Life cycle heterogeneity in animal models of human papillomavirus-associated disease

Journal of Virology

Volumn 76, Issue 20, 2002, Pages 10401-10416

  Peh, Woei Ling ^a   Middleton, Kate ^a   Christensen, Neil ^a   Nicholls, Philip ^a   Egawa, Kiyofumi ^a   Sotlar, Karl ^a   Brandsma, Janet ^a   Percival, Alan ^a   Lewis, Jon ^a   Liu, Wen Jun ^a   Doorbar, John ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RISK; CELL DIFFERENTIATION; CONDYLOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; EPITHELIUM CELL; GENETIC HETEROGENEITY; GENETIC ORGANIZATION; LIFE CYCLE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN EXPRESSION; VIRUS GENOME; VIRUS INFECTION; WART VIRUS;

ANIMALS; ANTIGENS, VIRAL; BOVINE PAPILLOMAVIRUS 1; CAPSID; CAPSID PROTEINS; COTTONTAIL RABBIT PAPILLOMAVIRUS; DISEASE MODELS, ANIMAL; GENES, VIRAL; HUMANS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; RABBITS; TIME FACTORS; TUMOR VIRUS INFECTIONS; VIRAL STRUCTURAL PROTEINS;

EID: 0036784584     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.20.10401-10416.2002     Document Type: Article

References (109)

1. Alderborn, A., and S. Burnett. 1994. Regulation of DNA synthesis in division-arrested mouse C127 cells permissive for bovine papillomavirus DNA amplification. J. Virol. 68:4349-4357.
2. Ashmole, I., P. H. Gallimore, and S. Roberts. 1998. Identification of conserved hydrophobic C-terminal residues of the human papillomavirus type 1 E1E4 protein necessary for E4 oligomerisation in vivo. Virology 240:221-231.
3. Baker, C. C., and P. M. Howley. 1987. Differential promoter utilization by the bovine papillomavirus in transformed cells and in productively infected wart tissues. EMBO J. 6:1027-1035.
4. Barrera-Oro, J. G., K. O. Smith, and J. L. Melnick. 1962. Quantitation of papova virus particles in human warts. J. Natl. Cancer Inst. 29:583-595.
5. Bell, J. A., J. P. Sundberg, S. J. Ghim, J. Newsome, A. B. Jenson, and R. Schlegel. 1994. A formalin-inactivated vaccine protects against mucosal papillomavirus infection: a canine model. Pathobiology 62:194-198.
6. Bellanger, S., C. Demeret, S. Goyat, and F. Thierry. 2001. Stability of the human papillomavirus type 18 E2 protein is regulated by a proteasome degradation pathway through its amino-terminal transactivation domain. J. Virol. 75:7244-7251.
7. Bishop, P. E., A. McMillan, and S. Fletcher. 1990. An immunohistological study of spontaneous regression of condylomata acuminata. Genitourin. Med. 66:79-81.
8. Bonnez, W. 1998. Murine models of human papillomavirus-infected human xenografts. Papillomavirus Rep. 9:27-38.
9. Bonnez, W., R. C. Rose, C. da Rin, C. Borkhuis, K. L. de Mesy Jensen, and R. C. Reichman. 1993. Propagation of human papillomavirus type 11 in human xenografts using the severe combined immunodeficiency (SCID) mouse and comparison to the nude mouse model. Virology 197:455-458.
10. Bouvard, V., G. Matlashewski, Z. M. Gu, A. Storey, and L. Banks. 1994. The human papillomavirus type 16 E5 gene cooperates with the E7 gene to stimulate proliferation of primary cells and increases viral gene expression. Virology 203:73-80.
11. Brandsma, J. L. 1994. Animal models of human-papillomavirus-associated oncogenesis. Intervirology 37:189-200.
12. Brandsma, J. L., and W. Xiao. 1993. Infectious virus replication in papillomas induced by molecularly cloned cottontail rabbit papillomavirus DNA. J. Virol. 67:567-571.
13. Brandsma, J. L., Z. Yang, S. W. Barthold, and E. A. Johnson. 1991. Use of a rapid, efficient inoculation method to induce papillomas by cottontail rabbit papillomavirus DNA shows that the E7 gene is required. Proc. Natl. Acad. Sci. USA 88:4816-4820.
14. Brandsma, J. L., Z. H. Yang, D. DiMaio, S. W. Barthold, E. Johnson, and W. Xiao. 1992. The putative E5 open reading frame of cottontail rabbit papillomavirus is dispensable for papilloma formation in domestic rabbits. J. Virol. 66:6204-6207.
15. Breitburd, F., and P. Coursaget. 1999. Human papillomavirus vaccines. Semin. Cancer Biol. 9:431-444.
16. Breitburd, F., R. Kirnbauer, N. L. Hubbert, B. Nonnenmacher, C. Trin-Dinh-Desmarquet, G. Orth, J. T. Schiller, and D. R. Lowy. 1995. Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection. J. Virol. 69:3959-3963.
17. Brown, D. R., J. Bryan, M. Rodriguez, R. C. Rose, and D. G. Strike. 1991. Detection of human papillomavirus types 6 and 11 E4 gene products in condylomata acuminatum. J. Med. Virol. 34:20-28.
18. Brown, D. R., J. T. Bryan, L. Pratt, V. Handy, K. H. Fife, and M. H. Stoler. 1995. Human papillomavirus type 11 E1Ê4 and L1 proteins colocalize in the mouse xenograft system at multiple time points. Virology 214:259-263.
19. Brown, D. R., J. T. Bryan, M. Rodriguez, and B. P. Katz. 1992. Factors associated with detection of human papillomvirus E4 and L1 proteins in condylomata acuminata. J. Infect. Dis. 166:512-517.
20. Brown, D. R., L. Fan, J. Jones, and J. Bryan. 1994. Colocalization of human papillomavirus type 11 E1Ê4 and L1 proteins in human foreskin implants grown in athymic mice. Virology 201:46-54.
21. Bryan, J. T., K. H. Fife, and D. R. Brown. 1998. The intracellular expression pattern of the human papillomavirus type 11 E1Ê4 protein correlates with its ability to self associate. Virology 241:49-60.
22. Cancer Research Campaign. 1995. Cancer - world perspectives. Factsheet 22.1. CRC, London, United Kingdom.
23. Chambers, V. C., and C. A. Evans. 1959. Canine oral papillomatosis. I. Virus assay and observations on the various stages of the experimental infection. Cancer Res. 19:1188-1195.
24. Chan, S.-Y., H. Delius, A. L. Halpern, and H.-U. Bernard. 1995. Analysis of genomic sequences of 95 papillomavirus types: Uniting typing, phylogeny and taxonomy. J. Virol. 69:3074-3083.
25. Chow, L. T., and T. R. Broker. 1994. Papillomavirus DNA replication. Intervirology 37:150-158.
26. Chow, L. T., M. Nasseri, S. M. Wolinsky, and T. R. Broker. 1987. Human papillomavirus types 6 and 11 mRNAs from genital condylomata acuminata. J. Virol. 61:2581-2588.
27. Chow, L. T., S. S. Reilly, T. R. Broker, and L. B. Taichman. 1987. Identification and mapping of human papillomavirus type 1 RNA transcripts recovered from plantar warts and infected epithelial cell cultures. J. Virol. 61:1913-1918.
28. Christensen, N. D., N. M. Cladel, C. A. Reed, L. R. Budgeon, P. A. Welsh, S. D. Patrick, and J. W. Kreider. 1996. Laboratory production of infectious stocks of rabbit oral papillomavirus.
29. Christensen, N. D., N. M. Cladel, C. A. Reed, and R. Han. 2000. Rabbit oral papillomavirus complete genome sequence and immunity following genital infection. Virology 269:451-461.
30. Christensen, N. D., and J. W. Kreider. 1990. Antibody-mediated neutralization in vivo of infectious papillomavirus. J. Virol. 64:3151-3156.
31. Chua, K. L., and A. Hjerpe. 1996. Persistence of human papillomavirus (HPV) infections preceding cervical carcinoma. Cancer 77:121-127.
32. Croissant, O., F. Breitburd, and G. Orth. 1985. Specificity of the cytopathic effect of cutaneous human papillomaviruses. Clin. Dermatol. 3:43-55.
33. Defeo-Jones, D., G. A. Vuocolo, K. M. Haskell, M. G. Hanobik, D. M. Kiefer, E. M. McAvoy, M. Iveyhole, J. L. Brandsma, A. Oliff, and R. E. Jones. 1993. Papillomavirus E7 protein-binding to the retinoblastoma protein is not required for viral induction of warts. J. Virol. 67:716-725.
34. Delius, H., M. A. van Ranst, A. B. Jenson, H. zur Hausen, and J. P. Sundberg. 1994. Canine oral papillomavirus genomic sequence: a unique 1.5Kb intervening sequence between the E2 and L2 open reading frames. Virology 204:447-452.
35. Desaintes, C., and C. Demeret. 1996. Control of papillomavirus DNA replication and transcription. Semin. Cancer Biol. 7:339-347.
36. Dollard, S. C., L. T. Chow, J. W. Kreider, T. R. Broker, N. L. Lill, and M. K. Howett. 1989. Characterization of an HPV type 11 isolate propagated in human foreskin implants in nude mice. Virology 171:294-297.
37. Doorbar, J. 1998. Late stages of the papillomavirus life cycle. Papillomavirus Rep. 9:119-123.
38. Doorbar, J., I. Coneron, and P. H. Gallimore. 1989. Sequence divergence yet conserved physical characteristics among the E4 proteins of cutaneous human papillomaviruses. Virology 172:51-62.
39. Doorbar, J., S. Ely, N. Coleman, M. Hibma, D. H. Davies, and L. Crawford. 1992. Epitope mapped monoclonal antibodies against the HPV16 E1Ê4 protein. Virology 187:353-359.
40. Doorbar, J., S. Ely, J. Sterling, C. McLean, and L. Crawford. 1991. Specific interaction between HPV16 E1Ê4 and cytokeratins results in collapse of the epithelial cell intermediate filament network. Nature 352:824-827.
41. Doorbar, J., H. S. Evans, I. Coneron, L. V. Crawford, and P. H. Gallimore. 1988. Analysis of HPV1 E4 gene expression using epitope-defined antibodies. EMBO J. 7:825-833.
42. Doorbar, J., C. Foo, N. Coleman, E. Medcalf, O. Hartley, T. Prospero, S. Napthine, J. Sterling, G. Winter, and H. Griffin. 1997. Characterisation of events during the late stages of HPV16 infection in vivo using high affinity synthetic Fabs to E4. Virology 238:40-52.
43. Doorbar, J., M. Medcalf, and S. Napthine. 1996. Analysis of HPV1 E4 complexes and their association with keratins in vivo. Virology 218:114-126.
44. Doorbar, J., and G. Myers. 1996. The E4 protein, p. 58-80. In G. Myers, H. Delius, J. Icenogel, H.-U. Bernard, C. Baker, A. Halpern, and C. Wheeler (ed.), Human papillomaviruses 1996, vol. III. Los Alamos National Laboratory, Los Alamos, N. Mex.
45. Dostatni, N., M. Yaniv, O. Danos, and R. C. Mulligan. 1988. Use of retroviral vectors for mapping of splice sites in cottontail rabbit papillomavirus. J. Gen. Virol. 69:3093-3100.
46. Egawa, K. 1994. New types of human papillomaviruses and intracytoplasmic inclusion bodies: a classification of inclusion warts according to clinical features, histology and associated HPV types. Br. J. Dermatol. 130:158-166.
47. Egawa, K., Y. Honda, T. Ono, and H. Kitasato. 2000. A case of viral warts with particular fibrillar intracytoplasmic inclusion bodies. Dermatology 200:275-278.
48. Egawa, K., Y. Inaba, K. Yoshimura, and T. Ono. 1993. Varied clinical morphology of HPV-1-induced warts, depending on anatomical factors. Br. J. Dermatol. 128:271-276.
49. Frattini, M. G., and L. A. Laimins. 1994. Binding of the human papillomavirus E1 origin recognition protein is regulated through complex formation with the E2 enhancer-binding protein. Proc. Natl. Acad. Sci. USA 91:12398-12402.
50. Frattini, M. G., H. B. Lim, J. Doorbar, and L. A. Laimins. 1997. Induction of human papillomavirus type 18 late gene expression and genomic amplification in organotypic cultures from transfected DNA templates. J. Virol. 71:7068-7072.
51. Gross, G. E, and R. Barrasso (ed.). 1997. Human papillomavirus infection: a clinical atlas. Ullstein Mosby, Berlin, Germany.
52. Gross, G. E., S. Jablonska, and H. Hugel. 1997. Skin diagnosis. In G. E. Gross and R. Barrasso (ed.), Human papillomavirus infection: a clinical atlas. Ullstein Mosby, Berlin, Germany.
53. Han, R., N. M. Cladel, C. A. Reed, X. Peng, L. R. Budgeon, M. Pickel, and N. D. Christensen. 2000. DNA vaccination prevents and/or delays carcinoma development of papillomavirus-induced skin papillomas on rabbits. J. Virol. 74:9712-9716.
54. Han, R., N. M. Cladel, C. A. Reed, X. Peng, and N. D. Christensen. 1999. Protection of rabbits from viral challenge by gene gun-based intracutaneous vaccination with a combination of cottontail rabbit papillomavirus E1, E2, E6, and E7 genes. J. Virol. 73:7039-7043.
55. Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
56. Harwood, C. A., and C. M. Proby. 2001. Human papillomavirus and immunosuppression, p. 102-117. In J. Sterling and S. K. Tyring (ed.), Human papillomaviruses. Arnold, London, United Kingdom.
57. Ho, G. Y., R. Bierman, L. Beardsley, C. J. Chang, and R. D. Burk. 1998. Natural history of cervicovaginal papillomavirus infection in young women. N. Engl. J. Med. 338:423-428.
58. Howley, P. M., and D. R. Lowy. 2001. Papillomaviruses and their replication, p. 2197-2229. In B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Fields virology, 4th ed. Lippincott Williams and Wilkins, Philadelphia, Pa.
59. Inglis, S. C., and T. O'Neill. 2001. Vaccines, p. 131-138. In J. Sterling and S. K. Tyring (ed.), Human papillomaviruses. Arnold, London, United Kingdom.
60. Keating, J. T., T. Ince, and C. P. Crum. 2001. Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis. Adv. Anat. Pathol. 8:83-92.
61. Klumpp, D. J., and L. A. Laimins. 1999. Differentiation-induced changes in promoter usage for transcripts encoding the human papillomavirus type 31 replication protein E1. Virology 257:239-246.
62. Kreider, J. W., and G. L. Bartlett. 1981. The Shope papilloma-carcinoma complex of rabbits: a model system of neoplastic progression and spontaneous regression. Adv. Cancer Res. 35:81-110.
63. Kreider, J. W., M. K. Howett, E. E. Leure-Dupree, R. J. Zaino, and J. A. Weber. 1987. Laboratory production in vivo of infectious human papillomavirus type 11 from condylomata accuminata. J. Virol. 61:590-593.
64. Laurent, R., J. L. Kienzler, O. Croissant, and G. Orth. 1982. two anatomicoclinical types of warts with plantar localisation: specific cytopathogenic effects of papillomavirus type 1 (HPV1) and type 2 (HPV2). Arch. Dermatol. Res. 274:101-111.
65. Leachman, S. A., R. E. Tigelaar, M. Shlyankevich, M. Slade, M. Irwin, E. Chang, T. C. Wu, W. Xiao, S. Pazhani, D. L. Zelterman, and J. L. Brandsma. 2000. GM-CSF priming plus papillomavirus E6 DNA vaccination: effects on papilloma formation and regression in the CRPV-rabbit model. J. Virol. 74:8700-8708.
66. Lowy, D. R., and P. M. Howley. 2001. Papillomaviruses, p. 2231-2264. In B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Fields virology, 4th ed. Lippincott Williams and Wilkins, Philadelphia, Pa.
67. Maitland, N. J., S. Conway, N. S. Wilkinson, J. Ramsdale, J. R. Morris, C. M. Sanders, J. E. Burns, P. L. Stern, and M. Wells. 1998. Expression patterns of the human papillomavirus type 16 transcription factor E2 in low- and high-grade cervical intraepithelial neoplasia. J. Pathol. 186:275-280.
68. Masterson, P. J., M. A. Stanley, A. P. Lewis, and M. A. Romanos. 1998. A C-terminal helicase domain of the human papillomavirus E1 protein binds E2 and the DNA polymerase alpha-primase p68 subunit. J. Virol. 72:7407-7419.
69. McBride, A. A., A. Dlugosz, and C. C. Baker. 2000. Production of infectious bovine papillomavirus from cloned viral DNA by using an organotypic raft/xenograft technique. Proc. Natl. Acad. Sci. USA 97:5534-5539.
70. Meyers, C., J. Harry, Y. L. Lin, and F. O. Wettstein. 1992. Identification of three transforming proteins encoded by cottontail rabbit papillomavirus. J. Virol. 66:1655-1664.
71. Mitsuishi, T., M. Kawashima, K. Egawa, and S. T. 2001. Novel intracytoplasmic inclusion bodies in human papillomavirus-associated warts. Br. J. Dermatol. 145:171-173.
72. Nasseri, M., C. Hirochika, T. R. Broker, and L. Chow. 1987. A human papillomavirus type 11 transcript encoding an E1Ê4 protein. Virology 159:433-439.
73. Nasseri, M., C. Meyers, and F. O. Wettstein. 1989. Genetic analysis of CRPV pathogenesis: the L1 open reading frame is dispensable for cellular transformation but is required for papilloma formation. Virology 170:321-325.
74. Nicholls, P., J. Doorbar, R. W. Moore, W. Peh, D. Anderson, and M. Stanley. 2001. Detection of Viral DNA and E4 protein in basal keratinocytes of experimental canine oral papillomavirus lesions. Virology 283:82-98.
75. Nicholls, P., B. Klaunberg, R. A. Moore, E. B. Santos, N. R. Parry, G. W. Gough, and M. A. Stanley. 1999. Naturally occurring, nonregressing canine oral papillomavirus infection: host immunity, virus characterization, and experimental infection. Virology 265:365-374.
76. Nicholls, P. K., P. F. Moore, D. M. Anderson, R. A. Moore, N. R. Parry, G. W. Gough, and M. A. Stanley. 2001. Regression of canine oral papillomas is associated with infiltration of CD4+ and CD8+ lymphocytes. Virology 283:31-39.
77. Oriel, J. D. 1971. Natural History of genital warts. Br. J. Vener. Dis. 47:1-13.
78. Ozbun, M. A., and C. Meyers. 1997. Characterisation of late gene transcripts expressed during vegetative replication of human papillomavirus type 31b. J. Virol. 71:5161-5172.
79. Ozbun, M. A., and C. Meyers. 1998. Human papillomavirus type 31b E1 and E2 transcript expression correlates with vegetative viral genome amplification. Virology 248:218-230.
80. Penrose, K. J., and A. A. McBride. 2000. Proteasome-mediated degradation of the papillomavirus E2-TA protein is regulated by phosphorylation and can modulate viral genome copy number. J. Virol. 74:6031-6038.
81. Pfister, H., and H. zur Hansen. 1978. Seroepidemiological studies of human papillomavirus (HPV1) infections. Int. J. Cancer 21:161-165.
82. Pray, T. R., and L. A. Laimins. 1995. Differentiation-dependent expression of E1Ê4 proteins in cell lines maintaining episomes of human papillomavirus type 31b. Virology 206:679-685.
83. Rogel-Gaillard, C., F. Breitburd, and G. Orth. 1992. Human papillomavirus type 1 E4 proteins differing by their N-terminal ends have distinct cellular locations when transiently expressed in vitro. J. Virol. 66:816-823.
84. Rogel-Gaillard, C., G. Pehau-Arnaudet, F. Breitburd, and G. Orth. 1993. Cytopathic effect in human papillomavirus type 1-induced inclusion warts: in vitro analysis of the contribution of two forms of the viral E4 protein. J. Investig. Dermatol. 101:843-851.
85. Ruesch, M. N., F. Stubenrauch, and L. Laimins. 1998. Activation of papillomavirus late gene transcription and genome amplification upon differentiation in semisolid medium is coincident with expression of involucrin and transglutaminase but not keratin-10. J. Virol. 72:5016-5024.
86. Schiller, J. T., and D. R. Lowy. 2001. Papillomavirus-like particle based vaccines: cervical cancer and beyond. Expert Opin. Biol. Ther. 1:571-581.
87. Schwartz, S. 2000. Regulation of human papillomavirus late gene expression. Ups. J. Med. Sci. 105:171-192.
88. Selvakumar, R., L. A. Borenstein, Y. L. Lin, R. Ahmed, and F. O. Wettstein. 1995. Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced papillomas. J. Virol. 69:602-605.
89. Shah, K. V., and P. M. Howley. 1996. Papillomaviruses, p. 2077-2109. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Virology, 3rd ed., vol. 2. Lippincott-Raven, Philadelphia, Pa.
90. Stanley, M. 1998. The immunology of genital human papilloma virus infection. Eur. J. Dermatol. 8:8-12.
91. Stanley, M. A., P. J. Masterson, and P. K. Nicholls. 1997. In vitro and animal models for antiviral therapy in papillomavirus infections. Antivir. Chem. Chemother. 8:381-400.
92. Stanley, M. A., R. A. Moore, P. K. Nicholls, E. B. Santos, L. Thomsen, N. Parry, S. Walcott, and G. Gough. 2001. Intra-epithelial vaccination with COPV L1 DNA by particle-mediated DNA delivery protects against mucosal challenge with infectious COPV in beagle dogs. Vaccine 19:2783-2792.
93. Stern, P. L., M. Brown, S. N. Stacey, H. C. Kitchener, I. Hampson, E. S. Abdel-Hady, and J. V. Moore. 2000. Natural HPV immunity and vaccination strategies. J. Clin. Virol. 19:57-66.
94. Straight, S., P. M. Hinckle, R. J. Jewers, and D. J. McCance. 1993. The E5 oncoprotein of HPV16 transforms fibroblasts and effects the downregulation of the EGF receptor in keratinocytes. J. Virol. 69:4521-4532.
95. Sundaram, P., R. E. Tigelaar, and J. L. Brandsma. 1997. Intracutaneous vaccination of rabbits with the cottontail rabbit papillomavirus (CRPV) L1 gene protects against virus challenge. Vaccine 15:664-671.
96. Suzich, J. A., S. J. Ghim, F. J. Palmer-Hill, W. I. White, J. K. Tamura, J. A. Bell, J. A. Newsome, A. B. Jenson, and R. Schlegel. 1995. Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas. Proc. Natl. Acad. Sci. USA 92:11553-11557.
97. Syrjanen, K. 1998. Anogenital human papilloma virus and the problem of persistence. Eur. J. Dermatol. 8:5-7.
98. Tokita, H., and S. Konishi. 1975. Studies on canine oral papillomatosis. II. Oncogenicity of canine oral papillomavirus to various tissues of dog with special reference to eye tumour. Jpn. J. Vet. Sci. 37:109-120.
99. Valle, G. F., and L. Banks. 1995. The human papillomavirus (HPV)-6 and HPV-16 E5 proteins co-operate with HPV-16 E7 in the transformation of primary rodent cells. J. Gen. Virol. 76:1239-1245.
100. van Belkum, A., L. Juffermans, L. Schrauwen, G. van Doornum, M. Burger, and W. Quint. 1995. Genotyping human papillomavirus type 16 isolates from persistently infected promiscuous individuals and cervical neoplasia patients. J. Clin. Microbiol. 33:2957-2962.
101. Venuti, A., D. Salani, F. Poggiali, V. Manni, and A. Bagnato. 1998. The E5 oncoprotein of human papillomavirus type 16 enhances endothelin-1-induced keratinocyte growth. Virology 248:1-5.
102. Wallin, K. L., F. Wiklund, T. Angstrom, F. Bergman, U. Stendahl, G. Wadell, G. Hallmans, and J. Dillner. 1999. Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer. N. Engl. J. Med. 341:1633-1638.
103. Wettstein, F. O., M. S. Barbosa, and M. Nasseri. 1987. Identification of the major cottontail rabbit papillomavirus late RNA cap site and mapping and quantitation of an E2 and minor E6 coding mRNA in papillomas and carcinomas. Virology 159:321-328.
104. Wright, T. C., R. J. Kurman, and A. Ferenczy. 1994. Precancerous lesions of the cervix, p. 229-277. In R. J. Kurman (ed.), Blaustein's pathology of the female genital tract. Springer-Verlag, New York, N.Y.
105. Wu, X., W. Xiao, and J. L. Brandsma. 1994. Papilloma formation by cottontail rabbit papillomavirus requires E1 and E2 regulatory genes in addition to E6 and E7 transforming genes. J. Virol. 68:6097-6102.
106. Yuan, H., P. A. Estes, Y. Chen, J. Newsome, V. A. Olcese, R. L. Garcea, and R. Schlegel. 2001. Immunization with a pentameric L1 fusion protein protects against papillomavirus infection. J. Virol. 75:7848-7853.
107. Zeltner, R., L. A. Borenstein, F. O. Wettstein, and T. Iftner. 1994. Changes in RNA expression pattern during the malignant progression of cottontail rabbit papillomavirus-induced tumors in rabbits. J. Virol. 68:3620-3630.
108. Zhang, P., M. Nouri, J. Brandsma, T. Iftner, and B. M. Steinberg. 1999. Induction of E6/E7 Expression in cottontail rabbit papillomavirus latency following UV activation. Virology 263:388-394.
109. Zhu, Q.-L., T. F. Smith, E. J. Lefkowitz, L. T. Chow, and T. R. Broker. 1994. Nucleic acid and protein sequence alignments of human and animal papillomaviruses constrained by functional sites. University of Alabama at Birmingham Press, Birmingham.