRAIT LOCI; REGRESSION ANALYSIS;

EID: 0036802676     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200843     Document Type: Article

References (27)

1. Schork NJ: Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. Am J Hum Genet 1993; 53: 1306-1319.
2. Fulker DW, Cardon LR: A sib-pair approach to interval mapping of quantitative trait loci. Am J Hum Genet 1994; 54: 1092-1103.
3. Fulker DW, Cherny SS, Cardon LR: Multipoint interval mapping of quantitative trait loci, using sibpairs. Am J Hum Genet 1995; 56: 1224-1233.
4. Almasy L, Blangero J: Multipoint quantitative trait linkage analysis in general pedigrees. Am J Hum Genet 1998; 62: 1198-1211.
5. Liang KY, Huang CY, Beaty TH: A unified sampling approach for multipoint analysis of qualitative and quantitative traits in sibs. Am J Hum Genet 2000; 66: 1631-1641.
6. Pratt SC, Daly M, Kruglyak L: Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components. Am J Hum Genet 2000; 66: 1153-1157.
7. Abecasis GR, Cardon LR, Cookson WOC: A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000; 66: 279-292.
8. Fulker DW, Cherny SS, Sham PC, Hewitt JK: Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet 1999; 64: 259-267.
9. Sham PC, Cherny SS, Purcell S, Hewitt JK: Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. Am J Hum Genet 2000; 66: 1616-1630.
10. Zhao J, Li W, Xiong M: Population based linkage disequilibrium mapping of QTL: an application to simulated data in an isolated population. Genetic Epidemiology 2001; 21 (S1): S655-S659.
11. The International SNP Map Working Group: A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 2001; 409: 928-933.
12. Hartl DL, Clark AG: Principles of Population Genetics. 2nd edn. Sunderland, MA: Sinauer Associates, 1989.
13. Hedrick PW: Gametic disequilibrium measures: proceed with caution. Genetics 1987; 117: 331-341.
14. Lewontin RC: The interaction of selection and linkage. I. General considerations; heterotic models. Genetics 1964; 49: 67.
15. Jacquard A: The Genetic Structure of Populations. New York: Springer-Verlag, 1974.
16. Falconer DS, Mackay TFC: Introduction to Quantitative Genetics. 4th edn. London: Longman, 1996.
17. Graybill FA: Theory and Application of the Linear Model. California: Pacific Grove, 1976.
18. Cardon LR, Bell J: Association study designs for complex diseases. Nature Reviews Genetics 2001; 2: 91-99.
19. Risch N, Merikangas K: The future of genetic studies of complex human diseases. Science 1996; 273: 1516-1517.
20. Amos C, Andrade MD: Genetic linkage methods for quantitative traits. Statistical Methods in Medical Research 2001; 10: 3-25.
21. Goldgar DE: Multipoint analysis of human quantitative genetic variation. Amr J Hum Genet 1990; 47; 957-967.
22. Haley CS, Knott SA: A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 1992; 69: 315-324.
23. Jansen RC: Interval mapping of multiple quantitative trait loci. Genetics 1993; 135: 205-211.
24. Xu SZ, Atchley WR: A random model approach to interval mapping of quantitative trait loci. Genetics 1995; 141: 1189-1197.
25. Zeng ZB: Precision mapping of quantitative trait loci. Genetics 1994; 136: 1457-1468.
26. Allison DB, Heo M, Kaplan N, Martin ER: Sibling-based tests of linkage and association for quantitative traits. Am J Hum Genet 1999; 64: 1754-1764.
27. Göring HHH, Terwillinger JD: Linkage analysis in the presence of error IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified. Am J Hum Genet 2000; 66