Oculomotor effects of δ-9-tetrahydrocannabinol in humans: Implications for the functional neuroanatomy of the brain cannabinoid system

Cerebral Cortex

Volumn 12, Issue 10, 2002, Pages 1016-1023

  Ploner, Christoph J ^a,c   Tschirch, Andrea ^a   Ostendorf, Florian ^a   Dick, Sandra ^a   Gaymard, Bertrand M ^b   Rivaud Péchoux, Sophie ^b   Sporkert, Frank ^a   Pragst, Fritz ^a   Stadelmann, Andreas M ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DRONABINOL;

ADULT; ARTICLE; ATTENTION; BASAL GANGLION; BEHAVIOR; BRAIN REGION; COGNITION; CONTROLLED STUDY; DRUG EFFECT; EYE MOVEMENT CONTROL; FEMALE; HUMAN; HUMAN EXPERIMENT; LATENT PERIOD; MALE; MOTOR PERFORMANCE; NEOCORTEX; NERVE CELL; NEUROANATOMY; NORMAL HUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SACCADIC EYE MOVEMENT; SIGNAL TRANSDUCTION; WORKING MEMORY;

ADULT; ANALYSIS OF VARIANCE; BRAIN; CANNABINOIDS; CHI-SQUARE DISTRIBUTION; EYE MOVEMENTS; FEMALE; HUMANS; MALE; MEMORY; NERVOUS SYSTEM; OCULOMOTOR NERVE; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL;

EID: 0036785395     PISSN: 10473211     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Ameri A (1999) The effects of cannabinoids on the brain. Prog Neurobiol 59:315-348.
2. Andreasson S, Allebeck P, Engstrom A, Rydberg U (1987) Cannabis and schizophrenia: a longtitudinal study of Swedish conscripts. Lancet 2:1483-1485.
3. Auclair N, Otani S, Soubrie P, Crepel F (2000) Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex pyramidal neurons. J Neurophysiol 83:3287-3293.
4. Baloh RW, Sharma S, Moskowitz H, Griffith R (1979) Effects of alcohol and marijuana on eye movements. Aviat Space Environ Med 50:18-23.
5. Becker W (1989) Metrics. In: The neurobiology of saccadic eye movements (Wurtz R, Goldberg ME, eds), pp. 13-67. Amsterdam: Elsevier.
6. Breivogel CS, Childers SR (1998) The functional neuroanatomy of brain cannabinoid receptors. Neurobiol Dis 5:417-431.
7. Broerse A, Holthausen EAE, van den Bosch RJ, den Boer JA (2001) Does frontal normality exist in schizophrenia? A saccadic eye movement study. Psychiat Res 103:167-178.
8. Bruce CJ, Goldberg ME (1985) Primate frontal eye fields. I. Single neurons discharging before saccades. J Neurophysiol 53:603-635.
9. Corbetta M, Akbudak E, Conturo TE, Snyder AZ, Ollinger JM, Drury HA, Linenweber MR, Petersen SE, Raichle ME, Van Essen DC, Shulman GL (1998) A common network of functional areas for attention and eye movements. Neuron 21:761-773.
10. 3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use. Neuroscience 103:9-15.
11. Deng SY, Goldberg ME, Segraves ME, Ungerleider LG, Mishkin M (1987) The effect of unilateral ablation of the frontal eye fields on saccadic performance in the monkey. In: Adaptive processes in visual oculomotor systems (Keller EL, Zee DS, eds), pp. 201-208. Oxford: Pergamon Press.
12. Devane WA, Dysarz FA, Johnson MR, Melvin LS, Howlett AC (1988) Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34:605-613.
13. Dias EC, Segraves MA (1999) Muscimol-induced inactivation of monkey frontal eye field: effects on visually and memory-guided saccades. J Neurophysiol 81:2191-2214.
14. Everling S, Fischer B (1998) The antisaccade: a review of basic research and clinical studies. Neuropsychologia 36:885-899.
15. Felder CC, Glass M (1998) Cannabinoid receptors and their endogenous agonists. Annu Rev Pharmacol Toxicol 38:179-200.
16. Ferraro L, Tomasini MC, Gessa GL, Bebe BW, Tanganelli S, Antonelli T (2001) The cannabinoid receptor agonist WIN 55.212-2 regulates glutamate transmission in rat prefrontal cortex: an in vivo and in vitro study. Cereb Cortex 11:728-733.
17. Flom MC, Brown B, Adams AJ, Jones RT (1977) Alcohol and marijuana effects on ocular tracking. Am J Optom Physiol Optics 53:764-773.
18. Funahashi S, Bruce CJ, Goldman-Rakic PS (1993) Dorsolateral prefrontal lesions and oculomotor delayed response performance: evidence for mnemonic 'scotomas'. J Neurosci 13:1479-1497.
19. Gaymard B, Ploner CJ, Rivaud-Péchoux S, Pierrot-Deseilligny C (1999) The frontal eye field is involved in spatial short-term memory but not in reflexive saccade inhibition. Exp Brain Res 129:288-301.
20. Gitelman DR, Nobre AC. Parrish TB, La Bar KS, Kim Y-H, Meyer JR, Mesulam MM (1999) A large-scale distributed network for covert spatial attention. Brain 122:1093-1106.
21. Glass M, Faull RL, Dragunow M (1993) Loss of cannabinoid receptors in the substantia nigra in Huntington's disease. Neuroscience 56:523-527.
22. Glass M, Dragunow M, Faull RLM (1997) Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience 77:299-318.
23. Glass M, Dragunow M, Faull RL (2000) The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease. Neuroscience 97:505-519.
24. Herkenham M, Lynn AB, Little MD, Johnson MR, Melvin LS, De Costa BR, Rice KC (1990) Cannabinoid receptor localization in brain. Proc Natl Acad Sci USA 87:1932-1936.
25. Hikosaka O, Wurtz RH (1985a) Modification of saccadic eye movements by GABA-related substances. I. Effect of muscimol and bicuculline in monkey superior colliculus. J Neurophysiol 53:266-291.
26. Hikosaka O, Wurtz RH (1985b) Modification of saccadic eye movements by GABA-related substances. II. Effect of muscimol in monkey substantia nigra pars reticulata. J Neurophysiol 53:292-308.
27. Hikosaka O, Takikawa Y, Kawagoe R (2000) Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol Rev 80:953-978.
28. Huestis MA, Gorelick DA, Heishman SJ, Preston KL, Nelson RA, Moolchan ET, Frank RA (2001) Blockade of effects of smoked marijuana by the CB-1-selective cannabinoid receptor antagonist SR141716. Arch Gen Psychiat 58:322-328.
29. Iversen LL (2000) The science of marijuana. Oxford: Oxford University Press.
30. 9-Tetrahydrocannabinol increases prefrontal catecholaminergic utilization and impairs spatial working memory in the rat: blockade of dopaminergic effects with HA 966. Neuropsychopharmacology 16:426-432.
31. Kanayama R, Bronstein AM, Shallo-Hoffmann J, Rudge P, Husain M (1994) Visually and memory guided saccades in a case of cerebellar saccadic dysmetria. J Neurol Neurosurg Psychiat 57:1081-1084.
32. Leigh RJ, Zee DS (1999) The neurology of eye movements. Oxford: Oxford University Press.
33. Leweke FM, Giuffrida A, Wurster U, Emrich HM, Piomelli D (1999) Elevated endogenous cannabinoids in schizophrenia. Neuroreport 10:1665-1669.
34. Lueck CJ, Tanyeri S, Crawford TJ, Henderson L, Kennard C (1990) Antisaccades and remembered saccades in Parkinson's disease. J Neurol Neurosurg Psychiat 53:284-288
35. Mathew RJ, Wilson WH, Coleman RE, Turkington TG, De Grado TR (1997) Marijuana intoxication and brain activation in marijuana smokers. Life Sci 23:2075-2089.
36. Matsuda LA, Lolait SJ, Bownstein MJ, Young AC, Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561-564.
37. O'Leary DS, Block RI, Flaum M, Schultz SK, Boles Ponto LL, Watkins GL, Hurtig RR, Andreasen NC, Hichwa RD (2000) Acute marijuana effects on rCBF and cognition: a PET study. Neuroreport 11:3835-3841.
38. Park S, Holzman PS (1992) Schizophrenics show spatial working memory deficits. Arch Gen Psychiat 55:105-116.
39. Perry RJ, Zeki S (2000) The neurology of saccades and covert shifts of attention. An event-related fMRI study. Brain 123:2273-2288.
40. Pierrot-Deseilligny C, Rivaud S, Gaymard B, Agid Y (1991a) Cortical control of reflexive visually guided saccades. Brain 114:1473-1485.
41. Pierrot-Deseilligny C, Rivaud S, Gaymard B, Agid Y (1991b) Cortical control of memory-guided saccades in man. Exp Brain Res 83: 607-617.
42. Pierrot-Deseilligny C, Rivaud S, Gaymard B, Müri RM, Vermersch A-I (1995) Cortical control of saccades. Ann Neurol 37:557-567.
43. Pistis M, Porcu G, Melis M, Diana M, Gessa GL (2001) Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation. Eur J Neurosci 14:96-102.
44. Ploner CJ, Gaymard B, Rivaud S, Agid Y. Pierrot-Deseilligny C (1998) Temporal limits of spatial working memory in humans. Eur J Neurosci 10:794-797.
45. Ploner CJ, Rivaud-Péchoux S, Gaymard BM, Agid Y, Pierrot-Deseilligny C (1999) Errors of memory-guided saccades in humans with lesions of the frontal eye field and the dorsolateral prefrontal cortex. J Neurophysiol 82:1086-1090.
46. Richfield EK, Herkenham M (1994) Selective vulnerability in Huntington's disease: preferential loss of cannabinoid receptors in lateral globus pallidus. Ann Neurol 36:577-584.
47. Rivaud S, Müri RM, Gaymard B, Vermersch A-I, Pierrot-Deseilligny C (1994) Eye movement disorders after frontal eye field lesions in humans. Exp Brain Res 102:110-120.
48. Rivaud-Péchoux S, Vermersch A-I, Gaymard B, Ploner CJ, Bejjani BP, Damier P, Demeret, S, Agid Y, Pierrot-Deseilligny C (2000) Improvement of memory-guided saccades in parkinsonian patients by high frequency subthalamic nucleus stimulation. J Neurol Neurosurg Psychiat 68:381-384.
49. Robinson FR, Straube A, Fuchs AF (1993) Role of the caudal fastigial nucleus in saccade generation. II. Effects of muscimol inactivation. J Neurophysiol 70:1741-1758.
50. Solowij N (1998) Cannabis and cognitive functioning. Cambridge: Cambridge University Press.
51. Sullivan JM (2000) Cellular and molecular mechanisms underlying learning and memory impairments by cannabinoids. Learn Mem 7:132-139.
52. Takagi M, Zee DS, Tamargo RJ (1998) Effects of lesions of the oculomotor vermis on eye movements in primate: saccades. J Neurophysiol 80:1911-1931.
53. Takagi M, Zee DS, Tamargo RJ (2000) Effects of lesions of the oculomotor vermis on eye movements in primate: smooth pursuit. J Neurophysiol 83:2047-2062.
54. Vahedi K, Rivaud S, Amarenco P, Pierrot-Deseilligny C (1995) Horizontal eye movement disorders after posterior vermis infarctions. J Neurol Neurosurg Psychiat 58:91-94.
55. Vermersch A-I, Müri RM, Rivaud S, Vidailhet M, Gaymard B, Agid Y, Pierrot-Deseilligny C (1996) Saccade disturbances after bilateral lentiform nucleus lesions in humans. J Neurol Neurosurg Psychiat 60:179-184.
56. Vermersch A-I, Gaymard BM, Rivaud-Péchoux S, Ploner CJ, Agid Y, Pierrot-Deseilligny C (1999) Memory-guided saccade deficit after caudate nucleus lesion. J Neurol Neurosurg Psychiat 66:524-527.
57. Vidailhet M, Rivaud S, Gouider-Khouja N, Pillon B, Bonnet A-M, Gaymard B, Agid Y, Pierrot-Deseilligny C (1994) Eye movements in parkinsonian syndromes. Ann Neurol 35:420-426.
58. Volkow ND, Gillespie H, Mullani N, Tancredi L, Grant C, Valentine A, Hollister L (1996) Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication. Psychiat Res 67:29-38.
59. Walker R, Husain M, Hodgson TL, Harrison J, Kennard C (1998) Saccadic eye movement and working memory deficits following damage to the human prefrontal cortex. Neuropsychologia 36:1141-1159.
60. Wang X-J (2001) Synaptic reverberation underlying mnemonic persistent activity. Trends Neurosci 24:455-463.
61. White JM, Sparks DL, Stanford TR (1994) Saccades to remembered target locations: an analysis of systematic and variable errors. Vision Res 34:79-92.