mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 283, Issue 4 27-4, 2002, Pages

  Tefft, D ^a   Lee, M ^a   Smith, S ^a   Crowe, D L ^a   Bellusci, S ^a,b   Warburton, D ^a,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CNRS   (France)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Differentially binding; Fibroblast growth factor 10 stimulation; Mouse lung epithelial cells; Murine Sprouty2

Indexed keywords

FIBROBLAST GROWTH FACTOR 10; GENE PRODUCT; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIC FACTOR; PROTEIN SPROUTY2; RAF PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CONTROLLED STUDY; ENZYME ACTIVATION; EXPRESSION VECTOR; INHIBITION KINETICS; LUNG ALVEOLUS EPITHELIUM; MESENCHYME; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0036784034     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00372.2001     Document Type: Article

References (18)

1. Sprouty, an intracellular inhibitor of Ras signaling
2. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways
3. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
4. The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
5. Mammalian Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells
6. Signal transduction pathway of human fibroblast growth factor receptor 3
7. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
8. Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation: Identification of a novel translocation domain
9. Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis
10. The ins and outs of fibroblast growth factors
11. Shp2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells
12. Receptor specificity of the fibroblast growth factor family
13. Sprouty is a general inhibitor of receptor tyrosine kinase signalling
14. The SH2 tyrosine phosphatase shp2 is required for mammalian limb development
15. Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis
16. From form to function: Signaling by protein tyrosine phosphatases
17. Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice
18. Evidence for direct interaction between Sprouty and Cbl