Comparative effects of loratadine and terfenadine on cardiac K+ channels

Journal of Cardiovascular Pharmacology

Volumn 30, Issue 1, 1997, Pages 42-54

  Ducic, I ^a   Ko, C M ^a   Shuba, Y ^a   Morad, M ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Delayed rectifier; H1 receptor antagonists (loratadine, descarboethoxyloratadine, terfenadine); HERG expressed in oocytes; Inward rectifier; Transient outward K+ channel; Ventricular myocytes

Indexed keywords

DESLORATADINE; LORATADINE; POTASSIUM CHANNEL; TERFENADINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; GUINEA PIG; HEART MUSCLE CELL; MALE; NONHUMAN; OOCYTE; PATCH CLAMP; PRIORITY JOURNAL; QT INTERVAL; RAT; XENOPUS LAEVIS;

ANIMALS; CATION TRANSPORT PROTEINS; ETHER-A-GO-GO POTASSIUM CHANNELS; GENE EXPRESSION; GUINEA PIGS; HEART VENTRICLES; HISTAMINE H1 ANTAGONISTS; LORATADINE; MALE; MEMBRANE POTENTIALS; MYOCARDIUM; OOCYTES; PATCH-CLAMP TECHNIQUES; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PYRIDINES; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; TERFENADINE; XENOPUS LAEVIS;

EID: 0030657531     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199707000-00007     Document Type: Article

References (30)

1. Craft TM. Torsades de pointes after astemizole overdose. Br Med J 1985;292:660-5.
2. Monohan BP, Ferguson CL, Killeavy ES, Lloyd BK, Troy J, Cantilena LR. Torsade de pointes occurring in association with terfenadine use. JAMA 1990;264:2788-90.
3. Bishop RO, Gaudry PL. Prolonged QT interval following astemizole overdose. Arch Emerg Med 1989;6:63-5.
4. Leor J, Harman M, Rabinovitz B, Mozes B. Giant U waves and associated ventricular tachycardia complicating astemizole overdose. Am J Med 1991;91:94-7.
5. 1 antagonists: comparative studies with loratadine, terfenadine and sedating antihistamines in guinea pigs. Clin Exp Allergy 1994; 93:163-71.
6. Woosley RL, Chen Y, Freiman JP, Gillis RA. Mechanism of the cardiotoxic actions of terfenadine. JAMA 1993;269:1532-6.
7. Rampke D, Wible B, Brown AM, Dage RC. Effects of terfenadine and its metabolites on a delayed rectifier K channel cloned from human heart. Mol Pharmacol 1994;44:1240-5.
8. Berul B, Morad M. Regulation of potassium channels by nonsedating antihistamines. Circulation 1995;91:2220-5.
9. 1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Circ Res 1995;76: 110-9.
10. Mitra R, Morad M. A uniform enzymatic method for the dissociation of myocytes from heart and stomach of vertebrates. Am J Physiol 1985;249:1056-60.
11. Hammil OP, Marty A, Neher E, Sakman B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981;391: 85-100.
12. Fabiato A. Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands. Methods Enzymol 1988;157:358-417.
13. + dependence. J Physiol 1991;435:395-420.
14. + channels in heart. Fundam Clin Pharmacol 1995;8:108-16.
15. Kr potassium channel. Cell 1995;81:299-307.
16. Shuba YM, Naidenov VG, Morad M. Glass-funnel technique for the recording of membrane currents and intracellular perfusion of Xenopus oocytes. Pflugers Arch 1996;432:562-20.
17. + current. J Gen Physiol 1990;66:195-215.
18. Trudeau MD, Warmke JW, Ganetzky G, Robertson GA. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 1995;269:92-5.
19. Clay RJ, Ogbaghebriel A, Paquette T, Sasyniuk BI, Shrier A. A quantitative description of the E-4031-sensitive repolarization current in rabbit ventricular myocytes. Biophys J 1995;69:1830-7.
20. Shibasaki T. Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J Physiol 1987;387:227-50.
21. Smith PL, Baukrowitz T, Yellen G. The inward rectification mechanism of the HERG cardiac potassium channel. Nature 1996; 379:833-6.
22. Hey JA, Del Prado M, Kreutner W, Chapman RW, Egan RW. Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental model of torsade de pointes. Drug Res 1996;46:159-63.
23. Honig PK, Worthan DC, Zamani K, Conner DP, Mullin JC, Cantilena LR. Terfenadine-ketoconazole interaction: pharmacokinetic and electrocardiographic consequences. JAMA 1993;269:1513-8.
24. Hey JA, Del Prado M, Sherwood J, Kreutner W, Chapman RW, Egan RW. Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects. Drug Res 1996;46:153-8.
25. 1-antagonist ebastine in guinea-pig ventricular myocytes. FASEB J 1996;10:A316.
26. + channels. Am J Physiol 1995;268:C535-56.
27. Komeichi K, Tohse N, Nakaya H, Shimizu M, Zhu MY, Kanno M. Effects of N-acetylprocainamide and sotalol on ion currents in isolated guinea-pig ventricular myocytes. Eur J Pharmacol 1990;187:313-22.
28. Snook J, Boothman-Burrel D, Watkins J, Colin-Jones D. Torsades de pointes ventricular tachycardia associated with astemizole over-dose. Br J Clin Pract 1988;42:247-58.
29. Davies AJ, Harindra V, McEwan A, Ghose RR. Cardiotoxic effect with convulsions in terfenadine overdose. Br Med J 1989;298: 325-31.
30. Levine JW, Spear JF, Guarnieri T, Weisfeldt ML, Becker LC, Moore EN. Cesium chloride-induced long QT syndrome: demonstration of after-depolarizations and triggering activity in vivo. Circulation 1985;72:1092-103.