Orderly pattern of development of the autoantibody response in (New Zealand White × BXSB)F1 lupus mice: Characterization of target antigens and antigen spreading by two-dimensional gel electrophoresis and mass spectrometry

Journal of Immunology

Volumn 169, Issue 7, 2002, Pages 4046-4053

  Thébault, Sandrine ^a   Gilbert, Danièle ^a   Hubert, Marie ^a   Drouot, Laurent ^a   Machour, Nadine ^a   Lange, Catherine ^a   Charlionet, Roland ^a   Tron, François ^a  

^a UNIVERSITÉ DE ROUEN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; AUTOANTIBODY; CARDIOLIPIN ANTIBODY; DNA ANTIBODY; ENOLASE; GENE PRODUCT; HEAT SHOCK PROTEIN 60; NUCLEOPHOSMIN; PROTEIN RAD23; RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOBLOTTING; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PATHOGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN TARGETING; PROTEOMICS; RECURRENT DISEASE; SYSTEMIC LUPUS ERYTHEMATOSUS; TWO DIMENSIONAL GEL ELECTROPHORESIS; Y CHROMOSOME;

EID: 0036784621     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.7.4046     Document Type: Article

References (51)

1. Bach, J. F., S. Koutouzov, and P. M. van Endert. 1998. Are there unique autoantigens triggering autoimmune diseases? Immunol. Rev. 164:139.
2. James, J. A., and J. B. Harley. 1998. B-cell epitope spreading in autoimmunity. Immunol. Rev. 164:185.
3. Vanderlugt, C. J., and S. D. Miller. 1996. Epitope spreading. Curr. Opin. Immunol. 8:831.
4. Greidinger, E. L., and R. W. Hoffman. 2001. The appearance of U1 RNP antibody specificities in sequential autoimmune human antisera follows a characteristic order that implicates the U1 70-kd and B/B′ proteins as predominant U1 RNP immunogens. Arthritis Rheum. 44:368.
5. McCluskey, J., A. D. Farris, C. L. Keech, A. W. Purcell, M. Rischmueller, G. Kinoshita, P. Reynolds, and T. P. Gordon. 1998. Determinant spreading: lessons from animal models and human diseases. Immunol. Rev. 164:209.
6. James, J. A., T. Gross, R. H. Scofield, and J. B. Harley. 1995. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PPPGMRPP and PPPGIRCP induce spliceosome autoimmunity. J. Exp. Med. 181:453.
7. Topfer, F., T. P. Gordon, and T. McCluskey. 1995. Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A). Proc. Natl. Acad. Sci. USA 92:875.
8. James, J. A., and J. B. Harley. 1998. A model of peptide-induced lupus autoimmune B cell epitope spreading is strain specific and is not H-2 restricted in mice. J. Immunol. 160:502.
9. Scofield, R. H., W. E. Henry, B. T. Kurien, J. A. James, and J. B. Harley. 1996. Immunization with short peptides from the sequence of the systemic lupus erythematosus-associated 60-kDa Ro autoantigen results in anti-Ro ribonucleoprotein autoimmunity. J. Immunol. 156:4059.
10. Keech, C. L., T. P. Gordon, and J. McCluskey. 1996. The immune response to 52-kDa and 60-kDa Ro is linked in experimental autoimmunity. J. Immunol. 157:3694.
11. Tseng, C. E., E. K. L. Chan, E. Miranda, M. Gross, F. Didonato, and J. P. Buyon. 1997. The 52-kDa protein as a target of intermolecular spreading of the immune response to components of the SS-A/Ro-SS-B/La complex. Arthritis Rheum. 40:936.
12. Fatenejad, S., W. Brooks, A. Schwartz, and J. Craft. 1994. Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target. J. Immunol. 152:5523.
13. Mohan, C., S. Adams, V. Stanik, and S. K. Datta. 1993. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J. Exp. Med. 177:1367.
14. Hudgins, C. C., R. T. Steinberg, D. M. Klinman, M. J. P. Reeves, and A. D. Steinberg. 1985. Studies of consomic mice bearing the Y chromosome of BXSB mouse. J. Immunol. 134:3849.
15. 1 hybrid mice with systemic lupus erythematosus and small coronary artery disease. Am. J. Pathol. 129:477.
16. 1 mouse, a new animal model of idiopathic thrombocytopenic purpura. J. Exp. Med. 167:2017.
17. 1 mice. A model of antiphospholipid syndrome. J. Immunol. 149:1063.
18. Murphy, E. D., and J. B. Roths. 1979. A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum. 22:1188.
19. Thébault, S., D. Gilbert, N. Machour, L. Marvin, C. Lange, F. Tron, and R. Charlionet. 2000. Two-dimensional electrophoresis and mass spectrometry identification of proteins bound by a murine monoclonal anti -cardiolipin antibody: a powerful technique to characterize the cross-reactivity of a single autoantibody. Electrophoresis 21:2531.
20. Alcover, A., F. Ramirez-Lafita, C. Hernandez, A. Nieto, and J. Avila. 1985. Antibodies to vimentin intermediate filaments in sera from patients with SLE and RA: quantification by solid phase radioimmunoassay. J. Rheumatol. 12:233.
21. Senecal, J. L., and J. Rauch. 1988. Hybridoma lupus autoantibodies can bind major cytoskeletal filaments in the absence of DNA-binding activity. Arthritis Rheum. 31:864.
22. Blaschek, M. A., M. Boehme, J. Jouquan, A. M. Simitzis, S. Fifas, P. Le Goff, and P. Youinou. 1988. Relation of antivimentin antibodies to anticardiolipin antibodies in systemic lupus erythematosus. Ann. Rheum. Dis. 47:708.
23. Li, X. Z., L. J. McNeilage, and S. Whittingham. 1989. Autoantibodies to the major nucleolar phosphoprotein B23 define a novel subset of patients with anti-cardiolipin antibodies. Arthritis Rheum. 32:1165.
24. Lin, L., L. Shroyer, A. Walter, T. W. Lyden, A. K. Ng, and N. S. Rote. 1995. Monoclonal IgM antiphosphophatidylserine antibody reacts against cytoskeleton-like structures in cultured human umbilical cord endothelial cells. Am. J. Reprod. Immunol. 33:97.
25. Lindquist, S., and E. A. Craig. 1988. The heat-shock proteins. Annu. Rev. Genet. 22:631.
26. Jarjour, W. N., B. D. Jeffries, J. S. Davis, W. J. Welch, T. Mimura, and J. B. Winfield. 1991. Autoantibodies to human stress proteins: a survey of various rheumatic and other inflammatory diseases. Arthritis Rheum. 34:1133.
27. Pratesi, F., S. Moscato, A. Sabbatini, D. Chimenti, S. Bombardieri, and P. Migliorini. 2000. Autoantibodies specific for α-enolase in systemic autoimmune disorders. J. Rheumatol. 27:109.
28. Bertolaet, B. L., D. J. Clarke, M. Wolff, M. H. Watson, M. Henze, G. Divita, and S. I. Reed. 2001. UBA domains of DNA damage-inducible proteins interact with ubiquitin. Nat. Struct. Biol. 8:417.
29. Skriner, K., W. H. Sommergruber, V. Tremmel, I. Fischer, A. Barta, J. S. Smolen, and G. Steiner. 1997. Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex: differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease. J. Clin. Invest. 100:127.
30. Montecucco, C., R. Caporali, F. Cobianchi, and G. Biamonti. 1996. Identification of autoantibodies to the I protein of the heterogeneous nuclear ribonucleoprotein complex in patients with systemic sclerosis. Arthritis Rheum. 39:1669.
31. Ghetti, A., S. Pinol-Roma, W. M. Michael, C. Morandi, and G. Dreyfuss. 1992. hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res. 20:3671.
32. + B cells to produce lupus autoantibodies in vivo. Eur. J. Immunol. 25:3412.
33. 1 hybrids between SB/Le and NZW mice: predominantly enhanced formation of gp70 immune complexes by a Y chromosome-associated factor from SB/Le mice. J. Immunol. 132:701.
34. Rosen, A., and L. A. Casciola-Rosen. 1999. Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. Cell Death Diff. 6:6.
35. Casciola-Rosen, L. A., F. Andrade, D. Ulanet, W. B. Wong, and A. Rosen. 1999. Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J. Exp. Med. 190:815.
36. Casciola-Rosen, L. A., G. Anhalt, and A. Rosen. 1994. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on cultured keratinocytes. J. Exp. Med. 179:1317.
37. Prasad, S. C., P. J. Thraves, M. R. Kuettel, G. Y. Srinivasarao, A. Dritschilo, and V. A. Soldatenkov. 1998. Apoptosis-associated proteolysis of vimentin in human prostate epithelial tumor cells. Biochem. Biophys. Res. Commun. 249:332.
38. Gensler, T. J., M. Hottelet, C. Zhang, S. Schlossman, P. Anderson, and P. J. Utz. 2001. Monoclonal antibodies derived from BALB/c mice immunized with apoptotic Jurkat T cells recognize known autoantigens. J. Autoimmun. 16:59.
39. Brockstedt, E., A. Rickets, S. Kostka, A. Laubersheimer, B. Dorken, B. Wittmann-Liebold, K. Bommert, and A. Otto. 1998. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line: cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. J. Biol. Chem. 273:28057.
40. Martelli, A. M., I. Robuffo, R. Bortul, R. L. Ochs, F. Luchetti, L. Cocco, M. Zweyer, R. Bareggi, and E. Falcieri. 2000. Behavior of nucleolar proteins during the course of apoptosis in camptothecin-treated HL60 cells. J. Cell. Biochem. 78:264.
41. Poccia, F., P. Piselli, S. Vendetti, S. Bach, A. Amendola, R. Placido, and V. Colizzi. 1996. Heat-shock protein expression on the membrane of T cells undergoing apoptosis. Immunology. 88:6.
42. Utz, P. J., M. Hottelet, P. H. Schur, and P. Anderson. 1997. Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. J. Exp. Med. 185:843.
43. Utz, P. J., M. Hottelet, W. J. van Venrooij, and P. Anderson. 1998. Association of phosphorylated SR proteins and the U1-small nuclear ribonuclear protein autoantigen complex accompanies apoptotic cell death. J. Exp. Med. 187:547.
44. Guillonneau, F., A. L. Guieysse, J. P. Le Caer, J. Rossier, and D. Praseuth. 2001. Selection and identification of proteins bound to DNA triple-helical structures by combination of 2D-electrophoresis and MALDI-TOF mass spectrometry. Nucleic Acids Res. 29:2427.
45. Wang, D., A. Baumann, A. Szebeni, and M. O. Olson. 1994. The nucleic acid binding activity of nucleolar protein B23.1 resides in its carboxyl-terminal end. J. Biol. Chem. 269:30994.
46. Araujo, S. J., and R. D. Wood. 1999. Protein complexes in nucleotide excision repair. Murat. Res. 435:23.
47. Amoura, Z., H. Chabre, S. Koutouzov, C. Lotton, A. Cabrespines, J. F. Bach, and L. Jacob. 1994. Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice. and are present in kidney eluates of lupus mice with proteinuria. Arthritis Rheum. 37:1684.
48. Hirata, D., M. Iwamoto, T. Yoshio, H. Okazaki, J. Masuyama, A. Mimori, and S. Minota. 2000. Nucleolin as the earliest target molecule of autoantibodies produced in MRL/lpr lupus-prone mice. Clin. Immunol. 97:50.
49. van Engeland, M., H. J. Kuijpers, F. C. Ramaekers, C. P. Reutelingsperger, and B. Schutte. 1997. Plasma membrane alterations and cytoskeletal changes in apoptotis. Exp. Cell Res. 235:421.
50. Brard, F., F. Jovelin, S. Petit, F. Tron, and D. Gilbert. 1996. Structural properties and mutation patterns of anti-nucleosome monoclonal antibodies are similar to those of anti-DNA antibodies. Eur. J. Immunol. 26:1587.
51. Bloom, D. D., J.-L. Davignon, P. L. Cohen, R. A. Eisenberg, and S. H. Clarke. 1993. Overlap of the anti-Sm and anti-DNA responses of MRL/Mp-lpr/lpr mice. J. Immunol. 150:1579.