Telomerase inhibition and telomere loss in BEL-7404 human hepatoma cells treated with doxorubicin

World Journal of Gastroenterology

Volumn 8, Issue 5, 2002, Pages 827-831

  Zhang, Ru Gang ^a   Guo, Li Xia ^a   Wang, Xing Wang ^a   Xie, Hong ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; MESSENGER RNA; TELOMERASE; TETRAZOLIUM;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL GROWTH; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG EFFICACY; DRUG EXPOSURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SUBUNIT; FLOW CYTOMETRY; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TELOMERE; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

EID: 0036790512     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v8.i5.827     Document Type: Article

References (28)

1. Yakoob J, Hu GL, Fan XG, Zhang Z. Telomere, telomerase and digestive cancer. World J Gastroenterol 1999; 5:334-337
2. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Linger J, Harley CW, Cech TR. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997; 277: 955-959
3. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, Le S, West M, Harley CB, Andrews WH, Greider CW, Villeponteau B. The RNA component of human telomerase. Science 1995; 269: 1236-1241
4. Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO. A mammalian telomerase-associated protein. Science 1997; 275: 973-977
5. Wang XW, Yuan JH, Zhang RG, Guo LX, Xie Y, Xie H. Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice. World J Gastroenterol 2001; 7: 345-351
6. Tahara H, Nakanishi T, Kitamoto M, Nakashio R, Shay JW, Tahara E, Kajiyama G, Ide T. Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas. Cancer Res 1995; 55: 2734-2736
7. Nakashio R, Kitamoto M, Tahara H, Nakanishi T, Ide T, Kajiyama G. Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinoma. Int J Cancer 1997; 74: 141-147
8. Kawakami Y, Kitamoto M, Nakanishi T, Yasui W, Tahara E, Nakayama J, Ishikawa F, Tahara H, Ide T, Kajiyama G. Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues. Oncogene 2000; 19: 3888-3893
9. Takahashi S, Kitamoto M, Takaishi H, Aikata H, Kawakami Y, Nakanishi T, Shimamoto F, Tahara E, Tahara H, Ide T, Kajiyama G. Expression of telomerase component genes in hepatocellular carcinomas. Eur J Cancer 2000; 36: 496-502
10. Toshikuni N, Nouso K, Higaashi T, Nakatsukasa H, Onishi T, Kaneyoshi T, Kobayashi Y, Kariyama K, Yamamoto K, Tsuji T. Expression of telomerase-associated protein 1 and telomerase reverse transcriptase in hepatocellular carcinoma. Br J Cancer 2000; 82: 833-837
11. Liu XL, Xiao B, Yu ZC, Guo JC, Zhao QC, Xu L, Shi YQ, Fan DM. Down-regulation of Hsp90 could change cell cycle distribution and increase drug sensitivity of tumor cells. World J Gastroenterol 1999; 5:199-208
12. Han R. Primary hepatocellular carcinoma. In Chemoprevention and drug therapy of cancer. Peking: Peking Med University Press, 1991:591-592
13. Wang XW, Xie H. Presence of Fas and Bcl-2 proteins in BEL-7404 human hepatoma cells. World J Gastroenterol 1998; 4: 540-543
14. Zhang RG, Wang XW, Yuan JH, Guo LX, Xie H. Using a non-radioisotopic, quantitative TRAP-based method detecting telomerase activities in human hepatoma cells. Cell Res 2000; 10: 71-77
15. Zhan WH, Ma JP, Peng JS, Gao JS, Cai SR, Wang JP, Zheng ZQ, Wang L. Telomerase activity in gastric cancer and its clinical implications. World J Gastroenterol 1999;5: 316-319
16. Counter CM, Avilion AA, Lefeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992; 11: 1921-1929
17. Ulaner GA, Hu JF, Vu TH, Giudice LC, Hoffman AR. Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development. Int J Cancer 2001;91:644-649
18. Yuan JH, Zhang RP, Zhang RG, Guo LX, Wang XW, Luo D, Xie Y, Xie H. Growth-inhibiting effects of taxol on human liver cancer in vitro and in nude mice. World J Gastroenterol 2000; 6: 210-215
19. Zhu X, Kumar R, Mandal M, Sharma N, Sharma HW, Dhingra U, Sokoloski J A, Hsiao R, Narayanan R. Cell cycle - dependent modulation of telomerase activity in tumor cells. Proc Natl Acad Sci USA 1996; 93: 6091-6095
20. Ku WC, Cheng AJ, Wang TCV. Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture. Biochem Biophys Res Commu 1997; 241: 730-736
21. Burger AM, Double JA, Newell DR. Inhibition of telomerase activity by cisplatin in human testicular cancer cells. Eur J Cancer 1997; 33: 638-644
22. Mese H, Ueyama Y, Suzuki A, Nakayma S, Sasaki A, Hamekawa H, Matsumura T. Inhibition of telomerase activity as a measure of tumor cell killing by cisplatin in squamous cell carcinoma cell line. Chemotherapy 2001;47:136-142
23. Liu JP. Studies of the molecular mechanisms in the regulation of telomerase activity. FASEB J 1999; 13: 2091-2104
24. Ishibashi T, Lippard SJ. Telomere loss in cells treated with cisplatin. Proc Natl Acad Sci USA 1998; 95: 4219-4223
25. Holt SE, Aisner DL, Shay JW, Wright WE. Lack of cell cycle regulation of telomerase activity in human cells. Proc Natl Acad Sci USA 1997; 94: 10687-10692
26. Zhang RG, Wang XW, Yuan JH, Xie H. Human hepatoma cell telomerase activity inhibition and cell cycle modulation by its RNA component antisense oligodeoxyri bonucleotides. Zhongguo Yaoli Xuebao 2000; 21: 673-678
27. Zhang RG, Wang XW, Guo LX, Xie H. Growth inhibition of BEL-7404 human hepatoma cells by expression of mutant telomerase reverse transcriptase. Int J Cancer 2002; 97: 173-179
28. Greider CW. Telomerase activity, cell proliferation, and cancer. Proc Natl Acad Sci USA 1998; 95: 90-92