Immunohistochemical detection of hepatocyte growth factor, transforming growth factor-β and their receptors in epithelial odontogenic tumors

Journal of Oral Pathology and Medicine

Volumn 31, Issue 9, 2002, Pages 539-548

  Kumamoto, Hiroyuki ^a   Yoshida, Mitsuhide ^a   Ooya, Kiyoshi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

c Met; Hepatocyte growth factor (HGF); Odontogenic tumor; Transforming growth factor (TGF ); Transforming growth factor receptor

Indexed keywords

SCATTER FACTOR; SCATTER FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; BIOSYNTHESIS; CELL TRANSFORMATION; CHEMISTRY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; ODONTOGENIC TUMOR; TOOTH FLORA;

CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTE GROWTH FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; ODONTOGENIC TUMORS; PROTO-ONCOGENE PROTEINS C-MET; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TOOTH GERM; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036786808     PISSN: 09042512     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0714.2002.00121.x     Document Type: Article

References (52)

1. Shear M. Developmental odontogenic cysts: an update. J Oral Pathol Med 1994; 23: 1-11.
2. Melrose RJ. Benign epithelial odontogenic tumors. Semin Diagn Pathol 1999; 16: 271-87.
3. Eversole LR. Malignant epithelial odontogenic tumors. Semin Diagn Pathol 1999; 16: 317-24.
4. Kramer IRH, Pindborg JJ, Shear M. WHO Histological Typing of Odontogenic Tumours. Berlin: Springer-Verlag, 1992:11-27.
5. Kumamoto H, Yamasaki S, Sato A, Yamaguchi T, Tezuka F, Ooya K. Clear cell odontogenic tumor in the mandible. J Oral Pathol Med 2000; 29: 43-7.
6. Eversole LR. On the differential diagnosis of clear cell tumors of the head and neck. Eur J Cancer B Oral Oncol 1993; 29B: 173-9.
7. Sciubba JJ, Fantasia JE, Kahn LB. Tumors and Cysts of the Jaw. Washington, DC: Armed Forces Institute of Pathology, 2001: 71-99.
8. Yoshida M, Kumamoto H, Ooya K, Mayanagi H. Histopathological and immunohistochemical analysis of calcifying odontogenic cysts. J Oral Pathol Med 2001; 30: 582-8.
9. Sporn MB, Todaro GJ. Autocrine secretion and malignant transformation of cells. N Engl J Med 1980; 303: 878-80.
10. Heldin C-H, Westermark B. Growth factors: mechanism of action and relation to oncogenesis. Cell 1984; 37: 9-20.
11. Miyazono K, Dijke PT, Ichijo H, Heldin C-H. Receptors for transforming growth factor-β. Adv Immunol 1994; 55: 181-220.
12. van der Voort R, Taher TEI, Decksen PWB, Spaargaren M, van der Neut R, Pals ST. The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation. Adv Cancer Res 2000; 79: 39-90.
13. Nakamura T, Kawa K, Ichihara A. Partial purification of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun 1984; 122: 1450-9.
14. Cooper CS, Park M, Blair DG, et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 1984; 311: 29-33.
15. Bottaro DP, Rubin JS, Faletto DL, et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991; 251: 802-4.
16. Di Renzo MF, Olivero M, Giacomini A, et al. Overexpression and amplification of the Met/HGF receptor gene during the progression of colorectal cancer. Clin Cancer Res 1995; 1: 147-54.
17. Olivero M, Rizzo M, Madeddu R, et al. Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas. Br J Cancer 1996; 74: 1862-8.
18. Tuck AB, Park M, Sterns EE, Boag A, Elliott BE. Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma. Am J Pathol 1996; 148: 225-32.
19. Nakamura K, Okamoto M, Hayashi Y, Oyasu R. Hepatocyte growth factor secreted by prostate-derived stromal cells stimulates growth of androgen-independent human prostatic carcinoma cells. Am J Pathol 2000; 157: 795-803.
20. Roberts AB, Anzano MA, Lamb LC, Smith JM, Sporn MB. New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissue. Proc Natl Acad Sci U S A 1981; 78: 5339-43.
21. Ravitz MJ, Wenner CE. Cyclin-dependent kinase regulation during G1 phase and cell cycle regulation by TGF-β. Adv Cancer Res 1997; 71: 165-207.
22. Taipale J, Saharinen J, Keski-Oja J. Extracellular matrix-associated transforming growth factor-β: role in cancer cell growth and invasion. Adv Cancer Res 1998; 75: 87-134.
23. Heldin C-H, Miyazono K, ten Dijke P. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 1997; 390: 465-71.
24. Park K, Kim S-J, Bang Y-J, et al. Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-β. Proc Natl Acad Sci USA 1994; 91: 8772-6.
25. Markowitz S, Wang J, Myeroff L, et al. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 1995; 268: 1336-8.
26. DeCoteau JF, Knaus PI, Yankelev H, et al. Loss of functional cell surface transforming growth factor β (TGF-β) type 1 receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 1997; 94: 5877-81.
27. Heikinheimo K, Happonen RP, Miettinen PJ, Ritvos O. Transforming growth factor β2 in epithelial differentiation of developing teeth and odontogenic tumors. J Clin Invest 1993; 91: 1019-27.
28. Comerci JT Jr, Runoeicz CD, Flanders KC, et al. Altered expression of transforming growth factor-β1 in cervical neoplasia as an early biomarker in carcinogenesis of the uterine cervix. Cancer 1996; 77: 1107-14.
29. Takata T, Miyauchi M, Ogawa I, et al. Immunoexpression of transforming growth factor β in desmoplastic ameloblastoma. Virchows Arch 2000; 436: 319-23.
30. Paterson IC, Matthews JB, Huntley, et al. Decreased expression of TGF-β cell surface receptors during progression of human oral squamous cell carcinoma. J Pathol 2001; 193: 458-67.
31. Kumamoto H. Detection of apoptosis-related factors and apoptotic cells in ameloblastomas: analysis by immunohistochemistry and an in situ DNA nick end-labelling method. J Oral Pathol Med 1997; 26: 419-25.
32. Kumamoto H, Ooya K. Immunohistochemical analysis of bcl-2 family proteins in benign and malignant ameloblastomas. J Oral Pathol Med 1999; 28: 343-9.
33. Kumamoto H, Kimi K, Ooya K. Detection of cell cycle-related factors in ameloblastomas. J Oral Pathol Med 2001; 30: 309-15.
34. Kumamoto H, Kimi K, Ooya K. Immunohistochemical analysis of apoptosis-related factors (Fas, Fas ligand, caspase-3 and single-stranded DNA) in ameloblastomas. J Oral Pathol Med 2001; 30: 596-602.
35. Shrestha P, Yamada K, Higashiyama H, Takagi H, Mori M. Epidermal growth factor receptor in odontogenic cysts and tumors. J Oral Pathol Med 1992; 21: 314-7.
36. Heikinheimo K, Voutilainen R, Happonen R-P, Miettinen PJ. EGF receptor and its ligands, EGF and TGF-α, in developing and neoplastic human odontogenic tissues. Int J Dev Biol 1993; 37: 387-96.
37. Myoken Y, Myoken Y, Okamoto T, Sato JD, Takada K. Immunohistochemical localization of fibroblast growth factor-1 (FGF-1) and FGF-2 in cultured human ameloblastoma epithelial cells and ameloblastoma tissues. J Oral Pathol Med 1995; 24: 387-92.
38. So F, Daley TD, Jackson L, Wysocki GP. Immunohistochemical localization of fibroblast growth factors FGF-1 and FGF-2, and receptors FGFR2 and FGFR3 in the epithelium of human odontogenic cysts and tumors. J Oral Pathol Med 2001; 30: 428-33.
39. Sonnenberg E, Meyer D, Weidner KM, Birchmeier C. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchymal and epithelia during mouse development. J Cell Biol 1993; 123: 223-35.
40. Matsumoto K, Nakamura T. Emerging multipotent aspects of hepatocyte growth factor. J Biochem 1995; 119: 591-600.
41. Heine UI, Munoz EF, Flanders KC, et al. Role of transforming growth factor-β in the development of the mouse embryo. J Cell Biol 1987; 105: 2861-76.
42. Vaahtokari A, Vainio S, Thesleff I. Associations between transforming growth factor β1 RNA expression and epithelial-mesenchymal interactions during tooth morphogenesis. Development 1991; 113: 985-94.
43. Tabata MJ, Kim K, Liu J-G, et al. Hepatocyte growth factor is involved in the morphogenesis of tooth germ in murine molars. Development 1996; 122: 1243-51.
44. Tabata MJ, Matsumoto T, Liu J-G, Wakisaka S, Kurisu K. Expression of cytokeratin 14 in ameloblast-lineage cells of the developing tooth of rat, both in vivo and in vitro. Arch Oral Biol 1996; 41: 1019-27.
45. Nakamura T, Matsumoto K, Kiritoshi A, Tano Y, Nakamura T. Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions. Cancer Res 1997; 57: 3305-13.
46. Matsumoto K, Tajima H, Okazaki H, Nakamura T. Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-β1 and glucocorticoids. J Biol Chem 1992; 267: 24917-20.
47. Massague J, Chen Y-G. Controlling TGF-β signaling. Genes Dev 2000; 14: 627-44.
48. Kumamoto H, Sato I, Tateno H, Yokoyama J, Takahashi T, Ooya K. Clear cell variant of calcifying epithelial odontogenic tumor (CEOT) in the maxilla: report of a case with immunohistochemical and ultrastructural investigations. J Oral Pathol Med 1999; 28: 187-91.
49. Elzay RP. Primary intraosseous carcinoma of the jaws: review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol 1982; 54: 299-303.
50. Slootweg PJ, Muller H. Malignant ameloblastoma or ameloblastic carcinoma. Oral Surg Oral Med Oral Pathol 1984; 57: 168-76.
51. Mizuno S, Kurosawa T, Matsumoto K, Mizuno-Horikawa Y, Okamoto M, Nakamura T. Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease. J Clin Invest 1998; 101: 1827-34.
52. Kretzschmar M, Doody J, Timohkina I, Massague J. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev 1999; 13: 804-16.