Elasticity analysis and design for large metabolic responses produced by changes in enzyme activities

Biochemical Journal

Volumn 367, Issue 1, 2002, Pages 41-48

  Ortega, Fernando ^a   Acerenza, Luis ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

Metabolic control analysis; Metabolic control design

Indexed keywords

BIOLOGICAL ORGANS; CELLS; ELASTICITY;

KETOGENESIS;

ENZYMES;

ANALYTIC METHOD; ARTICLE; ELASTICITY; ENZYME ACTIVITY; KETOGENESIS; LINEAR SYSTEM; LIVER MITOCHONDRION; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; REACTION ANALYSIS; STEADY STATE; STOICHIOMETRY; ANIMAL; CHEMISTRY; KINETICS; METABOLISM; PHYSIOLOGY; RAT; THEORETICAL MODEL;

ENZYME; KETONE;

ANIMALS; ENZYMES; KETONES; KINETICS; METABOLISM; MITOCHONDRIA, LIVER; MODELS, THEORETICAL; RATS;

EID: 0036796388     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020520     Document Type: Article

References (43)

1. Kacser, H. and Burns, J. A. (1973) The control of flux. Symp. Soc. Exp. Biol. 27, 65-104
2. Heinrich, R. and Rapoport, T. A. (1974) A linear steady-state treatment of enzymatic chains: general properties, control and effector strength. Eur. J. Biochem. 42, 89-95
3. Cornish-Bowden, A. and Cárdenas, M. L. (eds) (2000) Technological and Medical Implications of Metabolic Control Analysis, Kluwer Academic Publishers, Dordrecht
4. Cornish-Bowden, A. and Cárdenas, M. L. (eds) (1990) Control of Metabolic Processes, Plenum Press, New York
5. Heinrich, R. and Schuster, S. (1996) The Regulation of Cellular Systems, Chapman & Hall, New York
6. Fell, D. A. (1997) Understanding the Control of Metabolism, Portland Press, London
7. Reder, C. (1988) Metabolic control theory: a structural approach. J. Theor Biol. 135, 175-201
8. Kacser, H., Sauro, H. M. and Acerenza, L. (1990) Enzyme-enzyme interactions and control analysis. 1. The case of non-additivity: monomer-oligomer associations. Eur. J. Biochem. 187, 481-491
9. Sauro, H. M. and Kacser, H. (1990) Enzyme-enzyme interactions and control analysis. 2. The case of non-independence: heterologous associations. Eur. J. Biochem. 187, 493-500
10. Cascante, M., Franco, R. and Canela, E. I. (1989) Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. I. Unbranched pathways. Math. Biosci. 94, 271-288
11. Cascante, M., Franco, R. and Canela, E. I. (1989) Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. II. Complex systems. Math. Biosci. 94, 289-309
12. Acerenza, L. (1993) Metabolic control design. J. Theor. Biol. 165, 63-85
13. Acerenza, L. (1996) Sensitivity constraints in a chemical/biochemical highly responsive system. BioSystems 39, 109-116
14. Acerenza, L. (1996) How constrained is metabolic control? J. Theor. Biol. 182, 277-283
15. Acerenza, L. (2000) Metabolic control design: implications and applications. In Technological and Medical Implications of Metabolic Control Analysis (Cornish-Bowden, A. and Cárdenas, M. L., eds.), pp. 275-282, Kluwer Academic Publishers, Dordrecht
16. Ortega, F. and Acerenza, L. (1997) Design of a monocyclic cascade with a high sensitivity of response. In Biological Complexity (Mizraji, E., Acerenza, L., Alvarez, F. and Pomi, A., eds.), pp. 75-82, Ediciones de la Facultad de Ciencias, Montevideo
17. Ortega, F. and Acerenza, L. (1998) Optimal metabolic control design. J. Theor. Biol. 191, 439-449
18. Ortega, F., Acerenza, L., Westerhoff, H. V., Mas, F. and Cascante, M. (2002) Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades. Proc. Natl. Acad. Sci. U.S.A. 99, 1170-1175
19. Westerhoff, H. V., Hofmeyr, J.-H. S. and Kholodenko, B. N. (1994) Getting to the inside of cells using metabolic control analysis. Biophys. Chem. 50, 273-283
20. Hue, L. (2000) From control to regulation: a new prospect for metabolic control analysis. In Technological and Medical Implications of Metabolic Control Analysis (Cornish-Bowden, A. and Cárdenas, M. L., eds.), pp. 329-338, Kluwer Academic Publishers, Dordrecht
21. Kacser, H. and Acerenza, L. (1993) A universal method for achieving increases in metabolite production. Eur. J. Biochem. 216, 316-367
22. Acerenza, L. (2000) On the universality of the universal method. In Technological and Medical Implications of Metabolic Control Analysis (Cornish-Bowden, A. and Cárdenas, M. L., eds.), pp. 33-37. Kluwer Academic Publishers, Dordrecht
23. Fell, D. A. and Thomas, S. (1995) Physiological control of flux: the requirement for multisite modulation. Biochem. J. 311, 35-39
24. Acerenza, L. (2000) Design of large metabolic responses. Constraints and sensitivity analysis. J. Theor. Biol. 207, 265-282
25. Höfer, T. and Heinrich, R (1993) A second-order approach to metabolic control analysis. J. Theor. Biol. 164, 85-102
26. Small, J. R. and Kacser, H. (1993) Responses of metabolic system to large changes in enzyme activities and effectors. 1. The linear treatment of unbranched chains. Eur. J. Biochem. 213, 613-624
27. Small, J. R. and Kacser, H. (1993) Responses of metabolic system to large changes in enzyme activities and effectors. 2. The linear treatment of branched pathways and metabolite concentrations: assessment of the general non-linear case. Eur. J. Biochem. 213, 625-640
28. de Atauri, P., Acerenza, L., Kholodenko, B. N., de la Iglesia, N., Guinovart, J. J., Agius, L. and Cascante, M. (2001) Occurrence of paradoxical or sustained control by an enzyme when overexpressed: necessary conditions and experimental evidence in the case of hepatic glucokinase. Biochem. J. 355, 787-793
29. Thomas, S., Mooney, P. J. F., Burrell, M. M. and Fell, B. A. (1997) Finite change analysis of glycolytic intermediates in tuber tissue of lines of transgenic potato (Solanum tuberosum) overexpressing phosphofructokinase. Biochem. J. 322, 111-117
30. Burns, J. A., Cornish-Bowden, A., Groen, A. K., Heinrich, R., Kacser, H., Porteous, J. W., Rapoport, S. M., Rapoport, T. A., Stucki, J. W., Tager, J. M. et al. (1985) Control analysis of metabolic systems. Trends Biochem. Sci. 10, 16
31. Acerenza, L. and Kacser, H. (1990) Enzyme kinetics and metabolic control: a method to test and quantify the effect of enzymic properties on metabolic variables. Biochem. J. 269, 697-707
32. Westerhoff, H. V. and Chen, Y.-D. (1984) How do enzyme activities control metabolite concentrations? An additional theorem in the theory of metabolic control. Eur. J. Biochem. 142, 425-430
33. Brown, G. C., Hafner, R. P. and Brand, M. D. (1990) A 'top-down' approach to the determination of control coefficients in metabolic control theory. Eur. J. Biochem. 188, 321-325
34. Brand, M. D. (1996) Top-down metabolic control analysis. J. Theor. Biol. 182, 351-360
35. Schuster, S., Kahn, D. and Westerhoff, H. V. (1993) Modular analysis of the control of complex metabolic pathways. Biophys. Chem. 48, 1-17
36. Hofmeyr, J.-H. S. and Cornish-Bowden, A. (1991) Quantitative assessment of regulation in metabolic systems. Eur. J. Biochem. 200, 223-236
37. Goldbeter, A. and Koshland, Jr, D. E. (1982) Sensitivity amplification in biochemical systems. Q. Rev. Biophys. 15, 555-591
38. Quant, P. A., Robin, D., Robin, P., Girard, J. and Brand, M. D. (1993) A top-clown control analysis in isolated rat liver mitochondria: can the 3-hydroxi-3-methylglutaryl-CoA pathway be rate-controlling for ketogenesis? Biochim. Biophys. Acta 1156, 135-143
39. Quant, P. A. (1993) Experimental application of top-down control analysis to metabolic systems. Trends Biochem. Sci. 18, 26-30
40. Kholodenko, B. N. and Brown, G. C. (1996) Paradoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control? Biochem. J. 314, 753-760
41. Rohwer, J. M., Schuster, S, and Westerhoff, H. V. (1996) How to recognise monofunctional units in a metabolic system. J. Theor. Biol. 179, 213-228
42. Acerenza, L. and Cornish-Bowden, A. (1997) Generalization of the double modulation method for in situ determination of elasticities. Biochem. J. 327, 217-223
43. Ainscow, E. K. and Brand, M. D. (1999) Top-down control analysis of ATP turnover, glycolysis and oxidative phosphörylation in rat hepatocytes. Eur. J. Biochem. 263, 671-685