Breakdown of CTL tolerance to self HLA-B*2705 Induced by exposure to Chlamydia trachomatis

Journal of Immunology

Volumn 169, Issue 7, 2002, Pages 4033-4038

  Popov, Igor ^a   Dela Cruz, Charles S ^a   Barber, Brian H ^a   Chiu, Basil ^a   Inman, Robert D ^a  

^a TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; HLA A2 ANTIGEN; HLA B ANTIGEN; HLA B27 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTHRITIS; ARTICLE; BACTERIAL CELL; CHLAMYDIA TRACHOMATIS; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DISEASE ASSOCIATION; GENE EXPRESSION; GENE MUTATION; IMMUNIZATION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PATHOGENESIS; PLASMID; PRIORITY JOURNAL; RAT; SPLEEN CELL; SPONDYLOARTHROPATHY;

EID: 0036785625     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.7.4033     Document Type: Article

References (38)

1. Brewerton, D. A., F. D. Hart, M. Caffrey, A. Nichols, D. C. O. James, and R. D. Sturrock. 1973. Ankylosing spondylitis and HLA-A27. Lancet 1:904.
2. 2 microglobulin transgenic rats. J. Clin. Invest. 98:945.
3. Taurog, J. D., J. A. Richardson, J. T. Croft, W. A. Simmons, M. Zhou, J. L. Fernandez-Sueiro, E. Balish, and R. E. Hammer. 1994. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180:2359.
4. Feltkamp, T. E. W., M. A. Khan, and J. A. Lopez de Castro. 1996. The pathogenetic role of HLA-B27. Immunol. Today. 17:5.
5. Inman, R. D., J. A. Whittum-Hudson, H. R. Schumacher, and A. P. Hudson. 2000. Chlamydia and associated arthritis. Curr. Opin. Rheumatol. 12:254.
6. Inman, R. D., and R. H. Scofield. 1994. Etiopathogenesis of ankylosis spondylitis and reactive arthritis. Curr. Opin. Rheumatol. 6:360.
7. Pfeifer, J. D., M. J. Wick, L. Roberts, K. Finlay, S. J. Normark, and C. V. Harding. 1993. Phagocytic processing of bacterial antigens for class I MHC presentation to cells. Nature 361:359.
8. Kaufmann, S. H. E. 1993. Immunity to intracellular bacteria. Annu. Rev. Immunol. 11:129.
9. Bowness, P., P. A. Moss, J. S. Rowland, J. I. Bell, and A. J. McMichael. 1993. Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class 1-restricted responses. Eur. J. Immunol. 23:1417.
10. + T cell expansions in normal individuals and patients with rheumatoid arthritis. J. Immunol. 154:3538.
11. Moss, P. A. H., W. M. C. Rosenberg, and J. I. Bell. 1992. The human T cell receptor in health and disease. Annu. Rev. Immunol. 10:71.
12. Albert, L. J., and R. D. Inman. 1999. Molecular mimicry and autoimmunity. N. Engl. J. Med. 341:2068.
13. Zhou, M., A. Sayad, W. A. Simmons, R. C. Jones, S. D. Maika, N. Satumtira, M. L. Dorris, S. J. Gaskell, R. M. Bordoli, R. B. Sartor, et al. 1998. The specificity of peptides bound to human HLA-B27 influences the prevalence of arthritis in HLA-B27 transgenic rats. J. Exp. Med.188:877.
14. Starnbach, M. N., M. J. Bevan, and M. F. Lampe. 1994. Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis. J. Immunol. 153:5183.
15. Kaufmann, S. H. E. 1995. Immunity to intracellular microbial pathogens. Immunol. Today 16:338.
16. Lampe, M. F., C. B. Wilson, M. J. Bevan, and M. N. Stambach. 1998. γ Interferon production by cytotoxic T lymphocytes is required for resolution of Chlamydia trachomatis infection. Infect. Immun. 66:5457.
17. + CTLs specific for the major outer membrane protein of Chlamydia trachomatis in human genital tract infections. J. Immunol. 162:6855.
18. Kuon, W., H. G. Holzhutter, H. Appel, M. Grolms, S. Kolinberger, A. Traeder, E. Weiss. A. Thiel, R. Lauster, P. Bowness, et al. 2001. Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases. J. Immunol. 167:4738.
19. 2m: an animal model of HLA-B27-associated human disorders. Cell 63:1099.
20. Dela Cruz, C. S., J. W. Chamberlain, K. S. MacDonald, and B. H. Barber. 1999. Xenogeneic and allogeneic anti-MHC immune responses induced by plasmid DNA immunization. Vaccine 17:2479.
21. Melton, P., V. Parker, Y. Gluzman, and T. Maniatis. 1981. Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system. Cell 27:279.
22. Inman, R. D., and B. Chiu. 1998. Synoviocyte-packaged Chlamydia trachomatis induces a chronic aseptic arthritis. J. Clin. Invest. 102:1776.
23. Kapasi, K., and R. D. Inman. 1992. HLA-B27 expression modulates Gram-negative bacterial invasion into transfected L cells. J. Immunol. 148:3554.
24. Kapasi, K, and R. D. Inman. 1994. MEI epitope of HLA-B27 confers class 1-mediated modulation of Gram-negative bacterial invasion. J. Immunol. 153:833.
25. el-Zaatari, F. A., and J. D. Taurog. 1992. In vitro mutagenesis of HLA-B27: single and multiple amino acid substitutions at consensus B27 sites identify distinct monoclonal antibody-defined epitopes. Hum. Immunol. 33:243.
26. Popov, I., C. S. Dela Cruz, B. H. Barber, B. Chiu, and R. D. Inman. 2001. The effect of an anti-HLA-B27 immune response on CTL recognition of Chlamydia. J. Immunol. 167:3375.
27. Benjamin, R., and P. Parham. 1992, HLA-B27 and disease: a consequence of inadvertent antigen presentation. Rheum. Dis. Clin. N. Am. 18:11.
28. Hermann, E., D. T. Yu, K.-H. Meyer zum Buschenfelde, and B. Fleischer. 1993. HLA-B27-restrieted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet 342:646.
29. Scofield, R. H., W. L. Warren, G. Koelsch, and J. B. Harley. 1993. A hypothesis for the HLA-B27 immune dysregulation in spondyloarthopathy: contributions from enteric organisms, B27 structure, peptides bound by B27, and convergent evolution. Proc. Natl. Acad. Sci. USA 90:9330.
30. Goodnow, C. C. 1996. Balancing immunity and tolerance: deleting and tuning lymphocyte repertoire. Proc. Natl. Acad. Sci. USA 93:2246.
31. Krebs, S., D. Rognan, and J. A. Lopez de Castro. 1999. Long-range effects in protein-ligand interactions mediate peptide specificity in the human major histocompatibility antigen HLA-B27 (B*2701). Protein Sci. 8:1393.
32. Garcia-Peydro, M., A. Paradela, J. R. Lamas, and J. A. Lopez de Castro. 1999. Peptide presentation to an alloreactive CTL clone is modulated through multiple mechanisms involving polymorphic and conserved residues in HLA-B27. J. Immunol. 163:6060.
33. Taurog, J. D., S. D. Maika, N. Satumtira, M. L. Dorris, I. L. McLean, H. Yanagisawa, A. Sayad, A. J. Stagg, G. M. Fox, A. Le O'Brien, et al. 1999. Inflammatory disease in HLA-B27 transgenic rats. Immunol. Rev. 169:209.
34. Alvarez, I., M. Marti, J. Vasquez, E. Camafeita, S. Ogueta, and J. A. Lopez de Castro. 2001. The Cys67 residue of HLA-B27 influences cell surface stability, peptide specificity and T-cell antigen presentation. J. Biol. Chem. 276:48740.
35. Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.
36. Jardetzky, T. S., W. S. Lane, R. A. Robinson, D. R. Madden, and D. C. Wiley. 1991. Identification of self peptides bound to purified HLA-B27. Nature 353:326.
37. Sieper, J., C. Feindler, S. Laitko, H. Sorensen, C. Grippenberg-Lerche, F. Hiepe, R. Alten, W. Keitel, A. Groh, J. Uksila, et al. 1999. No benefit of long-term ciprofloxacin treatment in patients with reactive arthritis and undifferentiated oligoarthritis: a three-month, multicenter, double-blind, randomized, placebo-controlled study. Arthritis Rheum. 42:1386.
38. Stone, M., D. Salonen, M. Lax, U. Payne, V. Lapp, and R. D. Inman. 2001. Clinical and imaging correlates of response to treatment with infliximab in patient with ankylosing spondylitis. J. Rheumatol. 28:1605.