Mechanisms of action of midazolam on expression of contextual fear in rats

British Journal of Anaesthesia

Volumn 89, Issue 4, 2002, Pages 614-621

  Pain, L ^a,b,c   Launoy, A ^a   Fouquet, N ^b   Oberling, P ^b  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^b INSERM   (France)

^c UNIVERSITY OF VERMONT   (United States)

Author keywords

Hypnotics, benzodiazepine, midazolam; Memory; Model, rat; Psychological responses

Indexed keywords

MIDAZOLAM; SODIUM CHLORIDE;

AFFECT; AMNESIA; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; AVERSION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EMOTIONALITY; FEAR; LOCOMOTION; MALE; MEMORY; MOTOR DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; TASK PERFORMANCE; TRANQUILIZING ACTIVITY;

EID: 0036795604     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aef228     Document Type: Article

References (43)

1. Tinnin L. Conscious forgetting and subconscious remembering of pain. J Clin Ethics 1994; 5: 151-152
2. Andrade J. Learning during anaesthesia: a review. Br J Psychol 1995; 86: 479-506
3. Ghoneim MM, Block RI. Learning and memory during general anesthesia: an update. Anesthesiology 1997; 87: 387-410
4. Osterman JE, van der Kolb BA. Awareness during anesthesia and posttraumatic stress disorder. Gen Hosp Psychiatry 1998; 20: 274-81
5. Ghoneim MM, Melwaldt SP. Benzodiazepines and human memory: review. Anesthesiology 1990; 72: 926-38
6. Lister RG. The amnesic action of benzodiazepines in man. Neurosci Biobehav Rev 1985; 9: 87-94
7. Thiébot MH. Some evidence for amnesic-like effects of benzodiazepines in animals. Neurosci Biobehav Rev 1985; 9: 95-100
8. Borde N, Krazem A, Jaffard R, Beracochea DJ. Memory deficits following diazepam administration in mice: evidence for a time-dependent retrieval impairment. Psychobiology 1997; 25: 202-9
9. Curran HV. Benzodiazepines, memory and mood: a review. Psychopharmacology 1991; 105: 1-8
10. Blaney PH. Affect and memory: a review. Psychol Bull 1986; 99: 229-46
11. Eich E. Searching for mood dependent memory. Psychol Sci 1995; 6: 67-75
12. Veselis B, Reinsel R, Alagesan R, Heino R, Bedford R. The EEG as a monitor of midazolam amnesia: changes in power and topography as a function of amnesic state. Anesthesiology 1991; 74: 866-74
13. Polster MR, McCarthy RA, O'Sullivan G, Gray PA, Park GR. Midazolam-induced amnesia: implications for the implicit/explicit memory distinction. Brain Cogn 1993; 22: 244-65
14. Thomas-Anterion C, Koening O, Navez M, Laurent B. Midazolam effects on implicit and explicit memory processes in healthy subjects. Psychopharmacology 1999; 145: 139-43
15. Hirshman E, Passanante A, Arndt J. The effect of midazolam on the modality-match effect in implicit memory. Brain Res Cogn Brain Res 1999; 7: 473-9
16. Salonen M, Onaivi ES, Maze M. Dexmedetomidine synergism with midazolam in the elevated plus-maze test in rats. Psychopharmacology 1992; 108: 229-34
17. Pain L, Oberling P, Sandner G, Di Scala G. Effect of midazolam on propofol-induced pleasant affective state as assessed by place conditioning paradigm in rats. Anesthesiology 1997; 87: 935-44
18. Pearce JM, Bouton ME. Theories of associative learning in animals. Annu Rev Psychol 2001; 52: 111-39
19. Ohman A, Mineka S. Fears, phobias, and preparedness: toward an evolved module of fear and fear learning. Psychol Rev 2001; 3: 483-522
20. Bouton ME, Mineka S, Barlow DH. A modern learning theory perspective on the etiology of panic disorder. Psychol Rev 2001; 108: 4-32
21. Davis M. The role of the amygdala in conditioned fear. In: Aggleton JP, ed. The Amygdala: Neurobiological Aspects of Emotion, Memory and Mental Dysfunction. New York: Wiley-Liss 1992; 255-305
22. Mora PD, Fouquet N, Oberling P, Gobaille S, Graeff FG, Sandner G. A neurotoxic lesion of serotoninergic neurons using 5,7-dihydroxytryptamine does not disrupt latent inhibition in paradigms sensitive to low doses of amphetamine. Behav Brain Res 1999; 100: 167-75
23. Pain L, Oberling P, Launoy A, Di Scala G. Effect of non sedative doses of propofol on an innate anxiogenic situation in rats. Anesthesiology 1999; 90: 191-6
24. Grahame NJ, Barnet RC, Gunther LM, Miller RR. Latent inhibition as a performance deficit resulting from CS-context associations. Anim Learn Behav 1994; 22: 395-408
25. Oberling P, Gosselin O, Miller RR. Latent inhibition in animals as a model of acute schizophrenia: a reanalysis. In: Haug M, Whalen RE, eds. Animal Models of Human Emotion and Cognition. Washington DC American Psychological Association, 1999; 87-102
26. Harris JA, Westbrook RF. Midazolam impairs the acquisition of conditioned analgesia if rats are tested with an acute but not a chronic noxious stimulus. Brain Res Bull 1996; 39: 227-33
27. Zacny JP, Coalson D, Young C et al. A dose-response study of the effects of intravenous midazolam on cold pressor-induced pain. Anesth Analg 1995; 80: 521-5
28. Feldon J, Weiner I. Abolition of the acquisition but not the expression of latent inhibition by chlordiazepoxide in rats. Pharmacol Biochem Behav 1989; 32: 123-7
29. A transmission. Pharmacol Biochem Behav 2000; 4: 893-901
30. Harris JA, Westbrook RF. Contextual control over the expression of fear in rats conditioned under a benzodiazepine. Psychopharmacology 2001; 156: 92-7
31. Colpaert FC. Amnesic trace locked into the benzodiazepine state of memory. Psychopharmacology 1990; 102: 28-36
32. Bouton ME, Kenney FA, Rosengard C. State-dependent fear extinction with two benzodiazepine tranquilizers. Behav Neurosci 1990; 104: 44-55
33. File SE, Goodall EM, Mabbutt PS, Harris A, Skelly AM. State-dependent retrieval and midazolam. Human Psychopharmacol 1993; 8: 243-51
34. Killcross S, Balleine B. Role of primary motivation in stimulus preexposure effects. J Exp Psychol Anim Behav Process 1996; 22: 32-42
35. Nadin G, Coulthard P. Memory and midazolam conscious sedation. Br Dent J 1997; 183: 399-407
36. Wagner BK, O'Hara DA, Hammond JS. Drugs for amnesia in the ICU. Am J Crit Care 1997; 6: 192-201
37. Henderson A, Dipplesman J, Miller J. Failure of intravenous low dose to influence memory recall in drug paralysed post-operative patients sedated with papaveretum. Aust Crit Care 1994; 7: 22-4
38. Glass PS, Bloom M, Kearse L, Rosow C, Sebel P, Manberg P. Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers. Anesthesiology 1997; 86: 836-47
39. Thompson JM, Neave N, Moss MC, Scholey AB, Wesnes K, Girdler NM. Cognitive properties of sedation agents: comparison of the effects of nitrous oxide and midazolam on memory and mood. Br Dent J 1999; 187: 557-62
40. Ghoneim MM, Block RI, Ping ST, el-Zahaby HM, Hinrichs JV. The interactions of midazolam and flumazenil on human memory and cognition. Anesthesiology 1993; 79: 1183-92
41. Veselis RA, Reinsel RA, Feshenko VA, Wronski M. The comparative amnestic effects of midazolam, propofol, thiopental, and fentanyl at equisedative concentrations. Anesthesiology 1997; 87: 734-6
42. Rammsayer TH, Rodewald S, Groh D. Dopamine-antagonistic, anticholinergic, and GABAergic effects on declarative and procedural memory functions. Brain Res Cogn Brain Res 2000; 9: 61-71
43. Salinas JA, Dickinson-Anson H, McGaugh JL. Midazolam administered to rats induces anterograde amnesia for changes in reward magnitude. Behav Neurosci 1994; 108: 1059-64