Durable and stratum-specific gene expression in epidermis

Gene Therapy

Volumn 9, Issue 19, 2002, Pages 1278-1285

  Ghazizadeh, S ^a   Doumeng, C ^a   Taichman, L B ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Epidermis; Gene therapy; Retroviral vectors; Targeted expression

Indexed keywords

GREEN FLUORESCENT PROTEIN; INVOLUCRIN; RETROVIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL CULTURE; CELL DIFFERENTIATION; CELL SPECIFICITY; CLINICAL PROTOCOL; CONTROLLED STUDY; ENHANCER REGION; EPIDERMIS; EXPRESSION VECTOR; GENE CONSTRUCT; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC CODE; GENETIC DISORDER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYBRID GENE; IN VIVO STUDY; KERATINOCYTE; LONG TERMINAL REPEAT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; REPORTER GENE; SKIN DISEASE; SKIN MANIFESTATION; STEM CELL; STRATUM CORNEUM; TARGET CELL; TISSUE CULTURE; TISSUE SPECIFICITY; TRANSGENE; VIRAL GENE DELIVERY SYSTEM;

ADULT; ANIMALS; CELL CULTURE TECHNIQUES; EPIDERMIS; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; INFANT, NEWBORN; KERATINOCYTES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN PRECURSORS; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSDUCTION, GENETIC; TRANSGENES;

ANIMALIA; RNA VIRUSES; UNIDENTIFIED RETROVIRUS; VECTORS;

EID: 0036790465     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301800     Document Type: Article

References (31)

1. Khavari PA. Genetic correction of inherited epidermal disorders. Hum Gene Ther 2000; 11: 2277-2282.
2. Hall PA, Watt FM. Stem cells: the generation and maintenance of cellular diversity. Development 1989; 106: 619-633.
3. Robbins PB et al. In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa. Proc Natl Acad Sci USA 2001; 98: 5193-5198.
4. Arin MJ, Longley MA, Wang X-J, Roop DR. Focal activation of a mutant allele defines the role of stem cells in mosaic disorders. J Cell Biol 2001; 152: 645-649.
5. Mulligan RC. The basic science of gene therapy. Science 1993; 260: 926-932.
6. Kolodka TM, Garlick JA, Taichman LB. Evidence for keratinocyte stem cells in vitro: long-term engraftment and persistence of transgene expression from retrovirus-transduced keratinocytes. Proc Natl Acad Sci USA 1998; 95: 4356-4361.
7. Mathor MB et al. Clonal analysis of stably transduced human epidermal stem cells in culture. Proc Natl Acad Sci USA 1996; 93: 10371-10376.
8. Miller N, Whelan J. Progress in transcriptionally targeted and regulatable vectors for genetic therapy. Hum Gene Ther 1997; 8: 803-815.
9. Emerman M, Temin HM. Genes with promoters in retrovirus vectors can be independently supressed by an epigenic mechanism. Cell 1984; 39: 459-467.
10. Diaz RM, Eisen T, Hart IR, Vile RG. Exchange of viral promoter/enhancer elements with heterologous regulatory sequences generates targeted hybrid long terminal repeat vectors for gene therapy of melanoma. J Virol 1998; 72: 789-795.
11. Grande A et al. Transcriptional targeting of retroviral vectors to the erythroblastic progeny of transduced hematopoietic stem cells. Blood 1999; 93: 3276-3285.
12. Rice RH, Green H. Presence in human epidermal cells of a soluble protein precursor of the cross-linked envelope: activation of the cross-linking by calcium ions. Cell 1979; 18: 681-694.
13. Crish JF et al. Tissue-specific and differentiation-appropriate expression of the human involucrin gene in transgenic mice: an abnormal epidermal phenotype. Differentiation 1993; 53:191-200.
14. Carroll JM et al. Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice. Proc Natl Acad Sci USA 1993; 90: 10270-10274.
15. Efimova T, LaCelle P, Welter JF, Eckert RL. Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1, MEK3, p38/RK, API signal transduction pathway. J Biol Chem 1998; 273: 24387-24395.
16. Banks EB, Crish JF, Eckert RL. Transcription factor Sp1 activates involucrin promoter activity in non-epithelial cell types. Biochem J 1999; 337: 507-512.
17. Crish JF, Zaim TM, Eckert RL. The distal regulatory region of the human involucrin promoter is required for expression in epidermis. J Biol Chem 1998; 273: 30460-30465.
18. Burns JC et al. Vesicular somatitis virus G glycoprotein pseudo-typed retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc Natl Acad Sci USA 1993; 90: 8033-8037.
19. Banks-Schlegel S, Green H. Involucrin synthesis and tissue assembly by keratinocytes in natural and cultured human epithelia. J Cell Biol 1981; 90: 732-737.
20. Ghazizadeh S, Harrington R, Taichman LB. In vivo transduction of mouse epidermis with recombinant retroviral vectors: implications for cutaneous gene therapy. Gene Therapy 1999; 6: 1267-1275.
21. Potten CS. Cell replacement in epidermis (keratopoiesis) via discrete units of proliferation. Int Rev Cytol 1981; 69: 271-318.
22. Li ER, Owens DM, Djian P, Watt FM. Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes. Exp Dermatol 2000; 9: 431-438.
23. Zhan HC, Liu DP, Liang CC. Insulator: from chromatin domain boundary to gene regulation. Hum Genet 2001; 109: 471-478.
24. Ghazizadeh S, Carroll JM, Taichman LB. Repression of retrovirus-mediated transgene expression by interferons: implications for gene therapy. J Virol 1997; 71: 9163-9169.
25. Miller AD. Retroviral vectors. Curr Topics Microbiol Immunol 1992; 158: 3-24.
26. Kaptein LC, Breuer M, Valerio D, van Beusechem VW. Expression pattern of CD2 locus control region containing retroviral vectors in hemopoietic cells in vitro and in vivo. Gene Therapy 1998; 5: 320-330.
27. Sinha S, Degenstein L, Copenhaver C, Fuchs E. Defining the regulatory factors required for epidermal gene expression. Mol Cell Biol 2000; 20: 2543-2555.
28. Kinsella TM, Nolan GP. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther 1996; 7: 1405-1413.
29. Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 1993; 90: 8392-8396.
30. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinocyte colonies from single cells. Cell 1975; 6: 331-344.
31. Wu Y-J et al. The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells nonkeratinizing epithelia. Cell 1982; 31: 693-703.