P-glycoprotein as a therapeutic target: Good news [7]

Leukemia

Volumn 16, Issue 10, 2002, Pages 2169-2170

  Shitl, A A ^a  

^a N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; GLUCOSYLCERAMIDE; GLYCOPROTEIN P; VALSPODAR; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER; CELL DEATH; CELL MEMBRANE; CELL SURVIVAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SELECTIVITY; DRUG TARGETING; HUMAN; LETTER; LEUKEMIA CELL; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; TREATMENT FAILURE;

EID: 0036798452     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402664     Document Type: Letter

References (8)

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2. van Helvoort A, Smith AJ, Sprong H, Fritzsche I, Schinkel A, Borst P, van Meer G. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 1996; 87: 507-517.
3. Ambudkar SV, Dey S, Hrycyna CA. Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 1999; 39: 361-398.
4. Laurent G, Jaffrézou J-P. Signaling pathways activated by daunorubicin. Blood 2001; 98: 913-924
5. Senchenkov A, Litvak DA, Cabot MC. Targeting ceramide metabolism - a strategy for overcoming drug resistance. J Natl Cancer Inst 2001; 93: 347-357.
6. Nicholson KM, Quinn DM, Kellet GL, Warr JR. Preferential killing of multidrug-resistant KB cells by inhibitors of glucosylceramide synthase. Br J Cancer 1999; 81: 423-430.
7. Shtil AA. Signal transduction pathways and transcriptional mechanisms as targets for prevention of emergence of multidrug resistance in human cancer cells. Curr Drug Targets 2001; 2: 57-77.
8. Johnstone RW, Tainton KM, Ruefli AA, Froelich CJ, Cerruti L, Jane SM, Smyth MJ. P-glycoprotein does not protect cells agaisnt cytolysis induced by pore-forming proteins. J Biol Chem 2001; 276: 16667-16673.