Breast cancer and fanconi anemia: What are the connections?

Trends in Molecular Medicine

Volumn 8, Issue 10, 2002, Pages 458-460

  Zdzienicka, Malgorzata Z ^a   Arwert, Fré ^b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; CELL PROTEIN; FANCONI ANEMIA PROTEIN; RAD51 PROTEIN; UNCLASSIFIED DRUG;

BREAST CANCER; CANCER SUSCEPTIBILITY; DISEASE ASSOCIATION; DNA CROSS LINKING; DNA DAMAGE; FANCONI ANEMIA; GENE MUTATION; HUMAN; SHORT SURVEY;

BREAST NEOPLASMS; DNA-BINDING PROTEINS; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FEMALE; GENES, BRCA1; GENES, BRCA2; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MUTATION; NUCLEAR PROTEINS; PHENOTYPE; RAD51 RECOMBINASE;

EID: 0036787589     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02411-5     Document Type: Short Survey

References (21)

1. Ford, D. et al. (1998) Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am. J. Hum. Genet. 62, 676-689
2. Zheng, L. et al. (2000) Lessons learned from BRCA1 and BRCA2. Oncogene 19, 6159-6175
3. Venkitaraman, A.R. (2002) Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108, 171-182
4. Easton, D.F. (1999) How many more breast cancer predisposition genes are there? Breast Cancer Res. 1, 14-17
5. Thompson, D. et al. (2002) Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from Breast Cancer Linkage Consortium. Proc. Natl. Acad. Sci. U. S. A. 99, 827-831
6. Meijers-Heijboer et al. (2002) Low-penetrance susceptibility to breast cancer due to CHEK2* 1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat. Genet. 31, 55-59
7. Hall, J. and Angèle, S. (1999) Radiation, DNA damage and cancer. Mol. Med. Today 5, 157-164
8. Auerbach, A.D. et al. (2001) The Metabolic and Molecular Bases of Inherited Disease, McGraw-Hill
9. Joenje, H. and Patel, K.J. (2001) The emerging genetic and molecular basis of Fanconi anemia. Nat. Rev. Genet. 2, 446-457
10. Garcia-Higuera, I. et al. (2001) Interaction of the Fanconi proteins and BRCA1 in a common pathway. Mol. Cell 7, 249-262
11. Howlett, N.G. et al. (2002) Biallelic inactivation of BRCA2 in Fanconi anemia. Science 297, 606-609
12. Taniguchi, T. et al. (2002) Convergence of the Fanconi anemia and ataxia telangiectasia signaling pathways. Cell 109,459-472
13. Strathdee, C.A. et al. (1992) Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9. Nat. Genet. 1, 196-198
14. Yuan, S.S. et al. (1999) BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo. Cancer Res. 59, 3547-3551
15. Godthelp, B.C. et al. (2002) Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1. Oncogene 21, 5002-5005
16. Digweed, M. et al. (2002) Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia. Carcinogenesis 23, 1121-1126
17. van Gent, D.C. et al. (2001) Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2, 196-206
18. Thacker, J. (1999) The role of homologous recombination processes in the repair of severe forms of DNA damage in mammalian cells. Biochimie 81, 77-85
19. Takata, M. et al. (2001) Chromosome instability and defective recombinational repair in knockout mutants of five Rad51 paralogs. Mol. Cell. Biol. 21, 2858-2866
20. Godthelp, B.C. et al. (2002) Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Nucleic Acids Res. 30, 2172-2182
21. Kraakman-van der Zwet, M. et al. (2002) Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol. Cell. Biol. 22, 669-679